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| 1 | Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway显示文摘Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of cancer.Here,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying mechanism.SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells.It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis.Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.SW33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR pathways.Thus,SW33 appears to be a promising drug for treating GBM effectively and safely. | Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 2 | An Arctic sea ice thickness variability revealed from satellite altimetric measurements显示文摘A modified algorithm taking into account the first year(FY) and multiyear(MY) ice densities is used to derive a sea ice thickness from freeboard measurements acquired by satellite altimetry ICESat(2003–2008). Estimates agree with various independent in situ measurements within 0.21 m. Both the fall and winter campaigns see a dramatic extent retreat of thicker MY ice that survives at least one summer melting season. There were strong seasonal and interannual variabilities with regard to the mean thickness. Seasonal increases of 0.53 m for FY the ice and 0.29 m for the MY ice between the autumn and the winter ICESat campaigns, roughly 4–5 month separation, were found. Interannually, the significant MY ice thickness declines over the consecutive four ICESat winter campaigns(2005–2008) leads to a pronounced thickness drop of 0.8 m in MY sea ice zones. No clear trend was identified from the averaged thickness of thinner, FY ice that emerges in autumn and winter and melts in summer. Uncertainty estimates for our calculated thickness, caused by the standard deviations of multiple input parameters including freeboard, ice density, snow density, snow depth, show large errors more than 0.5 m in thicker MY ice zones and relatively small standard deviations under 0.5 m elsewhere. Moreover, a sensitivity analysis is implemented to determine the separate impact on the thickness estimate in the dependence of an individual input variable as mentioned above. The results show systematic bias of the estimated ice thickness appears to be mainly caused by the variations of freeboard as well as the ice density whereas the snow density and depth brings about relatively insignificant errors. | BI Haibo HUANG Haijun SU Qiao YAN Liwen LIU Yanxia XU Xiuli | 2014 | Acta Oceanologica Sinica2014，33，11： | 8 |
| 3 | Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese显示文摘Alzheimer's disease is the most common neurodegenerative disease,and has a high level of genetic heritability and population heterogeneity.In this study,we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease,followed by independent validation,imaging analysis and function characterization.We identified an exome-wide significant rare missense variant rs3792646(p.K420Q)in the C7 gene in the discovery stage(P=1.09×10^(-6),odds ratio=7.853)and confirmed the association in different cohorts and a combined sample(1615 cases and 2832 controls,P_(combined)=2.99×10^(-7),odds ratio=1.930).The risk allele was associated with decreased hippocampal volume and poorer working memory performance in early adulthood,thus resulting in an earlier age of disease onset.Overexpression of the mutant p.K420Q disturbed cell viability,immune activation and β-amyloid processing.Electrophysiological analyses showed that the mutant p.K420Q impairs the inhibitory effect of wild type C7 on the excitatory synaptic transmission in pyramidal neurons.These findings suggested that C7 is a novel risk gene for Alzheimer’s disease in Han Chinese. | Deng-Feng Zhang Yu Fan Min Xu Guihong Wang Dong Wang Jin Li Li-Li Kong Hejiang Zhou Rongcan Luo Rui Bi Yong Wu Guo-Dong Li Ming Li Xiong-Jian Luo Hong-Yan Jiang Liwen Tan Chunjiu Zhong Yiru Fang Chen Zhang Nengyin Sheng Tianzi Jiang Yong-Gang Yao | 2019 | National Science Review2019，6，2： | 6 |
