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| 1 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 2 | The Uplift of the Longmenshan Thrust Belt and Subsidence of the West Sichuan Foreland Basin显示文摘Based on fission track dating of apatite, and measurement of vitrinite reflectance of rock samples from the Longmenshan (Longmen Mountain)area and the West Sichuan foreland basin and computer modelling it is concluded that (l)the Songpan-Garze fold belt has uplifted at least by 3-4 km with an uplift rate of no less than 0.3-0.4 mm/a since 10 Ma B.P.; (2) the Longmenshan thrust nappe belt has uplifted at least by 5-6 km with an uplift rate of more than 0.5- 0.6 mm /a since 10 Ma B.P.; (3) the Longmenshan detachment belt has uplifted by 1 - 2 km at a rate of 0.016-0.032 mm/a since 60 Ma B.P.; (4) the West Sichuan foreland basin has uplifted by 1.7-3 km at a rate of 0.028-0.05 mm/a since 60 Ma B.P.; (5) the uplift rate of the area on the west side of the Beichuan-Yingxiu-Xiaoguanzi fault for the last 10 Ma is 40 times as much as that on its east side; (6) the uplifting of the the Songpan - Garze fold belt and the subsidence of the West Sichuan foreland basin 60 Ma ago exhibit a mirro-image correlation, i. | Liu Shugen, Luo Zhili, Dai Sulan, Changlu Institute of Technology, Chengdu, Sichuan, ChinaDennis Arne Dalhousie U niversity, Canadaand C.J.L. Wilson Melbourne U niversity, Australia Jiang M inxi | 1996 | Acta Geologica Sinica(English Edition)1996，70，1： | 21 |
| 3 | Continental- Margin Structure of Northeast China and Its Adjacent Areas显示文摘The continental margin of Northeast China and its adjacent areas is composed of two tectonic belts. The inner belt is a collage made up of fragments resulting from breakup of an old land with the north part related to the evolution of the Palaeo-Asian Ocean and the south part to the evolution of the Palaeo - Pacific Ocean. The outer belt is a Mesozoic terrane, which is a melange made up of fragments of the Late Palaeozoic to Early Mesozoic oceanic crust and the Late M esozoic trench accumulations.There existed another ocean-the Palaeo - Pacific Ocean during the period from the closing of the Palaeo-Asian Ocean to the opening of the modern Pacific Ocean or from the Devonian to Jurassic, and the ocean-floor spreading of the Palaeo - Pacific Ocean led to the formation of the above-mentioned tectonic belts. The development of the strike-slip fault system after the Late Jurassic and the formation of an epicontinental volcano -plutonic rock belt in the Late Cretaceous to Early Tertiary are attributed to the | Tang Kedong, Shenyang Institute of Geology and Mineral Resources, Shenyang,Liaoning ProvinceWang Ying,Bureau of Geology and Mineral Resources of Heilongjiang Province,Harbin, HeilingjiangHe Guoqi and Shao Ji’an Peking U niversity, Beijing Liu Xinzhu | 1995 | Acta Geologica Sinica(English Edition)1995，69，3： | 7 |
| 4 | Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders显示文摘Autism and autism spectrum disorders(ASD) refer to a range of conditions characterized by impaired social and communication skills and repetitive behaviors caused by different combinations of genetic and environmental influences. Although the pathophysiology underlying ASD is still unclear, recent evidence suggests that immune dysregulation and neuroinflammation play a role in the etiology of ASD. In particular, there is direct evidence supporting a role for maternal immune activation during prenatal life in neurodevelopmental conditions. Currently, the available options of behavioral