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| 1 | Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers显示文摘Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutathione(GSH) and reactive oxygen species(ROS) are highly upgraded in tumor tissues which makes them attractive targets for drug delivery system, we designed and synthetized a novel prodrug which utilized mono thioether bond as a linker to bridge linoleic acid(LA) and docetaxel(DTX). This mono thioether-linked conjugates(DTX-S-LA) could self-assemble into nanoparticles without the aid of much excipients. The mono thioether endowed the nanoparticles redox sensitivity resulting in specific release at the tumor tissue. Our studies demonstrated that the nanoassemblies had uniform particle size, high stability and fast release behavior. DTX-S-LA nanoassemblies outperformed DTX solution in pharmacokinetic profiles for it had longer circulation time and higher area under curve(AUC). Compared with DTX solution, the redox dual-responsive nanoassemblies had comparable cytotoxic activity. Besides, the antitumor efficacy was evaluated in mice bearing 4 T1 xenograft. It turned out this nanoassemblies couldenhance anticancer efficacy by increasing the dose because of higher tolerance. Overall, these results indicated that the redox sensitivity nanoassemblies may have a great potential to cancer therapy. | Meng Li Liwen Zhao Tao Zhang Yue Shu Zhonggui He Yan Ma Dan Liu Yongjun Wang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 10 |
| 2 | An Arctic sea ice thickness variability revealed from satellite altimetric measurements显示文摘A modified algorithm taking into account the first year(FY) and multiyear(MY) ice densities is used to derive a sea ice thickness from freeboard measurements acquired by satellite altimetry ICESat(2003–2008). Estimates agree with various independent in situ measurements within 0.21 m. Both the fall and winter campaigns see a dramatic extent retreat of thicker MY ice that survives at least one summer melting season. There were strong seasonal and interannual variabilities with regard to the mean thickness. Seasonal increases of 0.53 m for FY the ice and 0.29 m for the MY ice between the autumn and the winter ICESat campaigns, roughly 4–5 month separation, were found. Interannually, the significant MY ice thickness declines over the consecutive four ICESat winter campaigns(2005–2008) leads to a pronounced thickness drop of 0.8 m in MY sea ice zones. No clear trend was identified from the averaged thickness of thinner, FY ice that emerges in autumn and winter and melts in summer. Uncertainty estimates for our calculated thickness, caused by the standard deviations of multiple input parameters including freeboard, ice density, snow density, snow depth, show large errors more than 0.5 m in thicker MY ice zones and relatively small standard deviations under 0.5 m elsewhere. Moreover, a sensitivity analysis is implemented to determine the separate impact on the thickness estimate in the dependence of an individual input variable as mentioned above. The results show systematic bias of the estimated ice thickness appears to be mainly caused by the variations of freeboard as well as the ice density whereas the snow density and depth brings about relatively insignificant errors. | BI Haibo HUANG Haijun SU Qiao YAN Liwen LIU Yanxia XU Xiuli | 2014 | Acta Oceanologica Sinica2014，33，11： | 8 |
| 3 | AGC1.5 Kinase Phosphorylates RopGEFs to Control Pollen Tube Growth显示文摘在被子植物的两倍授精通过花粉试管要求无法移动的精子的指向的交货到卵。成长尖端的花粉试管的极性与顶端的血浆膜通过植物(ROP-GTP ) 的活跃 Rho GTPases 的动态协会被维持。为 ROP (RopGEFs ) 的 Guanine 核苷酸交换因素催化 ROP 的激活并且从而影响空间与时间的 ROP 发信号。而 RopGEFs 被发现了是 phosphorylated 蛋白质,为他们的 phosphorylation 在负责的 kinases ? vivo 和在花粉试管生长的 RopGEF phosphorylation 的生物后果仍然保持不清楚。我们这里报导细胞质的 kinases 的 Arabidopsis AGC1.5 亚科在花粉试管生长期间为 ROP-GTP 的限制本地化是批评的。AGC1.5 和 AGC1.7 功能的损失在花粉试管发信号的 ROP 下游地导致了活跃 ROP 和有缺点的事件的错误目标。AGC1.5 在容易的领域的保存重量的单位残余经由他们的催化容易的领域和 phosphorylates RopGEFs 与 RopGEFs 交往。AGC1.5 和 AGC1.7 功能的损失在花粉试管导致了 RopGEFs 的错误目标,类似于由 AGC1.5 显示 RopGEFs non-phosphorylatable 的变化引起的显型。一起,我们的结果在花粉试管的极的生长期间提供机械学的卓见进 ROP 的空间与时间的激活。 | En Li Yong Cui Fu-Rong Ge Sen Chai Wei-Tong Zhang Qiang-Nan Feng Liwen Jiang Sha Li Yan Zhang | 2018 | Molecular Plant2018，11，9： | 5 |
