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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Effect of temperature and oxygen on the formation of chlorobenzene as the indicator of PCDD/Fs显示文摘Sampling and analysis of polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs) are both time-consuming and expensive. In principle,real-time monitoring of chlorobenzene(CBz) as an indicator for PCDD/Fs could be useful to control and optimize incinerator operating conditions.To test this strategy,CBz was analyzed together with PCDD/Fs in flue gas samples collected from a hospital waste incinerator.Moreover,lab experiments were conducted to investigate the eect of temperature and oxygen on CBz formation from fly ash from the same incinerator.The experimental results demonstrate that chlorobenzene(in particular PeCBz) correlate well with PCDD/Fs,in line with previous research.The optimum temperature of CBz formation is in a range of 350 to 400°C and CBz yield increases significantly with oxygen,in line with PCDD/Fs formation.This study is useful for confirming the de novo mechanism and defining correlations between CBz and PCDD/Fs. | Mi Yan,Xiaodong LiTong Chen,Shengyong Lu,Jianhua Yan,Kefa Cen State Key Laboratory of Clean Energy Utilization,Zhejiang University,Hangzhou 310027,China | 2010 | Journal of Environmental Sciences2010，22，10： | 16 |
| 3 | Genome Sequences Provide Insights into the Reticulate Origin and Unique Traits of Woody Bamboos显示文摘Polyploidization is a major driver of speciation and its importance to plant evolution has been well recognized.Bamboos comprise one diploid herbaceous and three polyploid woody lineages,and are members of the only major subfamily in grasses that diversified in forests,with the woody members having a tree-like lignified culm.In this study,we generated four draft genome assemblies of major bamboo lineages with three different ploidy levels(diploid,tetraploid,and hexaploid).We also constructed a high-density genetic linkage map for a hexaploid species of bamboo,and used a linkage-map-based strategy for genome assembly and identification of subgenomes in polyploids.Further phylogenomic analyses using a large dataset of syntenic genes with expected copies based on ploidy levels revealed that woody bamboos originated subsequent to the divergence of the herbaceous bamboo lineage,and experienced complex reticulate evolution through three independent allopolyploid events involving four extinct diploid ancestors.A shared but distinct subgenome was identified in all polyploid forms,and the progenitor of this subgenome could have been critical in ancient polyploidizations and the origin of woody bamboos.Important genetic clues to the unique flowering behavior and woody trait in bamboos were also found.Taken together,our study provides significant insights into ancient reticulate evolution at the subgenome level in the absence of extant donor species,and offers a potential model scenario for broad-scale study of angiosperm origination by allopolyploidization. | Zhen-Hua Guo Peng-Fei Ma Guo-Qian Yang Jin-Yong Hu Yun-Long Liu En-Hua Xia Mi-Cai Zhong Lei Zhao Gui-Ling Sun Yu-Xing Xu You-Jie Zhao Yi-Chi Zhang Yu-Xiao Zhang Xue-Mei Zhang Meng-Yuan Zhou Ying Guo Cen Guo Jing-Xia Liu Xia-Ying Ye Yun-Mei Chen Yang Yang Bin Han Choun-Sea Lin Ying Lu De-Zhu Li | 2019 | Molecular Plant2019，12，10： | 13 |
