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| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | Development of SSR markers from ESTs of gramineous species and their chromosome location on wheat显示文摘407,663 的一个总数表示了小麦,大麦,玉米,米饭,和蜀黍的顺序标签(EST ) ,从 GenBank/dbEST 获得了,被用来寻找简单顺序重复(SSR ) 。10,253 EST-SSRs 的一个总数,说明了 2.52% 所有 EST,被识别。用教材首相 5.0, 1367 EST-SSR 教材对被设计,哪个 715 与高质量被综合。 715 教材对在五庄稼在一样的 PCR 条件,和有效教材对下面在小麦,米饭,玉米,棉花,和大豆上被测试是 500 (69.93%), 383 (53.57%), 452 (63.22%), 357 (49.93%),并且 388 (56.27%)分别地。这显示了在扩及远距离的种类之间的 EST-SSR 标记的高可转移性。另外,有 240 loci 的 139 EST-SSR 教材对在由使用小麦的中国春天 nulli-tetrasomic 线的所有 21 个小麦染色体上是局部性的。 | Linzhi Li Junjun Wang Ying Guo Fangshan Jiang Yunfeng Xu Yingying Wang Haitao Pan Guanzhu Han Ruijun Li Sishen Li | 2008 | Progress in Natural Science:Materials International2008，18，12： | 25 |
| 3 | Two Comparable Earthquakes Produced Greatly Different Coseismic Landslides:The 2015 Gorkha,Nepal and 2008 Wenchuan,China Events显示文摘The 2015 Gorkha Earthquake in Nepal and the 2008 Wenchuan Earthquake in China occurred at the south and southeast margins of the Tibetan Plateau, respectively. Both earthquakes had similar magnitudes of Mw 7.8 and 7.9, caused catastrophic loss of life and damage to property, and generated tens of thousands of landslides. Comparisons of pre- and post-quake satellite images supported by field investigations show that the Gorkha Earthquake triggered at least 2 064 large landslides(defined as covering an area ≥10 000 m^2) over a ~35 600 km^2 region with a volume of(444–584)×10~6(average 509×10~6) m^3 and total area of 44.78×10~6 m^2. In contrast, the Wenchuan Earthquake triggered 25 580 large landslides over a region of ~44 000 km^2 with a volume of(7 128–9 479)×10~6(average 8 219×10~6) m^3 and a total area of about 670.65×10~6 m^2. Several controlling factors including topographic relief, slope steepness, and regional peak ground acceleration(PGA) were investigated to try to explain the great differences between the number, volume and area of the coseismic landslides associated with the two similar earthquakes. We found that the differences primarily arose from an unexpected factor, the dip angle of the seismogenic fault. This discovery should aid understanding the failure mechanisms of quake-triggered landslides, and suggests that more factors should be taken into consideration in estimating coseismic landslide volumes from earthquake magnitudes. | Chong Xu Xiwei Xu Yingying Tian Lingling Shen Qi Yao Xueqiang Huang Junxue Ma Xi Chen Siyuan Ma | 2016 | Journal of Earth Science2016，27，6： | 14 |
| 4 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of the management of high-risk population显示文摘Aim Cerebrovascular disease is the leading cause of death and disability in China,causing a huge burden among patients and their families.Hence,stroke prevention is critical,especially in the high-risk population.Here,we present the evidence-based guideline suitable for the Chinese population.Methods Literature search of PubMed and Cochrane library(from January 1964 to June 2019)was done.After thorough discussion among the writing group members,recommendations were listed and summarised.This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.Results This evidence-based guideline was written in three parts:controlling the risk factors of stroke,utilisation of antiplatelet agents and assessing the risks of first-ever stroke.All recommendations were listed along with the recommending classes and levels of evidence.Conclusions This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China.Controlling related risk factors,appropriately using antiplatelet agents,assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China. | Yilong Wang Shangrong Han Haiqiang Qin Huaguang Zheng Bin Jiang Yong Cao Yuan Gao Ling Guan Qian Jia Yong Jiang Yuming Jiao Shuya Li Yapeng Li Zixiao Li Wei Liu Xiaojuan Ru Dongling Sun Haixin Sun Penglian Wang Tingting Wang Lixia Zong Lei Guo Xuewei Xie Yuming Xu Yuyuan Xu Xiaomeng Yang Yingying Yang Mengyuan Zhou Wenzhi Wang Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 11 |
