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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | Differentiation of neuron-like cells from mouse parthenogenetic embryonic stem cells显示文摘Parthenogenetic embryonic stem cells have pluripotent differentiation potentials,akin to fertilized embryo-derived embryonic stem cells.The aim of this study was to compare the neuronal differentiation potential of parthenogenetic and fertilized embryo-derived embryonic stem cells.Before differentiation,karyotype analysis was performed,with normal karyotypes detected in both parthenogenetic and fertilized embryo-derived embryonic stem cells.Sex chromosomes were identified as XX.Immunocytochemistry and quantitative real-time PCR detected high expression of the pluripotent gene,Oct4,at both the mRNA and protein levels,indicating pluripotent differentiation potential of the two embryonic stem cell subtypes.Embryonic stem cells were induced with retinoic acid to form embryoid bodies,and then dispersed into single cells.Single cells were differentiated in N2 differentiation medium for 9 days.Immunocytochemistry showed parthenogenetic and fertilized embryo-derived embryonic stem cells both express the neuronal cell markers nestin,βIII-tubulin and myelin basic protein.Quantitative real-time PCR found expression of neurogenesis related genes(Sox-1,Nestin,GABA,Pax6,Zic5 and Pitx1) in both types of embryonic stem cells,and Oct4 expression was significantly decreased.Nestin and Pax6 expression in parthenogenetic embryonic stem cells was significantly higher than that in fertilized embryo-derived embryonic stem cells.Thus,our experimental findings indicate that parthenogenetic embryonic stem cells have stronger neuronal differentiation potential than fertilized embryo-derived embryonic stem cells. | Xingrong Yan Yanhong Yang Wei Liu Wenxin Geng Huichong Du Jihong Cui Xin Xie Jinlian Hua Shumin Yu Liwen Li Fulin Chen | 2013 | Neural Regeneration Research2013，8，4： | 4 |
| 3 | Surface‑Enhanced Raman Scattering Fiber Probe Based on Silver Nanocubes显示文摘Surface-enhanced Raman scattering(SERS)provides a novel method for low concentration molecular detection.The performances were highly dependent on the sizes,geometries and distributions of metal nanostructures.Here,highly sensitive SERS fber probe based on silver nanocubes(Ag NCs)was fabricated,by assembled nanostructures on planar and tapered fber tips.Ag NCs were synthesized by polyol method,and controlled by reductant content,reaction temperatures and crystal growth durations.Tapered fbers with diferent cone angles were prepared by chemical etching.The electromagnetic distribution simulation indicated that nanocubes had stronger electric feld between two cubes and vertex corners than nanosphere,under 532 nm laser excitation.The intensity could reach 53.52 V/m,for cubes with 70 nm edge length.The SERS performance of probes was characterized using crystal violet analyte.The detectable lowest concentration could reach 10^(-9) and 10^(-10) M for planar and tapered fber probes,respectively.The corresponding enhancement factor could be 9.02×10^(7) and 6.22×10^(8).The relationship between SERS peak intensities and analyte concentrations showed well linear,which indicated both fber probes could be applied for both qualitative and quantitative analysis.Furthermore,optimal cone angle of tapered fber SERS probe was 8.3°.The tapered fber SERS probes have highly sensitive activity and great potential in substance detection. | Miao Yu Qihang Tian Guangyuan He Kaimin Cui Jihong Zhang | 2021 | Advanced Fiber Materials2021，3，6： | 3 |
| 4 | Alteration of protein glycosylation in human hepatic stellate cells activated with transforming growth factor-β1显示文摘 | Yannan Qin Yaogang Zhong Liuyi Dang Minzhi Zhu Hanjie Yu Wentian Chen Jihong Cui Huijie Bian Zheng Li | 2012 | Journal of Proteomics2012，，13： | 1 |
| 5 | 溃疡性结肠炎内镜严重度指数(UCEIS)预测溃疡性结肠炎患者行储袋成形术的截点值:多中心长期随访研究结果显示文摘背景:全结直肠切除回肠储袋肛管吻合(IPAA)是溃疡性结肠炎(UC)患者的首选外科治疗术式。溃疡性结肠炎内镜严重度指数(UCEIS)用以预测UC患者的IPAA手术需求,目前尚缺乏数据。本研究旨在建立明确UCEIS预测UC患者IPAA手术需求的截点值。方法:对1986年6月至2020年3月间两个中心收治的UC患者进行回顾性分析。基于入院后首次结肠镜检查结果进行UCEIS评分。采用受试者操作特征曲线分析确定UCEIS评分预测IPAA需求的截点值。结果:293例UC患者纳入研究,中位UCEIS为4分。13年随访期间,80例(28.3%)患者接受外科治疗,其中75例(93.8%)行IPAA手术,5例(6.2%)行次全结肠切除加永久性造口。采用6分作为截点值,UCEIS对IPAA手术需求的预测价值最高,曲线下面积为0.769(P<0.001),灵敏度和特异度分别为72.0%和81.8%。UCEIS≥6是需要行IPAA手术(P<0.001)和恶性转化(P=0.010)的独立预测因素。UCEIS≥6的患者无IPAA生存时间显著短缩(P<0.001)。结论:UCEIS≥6或可作为IPAA手术决策的依据,推荐对这些UC患者行手术治疗以减少恶性转化的发生率。 | Weimin Xu Weijun Ou Jihong Fu Yubei Gu Long Cui Jie Zhong Peng Du | 2021 | Gastroenterology Report2021，9，5： | 1 |
| 6 | Ginsenoside Rb3 exerts antidepressant-like effects in several animal models 显示文摘 | Jihong Cui Lingxi Jiang Hui Xiang | 2012 | Journal of Psychopharmacology2012，26，5： | 1 |
