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| 1 | Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry显示文摘BackgroundVery 老病人(年龄 85 年) 是人口的一个很快增加的片断。作为一个组,他们经历跟随经皮的冠的干预(一种总线标准) 的在里面医院死亡和流血复杂并发症的高率。然而,在流血和死亡在之间的关系老 unknown.MethodsRetrospective 评论在 Dartmouth-Hitchcock 从 2000 ~ 2015 在 17,378 连续一种总线标准过程上被执行医学中心。在索引一种总线标准承认期间流血的发生(流血要求的输送,存取地点 hematoma > 5 厘米, pseudoaneurysm,和 retroperitoneal 流血)? 并且在里面医院死亡为四个年龄组被报导(< 65 年, 65-74 年, 75-84 年,和 85 年) 。承受了谁的流血复杂并发症和那些的病人的死亡被计算, multivariate 分析为在里面医院被执行死亡。最后,知道流血的预言者在病人年龄之间被比较 < 85 年和年龄 17,378 个病人学习了的 85 years.ResultsOf,(5.9%) 1019 经历了流血,(2.1%) 369 死了在里面医院追随者一种总线标准。流血和在里面医院死亡的发生与增加年龄 monotonically 增加了(死亡:0.94% , 2.27% , 4.24% 和 4.58% ;流血:3.96% , 6.62% , 10.68% 和 13.99% 好久 < 65, 65-74, 75-84 和 85 年,分别地) 。除了病人年龄 85 年,在 multivariate 分析上,流血为所有年龄组与增加的死亡被联系[机会比率(95% CI ) :变老 < 65 年, 3.65 (1.99-6.74 ) ;年龄 65-74 年, 2.83 (1.62-4.94 ) ;年龄 75-84 年, 3.86 (2.56-5.82 ) ,年龄 85 年:1.39 (0.49-3.95 )] 有增加的 .ConclusionsBleeding 和死亡追随者一种总线标准增加变老。为老尽管有流血的高率,流血在里面医院死亡追随者一种总线标准不再是预兆的。 | Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries | 2018 | Journal of Geriatric Cardiology2018，15，2： | 6 |
| 2 | Proinflammatory cytokine TNFα promotes HPV-associated oral carcinogenesis by increasing cancer stemness显示文摘High-risk human papillomaviruses(HPVs) are involved in the development of several human cancers, including oropharyngeal squamous cell carcinomas. However, many studies have demonstrated that HPV alone is not sufficient for the oncogenic transformation of normal human epithelial cells, indicating that additional cofactors are required for the oncogenic conversion of HPV-infected cells. Inasmuch as chronic inflammation is also closely associated with carcinogenesis, we investigated the effect of chronic exposure to tumor necrosis factor α(TNFα), the major proinflammatory cytokine, on oncogenesis in two immortalized oral keratinocyte cell lines, namely, HPV16-immortalized and human telomerase reverse transcriptase(h TERT)-immortalized cells. TNFαtreatment led to the acquisition of malignant growth properties in HPV16-immortalized cells, such as(1) calcium resistance,(2)anchorage independence, and(3) increased cell proliferation in vivo. Moreover, TNFα increased the cancer stem cell-like population and stemness phenotype in HPV16-immortalized cells. However, such transforming effects were not observed in h TERTimmortalized cells, suggesting an HPV-specific role in TNFα-promoted oncogenesis. We also generated h TERT-immortalized cells that express HPV16 E6 and E7. Chronic TNFα exposure successfully induced the malignant growth and stemness phenotype in the E6-expressing cells but not in the control and E7-expressing cells. We further demonstrated that HPV16 E6 played a key role in TNFα-induced cancer stemness via suppression of the stemness-inhibiting micro RNAs mi R-203 and mi R-200 c. Overexpression of mi R-203 and mi R-200 c suppressed cancer stemness in TNFα-treated HPV16-immortalized cells. Overall, our study suggests that chronic inflammation promotes cancer stemness in HPV-infected cells, thereby promoting HPV-associated oral carcinogenesis. | Hannah SHong Jonathan Akhavan Sung Hee Lee Reuben HKim Mo KKang No-Hee Park Ki-Hyuk Shin | 2020 | International Journal of Oral Science2020，12，1： | 3 |
