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| 1 | Epidemiological and etiological investigation of dengue fever in the Fujian province of China during 2004–2014显示文摘Dengue fever(DF) is a vector-borne disease and a tremendous socioeconomic burden on tropical and subtropical countries worldwide. To explore the characteristics of DF epidemic in the Fujian province, information of DF cases in Fujian during 2004–2014 was collected and analyzed. The complete E genes of 48 viral isolates were amplified and sequenced for phylogenetic analysis. A total of 733 cases was reported, of which 612(83.5%) occurred during the peak period from August to October. Additionally, 76%(190/250) of imported cases originated from Southeast Asia countries, by the epidemiological investigation. Phylogenetic analysis of the 48 viral isolates revealed that three genotypes(I, IV, V) of DENV1, and one genotype each of DENV2(cosmopolitan) and DENV3(I) circulated in Fujian during 2004–2014. Similar to the results of the epidemiological investigations, the source of most of the viral isolates, including imported and indigenous cases, may be Southeast Asia countries; however, importation from adjacent provinces was also observed in recent years. Overall, DF is considered an imported epidemic disease in Fujian. Increasing diversity of the viral source and geographic expansion of the area affected by DF in recent years highlights the necessity for strengthening surveillance of the DF epidemic and developing strategies for DF prevention and control in Fujian. | Jinzhang Wang Hongbing Chen Meng Huang Yongjun Zhang Jianfeng Xie Yansheng Yan Kuicheng Zheng Yuwei Weng | 2017 | Science China(Life Sciences)2017，60，1： | 9 |
| 2 | Conceptual design of an extractive distillation process for the separation of azeotropic mixture of n-butanol-isobutanol-water显示文摘In many chemical processes, large amounts of wastewater containing butanol and isobutanol are produced.Given that n-butanol-isobutanol-water can form triple azeotrope, high-purity butanol cannot be recovered from the wastewater by ordinary distillation. To economically and effectively recover butanol from this kind of wastewater, 1,4-butanediol is selected as an extractant to break the formation of the azeotropes, and a doubleeffect extractive distillation process is proposed. The conceptual design of the proposed process is accomplished based on process simulation. With the proposed process, the purity of recovered butanol and water is greater than 99.99 wt%. In comparison with the conventional azeotropic distillation process, economic analysis shows that the operating cost of the proposed process is lower: when the capacity of wastewater treatment is 100 t·h^(-1), the total operating cost decreases by 5.385 ×10~6 USD per year, and the total annual cost of the new process decreases by 5.249 ×10~6 USD per year. In addition, in the extractive distillation system, variable effects on separation purities and cost are more complex than those in the ordinary distillation system. The method and steps to optimize the key variables of the extractive distillation system are also discussed in this paper and can provide reference for similar studies. | Hengjun Gai Kaiqiang Lin Yirong Feng Meng Xiao Kai Guo Hongbing Song | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 5 |
| 3 | U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population显示文摘在由维持 chromosomal 正直并且阻止染色体的生物变老的一个关键角色结束的 Telomeres 玩熔化。流行病学的研究建议了 telomere 长度的内部个人的差别能影响倾向到多重癌症,但是关于食道的有鳞的房间癌(ESCC ) 的证据仍然是不明确的。几 telomere 在白种人的长度相关的单个核苷酸多型性(TLSNP ) 在染色体宽的协会研究被报导了。然而,在 ESCC 开发的 telomere 长度和 TL-SNPs 的效果是不清楚的。因此,我们进行了盒子控制研究(1045 个 ESCC 案例和 1433 控制) 在中国人口评估在 telomere 长度, TL-SNPs,和 ESCC 风险之间的协会。作为结果, ESCC 案例显示出全面更短的相对 telomere 长度(RTL )( 中部:1.34 ) 比控制(中部:1.50, P < 0.001 ) 。更有趣地,一个明显的非线性的U字形的协会在 RTL 和 ESCC 风险之间被观察( P < 0.001 )与比率(95%信心间隔)等于到 2.40 的机会( 1.843.14 ), 1.36 ( 1.031.79 ), 1.01 ( 0.761.35 ),并且 1.37 ( 1.031.82 )为个人在第一(最短),第二,第三,并且 第5 (最长) quintile 分别地,在是的 第4 quintile 与那些相比引用组。没有重要协会在八报导 TL-SNPs 和 ESCC 危险性之间被观察。这些调查结果建议短或极其长的 telomeres 可以是为在中国人口的 ESCC 的风险因素。 | Jiangbo Du Wenjie Xue Yong Ji Xun Zhu Yayun Gu Meng Zhu Cheng Wang Yong Gao Juncheng Dai Hongxia Ma Yue Jiang Jiaping Chen Zhibin Hu Guangfu Jin Hongbing Shen | 2015 | Frontiers of Medicine2015，9，4： | 4 |