| 4 | Arctic sea ice volume export through the Fram Strait from combined satellite and model data:1979–2012显示文摘By combing satellite-derived ice motion and concentration with ice thickness fields from a popular model PIOMAS we obtain the estimates of ice volume flux passing the Fram Strait over the 1979–2012 period. Since current satellite and field observations for sea ice thickness are limited in time and space, the use of PIOMAS is expected to fill the gap by providing temporally continued ice thickness fields. Calculated monthly volume flux exhibits a prominent annual cycle with the peak record in March(roughly 145 km3/month) and the trough in August(10 km^3/month). Annual ice volume flux(1 132 km^3) is primarily attributable to winter(October through May) outflow(approximately 92%). Uncertainty in annual ice volume export is estimated to be 55 km^3(or 5.7%). Our results also verified the extremely large volume flux appearing between late 1980 s and mid-1990 s. Nevertheless, no clear trend was found in our volume flux results. Ice motion is the primary factor in the determination of behavior of volume flux. Ice thickness presented a general decline trend may partly enhance or weaken the volume flux trend. Ice concentration exerted the least influences on modulating trends and variability in volume flux. Moreover, the linkage between winter ice volume flux and three established Arctic atmospheric schemes were examined. Compared to NAO, the DA and EOF3 mechanism explains a larger part of variations of ice volume flux across the strait. | ZHANG Zehua BI Haibo SUN Ke HUANG Haijun LIU Yanxia YAN Liwen | 2017 | Acta Oceanologica Sinica2017，36，1： | 4 |
| 5 | Differentiation of neuron-like cells from mouse parthenogenetic embryonic stem cells显示文摘Parthenogenetic embryonic stem cells have pluripotent differentiation potentials,akin to fertilized embryo-derived embryonic stem cells.The aim of this study was to compare the neuronal differentiation potential of parthenogenetic and fertilized embryo-derived embryonic stem cells.Before differentiation,karyotype analysis was performed,with normal karyotypes detected in both parthenogenetic and fertilized embryo-derived embryonic stem cells.Sex chromosomes were identified as XX.Immunocytochemistry and quantitative real-time PCR detected high expression of the pluripotent gene,Oct4,at both the mRNA and protein levels,indicating pluripotent differentiation potential of the two embryonic stem cell subtypes.Embryonic stem cells were induced with retinoic acid to form embryoid bodies,and then dispersed into single cells.Single cells were differentiated in N2 differentiation medium for 9 days.Immunocytochemistry showed parthenogenetic and fertilized embryo-derived embryonic stem cells both express the neuronal cell markers nestin,βIII-tubulin and myelin basic protein.Quantitative real-time PCR found expression of neurogenesis related genes(Sox-1,Nestin,GABA,Pax6,Zic5 and Pitx1) in both types of embryonic stem cells,and Oct4 expression was significantly decreased.Nestin and Pax6 expression in parthenogenetic embryonic stem cells was significantly higher than that in fertilized embryo-derived embryonic stem cells.Thus,our experimental findings indicate that parthenogenetic embryonic stem cells have stronger neuronal differentiation potential than fertilized embryo-derived embryonic stem cells. | Xingrong Yan Yanhong Yang Wei Liu Wenxin Geng Huichong Du Jihong Cui Xin Xie Jinlian Hua Shumin Yu Liwen Li Fulin Chen | 2013 | Neural Regeneration Research2013，8，4： | 4 |
| 6 | Simultaneous gene editing of three homoeoalleles in self-incompatible allohexaploid grasses显示文摘Clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system has been widely used for precise gene editing in plants.However,simultaneous gene editing of multiple homoeoalleles remains challenging,especially in self-incompatible polyploid plants.Here,we simultaneously introduced targeted mutations in all three homoeoalleles of two genes in the self-incompatible allohexaploid tall fescue,using both CRISPR/Cas9 and LbCas12a(LbCpf1)systems.Loss-of-function mutants of FaPDS exhibited albino leaves,while knockout of FaHSP17.9 resulted in impaired heat resistance in T0 generation of tall fescue.Moreover,these mutations were inheritable.Our findings demonstrate the feasibility of generating loss-of-function mutants in T0 generation polyploid perennial grasses using CRISPR/Cas systems. | Liang Zhang Tao Wang Guangyang Wang Aoyue Bi Misganaw Wassie Yan Xie Liwen Cao Huawei Xu Jinmin Fu Liang Chen Yang Zhao Tao Hu | 2021 | Journal of Integrative Plant Biology2021，63，8： | 3 |
| 7 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 8 | Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance显示文摘Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way. | Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 9 | Exposure measurement, risk assessment and source identification for exposure of traffic assistants to particle-bound PAHs in Tianjin, China显示文摘To investigate the levels of exposure to particulate-bound polycyclic aromatic hydrocarbon(PAH) and to estimate the risk these levels pose to traffic assistants(TAs) in Tianjin(a megacity in North China), a measurement campaign(33 all-day exposure samples, 25 occupational-exposure samples and 10 indoor samples) was conducted to characterize the TAs' exposure to PAHs, assess the cancer risk and identify the potential