| 5 | DNA microarray analysis of fluconazole resistance in a laboratory Candida albicans strain显示文摘几机制为获得的 fluconazole (FLC ) 负责在 Candida albicans 的抵抗。在这研究,我们开发了 FLC 抵抗的 C。通过 FLC 易受影响的 C 的连续文化的 albicans 紧张。有 FLC 的禁止的集中的 albicans 紧张。赞美 DNA 微数组分析和即时反向的抄写聚合酶链反应被用来在易受影响的父母紧张和抵抗女儿紧张在 azole 抵抗的获得期间调查基因表示变化。表示基因代表了的差别工作象运输 ers 一样多样(例如 CDR1, PDR17 ) ,麦角固醇生合成(例如 ERG2, ERG9 ) ,甾醇新陈代谢(例如 ARE2, IPF6464 ) ,精力新陈代谢(例如 ADH3, AOX2 ) 并且抄写因素(例如 FCR1, ECM22 ) 。功能的分析表明膜运输 ers 的那项精力依赖者流出活动增加了,那个麦角固醇内容作为与易受影响的紧张相比在抵抗紧张与甾醇中介的累积减少了。我们发现在导致了 Tac1 的活动过度的抄写因素 TAC1 的一个点变化(N977K ) 能是原因为在在抵抗紧张的 CDR1, CDR2,和 PDR17 的表示上。而且,在导致的 ERG3 的单个氨基酸差别(D19E ) 在里面 Erg3 的激活能在这抵抗紧张在麦角固醇生合成基因的表示说明两甾醇先锋累积和变化。这些调查结果在临床的 C 扩展 FLC 抵抗的潜在的新奇分子的目标的理解。albicans 孤立。 | Lan Yan Jundong Zhang Miaohai Li Yongbing Cao Zheng Xu Yingying Cao Pinghui Gao Yan Wang Yuanying Jiang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 11 |
| 6 | Detailed Inventory Mapping and Spatial Analyses to Landslides Induced by the 2013 Ms 6.6 Minxian Earthquake of China显示文摘On July 22, 2013, an earthquake(Ms 6.6) occurred in Minxian, Gansu Province of China, causing a large number of landslides. Based on high resolution remote sensing images before and after this event, we made the visual interpretation to these coseismic landslides, and prepared a detailed inventory.The inventory registers totally 6 478 landslides in the study area. Of them, 3 322 landslides are larger than 100 m^2. Based on 5 m resolution DEM, these landslides were used to perform spatial analyses using landslide number density(LND) and landslide area percentage(LAP). The results show that the highest LND and LAP values are in the elevation range of 2 300–2 500 m and steeper slopes. Slopes facing E, SE, S and SW directions, slopes with larger absolute curvature values, ridges, scopes of gravel beds of Late Pleistocene(Qp) and the VIII-degree seismic intensity are more prone to sliding with high LND and LAP values. The largest LND and LAP values are in the scopes of 0.08 and 0.24 g, respectively. According to landslide distribution, we infer that F2-2 branch of Lintan-Dangchang fault is the seismogenic fault. With the increasing distances to this branch fault and drainages, LND and LAP values tend to decrease. | Yingying Tian Chong Xu Xiwei Xu Jian Chen | 2016 | Journal of Earth Science2016，27，6： | 10 |
| 7 | Hierarchical construction of CNT networks in aramid papers for high-efficiency microwave absorption显示文摘Carbon nanotubes(CNTs)incorporated polymeric composites have been extensively investigated for microwave absorption at target frequencies to meet the requirement of radar cross-section reduction.In this work,a strategy of efficient utilization of CNT in producing CNT incorporated aramid papers is demonstrated.The layer-by-layer self-assembly technique is used to coat the surfaces of meta-aramid fibers and fibrils with CNT,providing novel raw materials available for the large-scale papermaking.The hierarchical construction of CNT networks resolves the dilemma of increasing CNT content and avoiding the agglomeration of CNT,which is a frequent challenge for CNT incorporated polymeric composites.The composite paper,which contains abundant heterogeneous interfaces and long-range conductive networks,is capable of reaching a high permittivity and dielectric loss tangent at a low CNT loading,its complex permittivity is,so far,adjustable in the range of(1.20−j0.05)to(25.17−j18.89)at 10 GHz.Some papers with optimal matching thicknesses achieve a high-efficiency microwave absorption with a reflection loss lower than−10 dB in the entire X-band. | You Wu Li Chen Yixuan Han Panbo Liu Haihong Xu Guanze Yu Yingying Wang Tao Wen Wenbo Ju Junwei Gu | 2023 | Nano Research2023，16，5： | 9 |
| 8 | Enantioselective separation and zebrafish embryo toxicity of insecticide beta-cypermethrin显示文摘Enantioselectivity of chiral pollutants is receiving growing concern due to the difference in toxicology and environment fate between enantiomers.In this study,enantiomers of insecticide beta-cypermethrin (beta-CP) were separated on selected chiral column by HPLC,and the toxicity of enantiomers was evaluated using the zebrafish embryo-larval assays.The enantiomers of beta-CP were baseline separated on Chiralcel OD and Chiralpak AD columns and detected by circular dichroism (CD) at 236 nm.Better separation could be achieved at lower temperature (e.g.,20°C) and