| 4 | Three Cases of COVID-19 Variant Delta With and Without Vaccination——Chengdu City,Sichuan Province,April-May,2021显示文摘On April 26,2021,a 33-year-old male Chinese sailor returning from India via Kathmandu,Nepal,tested positive for the coronavirus disease 2019(COVID-19)by Chengdu Customs and was confirmed positive by Chengdu CDC(Case A).On May 2,2021,a housewife in the same flight tested positive for COVID-19 by Pengzhou CDC in Sichuan Province during her quarantine period and was confirmed positive by Chengdu CDC the next day(Case B). | Heng Chen Yi Mao Zhenhua Duan Liang Wang Yue Cheng Yingxue Dai Haixia Luo Wenjun Xie Shuangfeng Fan Yuzhen Zhou Jingpei Xu Lan Feng Liwen Hu Zhu Liu Xian Liang Liangshuang Jiang Xiaoli Tuo | 2021 | China CDC weekly2021，3，25： | 5 |
| 5 | The pleiotropic ABNORMAL FLOWER AND DWARF1 affects plant height, floral development and grain yield in rice显示文摘Moderate plant height and successful establishment of reproductive organs play pivotal roles in rice grain production. The molecular mechanism that controls the two aspects remains unclear in rice. In the present study,we characterized a rice gene, ABNORMAL FLOWER AND DWARF1(AFD1) that determined plant height, floral development and grain yield. The afd1 mutant showed variable defects including the dwarfism, long panicle, low seed setting and reduced grain yield. In addition, abnormal floral organs were also observed in the afd1 mutant including slender and thick hulls, and hull-like lodicules.AFD1 encoded a DUF640 domain protein and was expressed in all tested tissues and organs. Subcellular localization showed AFD1-green fluorescent fusion protein(GFP) was localized in the nucleus. Meantime, our results suggested that AFD1 regulated the expression of cell division and expansion related genes. | Deyong Ren Yuchun Rao Liwen Wu Qiankun Xu Zizhuang Li Haiping Yu Yu Zhang Yujia Leng Jiang Hu Li Zhu Zhenyu Gao Guojun Dong Guangheng Zhang Longbiao Guo Dali Zeng Qian Qian | 2016 | Journal of Integrative Plant Biology2016，58，6： | 4 |
| 6 | Clinical significance of germline copy number variation in susceptibility of human diseases显示文摘Germline copy number variation(CNV) is considered to be an important form of human genetic polymorphisms. Previous studies have identified amounts of CNVs in human genome by advanced technologies, such as comparative genomic hybridization, single nucleotide genotyping, and high-throughput sequencing. CNV is speculated to be derived from multiple mechanisms, such as nonallelic homologous recombination(NAHR) and nonhomologous end-joining(NHEJ). CNVs cover a much larger genome scale than single nucleotide polymorphisms(SNPs), and may alter gene expression levels by means of gene dosage, gene fusion, gene disruption, and long-range regulation effects, thus affecting individual phenotypes and playing crucial roles in human pathogenesis. The number of studies linking CNVs with common complex diseases has increased dramatically in recent years. Here, we provide a comprehensive review of the current understanding of germline CNVs, and summarize the association of germline CNVs with the susceptibility to a wide variety of human diseases that were identified in recent years. We also propose potential issues that should be addressed in future studies. | Liwen Hu Xinyue Yao Hairong Huang Zhong Guo Xi Cheng Yang Xu Yi Shen Biao Xu Demin Li | 2018 | Journal of Genetics and Genomics2018，45，1： | 4 |
| 7 | Microwave-assisted hydrothermal synthesis of Pt/SnO2 gas sensor for CO detection显示文摘In this paper,the Pt/SnO2 nanostructures were prepared via a facile one-step microwave assisted hydrothermal route.The structure of the introduced Pt/SnO2 and its gas-sensing properties toward CO were investigated.The results from the TEM test reveal that Pt grows on the SnO2 nanostructure,which was not found for bulk in this situ method,constructing Pt/SnO2.The results indicated that the sensor using 3.0 wt%Pt/SnO2 to 100 ppm carbon monoxide performed a superior sensing properties compared to 1.5 wt%and 4.5 wt%Pt/SnO2 at 225℃.The response time of 3.0 wt%sensor is 16 s to 100 ppm CO at225℃.Such enhanced gas sensing performances could be attributed to the chemical and electrical factors.In view of chemical factors,the presence of Pt facilitates the surface reaction,which will improve the gas sensing properties.With respect to the electrical factors,the Pt/SnO2 plays roles in increasing the sensor’s response due to its characteristic configuration.In addition,the one-step in situ microwave assisted process provides a promising and versatile choice for the preparation of gas sensing materials. | Qingji Wang Liwen Bao Zongqiang Cao Chaoyang Li Xu Li Fangmeng Liu Peng Sun Geyu Lu | 2020 | Chinese Chemical Letters2020，31，8： | 4 |
