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| 1 | Mechanism of electroacupuncture on inflammatory pain: neural-immune-endocrine interactions显示文摘Nociceptive signals are transmitted by peripheral afferents to the central nervous system under pain condition, a process that involves various neurotransmitters and pathways. Electroacupuncture (EA) has been widely used as a pain management technique in clinical practice. Emerging studies have shown that EA can inhibit the induction and transmission of pain signals and, consequently, mediate anti-nociceptive and anti-inflammatory effects by rebalancing the neural-immune-endocrine interactions. This review summarizes the neural-immune- endocrine circuit including peripheral afferent and central efferent, contributing to EA-induced neuroimmune and neuroendocrine modulation in inflammatory pain models. The peripheral afferent circuit includes crosstalk among immune cells, inflammatory cytokines, peripheral nociceptors. In central efferent primarily involves the neuroinflammatory interactions between spinal nociceptive neurons and glial cells. Furthermore, the hypothalamic- pituitary-adrenal axis, sympathetic and vagal nervous may serve as an essential pathway involved in the mechanism of acupuncture-mediated analgesia within the interactions of the central, immune and endocrine systems. Overall, this review focuses on the interactions of neural-immune-endocrine in inflammatory pain, which may be underlying the mechanism of EA-induced anti-inflammatory and antinociceptive effect. | Li Yuan Yang Mingxiao Wu Fan Cheng Ke Chen Haiyong Shen Xueyong Lao Lixing | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 20 |
| 2 | Single photon response of superconducting nanowire single photon detector显示文摘Single photon detection is one of the key technologies for quantum key distribution in quantum communication. As a novel single photon detection technology, superconducting nanowire single photon detector (SNSPD) surpasses conventional semiconducting single photon detectors with high count rate and low dark count rate. In this article, we introduce SNSPD fabricated from NbN ultrathin superconducting film and lab-based SNSPD system. The characteristics of single photon response pulse of SNSPD are analyzed in detail. Also discussed is the relationship between waveform of single photon response and system bandwidth. Circuit model is made to analyze the performance of SNSPD. The simulation result agrees well with the experimental data. Those results are valuable for understanding the mechanism of SNSPD and building future SNSPD system for quantum communication. | YOU LiXing SHEN XiaoFang YANG XiaoYan | 2010 | Chinese Science Bulletin2010，55，4： | 11 |
| 3 | Effect of moxa smoke produced during combustion of Aiye(Folium Artemisiae Argyi) on behavioral changes in mice inhaling the smoke显示文摘OBJECTIVE: To evaluate the effects that inhalation of the combustion products of the traditional Chinese herb Aiye(Folium Artemisiae Argyi) has on the central nervous system.METHODS: Forty Kunming mice(half male) were randomly assigned(n = 10/group) to a control group(C) or one of three moxa smoke concentration groups(% opacity): low(L1; 0.4%), medium(M1; 2%), and high(H1; 15%). Mice in the latter three groups were exposed to moxa smoke in a dynamic gas exposure cabinet for 20 min per day for7 days. Mice in control group were placed in the same cabinet without any intervention. For the sleep experiments, another 50 mice were divided into five groups of 10 mice each: a saline-injected control group, L1 + pentobarbital sodium(PS)-injected group, M1+PS group, H1(15%)+PS group,and a positive control group(10 mg/kg, chlorpromazine, p.o.). The weight, general activities, locomotor activities, rotarod performance, sleep duration,and sleeping rate induced by a subthreshold dose of pentobarbital sodium were recorded in the mice,and the composition of moxa smoke was analyzed using headspace gas chromatography(GC-HS).RESULTS: A low concentration of smoke significantly decreased the frequency of locomotor activities and the time for which the mice remaining on the rotarod; however, a high smoke concentration significantly prolonged the pentobarbital-induced sleeping time and sleeping rate.CONCLUSION: The concentration-dependent relaxing effects of moxa smoke on the Central Nervous System(CNS) were confirmed. Moreover, GC-HS analysis showed that the component present in the highest concentration in moxa smoke was eucalyp-tol, an essential oil well recognized for its soothing effects on the CNS. This may therefore be accountable for the sedative effects of moxa smoke. | Yang Jia Zheng Xiaojun Jin Ran Han Li Ha Lue Li Jun Wang Lei Liu Ping Chu Zhusheng Huang Chang Chang Hongsheng Lao Lixing Zhao Baixiao | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 8 |
