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| 1 | Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults:the China-PAR project显示文摘Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD(ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project(Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios(HRs) and their corresponding 95% confidence intervals(CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease(CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage(PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs(95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83(0.74–0.93), 0.66(0.59–0.74), 0.55(0.48–0.61), 0.44(0.38–0.50) and 0.24(0.18–0.31), respectively(P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure(BP) implied the largest public health gains against various ASCVD events(PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping ideal BP and dietary habits in general Chinese population to prevent the epidemic of ASCVD. | Chao Han Fangchao Liu Xueli Yang Jichun Chen Jianxin Li Jie Cao Ying Li Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Dongshen Hu Xiangfeng Lu Xigui Wu Dongfeng Gu | 2018 | Science China(Life Sciences)2018，61，5： | 60 |
| 2 | Predicting lifetime risk for developing atherosclerotic cardiovascular disease in Chinese population:the China-PAR project显示文摘Evidence on the lifetime risk for atherosclerotic cardiovascular disease(ASCVD) is insufficient;yet,estimating an individual's lifetime risk allows for a comprehensive assessment of ASCVD burden.We developed and validated lifetime risk prediction equations for ASCVD using four large and ongoing prospective cohorts of Chinese,the China-PAR project(Prediction for ASCVD Risk in China).Sexspecific equations were developed using two cohorts(as the derivation cohort) of 21,320 participants.Two other independent cohorts with 14,123 and 70,838 participants were used for their external validation,respectively.We evaluated both calibration and discrimination measures for model performance.Furthermore,we estimated ASCVD-free years lost or excess absolute risk attributable to high 10-year risk(!10.0%) and/or high lifetime risk(!32.8%).After 12.3 years' follow-up of the derivation cohort,1048 ASCVD events and 1304 non-ASCVD deaths were identified.Our sex-specific equations had good internal validation,with discriminant C statistics of 0.776(95% confidence interval [CI]:0.757–0.794) and 0.801(95% CI:0.778–0.825),and calibration χ~2 of 9.2(P = 0.418) and 5.6(P = 0.777) for men and women,respectively.Good external validation was also demonstrated with predicted rates closely matched to the observed ones.Compared with men having both low 10-year and low lifetime risk,men would develop ASCVD 3.0,4.6 and 8.6 years earlier if they had high 10-year risk alone,high lifetime risk alone,or both high 10-year and high lifetime risk at the index age of 35 years,respectively.We developed wellperformed lifetime risk prediction equations that will help to identify those with the greatest potential to avert ASCVD burden after implementation of innovative clinical and public health interventions in China. | Fangchao Liu Jianxin Li Jichun Chen Dongsheng Hu Ying Li Jianfeng Huang Xiaoqing Liu Xueli Yang Jie Cao Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Xigui Wu Dongfeng Gu Xiangfeng Lu | 2018 | Science Bulletin2018，63，12： | 30 |
| 3 | Spatial patterns of plant diversity and communities in Alpine ecosystems of the Hengduan Mountains, northwest Yunnan, China显示文摘Aims Conduct a quantitative,but rapid,regional-level assessment of the alpine flora across northwest Yunnan(NWY)to provide a broadbased understanding of local and regional patterns of the composition,diversity and health of alpine ecosystems across NWY.Methods A stratified random sampling design was employed to select sites across the different mountain ranges of NWY.Vegetation was sampled by stratifying each site by the three major alpine vegetation community types:meadow,dwarf shrub and scree.Two 50-m transects were randomly located within each community type at each sampling site with 101-m^(2) subplots systematically placed along each transect.Environmental