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| 1 | A rare Waxy allele coordinately improves rice eating and cooking quality and grain transparency显示文摘In rice(Oryza sativa), amylose content(AC) is the major factor that determines eating and cooking quality(ECQ). The diversity in AC is largely attributed to natural allelic variation at the Waxy(Wx)locus. Here we identified a rare Wx allele, Wx^(mw) ,which combines a favorable AC, improved ECQ and grain transparency. Based on a phylogenetic analysis of Wx genomic sequences from 370 rice accessions, we speculated that Wx^(mw) may have derived from recombination between two important natural Wx alleles, Wx^(in) and Wx^(b). We validated the effects of Wx^(mw) on rice grain quality using both transgenic lines and near-isogenic lines(NILs). When introgressed into the japonica Nipponbare(NIP) background, Wx^(mw) resulted in a moderate AC that was intermediate between that of NILs carrying the Wx^(b)allele and NILs with the Wx^(mp) allele. Notably, mature grains of NILs fixed for Wx^(mw) had an improved transparent endosperm relative to soft rice. Further, we introduced Wx^(mw) into a high-yielding japonica cultivar via molecular marker-assisted selection: the introgressed lines exhibited clear improvements in ECQ and endosperm transparency. Our results suggest that Wx^(mw) is a promising allele to improve grain quality, especially ECQ and grain transparency of high-yielding japonica cultivars, in rice breeding programs. | Changquan Zhang Yong Yang Shengjie Chen Xueju Liu Jihui Zhu Lihui Zhou Yan Lu Qianfeng Li Xiaolei Fan Shuzhu Tang Minghong Gu Qiaoquan Liu | 2021 | Journal of Integrative Plant Biology2021，63，5： | 18 |
| 2 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 3 | Multicomponent Tandem Polymerization of Aromatic Alkynes, Carbonyl Chloride, and Fischer's Base toward Poly(diene merocyanine)s显示文摘Summary of main observation and conclusion Multicomponent polymerization(MCP)is a popular tool to construct polymers with diverse structure,simple operation,and high efficiency,which faces the challenges of limited product structures.Multicomponent tandem polymerization(MCTP),combining two or multiple reactions in a one-pot fashion,could expand the scope of MCP and enrich the polymer structures.Herein,a one-pot three-component tandem polymerization of diynes,carbonyl chloride,and Fischer's base has been developed to afford conjugated poly(diene merocyanine)s with mild condition,satisfactory molecular weights(Mw up to 10900 g/mol)and yields(up to 81%).The polymers enjoy good solubility and high thermal stability.The unique emission behavior of the model compound and polymer show that they are aggregation-induced emission(AIE)-active,suggesting that the diene merocyanine moiety is a potential AIEgen.This MCTP shows great potential in the preparation of functional polymer materials,which could build new AlE functional units directly from the polymerization,demonstrating its synthetic simplicity and elegance. | Xiaojuan Tang Lihui Zhang Rongrong Hu Ben Zhong Tang | 2019 | Chinese Journal of Chemistry2019，37，12： | 3 |
| 4 | The solar wind plasma upstream of Mars observed by Tianwen-1:Comparison with Mars Express and MAVEN显示文摘On the great journey to Mars,China’s first planetary exploration mission,the Tianwen-1 came within 26 million kilometers of Mars from 31 October 2020 to 25 January 2021 and was getting closer to its destination,the red planet,in search of answers to the cataclysmic climate change that occurred in Martian history.Both the escape of the Martian atmosphere and the loss of surface water were firmly influenced by solar activities.Tianwen-1 provided a unique chance to depict the solar wind streams between Earth and Mars during the minimum of Solar Cycle 25.During the three-month cruise phase of Tianwen-1,the solar wind flows were successively observed at Earth,Tianwen-1,and Mars.After the field of view correction and noise