|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Focal depth research of earthquakes in China's Mainland: Implication for tectonics显示文摘Focal depth data of earthquakes in China's Mainland are processed and analyzed in this paper, as well as the relationship between the focal depths and large-scale tectonic structures. As a basic parameter for earthquakes, focal depth is used to investigate deep environment of seis-mogenic regions, tectonic backgrounds for concentration and release of seismic energy, the inner crustal deformation and its mechanic features. Depth data of 31282 ML≥2.0 events with 1st class and 2nd class precision in China's Mainland from Jan. 1, 1970 to May 31, 2000 are used to get spatial features of earthquakes distributed with depth and to provide average depth for each grid area throughout China. Researches show that the average depth (D) for all the earthquakes used in this paper is (16±7) km, and (13±6) km and (18±8) km for the events in eastern China and western China, respectively. The area with the deepest focal depth is located in southwest Xinjiang region, near the western and southwestern ends of the Tarim | ZHANG Guomin WANG Suyun LI Li ZHANG Xiaodong MA Hongsheng | 2002 | Chinese Science Bulletin2002，47，12： | 38 |
| 2 | Big data challenge: a data management perspective显示文摘 | Jinchuan CHEN Yueguo CHEN Xiaoyong DU Cuiping LI Jiaheng LU Suyun ZHAO Xuan ZHOU | 2013 | Frontiers of Computer Science2013，7，2： | 21 |
| 3 | Analysis of CD8+ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairment显示文摘 | Shuping Zhang | 2015 | Cellular & Molecular Immunology2015，12，5： | 17 |
| 4 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 5 | Velocity structure of uppermost mantle beneath North China from Pn tomography and its implications显示文摘20301 Pn arrival time data are collected from the seismological bulletins of both national and regional seismic networks. Pn travel time residuals are tomographically inverted for the Pn velocity structure of uppermost mantle beneath North China. The result indicates that the average Pn velocity in North China is 7.92 km/s, and the velocity varies laterally from ?0.21 to +0.29 km/s around the average. The approximately NNE trending high and low velocity regions arrange alternatively west-eastward. From west to east we can see high velocity in the middle Ordos region, the Shanxi graben low, the Jizhong depression high, the west Shandong uplift and Bohai Sea low, and the high velocity region to the east of the Tanlu fault. In the southern boundary zone of the North China block, except for the high velocity in the Qingling Mountains region, the velocity is generally lower than the average. Obvious velocity anisotropy is seen in the Datong Cenozoic volcanic region, with the fast velocity direction in NNE-SSW. Notable velocity anisotropy is also seen around the Bay of Bohai Sea, and the fast velocity directions seem to show a rotation pattern, possibly indicating a flow-like deformation in the uppermost mantle there. The Pn velocity variations show a reversed correlation with the Earth's heat flow. The low Pn velocity regions generally show high heat flow, e.g., the Shanxi graben and Bohai Sea region. While the high Pn velocity regions usually manifest low heat flow, e.g., the region of Jizhong depression. This indicates that the Pn velocity variation in the study region is mainly aroused by the regional temperature difference in the uppermost mantle. Strong earthquakes in the crust tend to occur in the region with the abnormal low Pn velocity, or in the transition zone between high and low Pn velocity regions. The earthquakes in the low velocity region are shallower, while that in the transition zone are deeper. | WANG Suyun (汪素云) XU Zhonghuai (许忠淮) PEI Shunping (裴顺平) | 2003 | Science China Earth Sciences2003，46，z2： | 13 |
