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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 3 | Remote sensing-based artificial surface cover classification in Asia and spatial pattern analysis显示文摘Artificial surfaces, characterized with intensive land-use changes and complex landscape structures, are important indicators of human impacts on terrestrial ecosystems. Without high-resolution land-cover data at continental scale, it is hard to evaluate the impacts of urbanization on regional climate, ecosystem processes and global environment. This study constructed a hierarchical classification system for artificial surfaces, promoted a remote sensing method to retrieve subpixel components of artificial surfaces from 30-m resolution satellite imageries(Globe Land30) and developed a series of data products of high-precision urban built-up areas including impervious surface and vegetation cover in Asia in 2010. Our assessment, based on multisource data and expert knowledge, showed that the overall accuracy of classification was 90.79%. The mean relative error for the impervious surface components of cities was 0.87. The local error of the extracted information was closely related to the heterogeneity of urban buildings and vegetation in different climate zones. According to our results, the urban built-up area was 18.18×104 km2, accounting for 0.59% of the total land surface areas in Asia; urban impervious surfaces were 11.65×104 km2, accounting for 64.09% of the total urban built-up area in Asia. Vegetation and bare soils accounted for 34.56% of the urban built-up areas. There were three gradients: a concentrated distribution, a scattered distribution and an indeterminate distribution from east to west in terms of spatial pattern of urban impervious surfaces. China, India and Japan ranked as the top three countries with the largest impervious surface areas, which respectively accounted for 32.77%, 16.10% and 11.93% of the urban impervious surface area of Asia. We found the proportions of impervious surface and vegetation cover within urban built-up areas were closely related to the economic development degree of the country and regional climate environment. Built-up areas in developed countries had relatively low impervious surface and high public green vegetation cover, with 50–60% urban impervious surfaces in Japan, South Korea and Singapore. In comparison, the proportion of urban impervious surfaces in developing countries is approaching or exceeding 80% in Asia. In general, the composition and spatial patterns of built-up areas reflected population aggregation and economic development level as well as their impacts on the health of the environment in the sub-watershed. | KUANG WenHui CHEN LiJun LIU JiYuan XIANG WeiNing CHI WenFeng LU DengSheng YANG TianRong PAN Tao LIU AiLin | 2016 | Science China Earth Sciences2016，59，9： | 12 |
| 4 | Grhl3 induces human epithelial tumor cell migration and invasion via downregulation of E-cadherin显示文摘Grainyhead 基因涉及愈合弯屈和发展神经试管闭合。转移在细胞从主要肿瘤的地点传播哪个癌症并且在远器官建立第二等的肿瘤期间是一个 multistep 过程。粘附蛋白质 E-cadherin 在转移起一个必要作用。考虑到在在皮或乳癌发生在侵略的获得期间的愈合创伤的过程和 EMT 发生的 epithelialmesenchymal 转变(EMT ) 的类似的高度,我们在癌症侵略调查了 Grainyhead 基因的角色。这里,我们证明在象 Grainyhead 一样之间有一种反的关系 3 (Grhl3 ) 并且在某上皮的肿瘤房间的 E-cadherin 表示排队。在 E-cadherin-positive 上皮的肿瘤房间线的 Grhl3 的 Overexpression,由更少的侵略描绘了,产生了 E-cadherin 基因的 transcriptional 阻塞并且支持了房间移植和房间侵略。相反地, Grhl3 弄空禁止了房间移植和房间侵略并且与 E-cadherin 表示的获得被联系。为了推进,探索 Grhl3 由调整了 E-cadherin 表示的机制, E-cadherin 倡导者报告分析被表现,结果出现了那 Grhl3 镇压 E-cadherin 基因表示由对在近似 E-cadherin 倡导者在场的电子盒子直接或间接地有约束力。一起拿,我们的调查结果在癌症房间由 E-cadherin 的 downregulation 在移植和侵略的正式就职为 Grhl3 定义一个主要角色。 | Pan Zhao Sijia Guo Zhenzhen Tu Lijun Di Xiaoiun Zha Haisheng Zhou Xuejun Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，0，3： | 9 |
| 5 | Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy显示文摘Objective:To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars(GNSs)with Chlorin e6 molecules(Ce6)into human peripheral blood mononuclear cells(PBMCs)-derived NK cells for tumor targeted therapy.Methods:GNS@CaCO3/Ce6 nanoparticles were prepared and characterized by TEM and UV-vis.The cell surface markers and cytokines secretion of NK cells before and after loading the GNS@CaCO3/Ce6 nanoparticles were detected by Flow Cytometry(FCM)and ELISA.Effects of the GNS@CaCO3/Ce6-NK cells on A549 cancer cells was determined by FCM and CCK-8.Intracellular fluorescent signals of GNS@CaCO3/Ce6-NK cells were detected via Confocal laser scanning microscopic(CLSM)and FCM at different time points.Intracellular ROS generation of GNS@CaCO3/Ce6-NK cells under laser irradiation were examined by FCM.The distribution of GNS@CaCO3/Ce6-NK in A549 tumor-bearing mice were observed by fluorescence imaging and PA imaging.The combination therapy of GNS@CaCO3/Ce6-NK under laser irradiation were investigated on tumor-bearing mice.Results:The coated CaC03 shell on the surface of GNSs exhibited prominent delivery and protection effect of Ce6 during the cellular uptake process.