with lower levels of polar modifiers.Pure enantiomers were obtained on Chiralcel OD.The CD spectra of enantiomers were recorded.By comparing the elution order with a previous similar study,the absolute configuration of beta-CP enantiomers was determined.The individual enantiomers were used in zebrafish embryo test,and the results showed that beta-CP enantioselectively induced yolk sac edema,pericardial edema and crooked body.The 1R-cis-αS and 1R-trans-αS enantiomers showed strong developmental toxicities at concentration of 0.1 mg/L,while the 1S-cis-αR and 1S-trans-αR induced no malformations at higher concentration (e.g.,0.3 mg/L).The results suggest that the enantioselective toxicological effects of beta-CP should be considered when evaluating its ecotoxicological effects. | Chao Xu,Wenqing Tu,Chun Lou,Yingying Hong,Meirong Zhao Research Center of Environmental Science,College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou 310032,China. | 2010 | Journal of Environmental Sciences2010，22，5： | 8 |
| 9 | FAM19A4 is a novel cytokine ligand of formyl peptide receptor I (FPR 1) and is able to promote the migration and phagocytosis of macrophages显示文摘FAM19A4 是为有顺序类似 19 的家庭的缩写(chemokine (C-C 主题)-like) 成员 A4,它能分泌的蛋白质在正常纸巾在底层被表示。坚定的 FAM19A4 遗体的生物功能,和它的潜在的受体是 unclarified。在这研究,我们证明 FAM19A4 是古典能分泌的蛋白质,我们第一次证实它的成熟蛋白质由 95 氨基酸组成。我们发现这新奇 cytokine 的表示是 upregulated 在里面 lipopolysaccharide (LPS ) 刺激了单核白血球和巨噬细胞并且典型地在极化的 M1。FAM19A4 在巨噬细胞上显示出趋化性的活动并且随蛋白质 kinase B (Akt ) 的 phosphorylation 的显著增加在 vitro 并且在 vivo 提高 zymosan 的巨噬细胞吞噬作用。FAM19A4 能也在 zymosan 刺激之上增加反应的氧种类(ROS ) 的版本。基于受体成为主观,收音机 ligand 绑定试金和受体阻塞,而且,我们第一次证明 FAM19A4 是甲酰肽受体 1 的新奇 ligand (FPR1 ) 。上述数据显示在煽动性的刺激之上, monocyte/macrophage-derived FAM19A4 可以在病原的感染期间在巨噬细胞的移植和激活起一个关键作用。 | Wenyan Wang Ting Li Xiaolin Wang Wanxiong Yuan Yingying Cheng Heyu Zhang Enquan Xu Yingmei Zhang Shuang Shi Dalong Ma Wenling Han | 2015 | Cellular & Molecular Immunology2015，12，5： | 8 |
| 10 | Inventory and Spatial Distribution of Landslides Triggered by the 8th August 2017 M_W 6.5 Jiuzhaigou Earthquake, China显示文摘An accurate and detailed seismic landslide inventory is essential to better understand the landslide mechanism and susceptibility. The 8 th August 2017 MW 6.5 Jiuzhaigou Earthquake of China initiated a large number of coseismic landslides. The results of the post-seismic survey show the actual landslide number might be underestimated in previous publications. Coupled with field investigation and visual interpretation on high-resolution remote sensing images before and after the main shock, we established a detailed inventory of landslides triggered by the earthquake. Results show that this event caused at least 4 834 individual landslides with a total area of 9.64 km^2. They are concentrated in an elliptical area of 434 km^2, dominated by medium-and small-scale rock falls and debris slides. Statistics indicate that, except for slope aspect that seems not significantly correlated with the landsliding, these landslides are most common in the places with following features: elevation of 2 800–3 400 m, slope angle greater than 30o, slope positions of upper, middle and flat slopes, and Carboniferous limestone and dolomite. Besides, the landslide area percentage(LAP) and landslide number density(LND) values decrease with the increasing distance to river channels and roads, implying a positive correlation. Instead of centering around the epicenter, most of these coseismic landslides are distributed along the inferred seismogenic fault, which means that the seismogenic structure played a more important role than the location of the epicenter. Remarkable differences in landslide densities along the fault indicate the varied landslide susceptibility which may be attributed to other varied controls along the fault such as the rock mass strength. In sum, this study presents a more detailed inventory of the landslides triggered by the 2017 MW 6.5 Jiuzhaigou Earthquake, describes their distribution pattern and analyzes its control factors, which would be helpful to understand the genesis of the coseismic landslides and further study their long-term impact on the environment of the affected area. | Yingying Tian Chong Xu Siyuan Ma Xiwei Xu Shiyuan Wang He Zhang | 2019 | Journal of Earth Science2019，30，1： | 7 |