| 6 | Effects of therapies for regulating and reinforcing lung and kidney on osteoporosis in rats with chronic obstructive pulmonary disease显示文摘OBJECTIVE:To evaluate the efficacy and long-term effects of the three therapies for regulating and reinforcing lung and kidney(reinforcing lung and invigorating spleen,reinforcing lung and replenishing kidney,and supplementing Qi and nourishing kidney) in Traditional Chinese Medicine(TCM) on osteoporosis in rats with chronic obstructive pulmonary disease.METHODS:Totally 120 rats were randomly divided into control,model,Bufeijianpi,Bufeiyishen,Yiqizishen,aminophyline groups.Repeated smoke inhalations and bacterial infections were used to duplicate the stable Chronic obstructive pulmonary disease rat model.Normal saline was given to the air control and model groups,while Bufeijianpi granule,Bufeiyishen granule,and Yiqizishen granule,and aminophylline were administrated to rats in the Bufeijianpi,Bufeiyishen,Yiqizishen,and aminophylline groups respectively from weeks 9 through 20.Another 12 weeks without medicines to observe the long-term effect.Rats were sacrificed at week 20 and week 32.Bone mass density(BMD),bone mineral content(BMC),morphology of the femoral head,lung function,and levels of serum interleukin(IL)-1β,IL-6,and tumor necrosis factor-a were detected.RESULTS:At weeks 20 and 32,tidal volume,peak expiratory flow and expiratory flow at 50% tidal volume in the three TCM-treated groups were higher than those in the model group(P < 0.05).Femur weight,BMD,and BMC were significantly higher in the three TCM-treated groups and the aminophylline-treated group compared with the model group(P < 0.01),except for BMC in the Yiqizishen-treated group at week 20.CONCLUSION:Bufeijianpi,Bufeiyishen,and Yiqizishen granules show good effects in the prevention and treatment of osteoporosis,which can alleviate airflow limitations and inflammation,improve BMD and BMC of the femur,and have favorable long-term effects. | Tian Yange Li Ya Li Jiansheng Li Suyun Jiang Suli Wang Ying Lu Xiaofan Li Weiwei | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 13 |
| 7 | Crosstalk of the Wnt/b-catenin pathway with other pathways in cancer cells显示文摘Many cancers have similar aberrations in various signaling cascades with crucial roles in cellular proliferation,differentiation,and morphogenesis.Dysregulation of signal cascades that play integral roles during early cellular development is well known to be a central feature of many malignancies.One such signaling cascade is the Wnt/b-catenin pathway,which has a profound effect on stem cell proliferation,migration,and differentiation.This pathway is dysregulated in numerous cell types,underscoring its global oncogenetic potential.This review highlights regulators and downstream effectors of this receptor cascade and addresses the increasingly apparent crosstalk of Wnt with other tumorigenic signaling pathways.As understanding of the genetic and epigenetic changes unique to these malignancies increases,identifying the regulatory mechanisms unique to the Wnt/b-catenin pathway and similarly aberrant receptor pathways will be imperative. | Saint-Aaron L.Morris Suyun Huang | 2016 | Genes & Diseases2016，3，1： | 12 |
| 8 | Fine structure of Pn velocity beneath Sichuan-Yunnan region显示文摘We use 23298 Pn arrival-time data from Chinese national and provincial earthquake bulletins to invert fine structure of Pn velocity and anisotropy at the top of the mantle beneath the Sichuan-Yunnan and its adjacent region. The results suggest that the Pn velocity in this region shows significant lateral variation; the Pn velocity varies from 7.7 to 8.3 km/s. The Pn-velocity variation correlates well with the tectonic activity and heat flow of the region. Low Pn velocity is observed in southwest Yunnan , Tengchong volcano area, and the Panxi tectonic area. These areas have very active seismicity and tectonic activity with high surface heat flow. On the other hand, high Pn velocity is observed in some stable regions, such as the central region of the Yangtze Platform; the most pronounced high velocity area is located in the Sichuan Basin, south of Chengdu. Pn anisotropy shows a complex pattern of regional deformation. The Pn fast direction shows a prominent clockwise rotation pattern from east of the Tibetan block to the Sichuan-Yunnan diamond block to southwest Yunnan, which may be related to southeastward escape of the Tibetan Plateau material due to the collision of the Indian Plate to the Eurasia Plate. Thus there appears to be strong correlation between the crustal deformation and the upper mantle structure in the region. The delay times of events and stations show that the crust thickness decreases from the Tibetan Plateau to eastern China, which is consistent with the results from deep seismic sounding. | HUANG Jinli (黄金莉) SONG Xiaodong (宋晓东) WANG Suyun (汪素云) | 2003 | Science China Earth Sciences2003，46，z2： | 12 |