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells possessed bimodal functions of fluorescence imaging and photoacoustic imaging.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells could actively target tumor tissues with the enhanced photothermal/photodynamic therapy and immunotherapy.Conclusions:The GNS@CaCO3/Ce6-NK shows effective tumor-targeting ability and prominent therapeutic efficacy toward lung cancer A549 tumor-bearing mice.Through fully utilizing the features of GNSs and NK cells,this new nanoplatform provides a new synergistic strategy for enhanced photothermal/photodynamic therapy and immunotherapy in the field of anticancer development in the near future. | Bin Liu Wen Cao Jin Cheng Sisi Fan Shaojun Pan Lirui Wang Jiaqi Niu Yunxiang Pan Yanlei Liu Xiyang Sun Lijun Ma Jie Song Jian Ni Daxiang Cui | 2019 | Cancer Biology & Medicine2019，16，4： | 7 |
| 6 | Strength and deformation behaviors of bedded rock mass under bolt reinforcement显示文摘The mechanism of bolt support is an important topic in mining engineering and slope treatment. The artificial material and loading system were self-developed to study the influence of bedding cohesion and bolt number on the anchoring behavior of bedded rock mass. The results show that, both peak strength and elasticity modulus increase gradually with the increase of bedding cohesion and bolt number. The axial stress–strain curve of bedded rock mass under the reinforcement of bolts presents the features of strain-softening and secondary strengthening. Finally, anchoring behavior of bedded rock mass with different bolt numbers was simulated by using FLAC3 D numerical program and the results were compared with the experimental results. This study can provide certain bases to the stability control and support design of bedded rock mass in roadway. | Wenxin Zhu Hongwen Jing Lijun Yang Bing Pan Haijian Su | 2018 | International Journal of Mining Science and Technology2018，28，4： | 7 |
| 7 | Signal processing in underwater acoustic communication system for manned deep submersible 'Jiaolong'显示文摘For the first time in the world,underwater acoustic transmission of images,human voice,data and texts between vehicle under 7000 m depth and surface ship was accomplished by underwater acoustic communication system of manned deep submersible 'Jiaolong'.In this paper,signal processing in underwater acoustic communication system for manned deep submersible 'Jiaolong' is introduced.(1) Four communication methods are integrated to meet different needs:1) coherent underwater acoustic communication,with a variable transmission rate from 5 kbps to 15 kbps,to transmit images.2) Non-coherent underwater acoustic communication, with a transmission rate 300 bps,to transmit texts,instructions,and sensor data. 3) Spread spectrum underwater acoustic communication,with a transmission rate 16 bps,to transmit instructions.4) Underwater voice communication,using single sideband modulation to transmit human voice.(2) Signal processing method in coherent communication mainly consists of concatenation of decision feedback equalizer and Turbo decoder,and wavelet based image compression with fixed length coding.In the equalizer,Doppler compensation,multichannel combining and equalizer coefficients updating are all using fast self-optimized adaptive algorithm.(3) A linear hydrophone array is lowered from the mother ship to certain depth, and spatial diversity combining technology is adopted.(4) Diving trials of 'Jiaolong' were carried out in Pacific Ocean.The communication range can cover nearly all ocean depth.One optical/acoustic image can be transmitted in 7 or 14 seconds. | ZHU Weiqing ZHU Min WU Yanbo YANG Bo XU Lijun FU Xiang PAN Feng | 2013 | Chinese Journal of Acoustics2013，32，1： | 7 |