therapies and pharmacological and supportive nutritional treatments in ASD are only symptomatic. Given the disturbing rise in the incidence of ASD, and the fact that there is no effective pharmacological therapy for ASD, there is an urgent need for new therapeutic options. Mesenchymal stem cells(MSCs) possess immunomodulatory properties that make them relevant to several diseases associated with inflammation and tissue damage. The paracrine regenerative mechanisms of MSCs are also suggested to be therapeutically beneficial for ASD.Thus the underlying pathology in ASD, including immune system dysregulation and inflammation, represent potential targets for MSC therapy. This review willfocus on immune dysfunction in the pathogenesis of ASD and will further discuss the therapeutic potential for MSCs in mediating ASD-related immunological disorders. | Qiang Liu Mo-Xian Chen Lin Sun Chloe U Wallis Jian-Song Zhou Li-Juan Ao Qi Li Pak C Sham | 2019 | World Journal of Stem Cells2019，11，2： | 5 |
| 5 | Role of granulocyte colony-stimulating factor in paclitaxel-induced intestinal barrier breakdown and bacterial translocation in rats显示文摘背景化疗引起肠的障碍的故障,它可以导致细菌的 translocation。Paclitaxel,一个反导管素代理人,有许多副作用;然而,它肠的障碍上的效果是未知的。以前的研究显示出刺激殖民地的因素(G-CSF ) 玩的那 granulocyte 在 modulating 的一个重要角色肠的障碍功能,而是这些研究不是最后的。这里,我们在肠的障碍上调查了 paclitaxel 的效果,并且 G-CSF 是否能阻止导致 paclitaxel 的细菌的 translocation.Methods 24 只男 Sprague-Dawley 老鼠被划分成三个组:控制组, paclitaxel 组和 paclitaxel + G-CSF 组。肠的渗透被 gavage 管理的 lactulose 和甘露糖醇的尿排泄率测量。mesenteric 淋巴节点,怒气和肝无菌地为细菌的文化被收获。血房间(白血球) 数的内毒素层次和白色被测量,细菌的 quantification 用相对即时 PCR 表现了。空肠样品也为组织学的观察被获得。肠的 apoptosis 用碎裂的 DNA 试金和终端 deoxynucleotidyl 被评估调停 transferase 的 deoxyuridine triphosphate (dUTP )-biotin 刻痕标记结束的染色。变化和菲希尔的单程的分析是准确的测试被用来比较 groups.Results Paclitaxel 之间的差别在 12.5% 空肠绒毛房间导致了 apoptosis,它被 G-CSF 处理归结为 3.8% 。在控制组的 Apoptosis 是 0.6% 。Paclitaxel 处理也在 WBC 计数导致了绒毛萎缩,增加的肠的渗透和减小。G-CSF 处理导致了增加的绒毛高度并且把白血球计数还给正常层次。而在 paclitaxel 组的 6/8,8/8,和 8/8 老鼠分别地在肝,怒气和 mesenteric 淋巴节点是文化积极的,没有细菌的 translocation 在控制组被检测。细菌的 translocation 被 G-CSF.Conclusions Paclitaxel 部分禁止破坏肠的障碍,导致细菌的 translocation。G-CSF 处理保护肠的障碍,阻止细菌的 translocation,并且稀释导致 paclitaxel 的肠的副作用。 | ZHANG Chi XU Yang-guang DUAN Xue-ning LIU Yin-hua ZHAO Jian-xin XU Uing YE Jing-ming | 2011 | Chinese Medical Journal2011，，12： | 4 |
| 6 | Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome显示文摘DNA methylation confers epigenetic regulation on gene expression and thereby on various biological processes.Tomato has emerged as an excellent system to study the function of DNA methylation in plant development.To date,regulation and function of DNA methylation maintenance remains unclear in tomato plants.Here,we report the critical function of tomato(Solanum lycopersicum)Methyltransferase 1(Sl MET1)in plant development and DNA methylome and transcriptome regulation.Using CRISPR-Cas9 gene editing,we generated slmet1 mutants and observed severe developmental defects with a frame-shift mutation,including small and curly leaves,defective inflorescence,and parthenocarpy.In leaf tissues,mutations in Sl MET1 caused CG hypomethylation and CHH hypermethylationon a whole-genome scale,leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues,which are normally expressed in fruits.Neither the CG hypomethylation nor CHH hypermethylation in the slmet1 mutants is related to tissue culture.Meanwhile,tissue culture induces non-CG hypomethylation,which occurs more frequently at gene regions than at TE regions.Our results depict Sl MET1-and tissue culture-dependent tomato DNA methylomes,and that Sl MET1 is required for maintaining a normal transcriptome and normal development of tomato. | Yu Yang Kai Tang Tatsiana U Datsenka Wenshan Liu Suhui Lv Zhaobo Lang Xingang Wang Jinghui Gao Wei Wang Wenfeng Nie Zhaoqing Chu Heng Zhang Avtar K HANDa Jian-Kang Zhu Huiming Zhang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 3 |