| 8 | Simultaneous gene editing of three homoeoalleles in self-incompatible allohexaploid grasses显示文摘Clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system has been widely used for precise gene editing in plants.However,simultaneous gene editing of multiple homoeoalleles remains challenging,especially in self-incompatible polyploid plants.Here,we simultaneously introduced targeted mutations in all three homoeoalleles of two genes in the self-incompatible allohexaploid tall fescue,using both CRISPR/Cas9 and LbCas12a(LbCpf1)systems.Loss-of-function mutants of FaPDS exhibited albino leaves,while knockout of FaHSP17.9 resulted in impaired heat resistance in T0 generation of tall fescue.Moreover,these mutations were inheritable.Our findings demonstrate the feasibility of generating loss-of-function mutants in T0 generation polyploid perennial grasses using CRISPR/Cas systems. | Liang Zhang Tao Wang Guangyang Wang Aoyue Bi Misganaw Wassie Yan Xie Liwen Cao Huawei Xu Jinmin Fu Liang Chen Yang Zhao Tao Hu | 2021 | Journal of Integrative Plant Biology2021，63，8： | 3 |
| 9 | Structural basis of pre-mRNA recognition by the human cleavage factor Im complex显示文摘劈开因素我 m ( CF 我 m ),由 25 kDa 子单元组成( CF 我 m 25)并且三个更大的子单元之一( CF 我 m 59, CF 我 m 68, CF 我 m 72),并且一为 pre-mRNA 的必要蛋白质建筑群 3 ′ ;结束劈开和 polyadenylation 。它认出在上游的顺序 poly 以一种顺序依赖者方式的(A) 地点。这里,我们报导人的 CF 的水晶结构我 m , 包括 CF 我 m 25 和 CF 的 RNA 识别主题领域我 m 68 (CF 我 m 68RRM), 和 CF 的水晶结构我 m -RNA 建筑群。这些结构显示出那二 CF 我 m 68RRM 分子绑在 CF 我 经由形成 heterotetramer 的一个新奇 RRM 蛋白质相互作用模式更暗淡的 m 25。与反平行的取向,二 UGUAA RNA 定序的 RNA 固定的结构表演绑在一 CF 我 m 25-CF 我 m 68RRM heterotetramer,为由 CF 的机制提供结构的基础我 m 同时在 pre-mRNA 的一个分子以内绑二个 UGUAA 元素。点变化和运动分析表明那 CF 我 m 68RRM 能绑立即在上游的 flanking UGUAA 元素的区域,和 CF 我 m 68RRM 绑定显著地增加建筑群的RNA有约束力的亲密关系,建议那 CF 我 m 68 做必要贡献到 pre-mRNA 有约束力。 | Heng Li | 2011 | Cell Research2011，21，7： | 3 |
| 10 | A Matrilineal Genetic Legacy from the Last Glacial Maximum Confers Susceptibility to Schizophrenia in Han Chinese显示文摘Mitochondrial dysfunction has been widely reported in schizophrenia patients.To dissect the matrilineal structure of Han Chinese with or without schizophrenia and to decipher the maternal influence and evolutionary history of schizophrenia,a total of 1212 schizophrenia patients and 1005 matched healthy controls,all of Han Chinese origin,were recruited in Hunan Province,China.We classified haplogroup for each individual based on mitochondrial DNA(mtDNA) sequence variations and compared the haplogroup distribution pattern between cases and controls.Haplogroup B5 a presented a higher frequency in cases than in controls(P = 0.02,OR = 1.67,95%CI =[1.09,2.56]),and this result could be confirmed by permutation analysis.Age estimation of haplogroup B5 a in cases revealed a much younger age than that of controls,which was coincident with the Northern Hemisphere deglaciation at the end of the Last Glacial Maximum.Analysis of complete mtDNA in five patients belonging to haplogroup B5 a showed that this background effect might be caused by haplogroupdefining variants m.8584G>A and m.l0398A>G.Our results showed that matrilineal risk factor for schizophrenia had an ancient origin and might acquire a predisposing effect on schizophrenia due to the environment change and/or orchestration with other nuclear genetic factors appeared recently in human evolutionary history. | Wen Zhang Jinsong Tang A-Mei Zhang Min-Sheng Peng Hai-Bing Xie Liwen Tan Lin Xu Ya-Ping Zhang Xiaogang Chen Yong-Gang Yao | 2014 | Journal of Genetics and Genomics2014，41，7： | 2 |
| 11 | Development and application of digital assistive teaching system for anatomy显示文摘Background Anatomy is a required course for all medicine-related industries.In recent decades,the teaching quality and effect of anatomy have been compromised by factors including a decrease in human body specimens,dampened enthusiasm for the discipline,reduced teaching hours of anatomy,scale expansion of medical education,and obstacles in performing field autopsies and observations.Methods Based on China's digitalized visible human research achievements,this article extracts the boundary information of anatomic structures from tomographic images,constructs three dimensional(3D)digital anatomical models with authentic texture information,and develops an anatomy assistive teaching system for teachers and students based on the