| 4 | Modeling and simulation for train control system using cellular automata显示文摘Train control system plays a key role in railway traffic. Its function is to manage and control the train movement on railway networks. In our previous works, based on the cellular automata (CA) model, we proposed several models and algorithms for simulating the train movement under different control system conditions. However, these models are only suitable for some simple traffic conditions. Some basic fac- tors, which are important for train movement, are not considered. In this paper, we extend these models and algorithms and give a unified formula. Using the pro- posed method, we analyze and discuss the space-time diagram of railway traffic flow and the trajectories of the train movement. The numerical simulation and analytical results demonstrate that the unified CA model is an effective tool for simulating the train control system. | LI KePing GAO ZiYou YANG LiXing | 2007 | Science China(Technological Sciences)2007，50，6： | 6 |
| 5 | Superconducting nanowire single-photon detection system and demonstration in quantum key distribution显示文摘We developed a superconducting nanowire single-photon detection(SNSPD) system based on Gifford-McMahon cryocooler for quantum communication applications.Environmental factors which may influence the system performance are intensively studied.Those factors include temperature fluctuations,the ambient magnetic field and the background radiation.By optimizing the bias circuit,the stability of SNSPD system to electrical noise and disturbance was effectively enhanced,thus making it more suitable for field application.A 4-channel SNSPD system with quantum efficiency higher than 4% at the dark count rate of 10 Hz for λ=1550 nm is integrated and applied into a quantum key distribution(QKD) experiment.QKD was successfully carried out over 100 km optical fiber with the final secure key rate of 1.6 kbps and the quantum bit error rate of less than 2%. | CHEN SiJing LIU DengKuan YOU LiXing WANG YongLiang QIU LongQing XIE XiaoMing JIANG MianHeng CHEN TengYun LIU Yang MIKI Shigehito WANG Zhen | 2013 | Chinese Science Bulletin2013，58，10： | 4 |
| 6 | Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression显示文摘Myocardial infarction triggers massive biochemical changes, even cardiac cell death. Endoplasmic reticulum stress is involved in the pathology of myocardial infarction-mediated apoptosis. In the present study, myocardial cell line H9c2 cells were treated with cobalt chloride(CoCl_2) to induce hypoxia. Isoproterenol was used for two successive days to induce myocardial infarction in SD rats. The cardioprotective effect of olive leaf extract(OLE) and its main constituent hydroxytyrosol and the underlying mechanisms were evaluated. The results showed that hydroxytyrosol markedly protected H9c2 cells against CoCl_2-induced apoptosis. Hydroxytyrosol could reduce the mRNA and protein expression of GRP78 and CHOP induced by CoCl_2 in vitro. In vivo, the decreased ejection fraction and fractional shortening, increased heart weight/body ratio, the formation of infarction, disordered cardiac muscle fibers and infiltration of inflammatory cells induced by isoproterenol could be significantly ameliorated by pretreatment with OLE for a month. Similarly, OLE could also reverse the increase of GRP78 and CHOP expression induced by isoproterenol. Therefore, OLE and hydroxytyrosol exert a cardioprotective effect through endoplasmic reticulum stress, which could be a new target for the prevention and treatment of cardiovascular diseases. | Lixing Wu Yuyu Xu Zhijian Yang Qing Feng | 2018 | The Journal of Biomedical Research2018，32，5： | 4 |
| 7 | Repeated exposure to moxa-burning smoke: its acute and chronic toxicities in rats显示文摘OBJECTIVE: To assess toxicities of the air in Chi-nese medicine clinics polluted by moxa-burning smoke due to moxibustion-derived burning products(MBP).METHODS: Both acute and chronic toxicity studies were conducted. For the acute toxicity study, five groups of Wistar rats(n = 16/group, male: female =1∶1) were exposed to five different concentrations(95%, 90%, 85%, 80% and 75%, respectively) of MBP for 2 h. For the chronic toxicity study, another three groups of male rats(n = 21/group) were exposed to MBP in three concentrations(10%, 40%and 70%, respectively) and one control group exposed to clean air 20 min/d for 144 d. Routine examinations were performed and analyzed by analysis of variance and dose-response relationship.RESULTS: In the acute toxicity study, the number of dead rats in the 95%, 90%, 85%, 80% and 75%groups were 16, 13, 7, 6 and 3, respectively, with LD50 of 86.274% after or during the 2 h exposure.In the chronic toxicity study, MBP exposure induced a decline in activity of the rats. Rats in the10% group showed no signs of toxicity, while those in the 40% MBP group showed toxicity effects on the body weights(P < 0.05) and lung. Rats in the70% MBP group also presented with reversible damage in the blood coagulation system(P < 0.05).CONCLUSION: Exposure to 10% MBP, which is equivalent to 27.45 mg/m3, was under the critical threshold for male rats' safety. Exposure to MBP above that limit induced lung damage. MBP in clinics need to be reduced to a safe level with enhanced ventilation. | Han Li Liu Changxi Liu Ping Hu Hai Yang Jia Cai Hong Lim Minyee Zhu Maoxiang Pan Xiujie Huang Jian Cui Yingxue Lao Lixing Zhao Baixiao | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 3 |