| 7 | Increased circulating level of interleukin-6 and CD8+T cell exhaustion are associated with progression of COVID-19显示文摘Background: Coronavirus disease 2019(COVID-19)is pandemic.It is critical to identify COVID-19 patients who are most likely to develop a severe disease.This study was designed to determine the clinical and epidemiological features of COVID-19 patients associated with the development of pneumonia and factors associated with disease progression.Methods:: Seventy consecutive patients with etiologically confirmed COVID-19 admitted to PLA General Hospital in Beijing,China from December 27,2019 to March 12,2020 were enrolled in this study and followed-up to March 16,2020.Differences in clinical and laboratory findings between COVID-19 patients with pneumonia and those without were determined by theχ2 test or the Fisher exact test(categorical variables)and independent group t test or Mann–Whitney U test(continuous variables).The Cox proportional hazard model and Generalized Estimating Equations were applied to evaluate factors that predicted the progression of COVID-19.Results: The mean incubation was 8.67(95%confidence interval,6.78–10.56)days.Mean duration from the first test severe acute respiratory syndrome coronavirus 2-positive to conversion was 11.38(9.86–12.90)days.Compared to pneumonia-free patients,pneumonia patients were 16.5 years older and had higher frequencies of having hypertension,fever,and cough and higher circulating levels of neutrophil proportion,interleukin-6,low count(<190/µl)of CD8+T cells,and neutrophil/lymphocyte ratio.Thirteen patients deteriorated during hospitalization.Cox regression analysis indicated that older age and higher serum levels of interleukin-6,C-reactive protein,procalcitonin,and lactate at admission significantly predicted the progression of COVID-19.During hospitalization,circulating counts of T lymphocytes,CD4+T cells,and CD8+T cells were lower,whereas neutrophil proportion,neutrophil/lymphocyte ratio,and the circulating levels of interleukin-6,C-reactive protein,and procalcitonin were higher,in pneumonia patients than in pneumonia-free patients.CD8+lymphocyte count in pneumonia patients did not recover when discharged.Conclusions: Older age and higher levels of C-reactive protein,procalcitionin,interleukin-6,and lactate might predict COVID-19 progression.T lymphocyte,especially CD8+cell-mediated immunity is critical in recovery of COVID-19.This study may help in predicting disease progression and designing immunotherapy for COVID-19. | Peng-Hui Yang Yi-Bo Ding Zhe Xu Rui Pu Ping U Jin Yan Ji-Luo Liu Fan-Ping Meng Lei Huang Lei Shi Tian-Jun Jiang En-Qiang Qin Min Zhao Da-Wei Zhang Peng Zhao Ling-Xiang Yu Zhao-Hai Wang Zhi-Xian Hong Zhao-Hui Xiao Qing Xi De-Xi Zhao Peng Yu Cai-Zhong Zhu Zhu Chen Shao-Geng Zhang Jun-Sheng Ji Fu-Sheng Wang Guang-Wen Cao | 2020 | Infectious Diseases of Poverty2020，9，6： | 3 |