| 3 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 4 | 人类对全球生态系统扰动的初步清查显示文摘本文将人类对自然生态系统的干扰按照程度的不同分成没有扰动、部分扰动和全被扰动三类,并采用这一分类体系进行制图。应用各种不同式样的图件做为原始资料,将其复制到一套覆盖全球的10张面积相等的底图上。这些图被数字化,并转换为地理信息系统以供分析。据此求得每个地区的表面积及其在三种扰动类型中的分配比例,还可推导出一个遗留下来的自然生境的指数。一个高的生境指数值表明一个区域全都是自然生境,人类的扰动很小。一个低的生境指数值表明一个区域受到了很大的扰动,几乎没有自然生境了。地球上尚有近9000万km^2的土地没有被扰动,约占地球陆地总面积52%。然而,地球上可居住部分,除了有岩石、冰的地方及荒地以外,近3/4都受到了某种方式的扰动。本文通过研究Udvardy8个生物地理带的扰动类型,对扰动的全球性模式的生物学意义进行了评价。本研究与早期的研究相比在方法上有所进步,包括绘图分辨率的提高、分类体系的扩大和对生境进行了生态学定义等。 | Lee Hannah Charles Hutchinson Johj L.Carr Ali Lankerani David Lohse 安逸 | 1994 | 人类环境杂志1994，23，4： | 1 |
| 5 | Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion显示文摘 | Chenell Donadee Nicolaas J.H. Raat Tamir Kanias Jesús Tejero Janet S. Lee Eric E. Kelley Xuejun Zhao Chen Liu Hannah Reynolds Ivan Azarov Sheila Frizzell E. Michael Meyer Albert D. Donnenberg Lirong Qu Darrel Triulzi Daniel B. Kim-Shapiro Mark T. Gladwin | 2011 | Circulation2011，，： | 1 |
| 6 | Antiviral Therapy for Chronic Hepatitis B in Pregnancy显示文摘 | Calvin Pan Hannah Lee | 2013 | Semin Liver Dis2013，，02： | 1 |
| 7 | Climate change, connectivity, and conservation success 显示文摘 | HANNAH LEE | 2011 | ConsmwationBiology2011，25，6： | 1 |
| 8 | VERNAUZATION1 Modulates Root System Architecture in Wheat and Barley显示文摘 | Kai P. Voss-Fels Hannah Robinson Stephen R. Mudge Cecile Richard Saul Newman Benjamin Wittkop Andreas Stahl Wolfgang Friedt Matthias Frisch lulian Gabur Anika Miller-Cooper Bradley C. Campbell Alison Kelly Glen Fox Jack Christopher Mandy Christopher Karine Chenu Jerome Franckowiak Emma S. Mace Andrew K. Borrell Howard Eagles David R. Jordan Jose R. Botella Graeme Hammer lan D. Godwin Ben Trevaskis Rod J. Snowdon Lee T. Hickey | 2018 | Molecular Plant2018，11，1： | 1 |
| 9 | TNFα enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells显示文摘 | Sung Hee Lee Hannah S. Hong Zi Xiao Liu Reuben H. Kim Mo K. Kang No-Hee Park Ki-Hyuk Shin | 2012 | Biochemical and Biophysical Research Communications2012，，1： | 1 |
| 10 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 11 | Functional properties of Lactobacillus strains isolated from kimchi显示文摘 | Heejae Lee Hongsup Yoon Yosep Ji Hannah Kim Hyunjoon Park Jieun Lee Heuynkil Shin Wilhelm Holzapfel | 2010 | International Journal of Food Microbiology2010，，1： | 1 |
| 12 | Antiviral Therapy for Chronic Hepatitis B in Pregnancy显示文摘 | Calvin Pan Hannah Lee | 2013 | Semin Liver Dis2013，，02： | 1 |