| 9 | Randomized controlled multicenter clinical trial for integrated treatment of community-acquired pneumonia based on Traditional Chinese Medicine syndrome differentiation显示文摘OBJECTIVE:To evaluate the efficacy and safety of treatment based on syndrome differentiation ofTraditional Chinese Medicine(TCM) for community-acquired pneumonia(CAP).METHODS:A total of 240 CAP patients were randomly divided into the following two groups:thecontrol group was treated by anti-infection plus conventional medicine treatment;and the trial group was treated by TCM plus the above-mentioned treatment given to the controls.The course of treatment was 14 days,and the patients were followed up for 7 days.RESULTS:Of the 240 patients,235 accomplished the whole process of treatment.The five patients who withdrew from the study were brought into an intent-to-treat analysis.The therapeutic effects of the trial group were superior to those of the control group(P<0.01).The trial group took less time to become clinically stable,with a higher score in the quality of life(P<0.01).There were no significant differences in mortality rate(P>0.05),white blood cell count(P>0.05),bacterial clearance rate(P>0.05),and adverse reactions between the two integrated groups.CONCLUSION:Treatment based on TCM syndrome differentiation for CAP has the advantages of resulting in less time to achieve a stable clinical condition,improvement of clinical symptoms and quality of life,and is comparatively safe. | Jiansheng Li Xueqing Yu Suyun Li Haifeng Wang Yunping Bai Minghang Wang Zikai Sun Wei Zhang Zhaoshan Zhou Xianhua Jia Qingwei Zhou | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 11 |
| 10 | Prediction of petroleum exploration risk and subterranean spatial distribution of hydrocarbon accumulations显示文摘油和煤气的资源和它的未被发现的资源的地理地点的精确预言的空间分发的调查为减少探索风险和改善探索利益是重要的。为预言油资源的空间分发的一个新方法在这份报纸被讨论。它在石油探索和烃丰富的模拟由风险概率的预言组成。 | Xie Hongbing Guo Qiulin Li Feng Li Jianzhong Wu Na Hu Suyun Liang Kun | 2011 | Petroleum Science2011，8，1： | 10 |
| 11 | Hydrocarbon generation characteristics and exploration prospects of Proterozoic source rocks in China显示文摘A large number of primary oil and gas reservoirs have been discovered in Proterozoic strata all over the globe.Proterozoic sequences are widely distributed in China, and the discovery of large Sinian-aged gas reservoirs in the Sichuan Basin and Mesoproterozoic liquid oil seepages in North China shows that attention should be paid to the exploration potential of Proterozoic strata. In this paper, the main controlling factors of Proterozoic source rocks are discussed. Principally, active atmospheric circulation and astronomical cycles may have driven intense upwelling and runoff to provide nutrients; oxygenated oceanic surface waters could have provided suitable environments for the organisms to thrive; volcanic activity and terrestrial weathering caused by continental break-up would have injected large amounts of nutrients into the ocean, leading to persistent blooms of marine organisms; and extensive anoxic deep waters may have created ideal conditions for the preservation of organic matter. Additionally, the appearance of eukaryotes resulted in diversified hydrocarbon parent material, which effectively improved the generation potential for oil and gas. Through the comparison of Formations across different cratons, seven sets of Proterozoic organic-rich source rocks have been recognized in China, which mainly developed during interglacial periods and are also comparable worldwide. The Hongshuizhuang and Xiamaling Formations in North China have already been identified previously as Mesoproterozoic source rocks. The early Proterozoic Changchengian System is highly promising as a potential source rock in the Ordos Basin. In the Upper Yangtze area, the Neoproterozoic Datangpo and Doushantuo Formations are extensively distributed, and represent the major source rocks for Sinian gas reservoirs in the Sichuan Basin. Moreover, the Nanhuan System may contain abundant shales with high organic matter contents in the Tarim Basin, although this possibility still needs to be verified. Indeed, all three cratons may contain source rocks of Proterozoic strata; thus, these strata represent major exploration targets worthy of great attention. | Wenzhi ZHAO Xiaomei WANG Suyun HU Shuichang ZHANG Huajian WANG Shuwei GUAN Yuntao YE Rong REN Tongshan WANG | 2019 | Science China Earth Sciences2019，62，6： | 9 |