| 4 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 5 | Conceptual design of energy-saving stripping process for industrial sour water显示文摘Sour water contains ammonia,carbon dioxide,and hydrogen sulfides,producing from oil refining,coking,and coal gasification.To reduce the energy consumption in sour water stripping,a novel process is proposed which integrates with the bottom flashing mechanical vapor recompression heat pump(MVRHP)for treating such wastewater.Here,Aspen PlusTM as a powerful set of chemical process simulation software is utilized to investigate the economy and feasibility of the novel process.Comparison of the results of two process simulations,it can be seen that it is possible to reduce the total annual cost by nearly 45%to adopt the novel process,despite the capital investment increase 45%more than the conventional process.Thus,the provided conceptual design will play a guiding role in the industrialization of the process. | Hengjun Gai Shuo Chen Kaiqiang Lin Xiaowei Zhang Chun Wang Meng Xiao Tingting Huang Hongbing Song | 2020 | Chinese Journal of Chemical Engineering2020，28，5： | 2 |
| 6 | Modified g-C_(3)N_(4) derived from ionic liquid and urea for promoting visible-light photodegradation of organic pollutants显示文摘In this work,modified g-C_(3)N_(4) was fabricated successfully by calcination of ionic liquid(IL) and urea.The addition of IL changed the polymerization mode of urea,induced the self-assembly of urea molecules,modified the morphological structure of the tightly packed g-C_(3)N_(4),and extended the electron conjugation system.When using 1-butyl-3-methylimidazolium chloride([Bmim]Cl) as a modifier,the heteroatom Cl could be inserted into the g-C_(3)N_(4) to optimize the electronic structure.The results of characterizations indicate that the unique structure of modified g-C_(3)N_(4) has an expanded electron delocalization range,introduces an interlayer charge transmission channel,promotes the charge transmission,reduces the band gap,enhances the absorption of visible light,and inhibits electron-hole recombination.Modified g-C_(3)N_(4) showed excellent photocatalytic performance for the degradation of rhodamine B and tetracycline.Furthermore,the effect of different anions in 1-butyl-3-methylimidazolium salts([Bmim]Cl,[Bmim]Br,[Bmim][BF_(4)],and [Bmim][PF_6]) on the structure and function of g-C_(3) N_(4) are discussed. | Hongbing Song Lei Liu Bingxiao Feng Haozhong Wang Meng Xiao Hengjun Gai Yubao Tang Xiaofei Qu Tingting Huang | 2021 | Chinese Journal of Chemical Engineering2021，34，12： | 2 |
| 7 | Polygenic risk scores:the future of cancer risk prediction,screening,and precision prevention显示文摘Genome-wide association studies(GWASs)have shown that the genetic architecture of cancers are highly polygenic and enabled researchers to identify genetic risk loci for cancers.The genetic variants associated with a cancer can be combined into a polygenic risk score(PRS),which captures part of an individual’s genetic susceptibility to cancer.Recently,PRSs have been widely used in cancer risk prediction and are shown to be capable of identifying groups of individuals who could benefit from the knowledge of their probabilistic susceptibility to cancer,which leads to an increased interest in understanding the potential utility of PRSs that might further refine the assessment and management of cancer risk.In this context,we provide an overview of the major discoveries from cancer GWASs.We then review the methodologies used for PRS construction,and describe steps for the development and evaluation of risk prediction models that include PRS and/or conventional risk factors.Potential utility of PRSs in cancer risk prediction,screening,and precision prevention are illustrated.Challenges and practical considerations relevant to the implementation of PRSs in health care settings are discussed. | Yuzhuo Wang Meng Zhu Hongxia Ma Hongbing Shen | 2021 | Medical Review2021，1，2： | 2 |
| 8 | Template-free synthesis of hollow TiO2 nanospheres supported Pt for selective photocatalytic oxidation of benzyl alcohol to benzaldehyde显示文摘Heterogeneous photocatalytic system are widely applied to degrade organic pollutants or converse into high value-added chemicals. Both environmental and energy aspects should be considered to improve these chemical processes, favoring reaction conditions that involve room temperature and ambient O2 pressure. In the present work, hollow titanium dioxide nanospheres were fabricated via template-free method. The prepared samples were characterized by X-ray diffraction, N2 adsorption–desorption isotherms, transmission electron microscopy, and X-ray photoelectron spectroscopy. The photocatalytic activity was evaluated by photocatalytic oxidation of benzyl alcohol to benzaldehyde with visible light under atmospheric pressure at room temperature. The designed hollow structure(2%Pt–TiO2–5) not only exhibited a very high surface area,but also promoted photonic behavior and multiple light scattering, which as an efficient photocatalyst performed moderate conversion(about 20%) and high selectivity(> 99%) for oxidation of benzyl alcohol to benzaldehyde at room temperature with visible light in solvent of toluene.This work suggests that both hollow structure and Pt nanoparticles have great potential for execution of oxidative transformations under visible light. | Hongbing Song Zong Liu Yongjie Wang Na Zhang Xiaofei Qu Kai Guo Meng Xiao Hengjun Gai | 2019 | Green Energy & Environment2019，4，3： | 2 |
