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| 1 | Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance显示文摘AIM To investigate the hepatitis C virus(HCV)infection in the tissues of carcinoma ofextrahepatic bile duct and study theircorrelation.METHODS HCV NS5 protein and HCV RNA weredetected by labeled streptavidin biotin(LSAB)method and in situ reverse transcriptionpolymerase chain reaction(IS-RT-PCR)insections of 51 cases of carcinoma ofextrahepatic bile duct and 34 cases of controlgroup(without malignant biliary disease).RESULTS In 51 cases of carcinoma ofextrahepatic bile duct,HCV NS5 protein wasdetected in 14(27.5%),which was clearlystained in the cytoplasm of cancer cell but not inthe nucleus or cell membrane.HCV RNA wasdetected in 18(35.4%),which was located inthe nucleus of cancer cell in 12 cases and in thecytoplasm in 6 cases.HCV NS5 protein and RNAcoexistence was found in 2 cases.In 34 cases ofcontrol group,HCV RNA was detected in 2(5.9%).HCV NS5 protein and RNA positive cellswere found either scattered or in clusters.CONCLUSION The prevalence of hepatitis C viral infection in the tissues of carcinoma ofextrahepatic bile duct was significantly higherthan in control group(X^2=9.808,P=0.002).The findings suggest a correlation between HCVinfection and carcinoma of extrahepatic bileduct,which is different from the traditionalviewpoint.HCV infection might be involved inthe development of carcinoma of extrahepaticbile duct. | Ming Yi Chen Zhi Qiang Huang Le Zhen Chen Ya Bing Gao Rui Yun Peng De Wen Wang | 2000 | World Journal of Gastroenterology2000，6，6： | 19 |
| 2 | In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine显示文摘Berberrubine (BRB ) 是在 vivo 比 BBR 显示出更强壮的葡萄糖阴沉的效果的 berberine (BBR ) 的主要代谢物。在另一方面, BRB 快速并且广泛地被使产生代射变化进 berberrubine-9-O -- 在在口头的管理以后的老鼠的 D-glucuronide (BRBG ) 。在这研究,我们在老鼠比较了 BRB 和 BRBG 的 pharmacokinetic 性质,并且探索了位于他们的葡萄糖阴沉的活动下面的机制。有导致 HFD 的多糖症的 C57BL/6 老鼠被管理 BRB (50 mg 吗?? | Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 9 |
| 3 | Serum uric acid as an index of impaired renal function in congestive heart failure显示文摘BackgroundHyperuricemia 经常是在有心失败的病人的现在。许多病理学的条件例如织物局部缺血,肾的功能缺陷,心脏的功能缺陷,新陈代谢的症候群,和煽动性的地位,可以影响尿酸(UA ) 新陈代谢。这研究是回顾地在心 failure.MethodsWe 估计他们的潜在的关系到 UA 新陈代谢估计的临床的特征, echocardiological ,肾,与充血的心失败在随机选择的成年人的一个大队在心血管的疾病和 UA 新陈代谢根据他们的参与的以前的证据选择的新陈代谢、煽动性的变量( n = 553 )。由索引聚类,那些变量用因素 analysis.ResultsIn 因素分析被探索,尿酸(SUA ) 形成了的浆液包括了浆液 creatinine (SCr ) 和血脲氮(甜面包) 的肾的功能的变量的主要的簇的部分。在有充血的心失败的病人的变量之间的 Univariate 关联系数证明为 SUA 的最强壮的关联与甜面包(r = 0.48, P <0.001 ) 并且 SCr (r = 0.47, P <0.001 ).ConclusionsThere 是在 SUA 层次和在有充血的心失败的病人的肾的功能的措施之间的一种反的关系。在 SUA 和 SCr 和甜面包层次之间的强壮的关联建议提高的 SUA 集中在心失败反映肾的功能的一个缺陷。 | Yu Tian Ying Chen Bao Deng Gang Liu Zhen-Guo Ji Qing-Zhen Zhao Yu-Zhi Zhen Yan-Qiu Gao Li Tian Le Wang Li-Shuang Ji Guo-Ping Ma Kun-Shen Liu Chao Liu | 2012 | Journal of Geriatric Cardiology2012，9，2： | 9 |
| 4 | Relationship between lipidslevelsand right ventricular volume overload in congestive heart failure显示文摘在类脂化合物和冠的动脉疾病之间的 BackgroundThe 关系很好被建立了。然而,这在类脂化合物和心失败之间不是事实。讽刺地,高类脂化合物层次充分在心失败与更好的结果被联系,但是位于现象下面的机制不是理解。这研究被执行到由于静脉的拥挤减少了肠的类脂化合物吸收的假设可以导致的测试低类脂化合物 levels.MethodsWe 与充血的心失败在 442 个 unselected 病人收集了临床的特征, echocardiograph,和类脂化合物侧面的数据。在类脂化合物层次之间的关联[包括的全部的胆固醇( TCL ),高密度的脂蛋白胆固醇(高级数据链路控制),低密度的脂蛋白胆固醇( LDL-C ),和 triglycerides ( TG )]并且正确的室结束心脏舒张的直径( RVEDD ),左室结束心脏舒张的直径( LVEDD ),正确中庭直径( RA ),左中庭直径( LA ),或左室喷射部分( LVEF )用皮尔森关联和部分关联被分析。RVEDD, LVEDD, RA,和 LA 被索引到身体表面 area.ResultsThere 是在 TCL 层次和 RVEDD 之间的显著地反的关联(r =− 0.34, P <0.001 ) 并且 RA (r =− 0.36, P <0.001 ) 。象 LDL-C,高级数据链路控制,和 TG 那样的另外的类脂化合物与 RVEDD 和 RA 有类似的反的关联。在好久调整以后未改变的仍然是的所有这些关联,性,吸烟地位,物理活动层次, comorbidities,和药 use.ConclusionsLipid 层次相反地与充血的心失败在病人被相关到 RVEDD;然而,因为这是观察研究,进一步的调查被需要验证我们的结果以及如果有的话识别一种原因的关系。 | Ying CHEN Xiao-Mei HE Hong MENG Qing-Zhen ZHAO Yu-Zhi ZHEN Li TIAN Le WANG Li-Shuang JI Guo-Ping MA Yu TIAN Gang LIU Zhen-Guo JI Kun-Shen LIU Chao LIU | 2014 | Journal of Geriatric Cardiology2014，11，3： | 3 |