variables were recorded at each transect.Multivariate analyses were used to classify the major plant community assemblages and link community patterns to environmental and habitat variables.Important Findings Forb species richness varied from 19 to 105 species per site(21 sites total)with an average of 59 species per site(60 m^(2) sampled per site).Most species were patchily distributed with narrow distributions and/or small population sizes;over half the species occurred at only one or two sites.Distinct species assemblages were identified in the meadow vegetation that was strongly aggregated by geographic location suggesting the presence of distinct phytogeographic zones of the meadow alpine flora.Elevation and geographic location were the dominant environmental gradients underlying the variations in species composition.Jaccard’s coefficient of similarity averaged only 10%among sites indicating there was little similarity in the alpine flora across the region.The alpine vegetation is highly heterogeneous across the complex landscape of the Hengduan Mountains of NWY.Conservation strategies need to take into account the large geographic differences in the flora to maximize protection of biodiversity. | Ruth Sherman Renee Mullen Li Haomin Fang Zhendong Wang Yi | 2008 | Journal of Plant Ecology2008，1，2： | 20 |
| 4 | Age of granulite from Huangtuling, Dabie Mountain:Pb-Pb dating of garnet by a stepwise dissolution technique显示文摘A new stepwise dissolution scheme, involving acids with different properties, enables the selective recovery of radiogenic and common Pb from a mineral, and makes single-mineral Pb-Pb dating possible. Garnet from a granulite sample from Huangtuling, northern Dabie Mountain yields a Pb-Pb isochron age of (1098 ± 35) Ma, which is interpreted as the timing of peak metamorphism of granulite facies. | Hanwen Zhou Xianhua Li Ying Liu Zhendong You Shutian Suo Zengqiu Zhong | 1999 | Chinese Science Bulletin1999，44，10： | 15 |
| 5 | Angular observation of joints of geckos moving on horizontal and vertical surfaces显示文摘Because of their outstanding climbing and motor coordination ability, geckos have provided the basis for a peculiar bionic model leading to the development of a geckorobot. A three-dimensional locomotion observation system was constructed to measure angular orientations of joints while geckos trotted (337.1 mm/s) and walked (66.7 mm/s) on horizontal surfaces, and trotted (241.5mm/s) and walked (30.6mm/s) on vertical surfaces. Moving over horizontal surfaces, the joints rotated more quickly the greater the speed, and the swinging scope of forelimbs stayed nearly at 59 degrees when swinging forward, but extended from 72 degrees to 79.2 degrees when swinging backward. The lifting angle of forelimbs was always positive to keep the center of mass close to the surface when moving up vertical surfaces, the scope of the forward swinging forelimbs forward extended from 33.7 degrees to 36.7 degrees with increasing speed, while the scope of backward swinging forelimbs remained almost the same at 87.5 degrees. Alternative gaits had little effect on the swing angle of hindlimbs of the geckos moving on both horizontal and vertical surfaces. | LI HongKai DAI ZhenDong SHI AiJu ZHANG Hao SUN JiuRong | 2009 | Chinese Science Bulletin2009，54，4： | 13 |
| 6 | Restudies on Body Surface of Dung Beetle and Application of Its Bionics Flexible Technique显示文摘A scanning electron microscope was used to observe the structures of the setae on the surface of a dung beetle Copris ochus, Motschulsky. There are lots of setae on the body surface, especially on the ventral part surface and lateral to the legs which are different in size, arrangement and shape. These setae have different lengths and many thorns on the whole seta. The top ends of these setae stand up without furcations which direct uprightly towards the surface of the touched soil. By the method of removing these setae, getting the insect weight before and after digging into the dung we affirm farther that the setae on the beetle body surface form the anti-stick and non-adherent gentle interface. The soil machines and components made by imitating the gentle body surface of beetles have favorable non-adherent results. | Jiurong Sun 1, Jianqiao Li 2, Hong Cheng 1, Zhendong Dai 3, Luquan Ren 2 1.College of Life Sciences, Peking University, Beijing, 100871,P.R. China 2.Key Laboratory of Terrain-Machine Bionics Engineering (Ministry of Education,China), Jilin University at Nanling Campus, Changchun, 130022,P.R.China 3.College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016,P.R.China | 2004 | Journal of Bionic Engineering2004，1，1： | 12 |
