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| 1 | Focal depth research of earthquakes in China's Mainland: Implication for tectonics显示文摘Focal depth data of earthquakes in China's Mainland are processed and analyzed in this paper, as well as the relationship between the focal depths and large-scale tectonic structures. As a basic parameter for earthquakes, focal depth is used to investigate deep environment of seis-mogenic regions, tectonic backgrounds for concentration and release of seismic energy, the inner crustal deformation and its mechanic features. Depth data of 31282 ML≥2.0 events with 1st class and 2nd class precision in China's Mainland from Jan. 1, 1970 to May 31, 2000 are used to get spatial features of earthquakes distributed with depth and to provide average depth for each grid area throughout China. Researches show that the average depth (D) for all the earthquakes used in this paper is (16±7) km, and (13±6) km and (18±8) km for the events in eastern China and western China, respectively. The area with the deepest focal depth is located in southwest Xinjiang region, near the western and southwestern ends of the Tarim | ZHANG Guomin WANG Suyun LI Li ZHANG Xiaodong MA Hongsheng | 2002 | Chinese Science Bulletin2002，47，12： | 38 |
| 2 | Big data challenge: a data management perspective显示文摘 | Jinchuan CHEN Yueguo CHEN Xiaoyong DU Cuiping LI Jiaheng LU Suyun ZHAO Xuan ZHOU | 2013 | Frontiers of Computer Science2013，7，2： | 21 |
| 3 | Effects of therapies for regulating and reinforcing lung and kidney on osteoporosis in rats with chronic obstructive pulmonary disease显示文摘OBJECTIVE:To evaluate the efficacy and long-term effects of the three therapies for regulating and reinforcing lung and kidney(reinforcing lung and invigorating spleen,reinforcing lung and replenishing kidney,and supplementing Qi and nourishing kidney) in Traditional Chinese Medicine(TCM) on osteoporosis in rats with chronic obstructive pulmonary disease.METHODS:Totally 120 rats were randomly divided into control,model,Bufeijianpi,Bufeiyishen,Yiqizishen,aminophyline groups.Repeated smoke inhalations and bacterial infections were used to duplicate the stable Chronic obstructive pulmonary disease rat model.Normal saline was given to the air control and model groups,while Bufeijianpi granule,Bufeiyishen granule,and Yiqizishen granule,and aminophylline were administrated to rats in the Bufeijianpi,Bufeiyishen,Yiqizishen,and aminophylline groups respectively from weeks 9 through 20.Another 12 weeks without medicines to observe the long-term effect.Rats were sacrificed at week 20 and week 32.Bone mass density(BMD),bone mineral content(BMC),morphology of the femoral head,lung function,and levels of serum interleukin(IL)-1β,IL-6,and tumor necrosis factor-a were detected.RESULTS:At weeks 20 and 32,tidal volume,peak expiratory flow and expiratory flow at 50% tidal volume in the three TCM-treated groups were higher than those in the model group(P < 0.05).Femur weight,BMD,and BMC were significantly higher in the three TCM-treated groups and the aminophylline-treated group compared with the model group(P < 0.01),except for BMC in the Yiqizishen-treated group at week 20.CONCLUSION:Bufeijianpi,Bufeiyishen,and Yiqizishen granules show good effects in the prevention and treatment of osteoporosis,which can alleviate airflow limitations and inflammation,improve BMD and BMC of the femur,and have favorable long-term effects. | Tian Yange Li Ya Li Jiansheng Li Suyun Jiang Suli Wang Ying Lu Xiaofan Li Weiwei | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 13 |
| 4 | Randomized controlled multicenter clinical trial for integrated treatment of community-acquired pneumonia based on Traditional Chinese Medicine syndrome differentiation显示文摘OBJECTIVE:To evaluate the efficacy and safety of treatment based on syndrome differentiation ofTraditional Chinese Medicine(TCM) for community-acquired pneumonia(CAP).METHODS:A total of 240 CAP patients were randomly divided into the following two groups:thecontrol group was treated by anti-infection plus conventional medicine treatment;and the trial group was treated by TCM plus the above-mentioned treatment given to the controls.The course of treatment was 14 days,and the patients were followed up for 7 days.RESULTS:Of the 240 patients,235 accomplished the whole process of treatment.The five patients who withdrew from the study were brought into an