| 8 | Enhancing phosphorus uptake efficiency through QTL-based selection for root system architecture in maize显示文摘Root system architecture(RSA) plays an important role in phosphorus(P) acquisition,but enhancing P use efficiency(PUE) in maize via genetic manipulation of RSA has not yet been reported.Here,using a maize recombinant inbred line(RIL) population,we investigated the genetic relationships between PUE and RSA,and developed P-efficient lines by selection of quantitative trait loci(QTLs) that coincide for both traits.In low-P(LP) fields,P uptake efficiency(Pup E) was more closely correlated with PUE(r =0.48-0.54),and RSA in hydroponics was significantly related to Pup E(r=0.25-0.30) but not to P utilization efficiency(Put E).QTL analysis detected a chromosome region where two QTLs for PUE,three for Pup E and three for RSA were assigned into two QTL clusters,Cl-bin3.04 a and Cl-bin3.04 b.These QTLs had favorable effects from alleles derived from the large-rooted and high-Pup E parent.Marker-assisted selection(MAS) identified nine advanced backcross-derived lines carrying Cl-bin3.04 a or Cl-bin3.04 b that displayed mean increases of 22%e26% in PUE in LP fields.Furthermore,a line L224 pyramiding Clbin3.04 a and Cl-bin3.04 b showed enhanced Pup E,relying mainly on changes in root morphology,rather than root physiology,under both hydroponic and field conditions.These results highlight the physiological and genetic contributions of RSA to maize Pup E,and provide a successful study case of developing P-efficient crops through QTL-based selection. | Riliang Gu Fanjun Chen Lizhi Long Hongguang Cai Zhigang Liu Jiabo Yang Lifeng Wang Huiyong Li Junhui Li Wenxin Liu Guohua Mi Fusuo Zhang Lixing Yuan | 2016 | Journal of Genetics and Genomics2016，43，11： | 3 |
| 9 | Robust train speed trajectory optimization: A stochastic constrained shortest path approach显示文摘Train speed trajectory optimization is a significant issue in railway traffic systems, and it plays a key role in determining energy consumption and travel time of trains. Due to the complexity of real-world operational environments, a variety of factors can lead to the uncertainty in energy-consumption. To appropriately characterize the uncertainties and generate a robust speed trajectory, this study specifically proposes distance-speed networks over the inter-station and treats the uncertainty with respect to energy consumption as discrete samplebased random variables with correlation. The problem of interest is formulated as a stochastic constrained shortest path problem with travel time threshold constraints in which the expected total energy consumption is treated as the evaluation index. To generate an approximate optimal solution, a Lagrangian relaxation algorithm combined with dynamic programming algorithm is proposed to solve the optimal solutions. Numerical examples are implemented and analyzed to demonstrate the performance of proposed approaches. | Li WANG Lixing YANG Ziyou GAO Yeran HUANG | 2017 | Frontiers of Engineering Management2017，4，4： | 3 |
| 10 | Robust energy-efficient train speed profile optimization in a scenario-based position-time-speed network显示文摘Train speed profile optimization is an efficient approach to reducing energy consumption in urban rail transit systems.Different from most existing studies that assume deterministic parameters as model inputs,this paper proposes a robust energy-efficient train speed profile optimization approach by considering the uncertainty of train modeling parameters.Specifically,we first construct a scenario-based position-time-speed(PTS)network by considering resistance parameters as discrete scenariobased random variables.Then,a percentile reliability model is proposed to generate a robust train speed profile,by which the scenario-based energy consumption is less than the model objective value at a confidence level.To solve the model efficiently,we present several algorithms to eliminate the infeasible nodes and arcs in the PTS network and propose a model reformulation strategy to transform the original model into an equivalent linear programming model.Lastly,on the basis of our field test data collected in Beijing metro Yizhuang line,a series of experiments are conducted to verify the effectiveness of the model and analyze the influences of parameter uncertainties on the generated train speed profile. | Yu CHENG Jiateng YIN Lixing YANG | 2021 | Frontiers of Engineering Management2021，8，4： | 3 |
