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| 1 | miR-137, a new target for post-stroke depression?显示文摘Expression of miR-137 is downregulated in brain tissue from patients with depression and suicidal behavior,and is also downregulated in peripheral blood from stroke patients.However,it is not yet known if miR-137 acts as a bridge between stroke and depression.To test this,we used middle cerebral artery occlusion and chronic mild stress to establish a post-stroke depression model in rats.Compared with controls,we found significantly lower miR-137 levels in the brain and peripheral blood from post-stroke depression rats.Injection of a miR-137 antagonist into the brain ventricles upregulated miR-137 levels,and improved behavioral changes in post-stroke depression rats.Luciferase assays showed miR-137 bound to the 3′UTR of Grin2A,regulating Grin2A expression in a neuronal cell line.Grin2A gene overexpression in the brain of post-stroke depression rats,noticeably suppressed the inhibitory effect of miR-137 on post-stroke depression.Overall,our results show that miR-137 suppresses Grin2A protein expression through binding to Grin2A mRNA,thereby exerting an inhibitory effect on post-stroke depression.Our results offer a new therapeutic direction for post-stroke depression. | Lixia Zhao Huazi Li Ruiyou Guo Teng Ma Rongyao Hou Xiaowei Ma Yifeng Du | 2013 | Neural Regeneration Research2013，8，26： | 8 |
| 2 | Corrosion Resistance of 316L Stainless Steel in Acetic Acid by EIS and Mott-Schottky显示文摘The properties of the passivation film formed on 316L stainless steel were studied by Electrochemical Impedance Spectroscopy(EIS),Mott-Schottky and Voltammetry measurements in high- temperature acetic acid.The results show that the passivation film formed on 316L stainless steel is stable in 60% acetic acid solution from 25℃to 85℃.As temperature increased,the polarization resistance decreased but the interface capacitance increased.There was hardly any relation between temperature and the intrinsic property semiconductor.The passivation film represents the p-semiconductor property in the potential interval of-0.5-0.1 V;represents the n-semiconductor property in the potential interval of 0.1-0.9 V;and represents the p-semiconductor property in the potential interval of 0.9-1.1 V.The voltammetry measurements show that the structure of the passivation film is stable when the temperature is lower than 55℃ and that its stability decreased when this temperature is exceeded. | CHENG Xuequn LI Xiaogang YANG Lixia DU Cuiwei | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 4 |
| 3 | Underreporting of Notifiable Pulmonary Tuberculosis Cases to the National Tuberculosis Information Management System--China,2015显示文摘What is already known about this topic?Tuberculosis(TB)notification data and the underreporting rate are major sources used in estimating TB incidence.China’s TB Information Management System(TBIMS)was launched in 2005 but has not yet been evaluated for sensitivity.What is added by this report?The average underreporting rate of pulmonary TB to TBIMS in selected facilities was 8.23%.However,provincial TB or infectious disease-specific health facilities,or general health facilities had higher underreporting rates.Children,migrants,and drug resistant TB patients had higher chances to be underreported than other populations.What are the implications for public health practice?Underreporting surveys should be routinely implemented in the future.This will be vital for enhancing TB reporting and the transfer mechanisms in TB or infectious disease-specific hospitals,or general hospitals and improving the case information registration procedures in designated health facilities(DHFs). | Tao Li Wei Chen Yanlin Zhao Lixia Wang Mingting Chen Xin Du Hui Zhang | 2020 | China CDC weekly2020，2，12： | 4 |