| 8 | Genetic analysis and fine mapping of an enclosed panicle mutant esp2 in rice (Oryza sativa L.)显示文摘The phenomenon of panicle enclosure in rice is mainly caused by the shortening of uppermost internode.Elucidating the molecular mechanism of panicle enclosure will be helpful for solving the problem of panicle enclosure in male sterile lines and creating new germplasms in rice.We acquired a monogenic recessive enclosed panicle mutant,named as esp2 (enclosed shorter panicle 2),from the tissue culture progeny of indica rice cultivar Minghui-86.In the mutant,panicles were entirely enclosed by flag leaf sheaths and the uppermost internode was almost completely degenerated,but the other internodes did not have obvious changes in length.Genetic analysis indicated that the mutant phenotype was controlled by a recessive gene,which could be steadily inherited and was not affected by genetic background.Apparently,ESP2 is a key gene for the development of uppermost internode in rice.Using an F 2 population of a cross between esp2 and a japonica rice cultivar Xiushui-13 as well as SSR and InDel markers,we fine mapped ESP2 to a 14-kb region on the end of the short arm of chromosome 1.According to the rice genome sequence annotation,only one intact gene exists in this region,namely,a putative phosphatidylserine synthase gene.Sequencing analysis on the mutant and the wild type indicated that this gene was inserted by a 5287-bp retrotransposon sequence.Hence,we took this gene as a candidate of ESP2.The results of this study will facilitate the cloning and functional analysis of ESP2 gene. | GUAN HuaZhong DUAN YuanLin LIU HuaQing CHEN ZhiWei ZHUO Ming ZHUANG LiJun QI WenMing PAN RunSen MAO DaMei ZHOU YuanChang WANG Feng WU WeiRen | 2011 | Chinese Science Bulletin2011，56，14： | 6 |
| 9 | Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells显示文摘Surgery is essential for controlling the symptoms and complications of stage IV breast cancer.However,locoregional treatment of primary tumors often results in distant progression,including lung metastasis,the most common type of visceral metastasis.As a minimally invasive thermal therapy,microwave ablation(MWA)has been attempted in the treatment of breast cancer,but the innate immune response after MWA has not yet been reported.Using two murine models of stage IV breast cancer,we found that MWA of primary breast cancer inhibited the progression of lung metastasis and improved survival.NK cells were activated after MWA of the primary tumor and exhibited enhanced cytotoxic functions,and the cytotoxic pathways of NK cells were activated.Depletion experiments showed that NK cells but not CD4+or CD8+T cells played a pivotal role in prolonging survival.Then,we found that compared with surgery or control treatment,MWA of the primary tumor induced completely different NK-cell-related cytokine profiles.Macrophages were activated after MWA of the primary tumor and produced IL-15 that activated NK cells to inhibit the progression of metastasis.In addition,MWA of human breast cancer stimulated an autologous NK-cell response.These results demonstrate that MWA of the primary tumor in metastatic breast cancer inhibits metastatic progression via the macrophage/IL-15/NK-cell axis.MWA of the primary tumor may be a promising treatment strategy for de novo stage IV breast cancer,although further substantiation is essential for clinical testing. | Muxin Yu Hong Pan Nan Che Li Li Cong Wang Yue Wang Ge Ma Mengjia Qian Jiawei Liu Mingjie Zheng Hui Xie Lijun Ling Yi Zhao Xiaoxiang Guan Qiang Ding Wenbin Zhou Shui Wang | 2021 | Cellular & Molecular Immunology2021，18，9： | 5 |
| 10 | The efficacy and safety of nimodipine in acute ischemic stroke patients with mild cognitive impairment: a double-blind, randomized,placebo-controlled trial显示文摘Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remains to be established. In this multicenter, double-blind trial, we randomly assigned 654 eligible patients to nimodipine 30 mg three times a day or placebo. The primary outcome was any cognitive decline defined by the changes on the Mini-Mental State Examination(DMMSE à3) or vascular AD assessment scale cognitive subscale(DADAS-cog ! 4) at 6 months. Secondary outcomes included any distribution shift of DADAS-cog, DMMSE or cognitive improvement defined by DADAS-cog à2, or DMMSE ! 0. The primary outcome in the nimodipine group and placebo group were similar for DMMSE à3(4.18% and 7.22%, respectively, P = 0.15) and DADAS-cog ! 4(8.36% and 8.93% respectively,P = 0.88). The distribution shift of DADAS-cog and DMMSE differed significantly between the two groups(P = 0.03 and P = 0.05 respectively). Cognitive improvement occurred in 55.4% in the nimodipine group and 43.6% in the placebo group measured by DADAS-cog à2(Odds Ratio, 1.54; 95% confidence interval[CI] 1.10–2.14, P < 0.01) or 84.0% and 74.6% respectively by DMMSE ! 