| 9 | Study on the Strategy of Rural Industry Development in the Central China under the Background of Urban-Rural Integration显示文摘Taking the rural areas in the central China s the target,the representative achievements and difficulties faced by rural industries in the process of urban-rural integration were sorted out systematically in this article. In the new stage of development,it is necessary to adjust the development strategy,focus on tapping the rural characteristic industries,accelerate the upgrading of agricultural products,aim at market demand,and implement multi-channel marketing strategies to expand the influence of agricultural brands. The government must actively promote the integration of urban and rural industries and the development of division of labor,actively cultivate and develop rural characteristic industrial clusters,and encourage farmers to explore various types of rural industrial models. | Ling MENG Wenhai ZENG Zewen GAN Hongbing ZHOU Peng ZHONG | 2018 | Asian Agricultural Research2018，10，9： | 2 |
| 10 | Amino-metalloporphyrin polymers derived Fe single atom catalysts for highly efficient oxygen reduction reaction显示文摘Recently,nitrogen-doped porous carbon supported single atom catalysts(SACs)have become one of the most promising alternatives to precious metal catalysts in oxygen reduction reaction(ORR)due to their outstanding performance,especially those derived from porphyrin-based materials.However,most of them involve other metal residuals,which would cause the tedious pre-and/or post-treatment,even mislead the mechanistic investigations and active-site identification.Herein,we report a precursor-dilution strategy to synthesize Fe SACs through the Schiff-based reaction via co-polycondensation of amino-metalloporphyrin,followed by pyrolysis at high temperature.Systematic characterization results provide the compelling evidence of the dominant presence of atomically dispersed Fe-Nxspecies.Our catalyst shows superior ORR performance with positive half-wave potential(E1/2=0.85 V vs.RHE)in alkaline condition and moderate activity(E1/2=0.68 V vs.RHE)under the acidic condition,excellent methanol tolerance and good long-term stability.All the results indicate Fe SACs would be a promising candidate for replacing the precious Pt in metal-air batteries and fuel cells. | Qian He Yuying Meng Hao Zhang Ying Zhang Qingdi Sun Tao Gan Huajian Xiao Xiaohui He Hongbing Ji | 2020 | Science China Chemistry2020，63，6： | 2 |
| 11 | Convergence of numerical solutions to stochastic age-dependent population equations显示文摘 | Li Ronghua Meng Hongbing Chang Qin | 2005 | Journal of Computational and Applied Mathematics2005，，1： | 1 |
| 12 | Curcumin enhances the radiosensitivity in nasopharyngeal carcinoma cellsinvolving the reversal of differentially expressed long non-coding RNAs显示文摘 | Qirui Wang Haoning Fan Ying Liu Zhixin Yin Hongbing Cai Jie Liu Zhiyuan Wang Meng Shao Xuegang Sun Jianxin Diao Yuanliang Liu Li Tong Qin Fan | 2014 | International Journal of Oncology2014，，3： | 1 |
| 13 | The valuation of compound options on jump-diffusions with time-dependent parameters显示文摘 | Ronghua Li Hongbing Meng Yonghong Dai | 2005 | IEEE2005，2，： | 1 |
| 14 | Exponential stability of numerical solutions to SDDEs with markovian switching显示文摘 | Li Ronghua Meng Hongbing Chang Qin | 2006 | Applied Mathematics and Computation2006，174，2： | 1 |
| 15 | Convergence of numerical solutions to stochastic age-structured population system显示文摘 | Li Ronghua Meng Hongbing Chang Qin | 2006 | Journal of Computational and Applied Mathematics2006，193，1： | 1 |
| 16 | Conver- gence of numerical solutions to stochastic age-dependent population equations显示文摘 | LI Ronghua MENG Hongbing CHANG Qin | 2006 | Journal of Computation and Ap- plied Mathematics2006，193，： | 1 |