| 4 | Hangzhou criteria as downstaging criteria in hepatocellular ca显示文摘Background:The downstaging of hepatocellular carcinoma(HCC)has been confirmed to benefit liver transplantation(LT)patients whose tumors are beyond the transplantation criteria.Milan criteria(MC),a tumor size and number-based assessment,is currently used as the endpoint in these patients.However,many studies believe that tumor biological behavior should be added to the evaluation criteria for downstaging efficacy.Hence,this study aimed to explore the feasibility of Hangzhou criteria(HC),which introduced tumor grading and alpha-fetoprotein in addition to tumor size and number,as an endpoint of downstaging.Methods:We performed a multicenter and retrospective study of 206 patients accepted locoregional therapy(LRT)as downstaging/bridge treatment prior to LT in three centers of China.Results:Recipients were divided into four groups:failed downstaging to the HC(group A,n=46),successful downstaging to the HC(group B,n=30),remained within the HC all the time(group C,n=113),and tumor progressed(group D,n=17).The 3-year HCC recurrence probabilities of groups B and C were not significantly different(10.3%vs.11.6%,P=0.87).The HCC recurrent rate was significantly higher in group A(52.3%)compared with that in group B/C(P<0.05).Seven patients(7/76,9.2%)whose tumor exceeded the the HC were successfully downstaged to the MC,and 39.5%(30/76)to the the HC.In group B,23 patients remained beyond the MC and their survivals were as well as those of patients within the MC.Conclusions:Compared to the MC,HC downstaging criteria can give more HCC patients access to LT and furthermore,the outcome of these patients is the same as those matching MC downstaging criteria.Hangzhou downstaging criteria therefore is applicable in clinical practice. | Qi-Fan Zhan Sun-Bin Ling Yi-Nan Deng Qiao-Nan Shan Qian-Wei Ye Sheng-Jun Xu Guang-Jiang Jiang Di Lu Xu-Yong Wei Li Zhuang Wu Zhang Tian Shen Bei-Ni Cen Hai-Yang Xie Ji-Min Liu Jian Wu Shu-Sen Zheng Yang Yang Xiao Xu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，4： | 11 |
| 5 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 6 | Destruction of PCDD/Fs by gliding arc discharges显示文摘PCDD/Fs 被变得一个严肃的问题因为他们的毒物学的效果和联系不利健康含意。在这研究,滑行的弧血浆为 polychlorinated dibenzo-p-dioxins (PCDD ) 和 polychlorinated dibenzofurans (PCDF ) 的处理被测试,它在 350 ° C 处于大气的状况从五氯苯酚被综合与或没有 CuCl2 的催化作用。从实验,我们发现在滑行以后的 PCDD/F 相当或相同事物的破坏效率是分泌物从 25% ~ 79%。这结果证明那滑行的弧血浆是一种有效技术在烟道气体分解 PCDDs/Fs。为由滑行的弧的 PCDD/Fs 的貌似合理的降级机制被讨论。最后,滑行的弧的多级式的反应堆结构被建议为 PCDD/Fs 升级移动效率。 | YAN Jian-hua PENG Zheng LU Sheng-yong DU Chang-ming LI Xiao-dong CHEN Tong NI Ming-jiang CEN Ke-fa | 2007 | Journal of Environmental Sciences2007，19，11： | 9 |
| 7 | Removal of PCDDs/Fs from municipal solid waste incineration by entrained-flow adsorption technology显示文摘Entrained flow adsorption using activated carbon as the adsorbent is widely adopted for PCDDs/Fs-abatement in municipal solid waste incineration (MSWI) process. The effects of operating parameters including flue gas temperature, feeding rate of activated carbon, polychlorinated dibenzodioxins and polychlorinated dibenzofurans (PCDDs/Fs) concentration at the inlet of the air pollution control device (APCD), filter materials, pressure drop on PCDDs/Fs removal efficiency are reviewed and commented upon in this paper. Evaluation on the various mechanistic models for entrained flow adsorption is carried out based on the computational simulation in terms of the actual operating condition and theoretical analysis. Finally, an advancement of en- trained flow adsorption in combination of dual bag filter is introduced. | YAN Jian-hua PENG Zheng LU Sheng-yong LI Xiao-dong CEN Ke-fa | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，11： | 8 |