intent-to-treat analysis.The therapeutic effects of the trial group were superior to those of the control group(P<0.01).The trial group took less time to become clinically stable,with a higher score in the quality of life(P<0.01).There were no significant differences in mortality rate(P>0.05),white blood cell count(P>0.05),bacterial clearance rate(P>0.05),and adverse reactions between the two integrated groups.CONCLUSION:Treatment based on TCM syndrome differentiation for CAP has the advantages of resulting in less time to achieve a stable clinical condition,improvement of clinical symptoms and quality of life,and is comparatively safe. | Jiansheng Li Xueqing Yu Suyun Li Haifeng Wang Yunping Bai Minghang Wang Zikai Sun Wei Zhang Zhaoshan Zhou Xianhua Jia Qingwei Zhou | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 11 |
| 5 | Prediction of petroleum exploration risk and subterranean spatial distribution of hydrocarbon accumulations显示文摘油和煤气的资源和它的未被发现的资源的地理地点的精确预言的空间分发的调查为减少探索风险和改善探索利益是重要的。为预言油资源的空间分发的一个新方法在这份报纸被讨论。它在石油探索和烃丰富的模拟由风险概率的预言组成。 | Xie Hongbing Guo Qiulin Li Feng Li Jianzhong Wu Na Hu Suyun Liang Kun | 2011 | Petroleum Science2011，8，1： | 10 |
| 6 | Effects of comprehensive therapy based on traditional Chinese medicine patterns on older patients with chronic obstructive pulmonary disease: a subgroup analysis from a four-center, randomized, controlled study显示文摘这研究试图基于繁体中文药(TCM ) 评估全面治疗的功效有通过四中心的、开标签的、使随机化的控制试用的长期的妨碍的肺的疾病(COPD ) 的更老的病人上的模式。病人们被划分成对待的试用组分别地基于 TCM 模式使用常规西方的药和 Bu-Fei Jian-Pi 小粒, Bu-Fei Yi-Shen 小粒,和 Yi-Qi Zi-Shen 小粒;并且控制组对待使用常规西方的药。136 个病人的一个总数 65 年完成了学习,与包括试用组并且 73 包括的 63 个病人一起控制组。在六月的治疗和 12 月的后续时期以后,重要差别在下列方面在试用和控制组之间被观察:尖锐恶化(P 0.040 ) 的频率,尖锐恶化的持续时间(P = 0.034 ) ,症状(P 0.034 ) , 6-min 走距离(6MWD )(P 0.039 ) ,呼吸困难规模(P 0.036 ) ;物理领域(P 0.019 ) ,心理领域(P 0.033 ) ,社会领域(P 0.020 ) ,和 WHOQOL-BREF 问询表的环境领域(P 0.044 ) ;并且每日的生活能力领域(P 0.007 ) ,社会活动领域(P 0.018 ) ,消沉症状领域(P 0.025 ) ,和焦虑症状 COPD-QOL 的领域(P 0.037 ) 。没有差别关于 FVC, FEV1,和 FEV1% 在试用和控制组之间被观察。 | Minghang Wang | 2014 | Frontiers of Medicine2014，8，3： | 8 |
| 7 | Transformation of organic matters in fresh leachate during anaerobic degradation under long hydraulic retention time显示文摘This study investigated the biodegradability of fresh leachate from a young municipal solid waste landfill at the inoculum to substrate ratios(V/V) of 10/100,25/100,50/100 and 100/100,as well as the transformation of organic matters in leachate under prolonged hydraulic retention time(HRT) of 50 d.Fresh leachate showed a good biodegradability,with chemical oxygen demand(COD) removal effciency as high as 87%-92%and cumulative methane yield close to theoretical value(0.35 L CH4/g CODdeg) .Methane production and COD depletion presented biphasic characteristics associated with the successive utilization of two major intermediates,acetate and propionate.The biphasic degradation of fresh leachate was resulted from the different hydrolysis rates of diverse substrates and the changes in microorganism community structure.After 50 d,the effuents were dominated by high-MW organic compounds(MW>10 kDa) at each inoculum ratio,which might be refractory compounds released from cell lyses. | XU Suyun,HE Pinjing,LU Fan,LI Min,SHAO Liming State Key Laboratory of Pollution Control and Resources Reuse,Key Laboratory of Yangtze River Water Environment,College of Environmental Science and Engineering,Tongji University,Shanghai 200092,China | 2009 | Journal of Environmental Sciences2009，21，9： | 5 |
| 8 | Brief Introduction to the 'Catalogue of Recent Chinese Earthquakes (1912~1990, M_S≥4.7)显示文摘This paper briefly introduces the principles and methods for compiling the 'Catalog of Recent Chinese Earthquakes (1912 ~ 1990, MS≥4.7).' This new catalog is compiled by revising and supplementing the 1983 version of the Catalog of Chinese Earthquakes. | Wang Suyun, Wu Ge, Shi Zhenliang, Li Qun, Zhai Wenjie, Gao Ajia, Wu Huanying, Guo Ying, and Zhang XiaodongInstitute of Geophysics, CSB, Beijing 100081, ChinaSeismological Bureau of Liaoning Province, Shenyang 110031, China | 1999 | Earthquake Research in China1999，13，1： | 4 |