| 11 | Hollow Gradient-Structured Iron-Anchored Carbon Nanospheres for Enhanced Electromagnetic Wave Absorption显示文摘In the present paper,a microwave absorber with nanoscale gradient structure was proposed for enhancing the electromagnetic absorption performance.The inorganic-organic competitive coating strategy was employed,which can effectively adjust the thermodynamic and kinetic reactions of iron ions during the solvothermal process.As a result,Fe nanoparticles can be gradually decreased from the inner side to the surface across the hollow carbon shell.The results reveal that it offers an outstanding reflection loss value in combination with broadband wave absorption and flexible adjustment ability,which is superior to other relative graded distribution structures and satisfied with the requirements of lightweight equipment.In addition,this work elucidates the intrinsic microwave regulation mechanism of the multiscale hybrid electromagnetic wave absorber.The excellent impedance matching and moderate dielectric parameters are exhibited to be the dominative factors for the promotion of microwave absorption performance of the optimized materials.This strategy to prepare gradient-distributed microwave absorbing materials initiates a new way for designing and fabricating wave absorber with excellent impedance matching property in practical applications. | Cao Wu Jing Wang Xiaohang Zhang Lixing Kang Xun Cao Yongyi Zhang Yutao Niu Yingying Yu Huili Fu Zongjie Shen Kunjie Wu Zhenzhong Yong Jingyun Zou Bin Wang Zhou Chen Zhengpeng Yang Qingwen Li | 2023 | Nano-Micro Letters2023，15，1： | 2 |
| 12 | Recent advances on π-conjugated polymers as active elements in high performance organic field-effect transistors显示文摘As high-performance organic semiconductors, π-conjugated polymers have attracted much attention due to their charming advantages including low-cost, solution processability, mechanical flexibility, and tunable optoelectronic properties. During the past several decades, the great advances have been made in polymers-based OFETs with p-type, n-type or even ambipolar characterics. Through chemical modification and alignment optimization, lots of conjugated polymers exhibited superior mobilities, and some mobilities are even larger than 10 cm^(2)·V^(−1)·s^(−1) in OFETs, which makes them very promising for the applications in organic electronic devices. This review describes the recent progress of the high performance polymers used in OFETs from the aspects of molecular design and assembly strategy. Furthermore, the current challenges and outlook in the design and development of conjugated polymers are also mentioned. | Lixing Luo Wanning Huang Canglei Yang Jing Zhang Qichun Zhang | 2021 | Frontiers of physics2021，16，3： | 2 |
| 13 | Energy-saving operation approaches for urban rail transit systems显示文摘With the accelerated urbanization in China, passenger demand has dramatically increased in large cities, and traffic congestion has become serious in recent years. Developing public urban rail transit systems is an indispensable approach to overcome these problems. However, the high energy consumption of daily operations is an emerging issue due to increased rail transit networks and passenger demands. Thus, reducing the energy consumption and operational cost by using advanced optimization methodologies is an urgent task for operation managers. This work systematically introduces energysaving approaches for urban rail transit systems in three aspects, namely, train speed profile optimization, utilization of regenerative energy, and integrated optimization of train timetable and speed profile. Future research directions in this field are also proposed to meet increasing passenger demands and network?based urban rail transit systems. | Ziyou GAO Lixing YANG | 2019 | Frontiers of Engineering Management2019，6，2： | 2 |
| 14 | Petrological and Geochemical Constraints on the Protoliths of Serpentine-Magnetite Ores in the Zhaoanzhuang Iron Deposit,Southern North China Craton显示文摘The uncommon Mg-rich and Ti-poor Zhaoanzhuang serpentine-magnetite ores within Taihua Group of the North China Craton(NCC) remain unclear whether the protolith was sourced from ultramafic rocks or chemical sedimentary sequences. Here we present integrated petrographic and geochemical studies to characterize the protoliths and to gain insights on the ore-forming processes. Iron ores mainly contain low-Ti magnetite(TiO_2 ~0.1 wt%) and serpentine(Mg#=92.42–96.55), as well as residual olivine(Fo=89–90), orthopyroxene(En=89–90) and hornblende. Magnetite in the iron ores shows lower Al, Sc, Ti, Cr, Zn relative to that from ultramafic Fe-Ti-V iron ores, but similar to that from metamorphic chemical sedimentary iron deposit. In addition, interstitial minerals of dolomite, calcite, apatite and