| 8 | Polychlorinated dibenzo-p-dioxins and dibenzofurans in flue gas emissions from municipal solid waste incinerators in China显示文摘在从市政的稳固的浪费焚烧装置(MSWI ) 的二种类型的烟道气体的排出物最通常在中国使用了的 Polychlorinated dibenzo-p-dioxins 和呋喃(PCDD/Fs ) 在这研究被调查。选择焚烧装置包括二刺激类型 MSWI:MSWI -- A (350 t/d ) 和 MSWI-B (150 t/d ) ,并且二使流体化床 MSWI:除了作为污染空气的物质控制设备(APCD ) 与气旋和湿 scrubber (WS ) 装备的 MSWI-D, MSWI-C (400 t/d ) 它是和 MSWI-D (400 t/d ) 都与半干燥的石灰 scrubber 和袋子过滤器装备了。结果显示排放集中和从栈的 PCDD/Fs 的国际有毒的等价物(I-TEQs ) 分别地在 1.210 ∼10.273 ng/Nm 3 和 0.019 ∼0.201 ng I-TEQ/Nm 3, 的范围。他们是极大地在中国比 PCDD/Fs 的排放规定标准降低(1.0 ng I-TEQ/Nm 3) 。然而,从 MSWI-C 的仅仅 PCDD/Fs 排放水平在 0.1 ng I-TEQ/Nm 3 下面。尽管相当或相同事物侧面是不同的,到全部的 I-TEQ 的 2,3,7,8-subsituted 同种的物的贡献在所有调查 MSWI 之中是类似的。二主要 2,3,7,8 代用品同种的物, 2,3,4,7,8-PeCDF 和 1,2,3,7,8-PeCDD,全部的 I-TEQ 的为 47% 和 9% 的报道(平均价值) 分别地珍视。在 PCDD/Fs 层次和烟道气体的作文之间的关联也被讨论。 | Tong CHEN Yue-ling GU Jian-hua YAN Xiao-dong LI Sheng-yong LU Hui-fen DAI Ke-fa CEN | 2008 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2008，9，9： | 8 |
| 9 | Bottom water temperature measurements in the South China Sea,eastern Indian Ocean and western Pacific Ocean显示文摘文章报道了一批新的海底底水温度(BWT)数据,其中南海(SCS)158个站位、东印度洋(EIO)30个站位及西太平洋(WPO)37个站位。基于这批新的BWT数据,获得南海和西太平洋海域底水温度与水深经验关系,可为地球物理和物理海洋提供准确、可靠的海底温度边界。这将有助于海底油气资源调查与评估。同时,这批实测数据表明:1)水深超过3500m的海域,其底水温度在南海约为2.47℃,比东印度洋(~1.34℃)和西太平洋(~1.60℃)稍微偏高。这与大洋传送带模式所预测的情况比较吻合。该模式认为:低温高盐的海水,从北大西洋格陵兰岛和冰岛附近海域下沉到深层,然后向南流动,再与南极洲周围海域的低温高盐海水一同向北进入印度洋和太平洋。而南海是一个相对比较封闭的热带边缘海,其内部海水与印度洋和菲律宾海交换有限,导致海水温度整体高于印度洋和太平洋。2)台西南盆地水深在2700~3000m的部分站位,其底水温高达约3.00℃,明显高于其周边同水深海域底水温度(平均值约为2.33℃)。这可能是台西南盆地海底水热活动导致的结果。3)在东印度洋和西太平洋水深超过4800m海域,底水温度随着水压增大稍有升高,其升高率分别为10.6mK·MPa^(-1)和12.0mK·MPa^(-1)。这与理论估算的深层底水绝热压力温度梯度范围较为吻合。这也意味着东印度洋和西太平洋深层底水,主要由绝热自压作用导致其温度随着深度的增大而升高。 | YANG Xiaoqiu SHI Xiaobin ZHAO Junfeng YU Chuanhai GAO Hongfang CHEN Aihua LU Yuanzheng CEN Xianrong LIN Weiren ZENG Xin XU Hehua REN Ziqiang ZHOU Shengqi XU Ziying SUN Jinlong KAMIYA Nana LIN Jian | 2018 | 热带海洋学报2018，37，5： | 8 |
| 10 | First Report of Botryosphaeria dothidea Causing Sweet Osmanthus Leaf Dieback in China显示文摘Sweet osmanthus is one of the ten traditional famous flowers in China.The occurrence of the diseases caused by fungi other than Botryosphaeria spp.has been reported mainly from China on sweet osmanthus.A leaf dieback of sweet osmanthus caused by Botryosphaeria sp.was found for the first time in 2007 in Nanning City,Guangxi,China.The objectives of the present study were to isolate and characterize the causal organism of sweet osmanthus leaf dieback.The fungus was isolated from the lesions of affected sweet osmanthus leaves and its pathogenicity to sweet osmanthus was confirmed using a detached-leaf-inoculation method.The identification of the pathogen was carried out mainly based on the morphological characters and molecular analysis of internal transcribed spacer (ITS) sequences.The morphological characters of the pathogenic isolate GHX6 were agreed with that of Botryosphaeria dothidea.The ITS sequence of the isolate was amplified with primers ITS1 and ITS4,and submitted to GenBank (accession no.GQ368251).Molecular analysis based on ITS sequence comparison between the isolate GHX6 and the other related fungi derived from GenBank supported that the causal agent of the sweet osmanthus leaf dieback belonged to Botryosphaeria dothidea.This is the first report of Botryosphaeria dothidea causing leaf dieback on sweet osmanthus in China. | XIE Ling HUANG Si-liang CEN Zhen-lu LU Wei-hong QIN Bi-xia TANG Chen-guang HU Chun-jin QIN Li-ping | 2010 | Agricultural Sciences in China2010，9，6： | 6 |