| 12 | The chromosome-scale assembly of the willow genome provides insight into Salicaceae genome evolution显示文摘Salix suchowensis is an early-flowering shrub willow that provides a desirable system for studies on the basic biology of woody plants.The current reference genome of S.suchowensis was assembled with 454 sequencing reads.Here,we report a chromosome-scale assembly of S.suchowensis generated by combining PacBio sequencing with Hi-C technologies.The obtained genome assemblies covered a total length of 356 Mb.The contig N50 of these assemblies was 263,908 bp,which was~65-fold higher than that reported previously.The contiguity and completeness of the genome were significantly improved.By applying Hi-C data,339.67 Mb(95.29%)of the assembled sequences were allocated to the 19 chromosomes of haploid willow.With the chromosome-scale assembly,we revealed a series of major chromosomal fissions and fusions that explain the genome divergence between the sister genera of Salix and Populus.The more complete and accurate willow reference genome obtained in this study provides a fundamental resource for studying many genetic and genomic characteristics of woody plants. | Suyun Wei Yonghua Yang Tongming Yin | 2020 | Horticulture Research2020，7，1： | 9 |
| 13 | Effects of comprehensive therapy based on traditional Chinese medicine patterns on older patients with chronic obstructive pulmonary disease: a subgroup analysis from a four-center, randomized, controlled study显示文摘这研究试图基于繁体中文药(TCM ) 评估全面治疗的功效有通过四中心的、开标签的、使随机化的控制试用的长期的妨碍的肺的疾病(COPD ) 的更老的病人上的模式。病人们被划分成对待的试用组分别地基于 TCM 模式使用常规西方的药和 Bu-Fei Jian-Pi 小粒, Bu-Fei Yi-Shen 小粒,和 Yi-Qi Zi-Shen 小粒;并且控制组对待使用常规西方的药。136 个病人的一个总数 65 年完成了学习,与包括试用组并且 73 包括的 63 个病人一起控制组。在六月的治疗和 12 月的后续时期以后,重要差别在下列方面在试用和控制组之间被观察:尖锐恶化(P 0.040 ) 的频率,尖锐恶化的持续时间(P = 0.034 ) ,症状(P 0.034 ) , 6-min 走距离(6MWD )(P 0.039 ) ,呼吸困难规模(P 0.036 ) ;物理领域(P 0.019 ) ,心理领域(P 0.033 ) ,社会领域(P 0.020 ) ,和 WHOQOL-BREF 问询表的环境领域(P 0.044 ) ;并且每日的生活能力领域(P 0.007 ) ,社会活动领域(P 0.018 ) ,消沉症状领域(P 0.025 ) ,和焦虑症状 COPD-QOL 的领域(P 0.037 ) 。没有差别关于 FVC, FEV1,和 FEV1% 在试用和控制组之间被观察。 | Minghang Wang | 2014 | Frontiers of Medicine2014，8，3： | 8 |
| 14 | Effects of dietary vitamin E on muscle vitamin E and fatty acid content in Aohan fine-wool sheep显示文摘value for consumers. Several laboratories have evaluated the effects of vitamin E on the fatty acid(FA) composition of muscle in sheep. However, little information is available on wool sheep, even though wool sheep breeds are an important source of mutton, especially in northern China where sheep are extensively farmed. The present study was designed to address the effects of vitamin E on muscle FA composition in male Aohan fine-wool sheep. Methods: Forty-two male Aohan fine-wool lambs(5 mo old) with similar initial body weight were randomly divided into seven groups and fed diets supplemented with 0(control group), 20, 100, 200, 1,000, 2,000, or 2,400 IU/sheep/d vitamin E for 12 mo. Three lambs from each group were slaughtered to measure vitamin E and FA content in the longissimus lumborum(LL) and gluteus medius(GM) muscles. Results: Vitamin E concentrations in the LL and GM increased significantly after 12 mo of vitamin E supplementation(P < 0.05). However, this increase did not occur in a dose-dependent manner because the muscle vitamin E concentration was highest in the 200 IU/sheep/d group. Dietary vitamin E supplementation also caused a significant reduction in SFA content and an increase in monounsaturated FA(MUFA) content in the LL and GM(P < 0.05). All six doses of vitamin E significantly increased cis9 trans11-conjugated linoleic acid(c9t11-CLA) content in the LL compared with the control group(P < 0.05). Conclusions: Dietary supplementation with vitamin E increased muscle vitamin E content and improved the nutritional value of mutton by decreasing SFA content and increasing MUFA and c9t11-CLA contents in Aohan fine-wool sheep. These effects were greatest in sheep fed a diet containing 200 IU/sheep/d vitamin E. | Kun Liu Suyun Ge Hailing Luo Dubing Yue Leyan Yan | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 6 |