| 7 | Observation of efficient population of the red-emitting state from the green state by non-multiphonon relaxation in the Er31–Yb31 system显示文摘The rare earth Er^(3+) and Yb^(3+) codoped system is the most attractive for showcasing energy transfer upconversion.This system can generate green and red emissions from Er^(3+) under infrared excitation of the sensitizer Yb^(3+).It is well known that the red-emitting state can be populated from the upper green-emitting state.The contribution of multiphonon relaxation to this population is generally considered important at low excitation densities.Here,we demonstrate for the first time the importance of a previously proposed but neglected mechanism described as a cross relaxation energy transfer from Er^(3+) to Yb^(3+),followed by an energy back transfer within the same Er^(3+)–Yb^(3+) pair.A luminescence spectroscopy study of cubic Y_(2)O_(3):Er^(3+),Yb^(3+) indicates that this mechanism can be more efficient than multiphonon relaxation,and it can even make a major contribution to the red upconversion.The study also revealed that the energy transfers involved in this mechanism take place only in the nearest Er^(3+)–Yb^(3+) pairs,and thus,it is fast and efficient at low excitation densities.Our results enable a better understanding of upconversion processes and properties in the Er^(3+)–Yb^(3+) system. | Jiahua Zhang Zhendong Hao Jing Li Xia Zhang Yongshi Luo Guohui Pan | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 8 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 9 | Genome-wide identification and analysis of the DREB genes and their expression profiles under abiotic stresses in Chinese jujube(Ziziphus jujuba Mill.)显示文摘CBF/DREB proteins play a critical role in abiotic stress-mediated gene expression and represent attractive regulons for plant breeding programs.However,no study has been conducted for CBF/DREB protein-related genes in jujube(Ziziphus jujuba Mill.).In this study,twenty-five ZjDREB genes were identified and annotated from the jujube(Z.jujuba‘Dongzao’)genome.Detailed analysis,including gene classification,annotation,phylogenetic evaluation,conserved motif determination and expression profiling were performed on all genes.Phylogenetic analysis showed that ZjDREB proteins were divided into five subgroups(A1–A5),but lacking a subgroup A6 corresponding to AtDREBs.The ZjDREB genes were distributed in nine of twelve chromosomes in the genome.Additionally,the expression patterns of the DREB genes under different abiotic stresses were investigated using q RT-PCR.Nineteen ZjDREB genes were down-regulated under low temperature,in contrast six ZjDREB genes(01,03,05,11,23 and 24)were up-regulated.Under drought,salinity and high temperature conditions,expression of ZjDREB03,09,10,14,15,17 and 20 genes were induced and showed similar expression patterns,suggesting that various stress conditions share common elements in the signaling pathway.The results suggest that the family of DREB genes play an important role in abiotic stresses in jujube,and provide a foundation for further functional studies of this important class of transcriptional regulators. | Heying Zhou Jiping Jia Decang Kong Zhendong Zhang Shuang Song Yingyue Li Xiaoming Pang | 2019 | Journal of Forestry Research2019，30，4： | 8 |