| 11 | Temporal and Spatial Variations of Abundance of Phycocyaninand Phycoerythrin-Rich Synechococcus in Pearl River Estuary and Adjacent Coastal Area显示文摘Three surveys were carried out in Pearl River Estuary and adjacent coastal area in May, August, and November, 2013, to investigate the temporal and spatial variations of abundance of phycoerythrin-rich Synechococcus(PE-rich SYN) and phycocyanin-rich Synechococcus(PC-rich SYN). The effects of environmental factors on the alternation of the different Synechococcus groups were also elucidated. PE-rich SYN was detected in three surveys, whereas PC-rich SYN was detected in May and August, but not in November. The highest abundances of PE-rich SYN and PC-rich SYN were recorded in August and May, with mean values of 74.17×103 and 189.92×103 cells m L-1, respectively. From May to November, the relative abundance of PE-rich SYN increased, whereas that of PC-rich SYN declined. PE-rich and PC-rich SYN presented similar horizontal distributions with high abundance in the southern estuary in May, and in the western estuary in August. The abundances of PE-rich and PC-rich SYN were high at 27–32℃and salinity of 10–20. PC-rich SYN was not detected at < 24℃, and PC:PE-rich SYN decreased in abundance with salinity increase. When less than 20 mg L-1, suspended particulate matter(SPM) was helpful for Synechococcus growth. PE-rich SYN decreased in abundance when the concentration of dissolved inorganic nitrogen increased in May and November, and the concentration of phosphate increased in November. However, PC-rich SYN abundance and nutrients showed no correlation. Principal component analysis and regression analysis indicated that PE-rich SYN significantly correlated with the principal components that were affected by environmental factors. | JIANG Tao CHAI Chao WANG Jifang ZHANG Ling CEN Jingyi LU Songhui | 2016 | Journal of Ocean University of China2016，15，5： | 6 |
| 12 | Effects of inorganic chlorine source on dioxin formation using fly ash from a fluidized bed incinerator显示文摘Chlorine source is indispensable for polychlorinated dibenzo-p-dioxin and furan(PCDD/F)formation during municipal solid waste(MSW)incineration.Inorganic chlorine compounds were employed in this study to investigate their effects on PCDD/F formationthrough heterogeneous synthesis on fly ash surfaces.A fly ash sample obtained from a fluidized bed incinerator was sieved to differentsize fractions which served as the PCDD/F formation sources.The capability of different metal chlorides which facilitate the formationof PCDDs/Fs was found to follow the trends:Na177μm and 104-125μm wereused in the experiments.However,the capability of NaCl,MgCl2 and KCl did not seem much different from each other,whereas CaCl2and AlCl3 were much more active in PCDD/F formation.NaCl and MgCl2 were relatively effective to produce more PCDDs,while KCl,AlCl3 and CaCl2 generated more PCDFs during heterogeneous reactions occurring on fly ash.2,3,7,8-TCDF was the most significantcontributor to the toxicity of the PCDDs/Fs formed from inorganic chlorine sources.Decreasing the sizes of fly ash particles led to moreactive formation of PCDDs/Fs when NaCl was used as inorganic chlorine in the experiment.The highest PCDDs/Fs produced fromparticles with size<37μm,while the lowest PCDDs/Fs produced from particles with size>177μm.The toxicity generally increasedwith decreasing size of the fly ash particles.The formation of PCDDs was mainly facilitated by the two size fractions,104-125μm and<37μm,while the formation of PCDFs was favored by the two other size fractions,>177μm and 53-104μm. | LU Sheng-yong YAN Jian-hua LI Xiao-dong Ni Ming-jiang CEN Ke-fa DAI Hui-fen | 2007 | Journal of Environmental Sciences2007，19，6： | 6 |