| 5 | Cobalt and nitrogen codoped porous carbon as superior bifunctional electrocatalyst for oxygen reduction and hydrogen evolution reaction in alkaline medium显示文摘Cobalt and nitrogen codoped carbon materials(Co-N-C) were fabricated by pyrolysis of the mixture of poly(4-vinylpyridine) and cobalt chloride using SiO_2 nanoparticles as hard template, which were the first transition metal/nitrogen-codoped carbon bifunctional electrocatalyst derived from noncarbonizable polymer for ORR and HER. The as-made Co-N-C possessed hierarchical pore structure and high specific surface area, achieving excellent electrocatalytic performances for ORR and HER. Its ORR catalytic performances were comparable to those of Pt/C catalyst and its HER catalytic performances were superior to those of most doped carbon catalysts in KOH electrolyte. Moreover, its bifunctional electrocatalytic performances for ORR and HER were better than those of most bifunctional doped carbon catalysts in alkaline electrolyte. | Xiaoxia Chen Xiangjun Zhen Hongyu Gong Le Li Jianwei Xiao Zhi Xu Deyue Yan Guyu Xiao Ruizhi Yang | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 6 | [Bmim]Br_3 as a New Reagent for Regioselective Mono-bromination of Activated Aromatics under Solvent-free Conditions显示文摘Reaction of activated aromatics containing phenols, naphthol, methoxynaphthalenes, anisole etc. with 1-butyl-3-methylimidazolium tribromide ([Bmim]Br3) under solvent-free conditions, selectively gave the corresponding monobromination products with excellent yields. | Zhang Gao LE Zhen Chu CHEN Yi HU Qin Guo ZHENG | 2005 | Chinese Chemical Letters2005，16，8： | 2 |
| 7 | Contribution of Temperature Increase to Restrain the Transmission of COVID-19显示文摘The COVID-19 outbreak has already become a global pandemic and containing this rapid worldwide transmission is of great challenge.The impacts of temperature and humidity on the COVID-19 transmission rate are still under discussion.Here,we elucidated these relationships by utilizing two unique scenarios,repeated measurement and natural experiment,using the COVID-19 cases reported from January 23–February 21,2020,in China.The modeling results revealed that higher temperature was most strongly associated with decreased COVID-19 transmission at a lag time of 8 days.Relative humidity(RH)appeared to have only a slight effect.These findings were verified by assessing SARSCoV-2 infectivity under the relevant conditions of temperature(4C–37C)and RH(>40%).We concluded that temperature increase made an important,but not determined,contribution to restrain the COVID19 outbreak in China.It suggests that the emphasis of other effective controlling polices should be strictly implemented to restrain COVID19 transmission in cold seasons. | Mengyuan Ren Rongjuan Pei Bahabaike Jiangtulu Junxi Chen Tao Xue Guofeng Shen Xiaoru Yuan Kexin Li Changxin Lan Zhen Chen Xinwen Chen Yun Wang Xiaoqian Jia Zewu Li Audil Rashid Tippawan Prapamontol Xiuge Zhao Zhaomin Dong Yali Zhang Le Zhang Rongwei Ye Zhiwen Li Wuxiang Guan Bin Wang | 2021 | The Innovation2021，2，1： | 2 |
| 8 | GmPIN1-mediated auxin asymmetry regulates leaf petiole angle and plant architecture in soybean显示文摘Crop breeding during the Green Revolution resulted in high yields largely due to the creation of plants with semi-dwarf architectures that could tolerate high-density planting.Although semi-dwarf varieties have been developed in rice,wheat and maize,none was reported in soybean(Glycine max),and few genes controlling plant architecture have been characterized in soybean.Here,we demonstrate that the auxin efflux transporter PINFORMED1(GmPIN1),which determines polar auxin transport,regulates the leaf petiole angle in soybean.CRISPR-Cas9-induced Gmpin1abc and Gmpin1bc multiple mutants displayed a compact architecture with a smaller petiole angle than wildtype plants.GmPIN1 transcripts and auxin were distributed asymmetrically in the petiole base,with high levels of GmPIN1a/c transcript and auxin in the lower cells,which