| 9 | Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein显示文摘Sortilin is closely associated with hyperlipidemia and the risk of atherosclerosis(AS).The role of sortilin and the underlying mechanism in peripheral macrophage are not fully understood.In this study,we investigated the effect of macrophage sortilin on ATP-binding cassette transporter A1(ABCA1)expression,ABCA1-mediated cholesterol efflux,and aortic AS.Macrophage sortilin expression was upregulated by oxidized low-density lipoproteins(ox-LDLs)in both concentration-and time-dependent manners.Its expression reached the peak level when cells were incubated with 50μg/ml ox-LDL for 24 h.Overexpression of sortilin in macrophage reduced cholesterol efflux,leading to an increase in intracellular total cholesterol,free cholesterol,and cholesterol ester.Sortilin was found to bind with ABCA1 protein and suppress macrophage ABCA1 expression,resulting in a decrease in cholesterol efflux from macrophages.The inhibitory effect of sortilin in cholesterol efflux was partially reversed by treatment with chloroquine,a lysosomal inhibitor.On the contrary,the ABCA1 protein level and ABCA1-mediated cholesterol efflux is increased by sortilin short hairpin RNA transfection.The fecal and biliary cholesterol 3H-sterol from cholesterol-laden mouse peritoneal macrophage was reduced by sortilin overexpression through lentivirus vector(LV)-sortilin in low-density lipoprotein receptor knockout mice,which was prevented by co-treatment with chloroquine.Treatment with LV-sortilin reduced plasma high-density lipoprotein and increased plasma ox-LDL levels.Accordingly,aortic lipid deposition and plaque area were exacerbated,and ABCA1 expression was reduced in mice in response to infection with LV-sortilin alone.These effects of LV-sortilin were partially reversed by chloroquine.Sortilin enhances lysosomal degradation of ABCA1 protein and suppresses ABCA1-mediated cholesterol efflux from macrophages,leading to foam cell formation and AS development. | Yuncheng Lv Jing Yang Anbo Gao Sha Sun Xilong Zheng Xi Chen Wei Wan Chaoke Tang Wei Xie Suyun Li Dongming Guo Tianhong Peng Guojun Zhao Liyuan Zhong | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 4 |
| 10 | Depositional System of the Carboniferous Huanglong Formation,Eastern Sichuan Basin:Constraints from Sedimentology and Geochemistry显示文摘Using analyses of the lithology,sequences,paleoenvironment,and tectonic setting,the depositional system of the Carboniferous Huanglong Formation in the eastern Sichuan Basin was identified.The lithological characteristics of the Lower Member,Middle Member,and Upper Member were analyzed and classified.Before the use of carbon,oxygen,and strontium isotopes in the analysis,all of the geochemical data were tested for validity.On the basis of the Z values obtained from carbon and oxygen isotopes,the paleoenvironments of the three members were elucidated.Lower Member was dominantly an enclosed marine environment with intense evaporation and little freshwater input into the sea.Middle Member developed in a semi-enclosed to normal marine environment with many rivers.Upper Member was formed in a normal marine environment.The east Sichuan Basin was enclosed by paleouplifts before the deposition of the Huanglong Formation,forming a relatively enclosed depositional setting.Paleogullies developed in the Silurian strata that underlie the Carboniferous rocks;these paleogullies can be identified.On the basis of a comprehensive analysis,we propose that the Huanglong Formation developed in a platform system.Four microfacies were identified:supratidal flat,dolostone flat,grain shoal,and shelf microfacies.The high-permeability and high-porosity characteristics of the grain shoal microfacies are favorable for hydrocarbon accumulation,while the supratidal flat and shelf microfacies developed very few high-quality reservoirs.The paleogullies,in which increased amounts of grain shoal microfacies developed,controlled the distribution of high-quality reservoirs. | WANG Kun HU Suyun LI Wei LIU Wei HUANG Qingyu MA Kui SHI Shuyuan | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 3 |
| 11 | Research on the epidemiology of chronic obstructive pulmonary disease显示文摘 | Qiao Cuixia Li Suyun | 2010 | Chinese Journal of Gerontology2010，30，11： | 1 |