anhydrite are intergrown with magnetite and serpentine, revealing they were metamorphic, but not magmatic or late hydrothermal minerals. Wall rocks principally contain magnesian silicates of olivine(Fo=83–87), orthopyroxene(En=82–86), humite(Mg#=82–84) and hornblende [XMg=0.87–0.96]. Dolomite, apatite and anhydrite together with minor magnetite, thorianite(Th-rich oxide) and monazite(LREE-rich phosphate) are often seen as relicts or inclusions within magnesian silicates in the wall rocks, revealing that they were primary or earlier metamorphic minerals than magnesian silicates. And olivine exists as subhedral interstitial texture between hornblende, which shows later formation of olivine than hornblende and does not conform with sequence of magmatic crystallization. All these mineralogical features thus bias towards their metamorphic, rather than magmatic origin. The dominant chemical components of the iron ores are SiO_2(4.77–25.23 wt%), Fe_2O_3 T(32.9–80.39 wt%) and MgO(5.72–27.17 wt%) and uniformly, those of the wall rocks are also SiO_2(16.34–48.72 wt%), Mg O(16.71–33.97 wt%) and Fe_2O_3 T(6.98–30.92 wt%). The striking high Fe-Mg-Si contents reveal that protolith of the Zhaoanzhuang iron deposit was more likely to be chemical sedimentary rocks. The distinct high-Mg feature and presence of abundant anhydrite possibly indicate it primarily precipitated in a confined seawater basin under an evaporitic environment. Besides, higher contents of Al, Ti, P, Th, U, Pb, REE relative to other Precambrian iron-rich chemical precipitates(BIF) suggest some clastic terrestrial materials were probably input. As a result, we think the Zhaoanzhuang iron deposit had experienced the initial Fe-Mg-Si marine precipitation, followed by further Mg enrichment through marine evaporated process, subsequent high-grade metamorphism and late-stage hydrothermal fluid modification. | MENG Jie LI Houmin LI Lixing SANTOSH M SONG Zhe YANG Xiuqing | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 2 |
| 15 | Solving the constrained shortest path problem using random search strategy显示文摘In this paper, we propose an improved walk search strategy to solve the constrained shortest path problem. The proposed search strategy is a local search algorithm which explores a network by walker navigating through the network. In order to analyze and evaluate the proposed search strategy, we present the results of three computational studies in which the proposed search algorithm is tested. Moreover, we compare the proposed algorithm with the ant colony algorithm and k shortest paths algorithm. The analysis and comparison results demonstrate that the proposed algorithm is an effective tool for solving the constrained shortest path problem. It can not only be used to solve the optimization problem on a larger network, but also is superior to the ant colony algorithm in terms of the solution time and optimal paths. | LI KePing, GAO ZiYou , TANG Tao & YANG LiXing State Key Laboratory of Rail Traffic Control and Safety, Beijing Jiaotong University, Beijing 100044, China | 2010 | Science China(Technological Sciences)2010，53，12： | 1 |
| 16 | FUZZY MULTI-LEVEL WAREHOUSE LAYOUT PROBLEM:NEW MODEL AND ALGORITHM显示文摘This paper deals with a multi-level warehouse layout problem under fuzzy environment, in which different types of items need to be placed in a multi-level warehouse and the monthly demand of each item type and horizontal distance traveled by clamp track are treated as fuzzy variables. In order to minimize the total transportation cost, chance-constrained programming model is designed for the problem based on the credibility measure and then tabu search algorithm based on the fuzzy simulation is designed to solve the model. Some mathematical properties of the model are also discussed when the fuzzy variables are interval fuzzy numbers or trapezoidal fuzzy numbers. Finally, a numerical example is presented to show the efficiency of the algorithm. | Lixing YANG Yuan FENG | 2006 | Journal of Systems Science and Systems Engineering2006，15，4： | 1 |
| 17 | Optical Perfect Shuffle Interconnection Using Computer-Generated Blazed Grating Array显示文摘 | Ping Xu Xiang Zhou Xiaochun Zhang Yongkang Guo Lurong Guo Hong Tang Shida Wu Lixing Yang Ying Chen | 1995 | Optical Review1995，，5： | 1 |
| 18 | Prevention of apoptosis by Bcl-2 release of cytochrome C from mitochondria block 显示文摘 | Yang J Lix X Bhalla K | 1997 | Science1997，275，5303： | 1 |
| 19 | Dosimetrie effects of patient rotational setup errors on prostate IMRT treatments 显示文摘 | Fu W Yang Y LiX | 2006 | Phys Med Biol2006，51，20： | 1 |
| 20 | Nanaomycin A methyl ester, an actinomycete metabolite: Algicidal activity and the physiological response of Microcystis aeruginosa显示文摘 | Yang Feng Xuexiu Chang Lixing Zhao Xiuping Li Wenjun Li Yi Jiang | 2012 | Ecological Engineering2012，，： | 1 |
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