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| 1 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 2 | Activation of liver X receptors promotes inflammatory cytokine mRNA degradation by upregulation of tristetraprolin显示文摘肝 X 受体(LXR ) 有反煽动性的性质。LXR 是否在煽动性的 cytokine 表示的 post-transcriptional 控制起一个作用,不是清楚的。这里,我们第一鉴别合成 LXR 收缩筋 T0901317 支持了 IL-1, IL-6 和 TNF mRNA 降级。而且, T0901317 使动摇通过它的 3-untranslated 区域的 TNF mRNA。另外, T0901317 增加了 tristetraprolin (TTP ) 的表示,当与 siRNA 反对 TTP 废除了调停 T0901317 的煽动性的 cytokine mRNA 腐烂时。有趣地, T0901317 镇压了 ERK1/2 和 p38 的导致 LPS 的 phosphorylation 在 THP-1 巨噬细胞的激活 mitogen 的蛋白质 kinase (MAPK ) 。这里介绍的证据证实有 T0901317 的 LXR 激活禁止 ERK1/2 和 p38 MAPK 的 phosphorylation,在 TTP 的增加的表示和 LPS 导致煽动性的 cytokine mRNAs 的腐烂的可能的结果。 | Ji Xiao Quan Chen Dan Tang Weiwei OU Jiazheng Wang1 Zhongcheng Mo Chaoke Tang Liangyu Peng Deming Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 7 |
| 3 | Inquiry style interactive virtual experiments: a case on circular motion显示文摘 | Shaona ZhouJing Han Nathaniel Pelz Xiaojun Wang Liangyu Peng Hua Xiao and Lei Bao | | EUROPEAN JOUKNAL OF PHYSJCS0，，： | 1 |
| 4 | Embryonic development and organogenesis of Chinese giant salamander,Andrias davidianus显示文摘The morphology and organogenesis of Chinese giant salamander, Andrias davidianus, in its different developmental periods and stages are described in detail, which provides an intact criterion for distinguishing different stages of its developmental process. Based on the external morphological and internal histological features, six periods including 20 stages of organogenesis of Chinese giant salamander are established, which are cleavage period, blastula period, gastrula period, neurula period, organogenesis stage and hatching stage. Generally, the embryonic development of Chinese giant salamander is consistent with those of Eastern newt, Cynops orientalis, and Black spots frog, R. nigromaculata. However, they have some differences in the early cleavage process and the development of digestive system. The cleavage of Chinese giant salamander, A. davidianus is not a discoidal division type, which is different from other species reported. And the first three cleavages being meridional and a retardant development of its digestive system without halter and sucker existing are the evident features of the embryonic development of Chinese giant salamander. | Luo Jian Xiao Yamei Luo Kaikun Huang Xiaoxi Peng Liangyue Liu Yun | 2007 | Progress in Natural Science:Materials International2007，17，11： | 1 |
| 5 | Improving harvest efficiency of maize varieties via accumulated temperature in a certain planting area显示文摘The ripening and drying of maize(Zea mays L.)grain are closely related to temperature.In accordance with maize grain drying characteristics,regional accumulated temperature(AT0≥0℃)distribution is of great significance for a rational allocation of maize varieties,thus reducing grain moisture content(MC)to improve maize harvest efficiency.From 2016 to 2018,a multi-site trial was carried out in the spring maize production area of Northeastern China.In this study,under a guaranteed rate of 80%for AT0,this area was divided into 15 accumulated temperature zones(ATZs)with an interval of 100℃ based on climatic data of 78 local weather stations.Then the AT0 demand of different maize varieties during different growth stages was calculated by combining experimental records with the established prediction model of MC,and then,the spatial partition for different types of maize varieties under different MCs was analyzed.The results showed that all the tested varieties could not reach physiological maturity(PM)at ATZs 13-15,hence,where maize planting is risky.With the increasing accumulated temperature demand of different types of maize varieties from planting to PM,to the MC of 25%and to the MC of 20%,the unplantable areas were gradually expanded from south to north while the region where the maize varieties could be harvested under different MCs was also moved southwardly.Additionally,at 1-2 ATZs,it is entirely possible to achieve mechanical kernel harvesting under the MC of 20%,even though the AT0 requirements of the varieties are relatively high.Conclusively,on the grounds of AT0 demand law of maize varieties and heat resource distribution in Northeastern China,the layout optimization for achieving different harvesting scenarios is conducive to providing a basis not only for selecting suitable varieties but also for promoting mechanical kernel harvesting in the spring maize production area of this region. | Zhaofu Huang Liangyu Hou Jun Xue Keru Wang Ruizhi Xie Peng Hou Bo Ming Shaokun Li | 2021 | International Journal of Agricultural and Biological Engineering2021，14，4： | 1 |