| 10 | Reconstruction of nerve root sheaths for sacral extradural spinal meningeal cysts with spinal nerve root fibers显示文摘This study analyzed the clinical characteristics and outcomes of sacral extradural spinal meningeal cysts with spinal nerve root fibers treated by reconstruction of the nerve root sheaths.The relationships between the cysts and spinal nerve root fibers were examined microscopically,the cysts were partially excised,and the defects were oversewn to reconstruct the nerve root sheaths.The Improved Japanese Orthopedic Association(IJOA)scoring system was used to evaluate preoperative and postoperative neurological function.Thirty-eight patients were included in this study,with a mean age of 41.4±15.57 years.The mean IJOA score was 18.8±1.32 preoperatively and 19.6±0.65 postoperatively,which was a significant difference(t=–3.77,P=0.001).These results indicate a significant improvement in neurological function after surgery.The most significant improvement in neurological function was sensation(z=–2.86,P=0.004),followed by bowel/bladder function(z=–2.31,P=0.02). | SUN JianJun WANG ZhenYu LI ZhenDong WU HaiBo YEN RuYu ZHENG Mei CHANG Qing LIU Isabelle Yisha | 2013 | Science China(Life Sciences)2013，56，11： | 8 |
| 11 | Research and application of a power-flow-calculation method in multiterminal VSC-HVDC power grid显示文摘For demonstrating a multiterminal voltage-source converter(VSC)-based high-voltage DC(HVDC)(VSCHVDC) project, this study puts forward a technical route for calculating the power flow in a 500-kV VSC-HVDC power grid in comparison with that of an AC power grid. The Jacobian matrix used in the power-flow calculation was deduced through methods such as Newton–Laphson iteration and Taylor series expansion. Further, the operation effect of powerflow calculation on a true bipolar VSC-HVDC power grid was analyzed briefly. The elements of the Jacobian matrix corresponding to VSC were studied under the mode of droop control and the control strategy of VSC-HVDC power grid was analyzed in detail. The power-flow calculation model for VSC-HVDC power grid of the master–slave control mode was simplified using the PQ decomposition method of the power-flow calculation of an AC power grid. Moreover, a four-terminal model of the Zhangbei VSC-HVDC demonstration project was established and tested on MATLAB. The simulation results under two kinds of operating conditions were analyzed and compared to the results of BPA; the deviation between the power-flow results was studied. The results show that the proposed calculation method can provide a feasible support for calculating the power flow in VSC-HVDC grids. | Linlin Wu Xiaowei Fan Man Xu Zhendong Li Xiao Wang Xiaofei Zhang Haiwang Jin | 2019 | Global Energy Interconnection2019，2，1： | 8 |
| 12 | Adhesion Characteristics of a Novel Synthetic Polydimethylsiloxane for Bionic Adhesive Pads显示文摘 | Qingsong He Min Yu Yang Li Xinlong Chen Hao Zhang Ling Gong Zhendong Dai | 2014 | Journal of Bionic Engineering2014，11，3： | 6 |
| 13 | SUMO E3 Ligases GmSIZ1a and GmSIZ1b regulate vegetative growth in soybean显示文摘SIZ1 is a small ubiquitin-related modifier(SUMO) E3 ligase that mediates post-translational SUMO modification of target proteins and thereby regulates developmental processes and hormonal and environmental stress responses in Arabidopsis. However,the role of SUMO E3 ligases in crop plants is largely unknown. Here, we identified and characterized two Glycine max(soybean) SUMO E3 ligases, GmSIZ1a and GmSIZ1b. Expression of GmSIZ1a and GmSIZ1b was induced in response to salicylic acid(SA), heat, and dehydration treatment, but not in response to cold, abscisic acid(ABA), and Na Cl treatment. Although GmSIZ1a was expressed at higher levels than GmSIZ1b, both genes encoded proteins with SUMO E3 ligase activity in vivo.Heterologous expression of GmSIZ1a or GmSIZ1b rescued the mutant phenotype of Arabidopsis siz1-2, including dwarfism, constitutively activated expression of pathogen-related genes, and ABA-sensitive seed germination.Simultaneous downregulation of GmSIZ1a and GmSIZ1b(GmSIZ1a/b) using RNA interference(RNAi)-mediated gene silencing decreased heat shock-induced SUMO conjugation in soybean. Moreover, GmSIZ1 RNAi plants exhibited reduced plant height and leaf size. However,unlike Arabidopsis siz1-2 mutant plants, flowering time and SA levels were not significantly altered in GmSIZ1 RNAi plants. Taken together, our results indicate that GmSIZ1a and GmSIZ1b mediate SUMO modification and positively regulate vegetative growth in soybean. | Bin Cai Xiangxiong Kong Chao Zhong Suli Sun Xiao Feng Zhou Yin Hua Jin Youning Wang Xia Li Zhendong Zhu Jing Bo Jin | 2017 | Journal of Integrative Plant Biology2017，59，1： | 5 |