reduction,the solar wind velocity and density measured by Tianwen-1 show good agreement with those at Earth and Mars.The results indicate that the performance of the ion analyzer onboard the Tianwen-1 orbiter is reliable and stable.It is worth looking forward to the joint observations of ion escape with other Mars probes in the following Martian years. | Kai FAN Limei YAN Yong WEI Aibing ZHANG Linggao KONG Markus FRÄNZ Fei HE Lihui CHAI Chongjing YUAN Yuqi WANG Jun ZHONG Zhaojin RONG Zhonghua YAO Yongxin PAN Jun CUI Jiansen HE Wenya LI Binbin TANG Chi WANG | 2022 | Science China Earth Sciences2022，65，4： | 2 |
| 5 | Paleoclimatic evolution indicated by major geochemical elements from aeolian sediments on the east of Qinghai Lake显示文摘As the largest inland lake of China, along with its unique landscape and geographical location, Qinghai Lake has got much atten- tion of the scientists for a long time. The precursors have done substantive researches by using the lake sediment, which deepen our understanding of the climate changes in this region. Although sand dunes and loess sediment are widely distributed around the lake, so far the researches on geochemical elements from aeolian sediment have been less reported. In this paper, we selected a typical aeolian profile on the east of Qinghai Lake. Based on systematic sampling and analysis of seven major geochemical elements, combined with OSL dating and previous researches, this paper discusses climate changes in the Qinghai Lake area since 12.5 ka B.P.. Our conclusions are: (1) Before 12.5 ka B.P., the climate in this region was dry, cold, and accompanied by strong wind-sand activities. (2) During 12.5-11.9 ka B.P., the climate became warm and wet. However, there was an abrupt climate cooling event during 12.2-11.9 ka B.P., which likely corresponded to the Younger Dryas event. (3) During 11.9-8.0 ka B.P., the climate fluctuated greatly and frequently from warm to cold, and three cooling events occurred. (4) During 8.0-2.6 ka B.P., the climate was warm and humid. (5) Since 2.6 ka B.P., similar to the modern climate, the climate was mainly dry and cold. | Yuan Shang RuiJie Lu FeiFei Jia LiHui Tian QingLiang Tang Yuan Chen Chao Zhao WangYang Wu | 2013 | Research in Cold and Arid Regions2013，5，3： | 2 |
| 6 | Microstructures and Mechanical Properties of Nb-Ti Bearing Hot-rolled TRIP Steels显示文摘有高粘性和保留的奥氏体的适当体积百分比的 Nb-Ti 热转动的帮助旅行的钢在实验基于好铁酸盐谷物被开发了。测试,结果证明铌趋于与更少的 降水,和铌钛在矩阵处于答案状态存在能被猛抛处于良好的竟技状态( Nb , Ti ) C 或( Nb , Ti )( C , N ),它在增加收益力量起一个重要作用(从 495 MPa 到 610 MPa )。而且,保留的奥氏体在在张力的变丑期间由转变改进粘性进马氏体上有积极效果。 | Yu CHEN Guoyi TANG Haoyang TIAN Feipeng LI Yu ZHANG Lihui WANG Zhaojun DENG Dexing LUO | 2006 | Journal of Materials Science & Technology2006，22，6： | 2 |
| 7 | AaWRKY17, a positive regulator of artemisinin biosynthesis, is involved in resistance to Pseudomonas syringae in Artemisia annua显示文摘Artemisia annua,a traditional Chinese medicinal plant,remains the only plant source for artemisinin production,yet few genes have been identified to be involved in both the response to biotic stresses,such as pathogens,and artemisinin biosynthesis.Here,we isolated and identified the WRKY transcription factor(TF)AaWRKY17,which could significantly increase the artemisinin content and resistance to Pseudomonas syringae in A.annua.Yeast one-hybrid(Y1H),dual-luciferase(dual-LUC),and electrophoretic mobility shift assay(EMSA)results showed that AaWRKY17 directly bound to the W-box motifs in the promoter region of the artemisinin biosynthetic pathway gene amorpha-4,11-diene synthase(ADS)and promoted its expression.Real-time quantitative PCR(RT-qPCR)analysis revealed that the transcript levels of two defense marker genes,Pathogenesis-Related 5(PR5)and NDR1/HIN1-LIKE 10(NHL10),were greatly increased in AaWRKY17-overexpressing transgenic A.annua plants.Additionally,overexpression of AaWRKY17 in A.annua resulted in decreased susceptibility to P.syringae.These results indicated that AaWRKY17 acted as a positive regulator in response to P.syringae infection.Together,our findings demonstrated that the novel WRKY transcription factor AaWRKY17 could potentially be used in transgenic breeding to improve the content of artemisinin and pathogen tolerance in A.annua. | Tiantian Chen Yongpeng Li Lihui Xie Xiaolong Hao Hang Liu Wei Qin Chen Wang Xin Yan Kuanyu Wu-Zhang Xinghao Yao Bowen Peng Yaojie Zhang Xueqing Fu Ling Li Kexuan Tang | 2021 | Horticulture Research2021，8，1： | 2 |