sources of exposure. The average total exposure concentration of 14 PAHs was approximately 2871 ± 928 ng/m3(on-duty), and 1622 ± 457 ng/m3(all-day). The indoor PAHs level was 1257 ± 107 ng/m3. After 8000 Monte Carlo simulations, the cancer risk resulting from exposure to PAHs was found to be approximately 1.05 × 10-4. A multivariate analysis was applied to identify the potential sources, and the results showed that, in addition to vehicle exhaust, coal combustion and cooking fumes were also another two important contributors to personal PAH exposure. The diagnostic ratios of PAH compounds agree with the source apportionment results derived from principal component analysis. | Xiaodan Xue Yan You Jianhui Wu Bin Han Zhipeng Bai Naijun Tang Liwen Zhang | 2014 | Journal of Environmental Sciences2014，26，2： | 2 |
| 10 | Synthesis of Ag@Al_2O_3 Core-shell Structure Nanoparticles and Their Enhancement Effect on Dielectric Properties for Ag@Al_2O_3/Polyimide Nanocomposites显示文摘A novel core-shell structure Ag@Al2O3 nano-particles were synthesized and doped into polyimide as conductive fillers to prepare the composite films with high dielectric properties and low dielectric loss. The morphology and structures of the Ag@Al2O3 nano-particles were characterized by transmission electron microscopy(TEM), X-ray diffraction(XRD), and UV-visible spectroscopy. All the results proved that the Ag@Al2O3 nano-particles had a typical core-shell structure, for the Ag particles were coated by Al2O3 shell and the average sizes of Ag@Al2O3 particles were between 30 to 150 nm. The as-prepared Ag@Al2O3 nanoparticles were doped into the polyimide with different mass fractions to fabricate the Ag@Al2O3/PI composite films via in-situ polymerization process. SEM analysis of composite films showed that the Ag@Al2O3 nanoparticles homogeneously dispersed in polyimide matrix with nanoscale. As dielectric materials for electronic packaging systems, the Ag@Al2O3/PI composites exhibited appropriate mechanical properties and enhanced dielectric properties, including greatly enhanced dielectric constant and just a slight increase in dielectric loss. These improvements were attributed to the core-shell structure of fillers and their fine dispersion in the PI matrix. | 翁凌 YAN Liwen LI Hongxia XIA Qianshan LIU Lizhu | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，1： | 2 |
| 11 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 12 | Effects of Suspended Culture of the Seaweed Laminaria japonica Aresch on the Flow Structure and Sedimentation Processes显示文摘The culture of suspended kelp, such as Laminaria japonica Aresch, has arisen in nearshore areas for approximately 30 years since the 1980 s. This long-term activity has significant impact on the regional hydrodynamic and sedimentary environments. In this study the impact was investigated, based on synchronized multi-station data from continuous observations made within and around the culture area. In total, three current velocity profiles were identified inside and on the landward side of the culture area. Based on the current velocity profiles we calculated the boundary layer parameters, the fluxes of erosion/deposition, and the rate of sediment transport in different times at each observation site. Comparison between culture and non-culture periods showed that the presence of suspended kelp caused the reduction in the average flow velocity by approximately 49.5%, the bottom friction velocity by 24.8%, the seabed roughness length by 62.7%, and the shear stress and the flux of resuspended sediment by approximately 50%. From analyses in combination with the corresponding vertical variation of the suspended sediment distribution, it is revealed that the lifted sediments by resuspension is mixed with the upper suspended material, which will modify the regional distribution of suspended sediment. These changes in flow structure and sediment movement will accelerate seabed siltation, which corresponds to the changes in seabed erosion/deposition. However, under the influences of the seasonal changes in kelp growth the magnitude of change with the seabed siltation was not obvious inside the culture area, but a fundamental change was apparent around the culture area. | ZHANG Zehua HUANG Haijun LIU Yanxia YAN Liwen BI Haibo | 2016 | Journal of Ocean University of China2016，15，4： | 1 |
| 13 | Notch Signaling Activation Promotes Seizure Activity in Temporal Lobe Epilepsy显示文摘 | Longze Sha Xiaofeng Wu Yuan Yao Bo Wen Jing Feng Zhiqiang Sha Xueqin Wang Xiaoliang Xing Wanchen Dou Liri Jin Wenting Li Naili Wang Yan Shen Jinhui Wang Liwen Wu Qi Xu | 2014 | Molecular Neurobiology2014，，2： | 1 |
| 14 | IFN-γ-primed human bone marrow mesenchymal stem cells induce tumor cell apoptosis in vitro via tumor necrosis factor-related apoptosis-inducing ligand显示文摘 | Jingchun Du Liwen Zhou Xiaoyong Chen Sunxing Yan Ming Ke Xiaofang Lu Zhen Wang Weihua Yu Andy Peng Xiang | 2012 | International Journal of Biochemistry and Cell Biology2012，，8： | 1 |