knowledge points of anatomy,to meet the anatomy teaching requirements of different majors at various levels.Results This scientific,complete,and holistic system has produced over 60003D digital anatomical models,5000 anatomy knowledge points,50 anatomical operation videos,and 150 micro demonstration classes,with teaching contents for different majors and levels,such as systematic anatomy,topographic anatomy,sectional anatomy,anatomy of motion,and virtual anatomical operation table.Ranging from network terminals,desktops,touchscreen 3D displays,desktops,and projection 3D volumetric displays to augmented reality,its diversified interactive forms meet the requirements for a learning environment in different settings.Conclusions With multiple teaching and learning links covered,such as teaching environment,teaching resources,instructional slides,autonomous learning,and learning effect evaluation,this novel teaching system serves as a vital component and a necessary resource in anatomy teaching and functions as an important supplement to traditional anatomy teaching.Applied and promoted in most medical colleges and schools in China,this system has been recognized and approved by anatomy teachers and students,and plays a positive role in guaranteeing the effect and quality of anatomy teaching. | Na ZHANG Liwen TAN Fengying LI Bing HAN Yifa XU | 2021 | Virtual Reality & Intelligent Hardware2021，3，4： | 1 |
| 12 | The roles of endomembrane trafficking in plant abiotic stress responses显示文摘Endomembrane trafficking is a fundamental cellular process in all eukaryotic cells and its regulatory mechanisms have been extensively studied.In plants,the endomembrane trafficking system needs to be constantly adjusted to adapt to the ever-changing environment.Evidence has accumulated supporting the idea that endomembrane trafficking is tightly linked to stress signaling pathways to meet the demands of rapid changes in cellular processes and to ensure the correct delivery of stress-related cargo molecules.However,the underlying mechanisms remain unknown.In this review,we summarize the recent findings on the functional roles of both secretory trafficking and endocytic trafficking in different types of abiotic stresses.We also highlight and discuss the unique properties of specific regulatory molecules beyond their conventional functions in endosomal trafficking during plant growth under stress conditions. | Xiangfeng Wang Min Xu Caiji Gao Yonglun Zeng Yong Cui Wenjin Shen Liwen Jiang | 2020 | Journal of Integrative Plant Biology2020，62，1： | 1 |
| 13 | Research and pro- gress of cluster algorithms based on granular computing显示文摘 | Ding Shifei Xu Li Zhu Hong Zhang Liwen | 2010 | Inter- national Journal of Digital Content Technology and its Applications2010，4，5： | 1 |
| 14 | Consistent nonnegative estimates of variance components 显示文摘 | Xu Liwen Wang Songgui Shi Jianhong | 2010 | Acta Mathematica Applicate Sinica2010，2，： | 1 |
| 15 | Simulation of Low-Carbon Tourism in World Natural and Cultural Heritage Areas: An Application to Shizhong District of Leshan City in China 显示文摘 | XU JIUPING YAO LIMING MO LIWEN | 2011 | Energy Policy2011，39，7： | 1 |
| 16 | Notch Signaling Activation Promotes Seizure Activity in Temporal Lobe Epilepsy显示文摘 | Longze Sha Xiaofeng Wu Yuan Yao Bo Wen Jing Feng Zhiqiang Sha Xueqin Wang Xiaoliang Xing Wanchen Dou Liri Jin Wenting Li Naili Wang Yan Shen Jinhui Wang Liwen Wu Qi Xu | 2014 | Molecular Neurobiology2014，，2： | 1 |
| 17 | A green,Ionic liquid and quaternary ammonium salts-catalyzed aza-michael reactions of α,β-ethylenic compounds with amines in water显示文摘 | Xu Liwen Li Jingwei Zhou Shaolin | 2004 | New Journal of Chemistry2004，28，2： | 1 |
| 18 | Dual amine-and brnsted acid-catalyzed α-allylic alkylation of aldehydes显示文摘 | Xu Liwen Gao Guang Gu Fenglei | 2010 | Advanced Synthesis & Catalysis2010，352，9： | 1 |
| 19 | The linear minimax estimator of stochastic regression coefficients and parameters under quadratic loss function显示文摘 | Xu liwen Wang songgui | 2005 | Chinese Annals of Mathematics Series A2005，26，： | 1 |
| 20 | Constitutive Modeling of Dynamic Recrystallization Kinetics and Processing Maps of Solution and Aging FGH96 Superalloy显示文摘 | Longfei Nie Liwen Zhang Zhi Zhu Wei Xu | 2013 | Journal of Materials Engineering and Performance2013，，： | 1 |
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