| 8 | Identification of A Novel SBF2 Frameshift Mutation in Charcot–Marie–Tooth Disease Type 4B2 Using Whole-exome Sequencing显示文摘Charcot–Marie–Tooth disease type 4B2 with early-onset glaucoma(CMT4B2, OMIM604563) is a genetically-heterogeneous childhood-onset neuromuscular disorder. Here, we report the case of a 15-year-old male adolescent with lower extremity weakness, gait abnormalities, foot deformities and early-onset glaucoma. Since clinical diagnosis alone was insufficient for providing pathogenetic evidence to indicate that the condition belonged to a consanguineous family, we applied whole-exome sequencing to samples from the patient, his parents and his younger brother,assuming that the patient's condition is transmitted in an autosomal recessive pattern. A frame-shift mutation, c.4571 del G(P.Gly1524Glufs*42), was revealed in the CMT4B2-related gene SBF2(also known as MTMR13, MIM 607697), and this mutation was found to be homozygous in the proband and heterozygous in his parents and younger brother. Together with the results of clinical diagnosis,this case was diagnosed as CMT4B2. Our finding further demonstrates the use of whole-exome sequencing in the diagnosis and treatment of rare diseases. | Meiyan Chen Jing Wu Ning Liang Lihui Tang Yanhua Chen Huishuang Chen Wei Wei Tianying Wei Hui Huang Xin Yi Ming Qi | 2014 | Genomics, Proteomics & Bioinformatics2014，12，5： | 1 |
| 9 | Research on the coupling airflows between subway piston wind and platform jet with liquid scale model test显示文摘 | Wang Lihui Liu Jiani Tang Daofa | 2011 | Advanced Material Research2011，，： | 1 |
| 10 | Dual-phase synergistic deformation characteristics and strengthening mechanism of AlCoCrFeNi_(2.1) eutectic high entropy alloy fabricated by laser powder bed fusion显示文摘Eutectic high entropy alloy(EHEA)possesses promising prospects for industrial application due to its controllable and near-equilibrium dual-phase structure.Due to the advantages of high material utiliza-tion,efficient production,and design freedom,the laser powder bed fusion(LPBF)technique provides a new path to prepare EHEA components with complex structure and excellent performance.In this study,near fully dense AlCoCrFeNi_(2.1) samples were obtained by adjusting the process parameters of LPBF.Con-sidering the balling phenomenon and powder splashing during the LPBF process,laser remelting was selected as an optimized scanning strategy to further improve the forming quality of AlCoCrFeNi21.The microstructure of remelted AlCoCrFeNi_(2.1) sample exhibited regular eutectic lamellae consisting of nano-scale face-centered-cubic(FCC)and B2 phases,in which the FCC phase accounted for a higher proportion.By investigating the tensile behavior and deformation mechanism,it was revealed that the ultrafine eu-tectic lamellae could induce a strong dual-phase synergistic strengthening,thereby significantly improv-ing the strength of the sample.Compared with the vacuum induction melted(VIM)sample,the remelted sample showed a 54%increase in ultimate tensile strength(UTS-1518 MPa)and a 130%increase in yield strength(YS-1235 MPa)with reasonable plasticity.This study indicates that by combining the design and manufacturing freedom of LPBF with the EHEA,it is expected to fabricate high-property 3D EHEA parts,expanding the application field of EHEA. | Xu Tang Hao Zhang Zhengwang Zhu Peng Xue Lihui Wu Fengchao Liu Dingrui Ni Bolv Xiao Zongyi Ma | 2023 | Journal of Materials Science & Technology2023，，19： | 0 |