| 11 | A Comparison Study of Working Memory Deficits between Patients with Methamphetamine-Associated Psychosis and Patients with Schizophrenia显示文摘 | Hong GAN Zhenhua SONG Peiwei XU Hang SU Yingying PAN Min ZHAO Dengtang LIU | 2018 | 上海精神医学2018，30，3： | 6 |
| 12 | Measurement and Analysis of Formation Conditions of Dew in Carex lasiocarpa Marsh显示文摘In order to investigate the dew amounts and analysis formation conditions of dew by examining the correlations between dew amounts and meteorological factors in Carex lasiocarpa marsh in the Sanjiang Plain,the dew amounts and several meteorological factors were monitored during the growing season from June to September in 2005 and 2008 at the Sanjiang Mire Wetland Experimental Station,Chinese Academy of Sciences.Dew was collected by woodstick made by poplar tree in Carex lasiocarpa marsh and the amounts were estimated by subtraction method.The results indicated that average daily accumulated dew amounts reached the peak in August.The highest dew amounts in Carex lasiocarpa marsh were 0.201 mm/d,and the most frequent dew volume ranged from 0.08 mm/d to 0.14 mm/d.The amounts correlated positively with relative humidity,dew point temperature,and water vapor pressure.Whereas it correlated negatively with wind speed.The dew production in Carex lasiocarpa marsh more frequently occurred under the conditions of wind speed around 2.0 m/s,the water vapor pressure above 9 hPa;the relative humidity between 90% and 95% and dew point temperature above 6 ℃. | XU Yingying YAN Baixing GUO Yuedong | 2009 | 湿地科学2009，7，2： | 6 |
| 13 | Geochemical characteristics of the Permian Changxing Formation reef dolomites,northeastern Sichuan Basin,China显示文摘The recent discovery of deep and ultra-deep gas reservoirs in the Permian Changxing Formation reefs, northeastern Sichuan Basin is a significant development in marine carbonate oil & gas exploration in China. Reef dolomites and their origins have been major research topics for sedimentologists and oil & gas geologists. The petrography, trace element and isotope geochemistry of the reef dolomites indicated that the dolomites are characterized by low Sr and Mn contents, relatively low Fe contents, very similar δ 13 C and δ 18 O values and very different 87 Sr/ 86 Sr ratios. Although the calculated results of the fluid mixing suggested that a mixture with 85%-95% meteoric water and 5%-15% seawater seemed to be the dolomitizing fluids of the reef dolomites, the low Mn contents, relatively low Fe contents, high δ 13 C values and high homogenization temperatures of the dolomites did not support that there were large proportions of meteoric water in the dolomitization process, and the 87 Sr/ 86 Sr ratios which were close to coeval seawater also did not support the possibility of the mixture of deep-burial circulated fluids from clastic rocks. High temperature deep-burial circulated seawater with low Mn and Fe contents, high Sr content and high δ 13 C values from the dissolution of widely distributed Triassic evaporites during the burial diagenetic processes (including dehydration of water-bearing evaporites) could have been the dolomitizing fluids of the reef dolomites. | Hu Zuowei Huang Sijing Li Zhiming Zhang Yingying Xu Ershe Qi Shichao | 2013 | Petroleum Science2013，10，1： | 6 |
| 14 | Application of Stable Isotope Tracing Technologies in Identification of Transformation among Waters in Sanjiang Plain,Northeast China显示文摘In order to investigate the transformation among the precipitation,groundwater,and surface water in the Sanjiang Plain,Northeast China,precipitation and groundwater samples which were collected at the meteorological station of the Sanjiang Mire Wetland Experimental Station,Chinese Academy of Sciences and the surface water which collected from the Wolulan River were used to identify the transformation of three types of water.The isotope composition of different kinds of water sources were analyzed via stable isotope(deuterium and oxygen-18) investigation of natural water.The results show a clear seasonal difference in the stable isotopes in precipitation.During the cold half-year,the mean stable isotope in precipitation in the Sanjiang Plain reaches