| 4 | Progress in the synthesis and applications of hierarchical flower-like TiO_2 nanostructures显示文摘Flower-like TiO_2 materials,with their advantages of high specific surface area,developed pore structure,and high photocatalytic activity,have been widely used in environmental management and air purification,sterilization,and surface self-cleaning,among other areas.This paper summarizes several methods used to fabricate the flower-like TiO_2 nanostructures,such as the hydrothermal,solvothermal,microemulsion,sol-gel,hydrolysis,and electrodeposition oxidation methods.In addition,the morphologies,properties,and performance of different flower-like TiO_2 structures are discussed.Meanwhile,the application progresses of different flower-like TiO_2 structures are also analyzed. | Zhijiao Wu Qian Wu Lixia Du Chao Jiang Lingyu Piao | 2014 | Particuology2014，12，4： | 3 |
| 5 | Colonization of endophyte Acremonium sp. D212 in Panax notoginseng and rice mediated by auxin and jasmonic acid显示文摘Endophytic fungi can be beneficial to plant growth. However, the molecular mechanisms under-lying colonization of Acremonium spp. remain unclear. In this study, a novel endophytic Acremonium strain was isolated from the buds of Panax notoginseng and named Acremonium sp. D212. The Acremonium sp. D212 could colonize the roots of P. notoginseng, enhance the resistance of P. notoginseng to root rot disease, and promote root growth and saponin bio-synthesis in P. notoginseng. Acremonium sp. D212 could secrete indole-3-acetic acid (IAA) and jasmonic acid (JA), and inoculation with the fungus increased the endogenous levels of IAA and JA in P. noto-ginseng. Colonization of the Acremonium sp. D212 in the roots of the rice line Nipponbare was dependent on the concentration of methyl jasmonate (MeJA) (2–15μmol/L) and 1-naphthalenacetic acid (NAA) (10–20μmol/L). Moreover, the roots of the JA signaling-defective coi1-18 mutant were colonized by Acremonium sp. D212 to a lesser degree than those of the wild-type Nipponbare and miR393b-overexpressing lines, and the colonization was res-cued by MeJA but not by NAA. It suggests that the cross-talk between JA signaling and the auxin biosynthetic pathway plays a crucial role in the colonization of Acremonium sp. D212 in host plants. | Li Han Xuan Zhou Yiting Zhao Shusheng Zhu Lixia Wu Yunlu He Xiangrui Ping Xinqi Lu Wuying Huang Jie Qian Lina Zhang Xi Jiang Dan Zhu Chongyu Luo Saijie Li Qian Dong Qijing Fu Kaiyuan Deng Xin Wang Lei Wang Sheng Peng Jinsong Wu Weimin Li JiǐíFriml Youyong Zhu Xiahong He Yunlong Du | 2020 | Journal of Integrative Plant Biology2020，62，9： | 2 |
| 6 | 3 - 43 Effects on Seedling Growth and Antioxidant Enzymes Activity of Oil-sunflower Irradiated by Carbon Ion Beams显示文摘 | Liu Qingfang Li Wenjian Qu Ying Zhou Libin Yu Lixia Du Yan | 2010 | IMP & HIRFL Annual Report2010，，1： | 2 |
| 7 | Increasingπ-electron availability in benzene ring incorporated graphitic carbon nitride for increased photocatalytic hydrogen generation显示文摘Increasing the availability ofπ-electron in graphitic carbon nitride(g-C_(3)N_(4))can reduce the band gap and thus enhance the photocatalytic hydrogen(H_(2))generation activity upon exposure to visible light,However,such strategy has not yet been largely applied to increase the H_(2)generation of g-C_(3)N_(4).Herein,we succes s fully increased the amount ofπ-electron in g-C_(3)N_(4)by incorporatingπ-electron-rich benzene rings through copolymerization of melamine and trimesic acid in air.The incorporation of benzene rings not only extends the light absorption of g-C_(3)N_(4)to 650 nm,but also improves the electrical conductivity due to delocalization ofπelectrons in benzene rings.As a result,a 3.4 times enhancement of photocatalytic H_(2)generation was achieved from the g-C_(3)N_(4)with benzene ring incorporation in comparing with that of pristine g-C_(3)N_(4).More interestingly,H_(2)generation still occurs under irradiation of the light ofλ≥490 nm,above the absorption edge of pristine g-C_(3)N_(4)(~460 nm),illustrating the positive effectiveness of incorporated benzene rings on enhancing the H_(2)generation capacity of g-C_(3)N_(4).The present work manifests the advantages of increasingπ-conjugated electrons on designing highly active g-C_(3)N_(4)photocatalysts. | Xiangang Lin Xiaojuan Hou Lixia Cui Shiqiang Zhao Hong Bi Haiwei Du Yupeng Yuan | 2021 | Journal of Materials Science & Technology2021，，6： | 2 |