| 11 | An improved hybrid bream derived from a hybrid lineage of Megalobrama amblycephala(♀)×Culter alburnus(♂)显示文摘Distant hybridization is an important technique in fish genetic breeding.In this study,based on the establishment of an allodiploid fish lineage(BT,2n=48,F_(1)–F_(6))derived from distant hybridization between female Megalobrama amblycephala(BSB,2n=48)and male Culter alburnus(TC,2n=48),and the backcross progeny(BTB,2n=48)derived by backcrossing female F_(1) of BT to male BSB,an improved hybrid bream(BTBB,2n=48)was obtained by backcrossing BTB(♀)to BSB(♂).Moreover,the morphological and genetic characteristics of BTBB individuals were investigated;BTBB was similar to BSB in appearance but had a higher body height than BSB.The study results regarding chromosome numbers and DNA content indicated that BTBB is a diploid hybrid fish.The 5S rDNA and Hox gene of BTBB were inherited from the original parents.Gonadal development in BTBB was normal.On the other hand,BTBB had a faster growth rate,higher muscle protein level,and lower muscle carbohydrate level than BSB.Hence,bisexual fertile BTBB is promoted and can be applied as a high-quality fish,and it can also be used as a new fish germplasm resource to develop high-quality fish further.Thus,this study is of great significance for fish genetic breeding. | Dingbin Gong Min Tao Lihui Xu Fangzhou Hu Zehong Wei Shi Wang Yude Wang Qingfeng Liu Chang Wu Kaikun Luo Chenchen Tang Rong Zhou Chun Zhang Yuequn Wang Shaojun Liu | 2022 | Science China(Life Sciences)2022，65，6： | 0 |
| 12 | Uncovering potential distinctive acoustic features of healing music显示文摘S Background Music therapy is a promising complementary intervention for addressing various mental health conditions.Despite evidence of the beneficial effects of music,the acoustic features that make music effective in therapeutic contexts remain elusive.Aims This study aimed to identify and validate distinctive acoustic features of healing music.Methods We constructed a healing music dataset(HMD)based on nominations from related professionals and extracted 370 acoustic features.Healing-distinctive acoustic features were identified as those that were(1)independent from genre within the HMD,(2)significantly different from music pieces in a classical music dataset(CMD)and(3)similar to pieces in a five-element music dataset(FEMD).We validated the identified features by comparing jazz pieces in the HMD with a jazz music dataset(JMD).We also examined the emotional properties of the features in a Chinese affective music system(CAMS).Results The HMD comprised 165 pieces.Among all the acoustic features,74.59%shared commonalities across genres,and 26.22%significantly differed between the HMD classical pieces and the CMD.The equivalence test showed that the HMD and FEMD did not differ significantly in 9.46%of the features.The potential healing-distinctive acoustic features were identified as the standard deviation of the roughness,mean and period entropy of the third coefficient of the mel-frequency cepstral coefficients.In a three-dimensional space defined by these features,HMD's jazz pieces could be distinguished from those of the JMD.These three features could significantly predict both subjective valence and arousal ratings in the CAMS.Conclusions The distinctive acoustic features of healing music that have been identified and validated in this study have implications for the development of artificial intelligence models for identifying therapeutic music,particularly in contexts where access to professional expertise may be limited.This study contributes to the growing body of research exploring the potential of digital technologies for healthcare interventions. | Yue Ding Jiaqi Jing Qihui Guo Jiajia Zhou Xinyao Cheng Xiaoya Chen Lihui Wang Yingying Tang Qing Fan | 2023 | General Psychiatry2023，36，6： | 0 |
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