| 17 | Gene amplification-driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A-YTHDF2-dependent in lung adenocarcinoma显示文摘Background:Epigenetic alterations have been shown to contribute immensely to human carcinogenesis.Dynamic and reversible N6-methyladenosine(m6A)RNA modification regulates gene expression and cell fate.However,the reasons for activation of KIAA1429(also known as VIRMA,an RNA methyltransferase)and its underlying mechanism in lung adenocarcinoma(LUAD)remain largely unexplored.In this study,we aimed to clarify the oncogenic role of KIAA1429 in the tumorigenesis of LUAD.Methods:Whole-genome sequencing and transcriptome sequencing of LUAD data were used to analyze the gene amplification of RNA methyltransferase.The in vitro and in vivo functions of KIAA1429 were investigated.Transcriptome sequencing,methylated RNA immunoprecipitation sequencing(MeRIP-seq),m6A dot blot assays and RNA immunoprecipitation(RIP)were performed to confirm the modified gene mediated by KIAA1429.RNA stability assays were used to detect the half-life of the target gene.Results:Copy number amplification drove higher expression of KIAA1429 in LUAD,whichwas correlatedwith poor overall survival.Manipulating the expression of KIAA1429 could regulate the proliferation and metastasis of LUAD.Mechanistically,the target genes of KIAA1429-mediated m6A modification were confirmed by transcriptome sequencing and MeRIP-seq assays.We also revealed that KIAA1429 could regulate BTG2 expression in an m6A-dependent manner.Knockdown of KIAA1429 significantly decreased the m6A levels of BTG2 mRNA,leading to enhanced YTH m6A RNA binding protein 2(YTHDF2,the m6A“reader”)-dependent BTG2 mRNA stability and promoted the expression of BTG2;thus,participating in the tumorigenesis of LUAD.Conclusions:Our data revealed the activation mechanism and important role of KIAA1429 in LUAD tumorigenesis,which may provide a novel view on the targeted molecular therapy of LUAD. | Chang Zhang Qi Sun Xu Zhang Na Qin Zhening Pu Yayun Gu Caiwang Yan Meng Zhu Juncheng Dai ChengWang Ni Li Guangfu Jin Hongxia Ma Zhibin Hu Erbao Zhang Fengwei Tan Hongbing Shen | 2022 | Cancer Communications2022，42，7： | 1 |
| 18 | An agent based approach for Constructing software systems of virtual simulation显示文摘 | Hongbing Li Bo Meng Shifu Chen | 2000 | International journal of Virtual Reality2000，4，4： | 1 |
| 19 | Member 1 of Yongji Formation(Ey1) sedimentary characteristics and its origin analysis in Yitong Graben显示文摘Ey1 has the unique desultory-weak or gap seismic reflection structure as its one of the most important characteristics.It is very important to clarify sedimentary characteristics and its origin for Yitong Graben and its sedimentary facies and tectonic evolution.On the basis of the research of core analyses,well logging data analyses,sedimentary facies analyses and seismic reflection structure analyses,the authors have concluded the sedimentary characteristics of Ey1,and have carried out Ey1 sedimentary environments and its origin.The result shows that Ey1 desultory-weak or gap seismic reflection may be a series of small scale secondary sediment fans superimposition. | Changwei CHEN Linfu XUE Hongbing DAI Jian WANG Xingke XU Qinglong MENG | 2007 | Global Geology2007，10，1： | 0 |
| 20 | A highly hydrothermal stable copper-based catalyst for catalytic wet air oxidation of m-cresol in coal chemical wastewater显示文摘Catalytic wet air oxidation(CWAO) can degrade some refractory pollutants at a low cost to improve the biodegradability of wastewater. However, in the presence of high temperature and high pressure and strong oxidizing free radicals, the stability of catalysts is often insufficient, which has become a bottleneck in the application of CWAO. In this paper, a copper-based catalyst with excellent hydrothermal stability was designed and prepared. TiO_(2) with excellent stability was used as the carrier to ensure the longterm anchoring of copper and reduce the leaching of the catalyst. The one pot sol–gel method was used to ensure the super dispersion and uniform distribution of copper nanoparticles on the carrier, so as to ensure that more active centers could be retained in a longer period. Experiments show that the catalyst prepared by this method has good stability and catalytic activity, and the catalytic effect is not significantly reduced after 10 cycles of use. The oxidation degradation experiment of m-cresol with the strongest biological toxicity and the most difficult to degrade in coal chemical wastewater was carried out with this catalyst. The results showed that under the conditions of 140℃, 2 MPa and 2 h, m-cresol with a concentration of up to 1000 mg·L^(-1) could be completely degraded, and the COD removal rate could reach 79.15%. The biological toxicity of wastewater was significantly reduced. The development of the catalyst system has greatly improved the feasibility of CWAO in the treatment of refractory wastewater such as coal chemical wastewater. | Bingxiao Feng Lining Hao Chaoting Deng Jiaqiang Wang Hongbing Song Meng Xiao Tingting Huang Quanhong Zhu Hengjun Gai | 2023 | Chinese Journal of Chemical Engineering2023，57，5： | 0 |
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