| 8 | Detection of Asymptomatic Carotid Artery Stenosis in High-Risk Individuals of Stroke Using a Machine-Learning Algorithm显示文摘Objective Asymptomatic carotid stenosis(ACS)is closely associated to the incidence of severe cerebrovascular diseases.Early identifying the individuals with ACS and its associated risk factors could be beneficial for primary prevention of stroke.This study aimed to investigate a machine-learning algorithm for the detection of ACS among high-risk population of stroke based on the associated risk factors.Methods A novel model of machine learning was utilized to screen the associated predictors of ACS based on 30 potential risk factors.The algorithm of this model adopted a random forest pattern based on the training data and then was verified using the testing data.All of the original data were retrieved from the China National Stroke Screening and Prevention Project(CNSSPP),including demographic,clinical and laboratory characteristics.The individuals with high risk of stroke were enrolled and randomly divided into a training group and a testing group at a ratio of 4:1.The identification of carotid stenosis by carotid artery duplex scans was set as the golden standard.The receiver operating characteristic(ROC)curve and the area under the curve(AUC)was used to evaluate the efficacy of the model in detecting ACS.Results Of 2841 high risk individual of stroke enrolled,326(11.6%)were diagnosed as ACS by ultrasonography.The top five risk fectors contributing to ACS in this model were identified as family history of dyslipidemia,high level of lowdensity lipoprotein cholesterol(LDL-c),low level of high-density lipoprotein cholesterol(HDL-c),aging,and low body. | Junxiong Yin Cheng Yu Lixia Wei Chuanyong Yu Hongxing Liu Mingyang Du Feng Sun Chongjun Wang Xiaoshan Wang | 2020 | Chinese Medical Sciences Journal2020，35，4： | 2 |
| 9 | Effect of compound Guizhu capsule on phosphate and tension homology deleted on chromsome ten and murine double mimute 2 gene expression in lung cancer of mice显示文摘OBJECTIVE: To observe the inhibitory effect of the Chinese herbal compound Guizhu capsule(CGZC)on lung cancer and explore the possible mechanism underlying its actions by evaluating its effects on the expression of phosphate and tension homology deleted on chromsome ten(PTEN) and murine double mimute 2(MDM2) in lung cancer model mice.METHODS: A mouse model of transplanted lung cancer was established by subcutaneous inoculation of cancer cells into the axillae of mice. Twenty-four hours later, the mice were weighed and randomly divided into the model control group, cisplatin group(DDP group), and high, moderate and low dosage CGZC groups, with ten mice in each group. The control mice received an equal volume of distilled water. DDP was intraperitoneally injected at 1 mg/kg in the DDP group, once a day for 3days. CGZC diluted with distilled water was admin-istered at 20 g/kg(10 times the clinical adult dosage) in the high-dose group, 10 g/kg(5 times the clinical adult dosage) in the moderate-dose group and 5 g/kg(2.5 times the clinical adult dosage) in the low-dose group once a day for 10 days. On the11 th day, the mice were weighed and killed. The tumor tissues were weighed and the tumor inhibition rate was calculated. PTEN and MDM2 protein expression were detected by immunohistochemical analysis of tumor tissues.RESULTS: The CGZC high-and moderate-dose groups showed a significant inhibitory effect on tumor growth(P < 0.05); there was no significant difference between the high dose group and the DDP group(P > 0.05). The CGZC high-dose group also showed enhanced expression of PTEN protein(P <0.01) and decreased expression of MDM2 protein(P < 0.01) in lung cancer cells of the mice. There was no significant difference between the high dose group and the DDP group.CONCLUSION: CGZC has a significant inhibitory effect on transplanted lung cancer in mice. The mechanism may involve reducing expression of PTEN and decreasing the expression of MDM2 in the lung cancer tissues of the mice. | Cao Yong Zhang Shuyong Zhang Ge Zhang Na Zhang Lixia Huang Yuanliang Yuan Naijun Tang Xiaojuan Du Jiajin Fang Jiuyun | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 1 |