| 7 | Na_(2)O/Li_(2)O Ratio Dependency on the Thermal,Mechanical,Dielectric Properties and Chemical Stabilities of Li_(2)O-Al_(2)O_(3)-SiO_(2) Glass显示文摘Li_(2)O-Al_(2)O_(3)-SiO_(2) based glasses were investigated as potential protection glass for electronic devices due to their excellent mechanical properties,such as high hardness,toughness,and scratch resistance.In this paper,Li_(2)O-Na_(2)O-Al_(2)O_(3)-SiO_(2) glass with different Li_(2)O/Na_(2)O ratio components were prepared by meltquenching method,and the effects of Na_(2)O/Li_(2)O ratio on the glass densities,structure,thermal,mechanical properties,and chemical stabilities were studied.The experimental results indicate that the glass transition temperature increases with the increases in Na_(2)O/Li_(2)O ratios,due to larger ion radius.While the thermal expansion coefficient slightly decreases from 11.4×10^(-6) to 11.09×10^(-6)/℃.The elastic modulus increases from 57 to 72 GPa.The bending strength reaches maximum 80.90 MPa when the Na_(2)O/Li_(2)O ratio is 1.7,then decreases as the ratio further increases.In addition,the Vicker’s hardness gets to 7.37 GPa with largest Na_(2)O/Li_(2)O ratio.Moreover,the dielectric loss and dielectric constant increases as the ratio increases.The Raman structure analysis shows the Q4[Si-O-Si]decreases as Na_(2)O/Li_(2)O ratio increases,which is responsible for the characteristic properties change.Moreover,the glass shows lowest mass loss in 10vol%HF solutions when the ratio is 1.4,while 1.7 in 5wt%NaOH solution. | 陈丽娜 谢俊 WANG Mingzhong CAO Shiyi CUI Xiuzhen LIANG Xinhui ZHANG Jihong HAN Jianjun HU Kaiwen | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，6： | 0 |
| 8 | Anti-oxidative effect of ribonuclease inhibitor by site-directed mutagenesis and expression in Pichia pastoris显示文摘Human placental ribonuclease inhibitor(hRI)is an acidic protein of Mr∼50kDa with unusually high contents of leucine and cysteine residues.It is a cytosolic protein that protects cells from the adventitious invasion of pancreatic-type ribonuclease.hRI has 32 cysteine residues,and the oxidative formation of disulfide bonds from those cysteine residues is a rapid cooperative process that inactivates hRI.The most proximal cysteine residues in native hRI are two pairs that are adjacent in sequence.In the present aork,two molecules of alanine substituting for Cys328 and Cys329 were performed by site-directed mutagenesis.The site-mutated RI cDNA was constructed into plasmid pPIC9K and then transformed Pichia pastoris GS115 by electroporation.After colony screening,the bacterium was cultured and the product was purified with affinity chromatography.The affinity of the recombinant human RI with double site mutation was examined for RNase A and its anti-oxidative effect.Results indicated that there were not many changes in the affinity for RNase A detected when compared with the wild type of RI.But the capacity of anti-oxidative effect increased by 7~9 times.The enhancement in anti-oxidative effect might be attributed to preventing the formation of disulfide bond between Cys328 and Cys329 and the three dimensional structure of RI was thereby maintained. | Wu Yu Cui Xiuyun Wang Jihong Zhao Peng Xu Yuefei Zhao Baochang | 2006 | Frontiers in Biology2006，1，2： | 0 |
| 9 | Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice显示文摘Wheat embryo globulin(WEG)has been proven to possess multiple biological activities,including antioxidative properties,immunomodulatory,and so on.Aged mouse model were established by subcutaneous injection of D-galactose(D-gal),and the effects of WEG on learning,memory,and antioxidant capacity in aging mice were explored through behavioural tests and antioxidant enzyme activities determination.Compared with the Model group,WEG improved the percentage of the platform quadrant,increased the number of crossing platforms,and enhanced the identification indexs.WEG also increased total antioxidant capacity(T-AOC),superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)activities in the liver and brains of aging mice,and reduced malondialdehyde(MDA)content.Pathological observations indicated that WEG protected against damage to brain in D-gal-induced aging mice.These results effectively revealed that WEG not only improved the abilities of learning and memory,and the cognitive impairment,but also delayed the aging process of the D-gal-induced mice. | Aimei Liao Xing Lyu Jiarui Ma Yinchen Hou Ming Hui Na Liu Yi Zhao Yixiang Cui Jihong Huang | 2023 | Food Science and Human Wellness2023，12，4： | 0 |
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