0(Odds Ratio, 1.79; 95% CI 1.18–2.70, P < 0.01). Nimodipine was associated with better cognitive function in the memory domain. The adverse events rate was similar in two groups. This study is registered with ClinicalTrials.gov,NCT01220622. Nimodipine did not show benefit to prevent cognitive decline in AIS patients with VaMCI, but improved cognition moderately, especially measured in the memory domain. | Huaguang Zheng Yilong Wang Anxin Wang Hao Li David Wang Xingquan Zhao Penglian Wang Haipeng Shen Lijun Zuo Yuesong Pan Zixiao Li Xia Meng Xianwei Wang Weixiong Shi Yi Ju Liping Liu Kehui Dong Chunxue Wang Rubo Sui Rong Xue Xiaoping Pan Xiaoyua Niu Benyan Luo Yi Sui Huali Wang Tao Feng Yongjun Wang | 2019 | Science Bulletin2019，64，2： | 5 |
| 11 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 12 | Impairment of cognition and sleep after acute ischaemic stroke or transient ischaemic attack in Chinese patients: design, rationale and baseline patient characteristics of a nationwide multicentre prospective registry显示文摘background and aim Cognitive impairment and sleep disorder are both common poststroke conditions and are closely related to the prognosis of patients who had a stroke.The Impairment of CognitiON and Sleep after acute ischemic stroke or transient ischemic attack in Chinese patients(ICONS)study is a nationwide multicentre prospective registry to investigate the occurrence and associated factors of cognitive impairment and sleep disorder after acute ischaemic stroke(AIS)or transient ischaemic attack(TIA).Methods Consecutive AIS or TIA in-hospital patients within 7 days after onset were enrolled from 40 participating sites in China.Comprehensive baseline clinical and imaging data were collected prospectively.Blood and urine samples were also collected on admission and follow-up visits.Patients were interviewed face to face for cognition and sleep related outcomes at 2 weeks,3,6 and 12 months after AIS/TIA and followed up for clinical outcomes by telephone annually over 5 years.results Between August 2015 and January 2018,a total of 2625 patients were enrolled.92.65% patients had AIS and 7.35% patients had TIA.Overall,the average age was 61.04 years,and 72.38% patients were male.Median National Institutes of Health Stroke Scale score was 3 in AIS patients.Conclusions The ICONS study is a large-scale nationwide prospective registry to investigate occurrence and the longitudinal changes of cognitive impairment and sleep disorder after AIS or TIA.Data from this registry may also provide opportunity to evaluate associated factors of cognitive impairment or sleep disorder after AIS or TIA and their impact on clinical outcome. | Yongjun Wang Xiaoling Liao Chunxue Wang Ning Zhang Lijun Zuo Yang Yang Yuesong Pan Xianglong Xiang Jing Jing Xia Meng Xingquan Zhao Yilong Wang Jiong Shi Hao Li | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 13 | GSH-triggered sequential catalysis for tumor imaging and eradication based on star-like Au/Pt enzyme carrier system显示文摘Distinctively different metabolism between tumor cells and normal cells endows tumor tissues unique microenvironment.In this regard,we have successfully prepared a sequential catalytic platform based on Au/Pt star for tumor theragnostic.The multifunctional probes consisted of a gold/platinum star-shaped core(Au/Pt star)conjugated with a GSH-sensitive disulfide bond(S–S),a targeting ligand(rHSA-FA),a near-infrared fluorophore(IR780)and glucose oxidase(GOx).When systemically administered in a xenografted murine model,the probes specifically targeted the tumor sites.As the disulfide linker was cleaved by intracellular GSH,the IR780 molecules could be released for photo-thermal therapy&photodynamic therapy(PTT&PDT)and imaging.Subsequently,the Pt nanolayer of the Au/Pt star and the GOx formed a sequential catalytic system:GOx effectively catalyzed intracellular glucose by consuming oxygen to generate H2O2 and enhance the local acidity,and the Pt layer exhibited peroxidase-like property to catalyze H2O2 producing toxic·OH for tumor oxidative damage.Here we demonstrated that our probes simultaneously possessed a GSH-sensitive release,real-time imaging ability,and synergetic cancer starving-like therapy/enzyme oxidative therapy/PTT/PDT features,which provides a potential strategy for effective tumor theragnostic. | Amin Zhang Qian Zhang Gabriel Alfranca Shaojun Pan Zhicheng Huang Jin Cheng Qiang Ma Jie Song Yunxiang Pan Jian Ni Lijun Ma Daxiang Cui | 2020 | Nano Research2020，13，1： | 4 |