resulted in asymmetric cell expansion.By contrast,the(iso)flavonoid content was greater in the upper petiole cells than in the lower cells.Our results suggest that(iso)flavonoids inhibit GmPIN1a/c expression to regulate the petiole angle.Overall,our study demonstrates that a signal cascade that integrates(iso)flavonoid biosynthesis,GmPIN1a/c expression,auxin accumulation,and cell expansion in an asymmetric manner creates a desirable petiole curvature in soybean.This study provides a genetic resource for improving soybean plant architecture. | Zhongqin Zhang Le Gao Meiyu Ke Zhen Gao Tianli Tu Laimei Huang Jiaomei Chen Yuefeng Guan Xi Huang Xu Chen | 2022 | Journal of Integrative Plant Biology2022，64，7： | 1 |
| 9 | Study on instability fracture and simulation of surrounding rock induced by fault activation under mining influence显示文摘The fault is potentially vulnerability's geological structure in the working face and its vicinity,and it is also a crucial geological factor affecting coal mine safety exploitation.To investigate the unstable failure of surrounding rock induced by fault activation under the influence of adoption,which was studied utilizing field case and numerical analysis for the deformation and failure process of surrounding rock near the fault-affected zone.Combined with field cases,this paper analyzes disturbance stress and roof abscission layer monitoring in effecting zones of fault activation.Using the discrete element 3DEC numerical analysis method,the model of surrounding rock unstable fracture induced by fault activation under adoption is established.The unstable fracture and stress variation characteristics of surrounding rock induced by fault activation during the excavation of the upper side wall and lower side wall of the faults are simulated and analyzed.Field analysis shows that as the coal working face continues to advance,the mining stress gradually increases.There is a zigzag wave on the relationship curve between coal mining and roof displacement near the fault,which reveals that the surrounding rock of the fault activation affected zone is in the superposition state of static load and dynamic load.Furthermore,the simulation results show that the stress and displacement of surrounding rock near the fault increase with the advance of coal mining face.The closer to the fault plane,the displacement gradually returns to zero,and the stress is also in a lower state. | Jie Chen Kaiwen Shi Yuanyuan Pu Derek B.Apel Chuanjiu Zhang Yujun Zuo Jiongkun Chen Le Xu Zhen Gui Longfei Song | 2023 | Rock Mechanics Bulletin2023，2，2： | 1 |
| 10 | Enantioselective Total Syntheses of (+)‐Gallocatechin, (?)‐Epigallocatechin, and 8‐C‐Ascorbyl‐(?)‐epigallocatechin显示文摘 | Guang Lin Le Chang Yongxiang Liu Zheng Xiang Jiahua Chen Zhen Yang | 2013 | Asian J2013，，4： | 1 |
| 11 | Prospective study of light dark matter search with a newly proposed DarkSHINE experiment显示文摘Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass range.Compared with collider experiments,fixed-target experiments provide a complementary approach to searching for dark photons,particularly in the lower mass range.We have studied the physics potential of the electron-on-target experiment based on the Shanghai SHINE facility,which provides 10 MHz single electron beam at 8 GeV energy.This analysis focuses on dark photons being produced via electron and nucleon interaction and then decays to dark matter candidates,which escape detection as missing momentum in the detector.This experiment takes advantage of using missing momentum to enhance signal versus background separation power.In this study,signal samples as a function of dark photon mass and an inclusive background sample with 2.5 billion events are simulated with GEANT4.For better background estimates,major rare background processes have also been simulated.This paper presents the experiment and detector design,signal and background simulations,analysis strategy,and the prospective study