| 13 | 2014年美国纽波特沙门菌感染暴发与黄瓜的关联性显示文摘2014年8月,美国国家食源性疾病分子分型监测网络(national molecular subtyping network for foodborne disease surveillance)———PulseNet,发现多个州出现纽波特沙门菌血清型聚集性感染,检测到的脉冲场凝胶电泳(pulse-field gel electrophoresis,PFGE)带型(限制性内切酶Xba I,带型为JJPX01.0061)难以鉴别。与疾病暴发相关的PF-GE带型曾与德玛瓦半岛地区弗吉尼亚东海岸生产销售的西红柿具有相关性,但尚未发现与黄瓜或其他农产品的相关性。 | Kristina M. Angelo Alvina Chu Madhu Anand Thai-An Nguyen Lyndsay Bottichio Matthew Wise Ian Williams Sharon Seelman Rebecca Bell Marianne Fatica Susan Lance Deanna Baldwin Kyle Shannon Hannah Lee Eija Trees Errol Strain Laura Gieraltowski 罗宝章(翻译) 厉曙光(审校) | 2018 | 上海预防医学2018，30，10： | 1 |
| 14 | One-stage screening for pregnancy complications by color Doppler assessment of the uterine arteries at 23 weeks’ gestation 1 1 The authors thank Paul Seed, Division of Primary Care and Health Sciences, Guy’s, King’s and St. Thomas’s Hospitals, for valuabl显示文摘 | Gerard Albaiges Hannah Missfelder-Lobos Christoph Lees Mauro Parra Kypros H Nicolaides | 2000 | Obstetrics & Gynecology2000，，4： | 1 |
| 15 | 美国新港沙门菌感染的暴发与黄瓜的关联性显示文摘2014年8月,美国国家食源性疾病监测分子分型网络(PulseN et)检测到一个跨州的新港沙门菌血清型感染的群组,其具有无法区分的脉冲场凝胶电泳(Pulse-Field Gel Electrophoresis,PFGE)带型(限制性内切酶XbaI,带型为JJPX01.0061。信息来源http://www.cdc.gov/pulsenet)。 | Kristina M.Angelo Alvina Chu Madhu Anand Thai-An Nguyen Lyndsay Bottichio Matthew Wise Ian Williams Sharon Seelman Rebecca Bell Marianne Fatica Susan Lance Deanna Baldwin Kyle Shannon Hannah Lee Eija Trees Errol Strain Laura Gieraltowski 罗宝章(译) 厉曙光(审校) | 2016 | 上海预防医学2016，28，5： | 1 |
| 16 | Climate Change, wine ,and conservation显示文摘 | Hannah Lee Roehrdanz Patrick R Ikegami Makihiko | 2013 | Proceedings of the National Academy of Sciences2013，110，17： | 1 |
| 17 | Functional properties of Lactobacillus strains isolated from kimchi显示文摘 | Heejae Lee Hongsup Yoon Yosep Ji Hannah Kim Hyunjoon Park Jieun Lee Heuynkil Shin Wilhelm Holzapfel | 2010 | International Journal of Food Microbiology2010，，1： | 1 |
| 18 | Progress, priorities, and potential beyond survival显示文摘 | Joy E Lawn Hannah Blencowe Shefali Oza Danzhen You Anne CC Lee Peter Waiswa Marek Lalli Zulfiqar Bhutta Aluisio JD Barros Parul Christian Colin Mathers Simon N Cousens | 2014 | The Lancet2014，，： | 1 |
| 19 | Preventing preterm births: analysis of trends and potential reductions with interventions in 39 countries with very high human development index显示文摘 | Hannah H Chang Jim Larson Hannah Blencowe Catherine Y Spong Christopher P Howson Sarah Cairns-Smith Eve M Lackritz Shoo K Lee Elizabeth Mason Andrew C Serazin Salimah Walani Joe Leigh Simpson Joy E Lawn | 2012 | The Lancet2012，，： | 1 |
| 20 | Comparison of open lateral release and transarticular lateral release in distal chevron metatarsal osteotomy for hallux valgus correction显示文摘 | Ji Yong Ahn Ho Seong Lee Hannah Chun Jin Sam Kim Dong Kyo Seo Young Rak Choi Sang Woo Kim | 2013 | International Orthopaedics2013，，9： | 1 |
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