| 14 | Quality metrology of carbon nanotube thin films and its application for carbon nanotube-based electronics显示文摘Large area,highly uniform,and density controllable carbon nanotube(CNT)films,either well-aligned or random network,are required for practical application of CNT-based electronics.Mass production methods for such CNT films and corresponding quality metrology,which are critical for pushing the CNT-based transistor technology to manufacturing,should be developed in advance.Much progress has been made on fabrication of CNT films;however,there still lacks a metrology for thoroughly quantifying their quality until now.In this paper,through comparing study of CNT films fabricated by dip-coating(DC)and direct deposition(DD)methods,local anisotropy in the film is revealed to impact the performance uniformity of devices so fabricated in a spatial scale dependent manner.The anisotropy effect should be taken into account for the quality characterization of CNT films,which was not noticed in previous studies.Based on these findings,we propose a four-parameter metrology to quantify the overall quality of the CNT films,which includes the local tube density(DL),global density uniformity(Cv),local degree of order(OL),and the relative tube proportion in a certain orientation(Pθ)at a location.The four-parameter characterization and corresponding device performance confirm DC films are superior to DD films for practical application.The four-parameter metrology is not only powerful for overall quality evaluation of CNT films,but also able to predict the fluctuation of devices’performance.Therefore,this material metrology is important for devices and circuits design and valuable for pushing the CNT-based transistor technology forward. | Jie Zhao Lijun Shen Fang Liu Pan Zhao Qi Huang Hua Han Lianmao Peng Xuelei Liang | 2020 | Nano Research2020，13，6： | 4 |
| 15 | 冷冻干燥更适合土壤活性氮气体(HONO和NO)排放的研究?显示文摘土壤活性氮气体(HONO和NO)排放是全球氮循环的关键过程,对大气化学具有重要意义。本研究采集了农田,草地和森林三种不同土地利用类型的土壤样品,分别对样品进行了风干,冻干和烘干三种处理,并与未处理的新鲜土壤进行比较研究。结果表明,三种类型土壤的冻干土与新鲜土样品的p H值差异最小。总的来说,三种干燥处理都能提高新鲜土壤NH4+-N, NO3--N和溶解态有机N的含量。与新鲜土壤相比,冻干土壤HONO和NO的最大排放通量及完整干湿交替循环的总排放量没有显著增加,而风干和烘干土壤显著增加。因此,冷冻干燥方法可能更适合涉及土壤活性氮气体排放通量的研究。这一发现的重要启示是,我们需要慎重评价以往基于不同干燥方法得到的有关陆地–大气界面活性氮交换过程和生物地球化学氮循环机制的认识。 | WU Dianming DENG Lingling LIU Yanzhuo XI Di ZOU Huilan WANG Ruhai SHA Zhimin PAN Yuepeng HOU Lijun LIU Min | 2020 | Atmospheric and Oceanic Science Letters2020，13，3： | 3 |
| 16 | Facilities for Centralized Isolation and Quarantine for the Observation and Treatment of Patients with COVID-19显示文摘The coronavirus disease 2019(COVID-19)pandemic increased the burden on many healthcare systems and in the process,exposed the need for medical resources and physical space.While few studies discussed the efficient utilization of medical resources and physical space so far.Therefore,this study aimed to summarize experiences related to facilities used for centralized isolation for medical observation and treatment during the COVID-19 pandemic in China and to provide suggestions to further improve the management of confirmed cases,suspected cases,and close contacts.In China,three types of facilities for centralized isolation(Fangcang shelter hospitals,refitted non-designated hospitals,and quarantine hotels)underwent retrofitting for the treatment and isolation of confirmed and suspected cases.These facilities mitigated the immediate high demand for space.Moreover,in order to minimize infection risks in these facilities,regulators and governmental agencies implemented new designs,management measures,and precautionary measures to minimize infection risk.Other countries and regions could refer to China’s experience in optimally allocating social resources in response to the COVID-19 pandemic.As a conclusion,government should allocate social resources and construct centralized isolation and quarantine facilities for an emergency response,health authorities should issue regulations for centralized isolation facilities and pay strict attention to the daily management of these facilities,a multidisciplinary administration team is required to support the daily operation of a centralized isolation facility,in-depth studies and international collaboration on the centralized isolation policy are encouraged. | Xianliang Wang Jiao Wang Jin Shen John SJi Lijun Pan Hang Liu Kangfeng Zhao Li Li Bo Ying Lin Fan Liubo Zhang Lin Wang Xiaoming Shi | 2021 | Engineering2021，7，7： | 3 |