of the experiment sensitivity.With 9×10^(14) electron-on-target events(about three years running),this experiment is expected to rule out most of the sensitive regions predicted by popular dark photon models. | Jing Chen Ji-Yuan Chen Jun-Feng Chen Xiang Chen Chang-Bo Fu Jun Guo Le He Zheng-Ting He Kim Siang Khaw Jia-Lin Li Liang Li Shu Li Meng Lv Dan-Ning Liu Han-Qing Liu Kun Liu Qi-Bin Liu Yang Liu Ze-Jia Lu Cen Mo Si-Yuan Song Xiao-Long Wang Yu-Feng Wang Zhen Wang Zi-Rui Wang Wei-Hao Wu Dao Xiang Hai-Jun Yang Jun-Hua Zhang Yu-Lei Zhang Zhi-Yu Zhao Xu-Liang Zhu Chun-Xiang Zhu Yi-Fan Zhu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，1： | 0 |
| 12 | Measurement of Br(n,γ)cross sections up to stellar s-process temperatures at the CSNS Back‑n显示文摘The neutron capture cross sections(n,γ)of bromine were obtained using the time-of-flight technique at the Back-n facility of the China Spallation Neutron Source.Promptγ-rays originating from neutron-induced capture events were detected using four C_(6)D_(6) detectors.The pulse-height weighting technique and double-bunch unfolding method based on Bayesian theory were used in the data analysis.Background deductions,normalization,and corrections were carefully considered to obtain reliable measurement results.The multilevel R-matrix Bayesian code SAMMY was used to extract the resonance parameters in the resolved resonance region(RRR).The average cross sections in the unresolved resonance region(URR)were obtained from 10 to 400 keV.The experimental results were compared with data from several evaluated libraries and previous experi-ments in the RRR and URR.The TALYS code was used to describe the average cross sections in the URR.The astrophysical Maxwell average cross sections(MACSs)of ^(79,81)Br from kT=5 to 100 keV were calculated over a sufficiently wide range of neutron energies.At a thermal energy of kT=30 keV,the MACS value for ^(79)Br 682±68 mb was in good agreement with the KADoNiS v1.0 recommended value.By contrast,the value of 293±29 mb for ^(81)Br was substantially higher than that of the evaluated database and the KADoNiS v1.0 recommended value. | Gao‑Le Yang Zhen‑Dong An Wei Jiang Xian‑Kai Li Wei‑Wei Qiu Zheng‑Fa Liao Zi‑Yue Zhuang Xiao‑Ping Zhang Sheng‑Li Chen Chen‑Chen Guo Er‑Xi Xiao Xiao Fang Xin‑Xiang Li Xin‑Rong Hu Bing Jiang Jin‑Cheng Wang Jie Ren Wen Luo Zhi‑Chao Zhu Hao‑Yang Lan Zong‑Wei Cao Xu Ma Ying‑Du Liu Pu‑Sen Wang Yi Yang Ping Su Xian‑Gai Deng Wan‑Bing He Chun‑Wang Ma Yu‑Ting Wang Zhi‑Tao Dai Peng‑Qin He Ren‑Guang Tang Tao Zhou Jing Wang Han Yi Yue Zhang Yong‑Hao Chen Rui‑Rui Fan Ke‑Qing Gao Qiang Li Kang Sun Zhi‑Xin Tan Min‑Hao Gu Han‑Tao Jing Jing‑Yu Tang | 2023 | Nuclear Science and Techniques2023，34，11： | 0 |
| 13 | Design,synthesis and applications of functional zirconium-based metal-organic frameworks显示文摘Zirconium-based metal-organic frameworks(Zr-MOFs)have been explored for applications including but not limited to water adsorption,gas storage and separation,heterogeneous catalysis,and chemical sensing.Zr-MOFs serve as a major class of functional MOFs thanks to their high thermal,chemical and hydrolytic stability,large surface area,and tunable structures with the versatile connectivity.In this work,we highlight the design and synthesis of zirconium-based MOFs as well as their applications.Specifically,we demonstrate how reticular chemistry can direct the rational design and synthesis of functional ZrMOFs and describe their structure–property relationship.In addition,we feature synthetic strategies,including isoreticular expansion,linker functionalization,node functionalization,and defect engineering,as toolkits to construct tailored material for specific applications. | Le Shi Zhenning Yang Fanrui Sha Zhijie Chen | 2023 | Science China Chemistry2023，66，12： | 0 |
