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| 1 | Artifact Versus Reality-How Astrocytes Contribute to Synaptic Events显示文摘一个世纪前发展的神经元学说,认为神经元网络是维持高级大脑功能的唯一细胞类型。胶质细胞生理学的最新进展,促进了另一种假说的提出,它认为大脑信息处理通过神经元-胶质细胞网络利用双重的(神经元动作电位)和同类的(第二信使/代谢物通过缝隙连接或递质在细胞间隙的扩散传播)信号编码来完成。这两种神经细胞间存在前馈和反馈通信,引起信息传递和处理,是通过神经元终端和星形胶质细胞突起的神经递质释放来完成。然而,对这个问题的认识,仍然是不完整的。一些重要的问题和争议有待解决。本文认为,突触旁的胶质细胞突起的主要功能是创建一个'星形胶质细胞摇篮',以保护突触免受大量来自突触外的信号活动的作用,并通过多种机制为突触联系提供多方面的支持和长期的可塑性保护,这些过程并不一定涉及胶质源性神经递质的释放。 | MAIKEN NEDERGAARD ALEXEI VERKHRATSKY | 2012 | 神经损伤与功能重建2012，7，4： | 7 |
| 2 | The blood–brain barrier: an overview显示文摘 | Praveen Ballabh Alex Braun Maiken Nedergaard | 2004 | Neurobiology of Disease2004，，1： | 2 |
| 3 | Effect of different haptencarrierconjugation ratios and molecular orientations on antibody affinityagainst a peptide antigen 显示文摘 | Maiken K Pedersen A Nanna S | 2006 | J Immunol Methods2006，311，12： | 1 |
| 4 | Cell-Free Plasma MicroRNA in Pancreatic Ductal Adenocarcinoma and Disease Controls显示文摘 | Anting Liu Carlsen Maiken Thyregod Joergensen Steen Knudsen Ove B. Schaffalitzky de Muckadell Niels H. H. Heegaard | 2013 | Pancreas2013，，7： | 1 |
| 5 | Garbage Truck of the Brain 显示文摘 | Maiken Nedergaard | 2013 | Science2013，340，6140： | 1 |
| 6 | Five-hour diagnosis of dermatophyte nail infections with specific detection of Trichophyton rubrum显示文摘 | ANNA B D DITTE M S MAIKEN C A | 2007 | J Clin Microbiol2007，45，4： | 1 |
| 7 | Genetic diversity of env V3 loop sequences in HIV type 1-infected homosexuals, heterosexuals, intravenous drug users ,and hemophilia patients in Norway:high prevalence of subtype B and detection of subtype C显示文摘 | Maiken E | 1996 | AIDS Research and Human Retrovirus1996，8，： | 1 |
| 8 | Characterization of the psychrotolerant acetogen strain SyrA5 and the emended description of the species Acetobacterium carbinolicum显示文摘 | Maiken Paarup Michael W. Friedrich Brian J. Tindall Kai Finster | 2006 | Antonie van Leeuwenhoek2006，，1： | 1 |
| 9 | Effect of different haptencarrier conjugation ratios and molecular orientations on antibody affinity against a peptide antigen显示文摘 | Maiken K Pedersen A Nanna S | 2006 | J Immunol Methods2006，311，12： | 1 |
| 10 | The blood-brain barrier: an overview Structure, regulation, and clinical implications显示文摘 | Praveen Ballabh Alex Braun Maiken Nedergaard | 2004 | Neurobiology of Disease2004，16，： | 1 |
| 11 | National surveillance of funge- mia in Denmark (2004 to 2009) 显示文摘 | Maiken Cavling Arendrup Brita Bruun | 2011 | J Clin Mierobiol2011，49，1： | 1 |
| 12 | The blood–brain barrier: an overview显示文摘 | Praveen Ballabh Alex Braun Maiken Nedergaard | 2004 | Neurobiology of Disease2004，，1： | 1 |
| 13 | Adenosine A1 receptors mediate local anti - nocieeptive effects of acupuncture显示文摘 | Maiken N | 2010 | Nature Neuroscience2010，，： | 1 |
| 14 | Astrocytes and Ischemic Injury显示文摘 | Takahiro Takano NancyAnn Oberheim Maria Luisa Cotrina Maiken Nedergaard | 2009 | 2009 (3 Su)2009，，3： | 1 |
| 15 | Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part I. Epidemiology and diagnosis显示文摘 | Beno?t P. Guery Maiken C. Arendrup Georg Auzinger élie Azoulay Márcio Borges Sá Elizabeth M. Johnson Eckhard Müller Christian Putensen Coleman Rotstein Gabriele Sganga Mario Venditti Rafael Zaragoza Crespo Bart Jan Kullberg | 2009 | Intensive Care Medicine2009，，1： | 1 |
| 16 | Diet-induced dyslipidemia leads to nonalcoholic fatty liver disease and oxidative stress in guinea pigs显示文摘 | Pernille Tveden-Nyborg Malene M. Birck David H. Ipsen Tina Thiessen Linda de Bie Feldmann Maiken M. Lindblad Henrik E. Jensen Jens Lykkesfeldt | 2015 | Translational Research2015，，： | 1 |