| 17 | Ecological Planning and Design of Waterfront in Xianghe County from the Perspective of Landscape Security Pattern显示文摘Waterfront is a precious resource in urban ecological construction,and also a key section for ecological protection,so ecological planning of urban waterfront has far-reaching influence on the whole region.This study explored ecological planning and design of waterfront from the perspective of landscape security pattern,analyzed current waterfront in Xianghe County and construction of landscape security pattern for waterfront,provided a basis for the ecological planning and design of landscape. | SHU Ping PAN Yunsheng WANG Lijun | 2013 | Journal of Landscape Research2013，5，6： | 3 |
| 18 | Rapid and simultaneous analysis of multiple wine quality indicators through near-infrared spectroscopy with twice optimization for wavelength model显示文摘Alcohol,total sugar,total acid,and total phenol contents are the main indicators of wine quality detection.This study aims to establish simultaneous analysis models for the four indicators through near-infrared(NIR)spectroscopy with wavelength optimization.A Norris derivative filter(NDF)platform with multiparameter optimization was established for spectral pretreatment.The optimal parameters(i.e.,derivative order,number of smoothing points,and number of differential gaps)were(2,9,3)for alcohol,(1,19,5)for total sugar,(1,17,11)for total acid,and(1,1,1)for total phenol.The equidistant combinationpartial least squares(EC-PLS)was used for large-scale wavelength screening.The wavelength step-by-step phaseout PLS(WSP-PLS)and exhaustive methods were used for secondary optimization.The final optimization models for the four indicators included 7,10,15,and 13 wavelengths located in the overtone or combination regions,respectively.In an independent validation,the root mean square errors,correlation coefficient for prediction(i.e.,SEP and RP),and ratio of performance-to-deviation(RPD)were 0.41 v/v,0.947,and 3.2 for alcohol;1.48 g/L,0.992,and 6.8 for total sugar;0.68 g/L,0.981,and5.1 for total acid;and 0.181 g/L,0.948,and 2.9 for total phenol.The results indicate high correlation,low error,and good overall prediction performance.Consequently,the established reagent-free NIR analytical models are important in the rapid and real-time quality detection of the wine fermentation process and finished products.The proposed wavelength models provide a valuable reference for designing small dedicated instruments. | Jiemei CHEN Sixia LIAO Lijun YAO Tao PAN | 2021 | Frontiers of Optoelectronics2021，14，3： | 2 |
| 19 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 20 | SSR markers development and their application in genetic diversity evaluation of garlic(Allium sativum)germplasm显示文摘Garlic(Allium sativum),an asexually propagated vegetable and medicinal crop,has abundant genetic variation.Genetic diversity evaluation based on molecular markers has apparent advantages since their genomic abundance,environment insensitivity,and non-tissue specific features.However,the limited number of available DNA markers,especially SSR markers,are insufficient to conduct related genetic diversity assessment studies in garlic.In this study,4372 EST-SSR markers were newly developed,and 12 polymorphic markers together with other 17 garlic SSR markers were used to assess the genetic diversity and population structure of 127 garlic accessions.The averaged polymorphism information content(PIC)of these 29 SSR markers was 0.36,ranging from 0.22 to 0.49.Seventy-nine polymorphic loci were detected among these accessions,with an average of 3.48 polymorphic loci per SSR.Both the clustering analyses based on either the genotype data of SSR markers or the phenotypic data of morphological traits obtained genetic distance divided the 127 garlic accessions into three clusters.Moreover,the Mantel test showed that genetic distance had no significant correlations with geographic distance,and weak correlations were found between genetic distance and the phenotypic traits.AMOVA analysis showed that the main genetic variation of this garlic germplasm collection existed in the within-population or cluster.Results of this study will be of great value for the genetic/breeding studies in garlic and enhance the utilization of these garlic germplasms. | Xiaxia Li Lijun Qiao Birong Chen Yujie Zheng Chengchen Zhi Siyu Zhang Yupeng Pan Zhihui Cheng | 2022 | Plant Diversity2022，44，5： | 2 |
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