| 13 | Driver Model-Based Fault-Tolerant Control of Independent Driving Electric Vehicle Suffering Steering Failure显示文摘This paper presents a fault-tolerant control(FTC)strategy for a four-wheel independent driving electric vehicle suffering steering failure.The method is based on the functional redundancy of driving and braking actuators to recover the vehicle’s steering ability.A dynamic vehicle model is derived with the function of four-wheel driving.A sliding mode controller with a combined sliding surface is employed as a motion controller,allowing the desired vehicle motion to be tracked by the adaptive drivermodel.An extended Kalman filter-based state estimator is adopted to virtually measure the sideslip anglewhile considering the nonlinear tire force.A new allocation strategy,involving two distribution modes of coordination,is designed.In addition,a weight coefficient adjustment strategy is implemented in optimal mode based on the lateral load transfer,thus improving the steering performance.Simulations are conducted to verify the proposed FTC algorithm.The results demonstrate that steering failure can be effectively covered by the functional redundancy of the driving/braking actuators. | Shaobo Lu Sheng Cen Yanpeng Zhang | 2018 | Automotive Innovation2018，1，1： | 4 |
| 14 | BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A-YAP axis显示文摘Sulfur mustard(SM)is a highly toxic chemical warfare agent that causes acute lung injury(ALI)and/or acute respiratory distress syndrome(ARDS).There are no effective therapeutic treatments or antidotes available currently to counteract its toxic effects.Our previous study shows that bone marrow-derived mesenchymal stromal cells(BMSCs)could exert therapeutic effects against SM-induced lung injury.In this study,we explored the therapeutic potential of BMSC-derived exosomes(BMSC-Exs)against ALI and the underlying mechanisms.ALI was induced in mice by injection of SM(30 mg/kg,sc)at their medial and dorsal surfaces.BMSC-Exs(20μg/kg in 200μL PBS,iv)were injected for a 5-day period after SM exposure.We showed that BMSC-Exs administration caused a protective effect against pulmonary edema.Using a lung epithelial cell barrier model,BMSC-Exs(10,20,40μg)dose-dependently inhibited SM-induced cell apoptosis and promoted the recovery of epithelial barrier function by facilitating the expression and relocalization of junction proteins(E-cadherin,claudin-1,occludin,and ZO-1).We further demonstrated that BMSC-Exs protected against apoptosis and promoted the restoration of barrier function against SM through upregulating G protein-coupled receptor family C group 5 type A(GPRC5A),a retinoic acid target gene predominately expressed in the epithelial cells of the lung.Knockdown of GPRC5A reduced the antiapoptotic and barrier regeneration abilities of BMSC-Exs and diminished their therapeutic effects in vitro and in vivo.BMSC-Exs-caused upregulation of GPRC5A promoted the expression of Bcl-2 and junction proteins via regulating the YAP pathway.In summary,BMSC-Exs treatment exerts protective effects against SM-induced ALI by promoting alveolar epithelial barrier repair and may be an alternative approach to stem cell-based therapy. | Guan-chao Mao Chu-chu Gong Zhen Wang Ming-xue Sun Zhi-peng Pei Wen-qi Meng Jin-feng Cen Xiao-wen He Ying Lu Qing-qiang Xu Kai Xiao | 2021 | Acta Pharmacologica Sinica2021，42，12： | 4 |
| 15 | Association between serumα-L-fucosidase andnon-alcoholic fatty liver disease:Cross-sectional study显示文摘AIM: To explore the association between serum α-Lfucosidase(Af U) and non-alcoholic fatty liver disease(NAf LD).METHODS: A total of 16473 individuals(9456 men and 7017 women) were included in the current study, who presented for a health examination at the first Affiliated hospital of Zhejiang University School of medicine in 2014. The baseline characteristics of the cohort were compared by NAf LD status. Linear regression analysis and stepwise multiple regression analysis were applied to assess the risk factors for NAf LD. Receiver