| 15 | Transformation of organic matters in fresh leachate during anaerobic degradation under long hydraulic retention time显示文摘This study investigated the biodegradability of fresh leachate from a young municipal solid waste landfill at the inoculum to substrate ratios(V/V) of 10/100,25/100,50/100 and 100/100,as well as the transformation of organic matters in leachate under prolonged hydraulic retention time(HRT) of 50 d.Fresh leachate showed a good biodegradability,with chemical oxygen demand(COD) removal effciency as high as 87%-92%and cumulative methane yield close to theoretical value(0.35 L CH4/g CODdeg) .Methane production and COD depletion presented biphasic characteristics associated with the successive utilization of two major intermediates,acetate and propionate.The biphasic degradation of fresh leachate was resulted from the different hydrolysis rates of diverse substrates and the changes in microorganism community structure.After 50 d,the effuents were dominated by high-MW organic compounds(MW>10 kDa) at each inoculum ratio,which might be refractory compounds released from cell lyses. | XU Suyun,HE Pinjing,LU Fan,LI Min,SHAO Liming State Key Laboratory of Pollution Control and Resources Reuse,Key Laboratory of Yangtze River Water Environment,College of Environmental Science and Engineering,Tongji University,Shanghai 200092,China | 2009 | Journal of Environmental Sciences2009，21，9： | 5 |
| 16 | Brief Introduction to the 'Catalogue of Recent Chinese Earthquakes (1912~1990, M_S≥4.7)显示文摘This paper briefly introduces the principles and methods for compiling the 'Catalog of Recent Chinese Earthquakes (1912 ~ 1990, MS≥4.7).' This new catalog is compiled by revising and supplementing the 1983 version of the Catalog of Chinese Earthquakes. | Wang Suyun, Wu Ge, Shi Zhenliang, Li Qun, Zhai Wenjie, Gao Ajia, Wu Huanying, Guo Ying, and Zhang XiaodongInstitute of Geophysics, CSB, Beijing 100081, ChinaSeismological Bureau of Liaoning Province, Shenyang 110031, China | 1999 | Earthquake Research in China1999，13，1： | 4 |
| 17 | The Regulation of cGAS显示文摘The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological conditions, such as virus induced cell death, DNA damage, mitochondria damage, gene mutations, which results in autoimmune diseases. Therefore, the cGAS-MITA pathway must be tightly controlled to ensure proper immune response against pathogens and to avoid autoimmune diseases. The regulation of cGAS-MITA pathway at MITA-level have been extensively explored and reviewed elsewhere,here we provide a summary and perspective on recent advances in understanding of the cGAS regulation. | Meiguang Xiong Suyun Wang Yan-Yi Wang Yong Ran | 2018 | Virologica Sinica2018，33，2： | 4 |
| 18 | Mechanisms involved in Korean mistletoe lectin-induced apoptosis of cancer cells显示文摘AIM: To investigate the anti-cancer mechanisms of Korean mistletoe lectin (Viscum album coloratum agglutinin,VCA) using a human colon cancer cell line (COLO). METHODS: Cytotoxic effects of VCA on COLO cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in vitro and tumor-killing effects in vivo. To study the mechanisms involved,the expression of various pro-caspases,anti-apoptotic proteins,and death receptors was determined by western blot. To determine which death receptor is involved in VCA-induced apoptosis of COLO cells,cytotoxicity was examined by MTT assay after treatment with agonists or antagonists of death receptors. RESULTS: VCA killed COLO cells in a time-and dose-dependent manner and induced complete regression of tumors in nude mice transplanted with COLO cells. Treatment of COLO cells with VCA activated caspase-2,-3,-8,and -9 and decreased expression of anti-apoptotic molecules including receptor interacting protein,nuclear factor-κB,X-linked inhibitor of apoptosis protein,and Akt/protein kinase B. We then examined the involvement of death receptors in VCA-induced apoptosis. Only tumor necrosis factor receptor 1,among the death receptors examined,was involved in apoptosis of COLO cells,evidenced by inhibition of VCA-induced apoptosis and decreased activation of caspases,particularly caspase-8,by tumor necrosis factor receptor 1 antagonizing antibody.CONCLUSION: VCA-induced apoptotic COLO cell death is due to the activation of caspases and inhibition of anti-apoptotic proteins,in part through the tumor necrosis factor receptor 1 signaling pathway. | Lee-Yong Khil Wi Kim Suyun Lyu Won Bong Park Ji-Won Yoon Hee-Sook Jun | 2007 | World Journal of Gastroenterology2007，13，20： | 4 |