| 15 | Circulating miR-221/222 reduces CD4^(+) T cells by inhibiting CD4 expression in colorectal cancer显示文摘Many patients with cancers have low levels of CD4+in their peripheral blood.However,the molecular mechanism is still unclear.Here,we found that the blood levels of miR-221 and miR-222 were dramatically increased in patients with colorectal cancer(CRC),and both circulating miR-211 and miR-222 served as sensitive diagnostic markers with an area under the curve of 0.8790 and 0.9148,respectively.Transfection of either miR-221 or miR-222 resulted in the reduction of the surface CD4 antigen level but not the surface CD8 antigen level.The luciferase reporter assay showed that miR-221/222 directly regulated CD4 expression in human primary T cells.These data showed that miR-221/222 levels were upregulated in the blood of patients with CRC and that the expression of CD4 in human primary T cells was inhibited by miR-221/222.These findings provide a novel strategy for modulating the number of CD4+T cells in the blood and further adjusting the microenvironment suitable for immunotherapy. | Jiajia Hu Jiawei Zhang Meng Yu Zukai Liu Yan Zou Liwen Hong Tianyu Zhang Jing Sun Minhua Zheng Xuekai Zhu Zhengting Wang Sanhong Liu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 1 |
| 16 | Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance显示文摘 | Liwu Fu Yongju Liang Liwen Deng Yan Ding Liming Chen Yanli Ye Xiaoping Yang Qichao Pan | 2004 | Cancer Chemotherapy and Pharmacology2004，，4： | 1 |
| 17 | Potential use an Actinobacillus pleuropneumoniae double mutant strain Δ apxIIC Δ apxIVA as live vaccine that allows serological differentiation between vaccinated and infected animals显示文摘 | Jinlin Liu Xia Chen Liwen Lin Chen Tan Yan Chen Yi Guo Meilin Jin Aizhen Guo Weicheng Bei Huanchun Chen | 2007 | Vaccine2007，，44： | 1 |
| 18 | Operation management of green ports and shipping networks: overview and research opportunities显示文摘Global ports and maritime shipping networks are important carriers for global supply chain networks, but they are also the main sources of energy consumption and pollution. To limit ship emissions in ports and offshore areas, the International Maritime Organization, as well as some countries, has issued a series of policies. This study highlights the importance and necessity of investigating emergent research problems in the operation management of green ports and maritime shipping networks. Considerable literature related to this topic is reviewed and discussed. Moreover, a comprehensive research framework on green port and shipping operation management is proposed for future research opportunities. The framework mainly comprises four research areas related to emission control and grading policies. This review may provide new ideas to the academia and industry practitioners for improving the performance and efficiency of the operation management of green ports and maritime shipping networks. | Lu ZHEN Dan ZHUGE Liwen MURONG Ran YAN Shuaian WANG | 2019 | Frontiers of Engineering Management2019，6，2： | 1 |
| 19 | Experimental investigation onheat transfer and pressure drop of a novel cylindrical oblique fin heatsink显示文摘 | FAN Yan LEE P S JIN Liwen | 2014 | International journal of thermal sciences2014，76，2： | 1 |
| 20 | Bioinspired Functional Surfaces for Medical Devices显示文摘Medical devices are a major component of precision medicine and play a key role in medical treatment,particularly with the rapid development of minimally invasive surgery and wearable devices.Their tissue contact properties strongly affect device performance and patient health(e.g.,heat coagulation and slipperiness on surgical graspers).However,the design and optimization of these device surfaces are still indistinct and have no supporting principles.Under such conditions,natural surfaces with various unique functions can provide solutions.This review summarizes the current progress in natural functional surfaces for medical devices,including ultra-slipperiness and strong wet attachment.The underlying mechanisms of these surfaces are attributed to their coupling effects and featured micronano structures.Depending on various medical requirements,adaptable designs and fabrication methods have been developed.Additionally,various medical device surfaces have been validated to achieve enhanced contact properties.Based on these studies,a more promising future for medical devices can be achieved for enhanced precision medicine and human health. | Liwen Zhang Guang Liu Yurun Guo Yan Wang Deyuan Zhang Huawei Chen | 2022 | Chinese Journal of Mechanical Engineering2022，35，3： | 1 |
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