| 8 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 9 | Pseudomonas sp.TK35-L enhances tobacco root development and growth by inducing HRGPnt3 expression in plant lateral root formation显示文摘Rhizosphere colonization is a key requirement for the application of plant growth-promoting rhizobacteria(PGPR)as a bioferilizer.Signaling molecules are often exchanged between PGPR and plants,and genes in plants may respond to the action of PGPR.Here,the luciferase luxAB gene was electrotransformed into Pseudomonas sp.strain TK35,a PGPR with an afinity for tobacco,and the labelled TK35(TK35-L)was used to monitor colonization dynamics in the tobacco rhizosphere and evaluate the effects of colonization on tobacco growth and root development.The transcript levels of the hydroxyproline rich glycoprotein HRGPnt3 gene,a lateral root induction indicator,in tobacco roots were examined by qPCR.The results showed that TK35-L could survive for long periods in the tobacco rhizosphere and colonize new spaces in the tobacco rhizosphere following tobacco root extension,exhibiting significant increases in root development,seedling growth and potassium accumulation in tobacco plants.The upregulation of HRGPnt3 transcription in the inoculated tobacco suggested that TK35-L can promote tobacco root development by upregulating the transcript levels of the HRGPnt3 gene,which promotes tobacco seedling growth.These findings lay a foundation for future studies on the molecular mechanism underlying the plant growth-promoting activities of PGPR.Futhermore,this work provided an ideal potential strain for biofertilizer production. | CAO Yuan-yuan NI Hai-ting LI Ting LAY Khien-duc LIU Dai-song U Kang-miao TANG Xin-yun WANG Xiao-bo QIU Li-juan | 2020 | Journal of Integrative Agriculture2020，19，10： | 2 |
| 10 | A High- efficiency Carrier Estimator for OFDM Communications显示文摘 | Liu H Tureli U | 1998 | IEEE Communication Letters1998，2，4： | 2 |
| 11 | Frequent rassfla promoter hypermethylation and K-ras mutations in pancreatic carcinoma显示文摘 | Dammann R Schagdarsurengin U Liu L | 2003 | Oncogene2003，22，24： | 1 |
| 12 | Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma显示文摘 | Dammann R Schagdarsurengin U Liu L | 2003 | Oncogene2003，22，24： | 1 |
| 13 | Cell cycle arrest and apoptosis induced by the coronavirus infectious bronchitis virus in the absence of p53显示文摘 | U F Q TAM J P LIU D X | 2007 | Virology2007，365，2： | 1 |
| 14 | The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance显示文摘 | Liu J Ishitani M Halfter U | 2000 | Proc Natl Acad Sci USA2000，97，7： | 1 |
| 15 | Low-complexity nonlinear least squares earlier offset estimator for OFDM: identifiability, diversity and performance 显示文摘 | Tureli U Honan P J Liu H | 2004 | Signal Processing IEEE Transactions on2004，52，9： | 1 |
| 16 | Improvement of the anodic bioelectrocatalytic activity of mixed culture biofilms by a simple consecutive electrochemical selection procedure显示文摘 | LIU Y HARNISCH F FRICKE K SIETMANN R SCHRODER U | 2008 | Biosens Bioeletron2008，24，4： | 1 |
| 17 | The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis 显示文摘 | FISCHER U Q LIU G DREYFUSS | 1997 | Cell1997，90，： | 1 |
| 18 | Existence of bounded nonoscillatory solutions of first-order nonlinear neutral delay differential equations显示文摘 | Liu Z Q Shin M K and Jeong S U | 2010 | Computers and Mathematics with Applications2010，59，： | 1 |
| 19 | The RNA helicase and nucleotide triphosphatase activities of the Bovine viral diarrhea virus NS3 protein are essential for viral replication显示文摘 | Baohua G U Changbao Liu Juili Lin | 2000 | J Virol2000，74，： | 1 |
| 20 | Feature-based representational scheme of a solid modular for providing dimensioning and tolerancing information 显示文摘 | ROY U LIU C R | 1988 | Robotics and Computer Integrated Manufacturing1988，4，3： | 1 |
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