| 12 | Inverted duplication including Endothelin 3 closely related to dermal hyperpigmentation in Silkie chickens显示文摘The dermal hyperpigmentation phenotype in chickens is controlled by the dominant fibromelanosis allele.One of the ten unique characteristics of Silkie chickens is the fibromelanosis phenotype,which is pigmentation in the dermal layer of the skin and connective tissue.In this study,we found a mutation of fibromelanosis,a genomic rearrangement that included an inverted duplication of endothelin3(EDN3),is responsible.We show that,as a stimulator of melanoblast proliferation,EDN3 expression was increased in silkie embryos and in both skin and muscle throughout adulthood.EDN3 expression led to an increase in expression of the downstream genes EDNRB2 and TYRP2,and was closely relate with the hyperpigmentation phenotype.We examined eight different Chinese chicken breeds showing hyperpigmentation and conclude that this structural genetic variant exists in all fibromelanosis chicken breeds. | Ming TIAN Suyun FANG Yanqiang WANG Xiaorong GU Chungang FENG Rui HAO Xiaoxiang HU Ning LI | 2014 | Frontiers of Agricultural Science and Engineering2014，1，2： | 1 |
| 13 | Factors af- fecting co-removal of chromium through copper precipita- tion 显示文摘 | Sun Jingmei Chang Suyun Li Rong | 2007 | Sep PurifTechnol2007，56，1： | 1 |
| 14 | Disruption of Klf4 in Villin-Positive Gastric Progenitor Cells Promotes Formation and Progression of Tumors of the Antrum in Mice显示文摘 | Qiang Li Zhiliang Jia Li Wang Xiangyu Kong Qi Li Kun Guo Dongfeng Tan Xiangdong Le Daoyan Wei Suyun Huang Lopa Mishra Keping Xie | 2012 | Gastroenterology2012，，3： | 1 |
| 15 | RASAL2 promotes lung cancer metastasis through epithelial–mesenchymal transition显示文摘 | Ning Li Suyun Li | 2014 | Biochemical and Biophysical Research Communications . 2014 (3-4)2014，，3： | 1 |
| 16 | Fuzzy factor rings显示文摘 | CHEN Degang LI Suyun | 1998 | Fuzzy sets and systems1998，31，1： | 1 |
| 17 | Bu-Fei Yi-Shen granule combined with acupoint sticking therapy in patients with stable chronic obstructive pulmonary disease:A random- ized, double-blind, double-dummy, active-controlled, 4-center study显示文摘 | Jiansheng Li Suyun Li Xueqing Yu | 2012 | J Ethnopharmacol2012，141，2： | 1 |
| 18 | Dodecanol-poly(D,L-lactic acid)-b-poly(ethylene glycol)-folate(Dol-PLA-PEG-FA)nanoparticles:evaluation of cell cytotoxicity and selecting capability in vitro显示文摘 | Wang Sujun Luo Yanfeng Zeng Suyun Luo Chunhua Yang Li Liang Zhiqing Wang Yuanliang | | 0，，： | 1 |
| 19 | Detecting circulating antigen in human cysticercosis and itsclinical application显示文摘 | Li Suyun Wang Enrong | 1995 | J Pract Parasit Dis1995，3，1： | 1 |
| 20 | A fatal case of liver abscess caused by hypervirulent Klebsiella pneumoniae in a diabetic adolescent:A clinical and laboratory study显示文摘Importance Hypervirulent variants of Klebsiella pneumoniae(hvKp)are capable of causing life-threatening pyogenic liver abscesses(PLAs),but hvKp caused PLAs was seldom reported in pediatric populations.Hence,there is an urgent need to raise our awareness of this phenomenon in pediatric populations.Objective This study aimed to report the clinical characteristics of hvKp that caused fatal PLA complicated by bacteremia in an adolescent and further identify the microbiological and genomic features of the causative strain.Methods A 14-year-old boy with diabetes mellitus was admitted to our hospital with a diagnosis of PLA complicated by bacteremia.A hypermucoviscous hvKp strain,KPN_19-106,was isolated from the drainage fluid present within the liver abscess cavity and blood.The hypermucoviscosity phenotype of the causative strain was determined by string test.Its virulence was measured using serum resistance assay and Galleria mellonella larvae-killing assay.Antimicrobial susceptibility was determined by broth microdilution method.Genetic information was obtained by whole-genome sequencing and bioinformatics analysis.Results KPN_19-106 belonged to sequence type 380 and serotype K2 and exhibited stronger serum resistance and higher in vivo lethality than the well-characterized hvKp NTUH-K2044 strain.Although KPN_19-106 is susceptible to most antibiotics,no sign of improvement was observed during treatment with such drugs.Whole-genome sequencing revealed that the isolate had integrated multiple mobile genetic elements related to virulence.Interpretation Antibiotic-susceptible hvKp can cause fatal PLA complicated by bacteremia in adolescents,with no improvement during antimicrobial therapy.The causative strain in this case had integrated multiple virulence genes and thus exhibited higher virulence both in vitro and in vivo when compared with NTUH-K2044. | Yue Li Zheng Li Suyun Qian Fang Dong Qing Wang Pengfei Zhang Kaihu Yao | 2021 | Pediatric Investigation2021，5，2： | 1 |
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