| 19 | Organellar genome assembly methods and comparative analysis of horticultural plants显示文摘Although organellar genomes(including chloroplast and mitochondrial genomes)are smaller than nuclear genomes in size and gene number,organellar genomes are very important for the investigation of plant evolution and molecular ecology mechanisms.Few studies have focused on the organellar genomes of horticultural plants.Approximately 1193 chloroplast genomes and 199 mitochondrial genomes of land plants are available in the National Center for Biotechnology Information(NCBI),of which only 39 are from horticultural plants.In this paper,we report an innovative and efficient method for high-quality horticultural organellar genome assembly from next-generation sequencing(NGS)data.Sequencing reads were first assembled by Newbler,Amos,and Minimus software with default parameters.The remaining gaps were then filled through BLASTN search and PCR.The complete DNA sequence was corrected based on Illumina sequencing data using BWA(Burrows–Wheeler Alignment tool)software.The advantage of this approach is that there is no need to isolate organellar DNA from total DNA during sample preparation.Using this procedure,the complete mitochondrial and chloroplast genomes of an ornamental plant,Salix suchowensis,and a fruit tree,Ziziphus jujuba,were identified.This study shows that horticultural plants have similar mitochondrial and chloroplast sequence organization to other seed plants.Most horticultural plants demonstrate a slight bias toward A+T rich features in the mitochondrial genome.In addition,a phylogenetic analysis of 39 horticultural plants based on 15 protein-coding genes showed that some mitochondrial genes are horizontally transferred from chloroplast DNA.Our study will provide an important reference for organellar genome assembly in other horticultural plants.Furthermore,phylogenetic analysis of the organellar genomes of horticultural plants could accurately clarify the unanticipated relationships among these plants. | Xuelin Wang Feng Cheng Dekai Rohlsen Changwei Bi Chunyan Wang Yiqing Xu Suyun Wei Qiaolin Ye Tongming Yin Ning Ye | 2018 | Horticulture Research2018，5，1： | 4 |
| 20 | Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein显示文摘Sortilin is closely associated with hyperlipidemia and the risk of atherosclerosis(AS).The role of sortilin and the underlying mechanism in peripheral macrophage are not fully understood.In this study,we investigated the effect of macrophage sortilin on ATP-binding cassette transporter A1(ABCA1)expression,ABCA1-mediated cholesterol efflux,and aortic AS.Macrophage sortilin expression was upregulated by oxidized low-density lipoproteins(ox-LDLs)in both concentration-and time-dependent manners.Its expression reached the peak level when cells were incubated with 50μg/ml ox-LDL for 24 h.Overexpression of sortilin in macrophage reduced cholesterol efflux,leading to an increase in intracellular total cholesterol,free cholesterol,and cholesterol ester.Sortilin was found to bind with ABCA1 protein and suppress macrophage ABCA1 expression,resulting in a decrease in cholesterol efflux from macrophages.The inhibitory effect of sortilin in cholesterol efflux was partially reversed by treatment with chloroquine,a lysosomal inhibitor.On the contrary,the ABCA1 protein level and ABCA1-mediated cholesterol efflux is increased by sortilin short hairpin RNA transfection.The fecal and biliary cholesterol 3H-sterol from cholesterol-laden mouse peritoneal macrophage was reduced by sortilin overexpression through lentivirus vector(LV)-sortilin in low-density lipoprotein receptor knockout mice,which was prevented by co-treatment with chloroquine.Treatment with LV-sortilin reduced plasma high-density lipoprotein and increased plasma ox-LDL levels.Accordingly,aortic lipid deposition and plaque area were exacerbated,and ABCA1 expression was reduced in mice in response to infection with LV-sortilin alone.These effects of LV-sortilin were partially reversed by chloroquine.Sortilin enhances lysosomal degradation of ABCA1 protein and suppresses ABCA1-mediated cholesterol efflux from macrophages,leading to foam cell formation and AS development. | Yuncheng Lv Jing Yang Anbo Gao Sha Sun Xilong Zheng Xi Chen Wei Wan Chaoke Tang Wei Xie Suyun Li Dongming Guo Tianhong Peng Guojun Zhao Liyuan Zhong | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员