| 14 | Middle and near ultraviolet spectrograph of the Scientific Experimental system in Near SpacE(SENSE)显示文摘The Scientific Experimental system in Near SpacE(SENSE)consists of different types of instruments that will be installed on a balloon-based platform to characterize near-space environmental parameters.As one of the main scientific payloads,the middle and near ultraviolet spectrograph(MN-UVS)will provide full spectra coverage from middle ultraviolet(MUV,200−300 nm)to near ultraviolet(NUV,300−400 nm)with a spectral resolution of 2 nm.Its primary mission is to acquire data regarding the UV radiation background of the upper atmosphere.The MN-UVS is made up of six primary components:a fore-optical module,an imaging grating module,a UV intensified focal plane module,a titanium alloy frame,a spectrometer control module,and a data processing module.This paper presents in detail the engineering design of each functional unit of the MN-UVS,as well as the instrument’s radiometric calibration,wavelength calibration,impact test,and low-pressure discharge test.Furthermore,we are able to report ground test and flight test results of high quality,showing that the MN-UVS has a promising future in upcoming near-space applications. | Xin Sun DaLian Shi Zhen Chen Ran Li WeiWei Cao Jun Zhu YongLin Bai Le Wang Fei He | 2023 | Earth and Planetary Physics2023，7，6： | 0 |
| 15 | NνDEx-100 conceptual design report显示文摘Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle physics.Observing such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number violation.We propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx experiment.Besides being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological characteristics.This makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββsearches.NvDEx-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by 2025.This report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation. | Xi-Guang Cao Yan-Long Chang Kai Chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-Yuan Huang Ze-Yu Huang Lei Lang Yu-Lan Li Zhi-Jie Li Tian-Yu Liang Jun Liu Chen-Gui Lu Fa-Tai Mai Yuan Mei Hao Qiu Xiang-Ming Sun Xiao-Xing Tang Hu-Lin Wang Qian-Ming Wang Le Xiao Mu-Yun Xiao Jian-Yu Xin Nu Xu Peng Yang Yi-Chen Yang Zhen Yang Zong-Yang Yu Dong-Liang Zhang Jun-Wei Zhang Cheng-Xin Zhao Dou Zhu NνDEx-100 collaboration | 2024 | Nuclear Science and Techniques2024，35，1： | 0 |
| 16 | Role of the immune microenvironment in bone,cartilage,and soft tissue regeneration:from mechanism to therapeuticopportunity显示文摘Bone,cartilage,and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types,whose activity and interplay must be precisely mediated for effective healing post-injury.Although extensive strides have been made in the understanding of the immune microenvironment processes governing bone,cartilage,and soft tissue regeneration,effective clinical translation of these mechanisms remains a challenge.Regulation of the immune microenvironment is increasingly becoming a favorable target for bone,cartilage,and soft tissue regeneration;therefore,an in-depth understanding of the communication between immune cells and functional tissue cells would be valuable.Herein,we review the regulatory role of the immune microenvironment in the promotion and maintenance of stem cell states in the context of bone,cartilage,and soft tissue repair and regeneration.We discuss the roles of various immune cell subsets in bone,cartilage,and soft tissue repair and regeneration processes and introduce novel strategies,for example,biomaterial-targeting of immune cell activity,aimed at regulating healing.Understanding the mechanisms of the crosstalk between the immune microenvironment and regeneration pathways may shed light on new therapeutic opportunities for enhancing bone,cartilage,and soft tissue regeneration through regulation of the immune microenvironment. | Yuan Xiong Bo‑Bin Mi Ze Lin Yi‑Qiang Hu Le Yu Kang‑Kang Zha Adriana CPanayi Tao Yu Lang Chen Zhen‑Ping Liu Anish Patel Qian Feng Shuan‑Hu Zhou Guo‑Hui Liu | 2023 | Military Medical Research2023，10，4： | 0 |
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