its minimum with the minimum temperature.The δ18O and δD values are high in the rainy season.In the Wolulan River,the evaporation is the highest in August and September.The volume of evaporation and the replenishment to the river is mostly same.The groundwater is recharged more by the direct infiltration of precipitation than by the river flow.The results of this study indicate that the water bodies in the Sanjiang Plain have close hydrologic relationships,and that the transformation among each water system frequently occurs. | XU Yingying YAN Baixing LUAN Zhaoqing ZHU Hui WANG Lixia | 2013 | Chinese Geographical Science2013，23，4： | 6 |
| 15 | Transformers in computational visual media:A survey显示文摘Transformers,the dominant architecture for natural language processing,have also recently attracted much attention from computational visual media researchers due to their capacity for long-range representation and high performance.Transformers are sequence-to-sequence models,which use a selfattention mechanism rather than the RNN sequential structure.Thus,such models can be trained in parallel and can represent global information.This study comprehensively surveys recent visual transformer works.We categorize them according to task scenario:backbone design,high-level vision,low-level vision and generation,and multimodal learning.Their key ideas are also analyzed.Differing from previous surveys,we mainly focus on visual transformer methods in low-level vision and generation.The latest works on backbone design are also reviewed in detail.For ease of understanding,we precisely describe the main contributions of the latest works in the form of tables.As well as giving quantitative comparisons,we also present image results for low-level vision and generation tasks.Computational costs and source code links for various important works are also given in this survey to assist further development. | Yifan Xu Huapeng Wei Minxuan Lin Yingying Deng Kekai Sheng Mengdan Zhang Fan Tang Weiming Dong Feiyue Huang Changsheng Xu | 2022 | Computational Visual Media2022，8，1： | 6 |
| 16 | Hydrothermal Self-assembly Synthesis of Mn3O4Reduced Graphene Oxide Hydrogel and Its High Electrochemical Performance for Supercapacitors显示文摘在现在的工作 Mn3O4/reduced graphene 氧化物 hydrogel (Mn3O4-rGOH ) 与三维(3D ) 网络被制作由一热水自己组装线路。同样获得的样品的形态学,作文,和微观结构用粉末X光检查衍射( XRD )被描绘,X光检查光电子光谱学( XPS ), thermogravimetry 分析( TG ),原子吸收 spectrometry ( AAS ),回答扫描电子显微镜学( FESEM )和传播电子显微镜( TEM )的排放。而且,电气化学的行为被周期的 voltammogram (CV ) 评估, galvanostatic 费用分泌物和电气化学的阻抗光谱学(EIS ) 。测试结果显示有 6.9% Mn3O4 的 hydrogel 完成了 148 F | Li Li Zhongai Hu Yuying Yang Pengju Liang Ailian Lu Huan Xu Yingying Hu Hongying Wu | 2013 | Chinese Journal of Chemistry2013，31，10： | 6 |
| 17 | Dispersion stability of thermal nanofluids显示文摘Thermal nanofluids, the engineered fluids with dispersed functional nanoparticles, have exhibited extraordinary thermophysical properties and added functionalities, and thus have enabled a broad range of important applications. The poor dispersion stability of thermal nanofluids, however, has been considered as a longexisting issue that limits their further development and practical application. This review overviews the recent efforts and progresses in improving the dispersion stability of thermal nanofluids such as mechanistic understanding of dispersion behavior of nanofluids, examples of both water-based and oil-based nanofluids,strategies to stabilize nanofluids, and characterization techniques for dispersion behavior of nanofluids. Finally,on-going research needs, and possible solutions to research challenges and future research directions in exploring stably dispersed thermal nanofluids are discussed. | Fan Yu Yingying Chen Xingbo Liang Jiale Xu Chiahsun Lee Qi Liang Peng Tao Tao Deng | 2017 | Progress in Natural Science:Materials International2017，27，5： | 5 |