| 14 | Fano resonance boosted cascaded optical field enhancement in a plasmonic nanoparticle-in-cavity nanoantenna array and its SERS application显示文摘Cascaded optical field enhancement(CFE)can be realized in some specially designed multiscale plasmonic nanostructures,in which the generation of extremely strong fields at nanoscale volume is crucial for many applications,for example,surface-enhanced Raman spectroscopy(SERS).In this paper,we propose a strategy for realizing a high-quality plasmonic nanoparticle-in-cavity(PIC)nanoantenna array,in which strong coupling between a nanoparticle(NP)dark mode with a high-order nanocavity bright mode can produce strong Fano resonance at the target wavelength.The Fano resonance can effectively boost the CFE in a PIC.A cost-effective and reliable nanofabrication method is developed using room temperature nanoimprinting lithography to manufacture high-quality PIC arrays.This technique guarantees the generation of only one gold NP at the bottom of each nanocavity,which is crucial for the generation of the expected CFE.To demonstrate the performance and application of the PIC array,the PIC array is employed as an active SERS substrate for detecting 4-aminothiophenol molecules.An experimental SERS enhancement factor of 2×10^(7) is obtained,which verifies the field enhancement and the potential of this device. | Zhendong Zhu Benfeng Bai Oubo You Qunqing Li Shoushan Fan | 2015 | Light(Science & Applications)2015，4，1： | 5 |
| 15 | Movement behavior of a spider on a horizontal surface显示文摘Studying the locomotive behavior of animals has the potential to inspire the design of the mechanism and gait patterns of robots ('bio-inspired robots'). The kinematics characteristics of a spider (Ornithoctonus huwena), including movement of the legs, movement of the center of mass (COM) and joint-rotation angle, were obtained from the observation of locomotion behaviors recorded by a three-dimensional locomotion observation system. Our results showed that one set of the stance phase consists of four legs, which were leg-1 and leg-3 on one side and leg-2 and leg-4 on the other side. Additionally, two sets of the stance phase comprised eight legs alternately supporting and driving the motion of the spider's body. The spider primarily increased its movement velocity by increasing stride frequency. In comparison to other insects, the spider, O. huwena, has superior movement stability. The velocity and height of COM periodically fluctuated during movement, reaching a maximum during alternation of leg phase, and falling to a minimum in the steady stance phase. The small change in deflection angle of the hind-leg was effective in driving locomotion, whereas each joint-rotation angle of the fore-leg changed irregularly during locomotion. This research will help in the design of bio-inspired robots, including the selection of gait planning and its control. | WANG ZhouYi WANG JinTong JI AiHong LI HongKai DAI ZhenDong | 2011 | Chinese Science Bulletin2011，56，25： | 5 |
| 16 | Molecular and Physical Mapping of Powdery Mildew Resistance Genes and QTLs in Wheat: A Review显示文摘Wheat powdery mildew(Pm) is a major disease of wheat worldwide. During the past years, numerous studies have been published on molecular mapping of Pm resistance gene(s) in wheat. We summarized the relevant findings of 89 major resistance gene mapping studies and 25 quantitative trait loci(QTL) mapping studies. Major Pm resistance genes and QTLs were found on all wheat chromosomes, but the Pm resistance genes/QTLs were not randomly distributed on each chromosome of wheat. The summarized data showed that the A or B genome has more major Pm resistance genes than the D genome and chromosomes 1A, 2A, 2B, 5B, 5D, 6B, 7A and 7B harbor more major Pm resistance genes than the other chromosomes. For adult plant resistance(APR) genes/QTLs, B genome of wheat harbors more APR genes than A and D genomes, and chromosomes 2A, 4A, 5A, 1B, 2B, 3B, 5B, 6B, 7B, 2D, 5D and 7D harbor more Pm resistance QTLs than the other chromosomes,suggesting that A genome except 1A, 3A and 6A, B genome except 4B, D genome except 1D, 3D, 4D, and 6D play an important role in wheat combating against powdery mildew. Furthermore, Pm resistance genes are derived from wheat and its relatives, which suggested that the resistance sources are diverse and Pm resistance genes are diverse and useful in combating against the powdery mildew isolates. In this review, four APR genes, Pm38/Lr34/Yr18/Sr57, Pm46/Lr67/Yr46/Sr55, Pm?