| 10 | Drug Utilization Knowledge Discovery Using Self-organizing Map and Rough Set Theory 显示文摘 | DU Lixia CAO Yan | 2008 | Journal of Computational Information Systems2008，4，2： | 1 |
| 11 | The application of A Markov Chain Model of Algorithmic Efficiency in termination time of TV shows 显示文摘 | DU Lixia CAO Yan | 2008 | Proceedings IEEE2008，，3： | 1 |
| 12 | Effectiveness of the Integrated TB Surveillance System--China,2018-2019显示文摘What is already known about this topic?China’s national health information system provides important support and means for deepening the country’s medical and health reform,for improving relevant delivery services,for enhancing the level of scientific management of health,and for promoting the goal of basic medical and health services for everyone in China.What is added by this report?To further the construction of the national health information system,the National Center for Tuberculosis Control and Prevention of China CDC,started a pilot project for a new tuberculosis(TB)integrated health(iHealth)surveillance system,which was integrated with regional health information platforms.The goal was to explore automatic data exchange between hospitals and disease control facilities to reduce the workload of data-entry.What are the implications for public health practice?This pilot proved that data sharing and automatic exchanges between different information systems can be achieved through a unified surveillance dataset,which could provide a reference point for the construction of surveillance systems for other infectious diseases or for the entire public health information system. | Ni Wang Tao Li Xin Du You Li Miaomiao Sun Shitong Huan Hui Zhang Lixia Wang Mingting Chen Fei Huang Yanlin Zhao | 2020 | China CDC weekly2020，2，12： | 1 |
| 13 | Age-Specific Pulmonary Tuberculosis Notification Rates—China,2008–2018显示文摘What is already known about this topic?The incidence of tuberculosis(TB)was declining in China but has plateaued in recent years.What is added by this report?Notifications of pulmonary TB declined by 27.7%between 2008 and 2018,with an average crude decline of 3.4%per year and an average age-adjusted decline of 4.3%per year.Notifications decreased faster among older people,but slower in western China;the combination of trends led to an inflection in 2016 in the overall notification trend from decreasing to stable.What are the implications for public health practice?Population ageing and geographic disparities slowed tuberculosis control progress in China.Enhanced,targeted,and proactive responses are recommended to achieve the End TB targets. | Tao Li Jun Li Xin Du Qiang Sun Lixia Wang Yanlin Zhao Fei Huang Ni Wang Kui Yang Wei Chen Hui Zhang | 2022 | China CDC weekly2022，4，38： | 1 |
| 14 | Effect of selenium on increasing free radical scavenging activities of polysaccharide extracts from a Se-enriched mushroom species of the genus Ganoderma显示文摘 | Lei Zhao Guanghua Zhao Ming Du Zhengdong Zhao Lixia Xiao Xiaosong Hu | 2008 | European Food Research and Technology2008，，3： | 1 |
| 15 | Ocotillol Enhanced the Antitumor Activity of Doxorubicin via p53-Dependent Apoptosis显示文摘 | Hongbo Wang Pengfei Yu Jing Bai Jianqiao Zhang Liang Kong Fangxi Zhang Guangying Du Shiqian Pei Lixia Zhang Yongtao Jiang Jingwei Tian Fenghua Fu Gautam Sethi | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 16 | Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic显示文摘In early 2020,the COVID-19 outbreak complicated the diagnosis,treatm ent and rehabilitation of patients with substance use disorders and increased the risks of substance abuse and addictive behaviours,such as online gaming disorders,in the general public.Substance use disorder is a chronic recurrent brain disease characterised by strong cravings,high recurrence rates,and a high proportion of comorbidity of mental and physical disorders.1 Therefore,regular long-term therapeutic interventions are critical to preventing dm g relapses while maintaining withdrawal. | Jiang Du Ni Fan Min Zhao Wei Hao Tieqiao Liu Lin Lu Jie Shi Haifeng Jiang Na Zhong Xiaochang Lan Shichao Xu Hongxian Chen Xiaojun Xiang Xuyi Wang Hongqiang Sun Bing Li Yu-Ping Ning Jing Li Wanjun Guo Yajuan Niu Lixia Sheng Yi Li Xuebin Liu Xuhui Zhou Mincai Qian Wenhua Zhou Ruiling Zhang Hongxing Hu Yan Xia Zhonghua Su Ruimin Zhang Mei Yang Fen Liu Wei Yuan | 2020 | General Psychiatry2020，33，4： | 1 |