| 17 | Influence of anastomoses on intestine ischemia and cefuroxime concentrations:Evaluated in the ileum and colon in a porcine model显示文摘BACKGROUND Anastomotic leakage is a serious complication following gastrointestinal surgery and is associated with increased morbidity and mortality.The incidence of anastomotic leakage is determined by anatomy and is reported to be between 4%-33%for colon anastomosis and 1%-3%for small intestine anastomosis.The etiology of anastomotic leakage of the intestine has been divided into three main factors:healing disturbances,communication between intra-and extra-luminal compartments,and infection.All three factors interact,and one factor will inevitably lead to the other two factors resulting in tissue ischemia,tissue necrosis,and anastomotic leakage.AIM To evaluate ischemic metabolites and cefuroxime concentrations in both anastomosis and non-anastomosis ileum and colon in a porcine model.METHODS Eight healthy female pigs(Danish Landrace breed,weight 58-62 kg)were included in this study.Microdialysis catheters were placed for sampling of ischemic metabolites(glucose,lactate,glycerol,and pyruvate)and cefuroxime concentrations in both anastomosis and non-anastomosis ileum and colon.Cefuroxime 1.5 g was administered as an intravenous infusion over 15 min.Subsequently,dialysates and blood samples were collected over 8 h and the ischemic metabolites and cefuroxime concentrations were quantified in all samples.The concentrations of glucose,lactate,glycerol and pyruvate were determined using the CMA 600 Microdialysis Analyzer with Reagent Set A(M Dialysis AB,Sweden),and the concentrations of cefuroxime and meropenem were quantified using a validated ultra-high-performance liquid chromatography assay.RESULTS Only the colon anastomosis induced mean ischemic lactate/pyruvate ratios above 25(ischemic cut-off)throughout the entire sampling interval,and simultaneously decreased glucose concentrations.The mean time for which cefuroxime concentrations were maintained above the clinical breakpoint minimal inhibitory concentration for Escherichia coli(8μg/mL)ranged between 116-128 min across all the investigated compartments,and was similar between the anastomosis and non-anastomosis ileum and colon.For all pigs and in all the investigated compartments,a cefuroxime concentration of 8μg/mL was reached within 10 min after administration.When comparing the pharmacokinetic parameters between the anastomosis and non-anastomosis sites for both ileum and colon,only colon Tmax and half-life differed between anastomosis and non-anastomosis(P<0.03).Incomplete tissue penetrations were found in all tissues except for the nonanastomosis colon.CONCLUSION Administering 1.5 g cefuroxime 10 min prior to intestine surgery seems sufficient,and effective concentrations are sustained for approximately 2 h.Only colon anastomosis was locally vulnerable to ischemia. | Pelle Hanberg Mats Bue Maja Thomassen Uffe Schou Løve Josephine Olsen Kipp Christina Harlev Elisabeth Petersen Kjeld Søballe Maiken Stilling | 2021 | World Journal of Gastrointestinal Pathophysiology2021，12，1： | 0 |
| 18 | Astrocyte chloride,excitatory-inhibitory balance and epilepsy显示文摘Excitation and inhibition are at the core of brain function and malfunction.To sustain the activity of neuronal networks over time and space,glutamatergic excitation is balanced by GABAergic inhibition.The equipoise of excitation and inhibition,known as the excitation/inhibition(E/I)balance,is crucial for proper brain function.The E/I balance is highly dynamic and shifts across different brain states:wakefulness primarily augments excitatory activity,while sleep promotes a decrease in excitation and an increase in inhibition(Bridi et al.,2020).Neuronal activity during various brain states is primarily regulated by neurotransmitters(Schiemann et al.,2015),alongside non-synaptic mechanisms that operate on a slower timescale.The non-synaptic mechanisms are many,with the ionic composition of the extracellular space playing a significant role;altering extracellular ion concentrations affects sleep,arousal,electroencephalogram patterns,and behavioral states(Ding et al.,2016). | Verena Untiet Maiken Nedergaard Alexei Verkhratsky | 2024 | Neural Regeneration Research2024，19，9： | 0 |
| 19 | 爱如潮水:来自上世纪的情书显示文摘你现在还会用笔写信吗?在网络时代,手写信似乎已经成为了古董。比起电子邮件,这种传统的写信方式显得更为亲切真实,也更为珍贵。手写情书所传递的爱意是电子屏幕无法取代的. | Maiken Scott 洪馥芝 | 2013 | 疯狂英语(初中天地)2013，，2： | 0 |
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