/Lr27/Yr30/Sr2 and Pm39/Lr46/Yr29, are not only resistant to powdery mildew but also effective for rust diseases in the field, indicating that such genes are stable and useful in wheat breeding programmes. The summarized data also provide chromosome locations or linked markers for Pm resistance genes/QTLs. Markers linked to these genes can also be utilized to pyramid diverse Pm resistance genes/QTLs more efficiently by marker-assisted selection. | Jun GUO Cheng LIU Shengnan ZHAI Haosheng LI Aifeng LIU Dungong CHENG Ran HAN Jianjun LIU Lingrang KONG Zhendong ZHAO Jianmin SONG | 2017 | Agricultural Science & Technology2017，18，6： | 5 |
| 17 | Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial显示文摘Objective:This phase 3 study aimed to test equivalence in efficacy and safety for QL1101,a bevacizumab analogue in Chinese patients with untreated locally advanced non-squamous non-small cell lung cancer(NSCLC).Methods:Eligible patients were randomly assigned 1:1 to receive carboplatin and paclitaxel in combination with either QL1101 or bevacizumab,15 mg/kg every 3-week for 6 cycles.This was followed by maintenance treatment with single agent QL1101 every 3-week.The primary end-point was objective response rate(ORR),with secondary end-points being progression-free survival(PFS),overall survival(OS),disease control rate(DCR),and adverse events(AEs).Results:Of 675 patients,535 eligible patients were randomized to the QL1101 group(n=269)and bevacizumab group(n=266).ORRs were 52.8%and 56.8%,respectively,for the QL1101 and bevacizumab groups,with an ORR hazard ratio 0.93(95%confidence interval:0.8-0131.1).The PFS,OS,DCR,and AEs were comparable between the 2 groups,which remained the same after stratification according to epidermal growth factor receptor mutation or smoking history.Conclusions:QL1101 showed similar efficacy and safety profiles as compared to bevacizumab among Chinese patients with untreated locally advanced non-squamous NSCLC. | Tianqing Chu Jun Lu Minghong Bi Helong Zhang Wu Zhuang Yan Yu Jianhua Shi Zhendong Chen Xiaochun Zhang Qisen Guo Quan Liu Huijuan Wu Jian Fang Yi Hu Xiuwen Wang Cuicui Han Kai Li Baohui Han | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 18 | Microemulsion-mediated hydrothermal synthesis of flower- like MoS2 nanomaterials with enhanced catalytic activities for anthracene hydrogenation显示文摘 | Yuxia Jiang Donge Wang Zhendong Pan Huaijun Ma Min Li Jiahe Li Anda Zheng Guang Lv Zhijian Tian | 2018 | Frontiers of Chemical Science and Engineering2018，12，1： | 4 |
| 19 | Strength softening models of soil and its application in rainfall-induced landslide simulation显示文摘In this study, strength softening models are developed for exploring rainfall-induced landslide mechanism based on Mohr-Coulomb strength theory with both saturation degree and temporal evolution into consideration. According to the ratio of two time scales available, the model can be classified into three categories, i.e., instant softening model, delay softening model, and coupling softening model. Corresponding evolution functions are specified to represent these kinds of softening processes and then applied to simulate landslide of homogeneous slopes triggered by rainfall, therefrom, useful conclusions can be drawn in the end. | Zhendong Fu Jiachun Li | 2013 | Theoretical & Applied Mechanics Letters2013，3，4： | 3 |
| 20 | Investigation of Ionic Polymer Metal Composite Actuators Loaded with Various Tetraethyl Orthosilicate Contents显示文摘 | Qingsong He Min Yu Yuxiu Li Yan Ding Dongjie Guo Zhendong Dai | 2012 | Journal of Bionic Engineering2012，9，1： | 3 |
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