| 17 | Effect of Mg-based spherical quasi-crystals on microstructure and mechanical properties of AZ91 alloy 显示文摘 | Zhang Jinshan Pei Lixia Du Hongwei | 2008 | J Alloys Compounds2008，453，： | 1 |
| 18 | Outbreak of acute respiratory disease caused by human adenovirus type 7 in a military training camp in Shaanxi, China显示文摘 | Pengbo Yu Chaofeng Ma Muhammad Nawaz Lei Han Jianfang Zhang Quanli Du Lixia Zhang Qunling Feng Jingjun Wang Jiru Xu | 2013 | Microbiol Immunol2013，，8： | 1 |
| 19 | Hierarchical micro-nanostructures from polyoxometalates and polydopamine:Characterization,electrochemical and intrinsic peroxidase-like properties显示文摘Hybrid composite materials with hierarchical structures have attracted continuing attention for their enhanced features and various applications.The new hybrid composites XW_(9)@PDA(XW_(9) means Na_(8)H[α-PW_(9)O_(34)],Na_(10)[α-SiW_(9)O_(34)]and Na_(10)[α-GeW_(9)O_(34)];PDA means polydopamine)have been synthesized for potential sensing applications.The effect of polyoxometalates on the formation of the hybrid composites was investigated.Scanning electron microscopy(SEM)supported the obtained XW_(9)@PDA were hierarchical microsphere.By monitoring the reaction of classical peroxidase substrate o-phenylenediamine(OPD)to form yellow 2,3-diaminophenazine(DAB)in the presence of H_(2)O_(2),the peroxidase-like activity of XW_(9)@PDA was calculated.The results showed that XW_(9)@PDA still keep the peroxidase-like activity and have 505.98%,208.58%and 582.78%enhancement in intrinsic catalytic activity for PW_(9)@PDA,SiW_(9)@PDA and GeW_(9)@PDA.Among the three composites,PW_(9)@PDA showed the highest peroxidase-like activity.Therefore,PW_(9)@PDA was applicable to the colorimetric and electrochemical sensing for H_(2)O_(2). | Ruijuan Lv Xinming Zhang Ruimeng Sun Lixia Chen Yang Zhang Rongtian Sheng Ting Du Yuhan Li Yanfei Qi | 2022 | Particuology2022，20，5： | 1 |
| 20 | First Report of Fusarium striatum Causing Root Rot Disease of Panax notoginseng in Yunnan,China显示文摘Panax notoginseng is a traditional Chinese medicinal plant.Root rot of P.notoginseng is one of the most serious diseases affecting P.notoginseng growth and causes wilted leaves,fewer lateral roots and rotten roots.Root rot is a soil-borne disease,and mainly occurs from June to August in Yunnan Province when the temperatures are high and the air is humid.In this study,the endophytic fungal genus Fusarium isolate E-2018.1.22-#3.2 was obtained from a P.notoginseng embryo.Fusarium isolate E-2018.1.22-#3.2 was identified as Fusarium striatum based on morphological characteristics and molecular analysis.The fungus was found to have conidiophores and macroconidia,and its ITS,LSU and TEF-1αgenes shared 100%,99.2%and 99%identities with the homologous genes of Fusarium striatum,respectively.Isolate F.striatum E-2018.1.22-#3.2 can cause root rot symptoms,including black,soft roots,fewer lateral roots and leaf wilt,in 93%of the experimental P.notoginseng plants,and could be re-isolated,fulfilling Koch’s postulates.When the P.notoginseng plants were treated with the fungicide pyraclostrobin,isolate F.striatum E-2018.1.22-#3.2 was unable to cause root rot.We have therefore demonstrated that F.striatum E-2018.1.22-#3.2 is able to cause root rot disease in P.notoginseng.This is the first report of root rot disease caused by F.striatum on P.notoginseng in China. | Xuan Zhou Chongyu Luo Kuixiu Li Dan Zhu Lihui Jiang Lixia Wu Youchun Li Xiahong He Yunlong Du | 2022 | Phyton-International Journal of Experimental Botany2022，91，1： | 0 |
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