| 18 | A Plant Lectin Receptor-like Kinase Phosphorylates the Bacterial Effector AvrPtoB to Dampen Its Virulence in Arabidopsis显示文摘Plasma membrane-localized receptor-like kinases(RLKs)perceive conserved pathogen-associated molecular pattems(PAMPs)in plants,leading to PAMP-triggered immunity(PTI).TheArabidopsis thaliana lectin RLK LecRK-Ⅸ.2 has been shown to regulate the bacterial flagellin-derived peptide flg22-induced PTI.Here,we discover that Pseudomonas syringae effector AvrPtoB targets LecRK-Ⅸ.2 for degradation,which subsequently suppresses LecRK-Ⅸ.2-mediated PTI and disease resistance.However,LecRK-Ⅸ.2 can interact with and phosphorylate AvrPtoB at serine site 335(S335).AvrPtoB self-associates in vitro and in vivo,and the association appears to be essential for its E3 ligase activity in ubiquitinating substrate in plants.Phosphorylation of S335 disrupts the self-association and as a result,phosphomimetic AvrPtoBS335D cannot ubiquitinate LecRK-Ⅸ.2 efficiently,leading to the compromised virulence of AvrPtoB in suppressing PTI responses.fig22 enhances AvrPtoB S335 phosphorylation by inducing the expression and activating of LecRK-Ⅸ.2.Our study demonstrates that host RLKs can modify pathogen effectors to dampen their virulence and undermine their ability in suppressing PTI. | Ning Xu Xuming Luo Wei Wu Yingying Xing Yingbo Liang Yanzhi Liu Huasong Zou Hai-Lei Wei Jun Liu | 2020 | Molecular Plant2020，13，10： | 5 |
| 19 | High-density genetic map construction and identification of loci controlling flower-type traits in Chrysanthemum(Chrysanthemum×morifolium Ramat.)显示文摘Flower type is an important and extremely complicated trait of chrysanthemum.The corolla tube merged degree(CTMD)and the relative number of ray florets(RNRF)are the two key factors affecting chrysanthemum flower type.However,few reports have clarified the inheritance of these two complex traits,which limits directed breeding for flower-type improvement.In this study,305 F1 hybrids were obtained from two parents with obvious differences in CTMD and RNRF performance.Using specific-locus amplified fragment sequencing(SLAF-seq)technology,we constructed a high-density genetic linkage map with an average map distance of 0.76 cM.Three major QTLs controlling CTMD and four major QTLs underlying RNRF were repeatedly detected in the 2 years.Moreover,the synteny between the genetic map and other Compositae species was investigated,and weak collinearity was observed.In QTL regions with a high degree of genomic collinearity,eight annotated genes were probed in the Helianthus annuus L.and Lactuca sativa L.var.ramosa Hort.genomes.Furthermore,20 and 11 unigenes were identified via BLAST searches between the SNP markers of the QTL regions and the C.vestitum and C.lavandulifolium transcriptomes,respectively.These results lay a foundation for molecular marker-assisted breeding and candidate gene exploration in chrysanthemum without a reference assembly. | Xuebin Song Yuhui Xu Kang Gao Guangxun Fan Fan Zhang Chengyan Deng Silan Dai He Huang Huaigen Xin Yingying Li | 2020 | Horticulture Research2020，7，1： | 5 |
| 20 | LRIF1 interacts with HPla to coordinate accurate chromosome segregation during mitosis显示文摘Heterochromatin protein 1α (HP1α)regulates chromatin specification and plasticity during cell fate decision.Different structural determinants account for HP1α Localization and function during cell division cycle.Our earlier study showed that centromeric Localization of HP1α depends on the epigenetic mark H3K9me3 in interphase,while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors.Here,we identified a PXVXL-containing protein,Ligand-dependent nuclear receptorinteracting factor 1 (LRIF1),which recruits HPla to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis.LRIF1 interacts directly with HPla chromoshadow domain via an evolutionariLy conserved PXVXL motif within its C-terminus.Importantly,the LRIF1-HPla interaction is critical for Aurora B activity in the inner centromere.Mutation of PXVXL motif of LRIF1 Leads to defects in HPla centromere targeting and aberrant chromosome segregation.These findings reveal a previously unrecognized direct Link between LRIF1 and HP1α in centromere plasticity control and illustrate the critical role of LRIF1-HP1α interaction in orchestrating accurate cell division. | Saima Akram Fengrui Yang Junying Li Gregory Adams Yingying Liu Xiaoxuan Zhuang Lingluo Chu Xu Liu Nerimah Emmett Winston Thompson McKay Mullen Saravana Muthusamy Wenwen Wang Fei Mo Xing Liu | 2018 | Journal of Molecular Cell Biology2018，10，6： | 5 |
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