operating characteristic curve was used to determine the sensitivity and specificity of Af U in the diagnosis of NAf LD.RESULTS: The prevalence rates of NAf LD and metabolic syndrome(met S) were 38.0% and 25.4%, respectively. The NAf LD group had significantly higher Af U levels than the non-NAf LD group(28.7 ± 7.9 U/L vs 26.0 ± 7.3 U/L, P < 0.001) and the prevalence rate of NAf LD increased with progressively higher serum Af U levels. Af U was positively correlated with met S and its five components: central obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol, and elevated blood pressure and fasting glucose. Stepwise multiple logistic regression analysis showed that Af U was associated with an increased risk of NAf LD(OR = 1.009, 95%CI: 1.003-1.014, P < 0.001). The best cut-off value of Af U for the diagnosis of NAf LD was 27.5 U/L. The area under the curve(diagnostic efficacy index) was 0.606. The sensitivity and specificity were 54.6% and 61.8%, respectively. CONCLUSION: Af U level is significantly associated with NAf LD, and elevated Af U level is an independent risk factor for NAf LD. | Zhen-ya Lu Chao Cen Zhou Shao Xin-hua Chen Cheng-fu Xu You-ming Li | 2016 | World Journal of Gastroenterology2016，22，5： | 4 |
| 16 | Laboratory-scale study of the suppression of PCDD/F emission during coal and MSW co-incineration显示文摘The experimental test of co-incinerating Chinese raw municipal solid waste(MSW)and coal in a laboratory-scale tubular reactorwas first reported in present study,and the emission of normal gas components and the effects of the S/Cl molar ratio or coal mixingpercentages on polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDDs/Fs)emission were investigated and discussed.Theresults indicated that OCDD was the only PCDD homologues since others like TCDD-HpCDD was hardly detected,while as thecategories of PCDF homologues were comparatively much more general.The amount of PCDD was much larger than that of PCDFin all operating conditions.Since PCDF/PCDD<<1,the dominant role of the precursor formation was proven in our experimentalconductions.With increasing the coal addition to MSW(from 0 to 16%),PCDD and PCDF were reduced considerably.Coal and MSWmay suppress the PCDD/F emissions effciently(over 95%)during the MSW incineration process.The PCDD/F suppression results ofthe present study could be helpful guidance to the industrial application of Chinese MSW and auxiliary coal co-incineration processes.The PCDD/F stack emission data of two industrial incinerators using co-incineration technology in China seem to have a great positivereduction of PCDDs/Fs. | LU Sheng-yong YAN Jian-hua LI Xiao-dong NI Ming-jiang CEN Ke-fa | 2007 | Journal of Environmental Sciences2007，19，6： | 4 |
| 17 | 危重型新型冠状病毒肺炎患者床边内镜诊疗后内镜再处理流程改良分析显示文摘目的:在疫情期间,需要通过保证内镜处理质量,避免过程环节操作中的接触污染,防止气溶胶的散发,从而保护从业人员,杜绝院内感染。创新点:内镜诊疗对改善重症患者预后及降低患者死亡率有重要作用。该研究依据实际临床工作特质,对内镜再处理过程中的部分方法及化学清洗消毒剂的选择进行了改良与替换。方法:从12例重症患者行23次内镜诊治后的内镜处理操作中提取经验,结合相关指南规范,提出了新型冠状病毒肺炎患者床边内镜诊疗后内镜再处理改良流程。结论:内镜诊疗在重症及危重症患者治疗中不可或缺。临床工作中床旁预处理操作及专线转运流程对于预防院内感染具有重要意义。替换后的化学清洗消毒剂(0.23%过氧乙酸)对新冠病毒可达到高水平消毒。改良后的床边内镜诊疗后内镜再处理操作流程顺畅,感染控制严谨,值得临床进一步推广。 | Qing GU Hua-fen WANG Ying FANG Ye LU Zhe SHEN Yan WANG Xin WU Li CEN Yi-shu CHEN | 2020 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2020，21，5： | 3 |