| 6 | PML–LRIF1 interactions form a novel link between promyelocytic leukemia bodies and centromeres显示文摘Dear Editor,Promyelocytic leukemia(PML)is the scaffold protein that organizes PML bod-ies,which are nuclear membraneless organelles involved in various biologi-cal processes,including tumor suppres-sion and antiviral responses(Ugge et al.,2022).Early electron microscopic analy-ses revealed contacts between the sur-face of PML bodies and chromatin struc-ture(Corpet et al.,2020).In fact,sev-eral chromatin and cell cycle regulators,such as TIP60,P300,and heterochro-matin protein 1(HP1),are localized in PML bodies in interphase cells(Corpet et al.,2020). | Junying Li Xiao Yuan Fengrui Yang Jun Cao Chunyue Wang Saima Akram Peng Zou Felix Aikhionbare Xuejun Li Yong Chen Liangyu Zhang Chuanhai Fu Zhikai Wang Xing Liu Xuebiao Yao | 2023 | Journal of Molecular Cell Biology2023，15，6： | 0 |
| 7 | Correction to: Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/ licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2019 | Protein & Cell2019，10，9： | 0 |
| 8 | Response of Different Varieties of Red Cartridge Kiwifruit to Temperature and Precipitation in Growth Stages显示文摘The responses of Hongyang,Donghong and Jinhong varieties to temperature and precipitation were analyzed by observing the growth stages of different kiwifruit varieties in Longhe red cartridge kiwifruit base of Liuzhi Special Zone of Guizhou Province in 2021 and combining with the meteorological data of temperature and precipitation in the base in the same period.The results showed that Hongyang,Donghong and Jinhong all sprouted on February 1,and had the same response to temperature and precipitation.From germination to leaf spreading stage,Hongyang and Donghong had the same response to precipitation,while Donghong and Jinhong had the same response to temperature,but Jinhong needed 32.5 mm precipitation to meet its growth and development.From leaf spreading stage to budding stage,Hongyang and Donghong had similar responses to temperature and precipitation,while Jinhong needed average daily temperature of 16.5℃and precipitation of 2.1 mm.The responses of the three varieties from budding to flowering to temperature and precipitation were consistent.From flowering to fruiting,Hongyang needed 19.9℃temperature and the least precipitation,while Jinhong needed the lowest temperature and the maximum precipitation.Donghong's response to temperature and precipitation was between Hongyang and Jinhong.During the period from fruit setting to fruit ripening and picking,Hongyang needed the least temperature and precipitation,while Donghong and Jinhong had the same response to temperature and precipitation.In the key period of fruit expansion of the three kiwifruit varieties in 2021,temperature and precipitation were the most suitable for fruit expansion.In short,red cartridge kiwifruit has a good response to temperature and precipitation in different growth stages,and it requires 201 d for Hongyang variety from germination to maturity and picking,211 d for Donghong variety and 218 d for Jinhong variety. | Lijuan LIU Liangyu PENG Zaixiang CHI Bo LI Jinmei CHEN Tianfu HUANG | 2022 | Meteorological and Environmental Research2022，13，2： | 0 |
| 9 | DESIGN OF MULTIPLE-LOOP FEEDBACK HIGH-ORDER CURRENT-MODE FILTER BASED ON FTFNS显示文摘A general multiple-loop feedback approach for realization of Four-Terminal Floating Nullor RC(FTFN-RC) filter is presented.The proposed filter is constructed by multi-output FTFNs, capacitors and resistors.It can simultaneously realize slow-pass, band-pass(if order is even number), and high-pass filter responses.With RC elements grounded and requiring no component matching con-straints, it is fully integrated conveniently.Simulations are performed for the fourth-order Butterworth filter to verify the validity of the circuit. | Xi Yanhui Peng Liangyu | 2009 | Journal of Electronics(China)2009，26，3： | 0 |
| 10 | Natural killer cells in obstetric antiphospholipid syndrome显示文摘Antiphospholipid syndrome(APS)is a systemic autoimmune disease characterized by thrombotic or obstetric events caused by persistent antiphospholipid antibodies(aPLs),namely lupus anticoagulant,anticardiolipin antibodies,or anti-β2 glycoprotein I(anti-β2GPI)antibodies.^([1])The main target antigen in APS isβ2GPI,through which aPL binds to the cell membrane and subsequently activates membrane receptors and down-stream signal transducers.This may activate natural killer(NK)cells,leading to obstetric complications. | Rongxiu Huo Qianyu Guo Junping Hu Na Li Hechao Liu Zhaoliang Zhang Liangyu Mi Xinyue Peng Liyun Zhang Ke Xu | 2022 | Chinese Medical Journal2022，，7： | 0 |
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