| 18 | C–C motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells显示文摘Background:Liver cirrhosis results from many forms of chronic damage,characterized by accumulation of extracellular matrix.The present study aimed to explore a potential non-invasive biomarker and its mechanism in the progression of liver cirrhosis.Methods:Gene Expression Omnibus(GEO)dataset(GSE15654,n=216)was analyzed to screen genes associated with progression of liver cirrhosis.A total of 181 plasma samples,including healthy control(HC,n=20),chronic hepatitis B(CHB,n=77)and HBV-related liver cirrhosis(LC,n=84),were enrolled for validation.In vitro and in vivo experiments were employed for the mechanistic investigation.Results:GEO dataset analysis showed that relatively low mRNA-expression of C–C motif chemokine ligand 16(CCL16)was associated with elevated Child-Pugh score(P=0.034)and worse prognosis(P=0.025).Plasma CCL16 level decreased in a stepwise pattern,with a median concentration of 10.29,6.57 and 4.47 ng/mL in the HC,CHB and LC groups,respectively(P<0.001).Low plasma CCL16 was significantly related to hepatic dysfunction both in the CHB and LC groups(P<0.05).Combination of CCL16 and ALT showed improved distinguishing capability for LC compared to either alone.In vitro,CCL16 expression was downregulated by lipopolysaccharide and hypoxia.Overexpression of CCL16 from human normal liver cell line(LO2)reduced the extracellular matrix associated proteins(Col1 and Col4)in human hepatic stellate cell line(LX-2).In vivo,the pathological feature of cirrhosis was alleviated by the hepatocytespecific expression of CCL16.Conclusions:CCL16 could be a feasible plasma marker to predict the occurrence and progression of liver cirrhosis.CCL16 might impact liver cirrhosis through inactivating hepatic stellate cells. | Jian-Yong Zhuo Di Lu Zu-Yuan Lin Bei-Ni Cen Xu-Yong Wei Hai-Yang Xie Shu-Sen Zheng Xiao Xu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 3 |
| 19 | Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma显示文摘气喘是在多重基因、环境的因素之中包含复杂相互影响的普通过敏混乱。最近的研究作为一个新奇气喘危险性因素识别了人的 GAB1 的基因变体。然而,在肺的 Gab1 的功能仍然保持大部分未经勘探。在这研究,我们首先在尖锐恶化期间从气喘的病人在外部血 mononuclear 房间观察了 Gab1 水平的举起与康复相比。有在 myeloid 的有选择地破坏的 Gab1 的老鼠树枝状的房间(mDCs ) 更加在气喘的试验性的模型稀释了过敏发炎。进一步的调查在 Gab1 缺乏的 mDCs 的调停 CCL19 的移植揭示了突出的减小到排干淋巴节点和驾驶 Th2 的适应激活的随后的缺陷。机械学地, Gab1 是在气喘的回答期间调整 mDC 移植的 CCL19/CCR7 chemokine 轴的一个必要部件。一起,这些调查结果在肺为 Gab1 的角色提供第一条证据,给我们气喘的致病的更深的理解。 | Yun Zhang Yun Xu Shuwan Liu Xiaohong Guo Dong Cen Jiaqi Xu Heyuan Li Kaijun Li Chunlai Zeng Linrong LU Yiting Zhou Huahao Shen Hongqiang Cheng Xue Zhang Yuehai Ke | 2016 | Cell Research2016，26，11： | 3 |
| 20 | Atmospheric emission characterization of a novel sludge drying and co-combustion system显示文摘A novel system combining sludge drying and co-combustion with coal was applied in disposing sludge and its atmospheric emission characteristics were tested. The system was composed of a hollow blade paddle dryer, a thermal drying exhaust gas control system,a 75 tons/hr circulating fluidized bed and a flue gas cleaning system. The emissions of NH3, SO2, CH4and some other pollutants released from thermal drying, and pollutants such as NOx, SO2etc. discharged by the incinerator, were all tested. Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans(PCDD/Fs) in the flue gas from the incinerator were investigated as well. The results indicated that the concentrations of NOx and SO2in the flue gas from the incinerator were 145 and 16 mg/m3, respectively,and the I-TEQ concentration of 2,3,7,8-substitued PCDD/Fs was 0.023 ng I-TEQ/Nm3. All these values were greatly lower than the emission standards of China. In addition, there was no obvious odor in the air around the sludge dryer. The results demonstrated that this drying and co-combustion system is efcient in controlling pollutants and is a feasible way for large-scale treatment of industrial sludge and sewage sludge. | Shengyong Lu Liqin Yang Fa Zhou Fei Wang Jianhua Yan Xiaodong Li Yong Chi Kefa Cen | 2013 | Journal of Environmental Sciences2013，25，10： | 3 |
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