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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Use of secondary preventive medications in patients with atherosclerotic disease in urban China: a cross-sectional study of 16 860 patients显示文摘 | LI Jing CHEN Yi-ping LI Xi Jane Armitage FENG Fang LIU Jia-min GAO Yan ZHANG Hai-bo ZHANG Dan HUNDEI Wuhan-bilige CHEN Zheng-ming CHEN Fang Jemma C Hopewell Elsa Valdes-Marquez Martin Landray JIANG Li-xin | 2012 | Chinese Medical Journal2012，，24： | 10 |
| 4 | Underuse of statins in patients with atherosclerotic ischemic stroke in China显示文摘 | LI Xi GAO Yan FENG Fang LIU Jia-min ZHANG Hai-bo ZHANG Dan HUNDEI Wu-han-bi-li-ge CHEN Fang CHEN Yi-ping CHEN Zheng-ming Martin Landray Jane Armitage JIANG Li-xin LI Li-ming | 2012 | Chinese Medical Journal2012，，10： | 9 |
| 5 | MDF纤维中脲醛胶含量的定量分析显示文摘脲醛树脂胶是中密度纤维板生产的常用胶种,它的用量直接关系到产品的生产成本和产品质量及性能.本文利用在X-射线的照射下,不同的金属离子具有对应的波长衍射,含量的多少反映为衍射强度的原理,应用X-射线衍射仪(WDXRF)对MDF所含的脲醛树脂胶(UF)的含量进行定量分析.分析中采用与胶料固含量2.4%的比例将硫酸铜(CuSO45H2O)与脲醛树脂胶均匀混合和并按照生产工艺的施胶要求加入到纤维的方法,使铜离子成为UF胶料的分布标记.并通过实验室的标准含量的样品和衍射强度之间关系进行标定,从而实现对UF树脂胶料的定量测量.结果表明,Cu离子的波段位置清晰,X-射线的衍射强度和金属含量之间存在良好相关性,并以此建立了中密度纤维板中UF树脂胶含量和X-射线衍射强度之间的线性关系式.经验表明这一关系是精确可靠的. | 谢拥群 Martin FENG James DENG | 2005 | 福建林学院学报2005，25，4： | 6 |
| 6 | Tetrahymena Gene Expression Database (TGED):A resource of microarray data and co-expression analyses for Tetrahymena显示文摘Tetrahymena thermophila is a model eukaryotic organism. Functional genomic analyses in Tetrahymena present rich opportunities to address fundamental questions of cell and molecular biology. The Tetrahymena Gene Expression Database (TGED; available at http://tged.ihb.ac.cn) is the first expression database of a ciliated protozoan. It covers three major physiological and developmental states: growth, starvation, and conjugation, and can be accessed through a user-friendly web interface. The gene expression profiles and candidate co-expressed genes for each gene can be retrieved using Gene ID or Gene description searches. Descriptions of standardized methods of sample preparation and the opportunity to add new Tetrahymena microarray data will be of great interest to the Tetrahymena research community. TGED is intended to be a resource for all members of the scientific research community who are interested in Tetrahymena and other ciliates. | XIONG Jie LU XingYi LU YuMing ZENG HongHui YUAN DongXia FENG LiFang CHANG Yue Josephine BOWEN Martin GOROVSKY FU ChengJie MIAO Wei | 2011 | Science China(Life Sciences)2011，54，1： | 5 |
| 7 | DMP1 prevents osteocyte alterations,FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease显示文摘During chronic kidney disease (CKD),alterations in bone and mineral metabolism include increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute to cardiovascular mortality.The osteocyte protein dentin matrix protein 1 (DMP1) reduces FGF23 and enhances bone mineralization,but its effects in CKD are unknown.We tested the hypothesis that DMP1 supplementation in CKD would improve bone health,prevent FGF23 elevations and minimize consequent adverse cardiovascular outcomes.We investigated DMP1 regulation and effects in wild-type (WT) mice and the Col4a3^-/- mouse model of CKD.Col4a3^-/- mice demonstrated impaired kidney function,reduced bone DMP1 expression,reduced bone mass,altered osteocyte morphology and connectivity,increased osteocyte apoptosis,increased serum FGF23,hyperphosphatemia,left ventricular hypertrophy (LVH),and reduced survival.Genetic or pharmacological supplementation of DMP1 in Col4a3^-/- mice prevented osteocyte apoptosis,preserved osteocyte networks,corrected bone mass,partially lowered FGF23 levels by attenuating NFAT-induced FGF23 transcription,and further increased serum phosphate.Despite impaired kidney function and worsened hyperphosphatemia,DMP1 prevented development of LVH and improved Col4a3^-/- survival.Our data suggest that CKD reduces DMP1 expression,whereas its restoration represents a potential therapeutic approach to lower FGF23 and improve bone and cardiac health in CKD. | Corey Dussold Claire Gerber Samantha White Xueyan Wang Lixin Qi Connor Francis Maralee Capella Guillaume Courbon Jingya Wang Chaoyuan Li Jian Q. Feng Tamara Isakova Myles Wolf Valentin David Aline Martin | 2019 | Bone Research2019，7，2： | 4 |
| 8 | Ten-Microsecond Molecular Dynamics Simulation of a Fast-Folding WW Domain显示文摘 | Peter L. Freddolino Feng Liu Martin Gruebele Klaus Schulten | 2008 | Biophysical Journal2008，，10： | 2 |
| 9 | Increased platelet aggregability associated with platelet GP Ⅲ a PIA2 polymorphism:the Framingham Offspring Study显示文摘 | Feng DL Klaus L Martin GL | 1999 | Arterioscler Thromb Vase Bio11999，19，4： | 1 |
| 10 | Transient fluid flow in the Binbei district of the Songliao Basin, China Evidence from apatite fission track thermochronology显示文摘Songliao 盆以 Daqing 油矿著名,在中国最大。然而,没有经济烃水库在东北 Binbei 区域被发现了。它的热历史,为烃产生和移植很重要,与磷灰石分裂轨道被学习(在船尾) thermochronology。有迟了的白垩纪(10873 妈) 的 depositional 年龄的样品被分析。在船尾,从水库的样品的年龄摇(depositional 年龄 > 76.1 妈) 在迟了的白垩纪之间的秋天(72 ? 湅楰杮匠条愠摮瀠楯瑮摥琠?? 敮 ? 楤敲瑣潩 ? 潦 ? 桴 ? 票牤 ' 夷典?硥汰牯瑡潩 ?湩琠敨猠畴祤愠敲 | Xiang Caifu Martin Daniík Feng Zihui | 2013 | Petroleum Science2013，10，3： | 1 |
| 11 | Gain and noise in ytterbium-sensitized erbium-doped fiber amplifiers: measurements and simulations显示文摘 | MARTIN A ROBERT J FENG P | 2001 | Journal of Li ghtwave Technology2001，19，10： | 1 |
| 12 | Over-expression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice显示文摘 | Martin A David V Li H Dai B Feng JQ Quarles LD | | 0，，： | 1 |
| 13 | Thermal degradation characteristics of phenol-formaldehyde resins derived from beetle infested pine barks显示文摘 | Zhao Yong Ning Yana Feng Martin W | 2013 | Thermochimica Acta2013，555，： | 1 |
| 14 | Inactivation of Escherichia coli with power ultrasound in apple cider 显示文摘 | Ugarte - Romero E Hao Feng Martin S E | 2006 | Journal of Food Science2006，71，2： | 1 |
| 15 | A genetic screen for candidate tumor suppressors identifies REST显示文摘 | Martin ES Schlabach MR Leng Y Liang AC Feng B Zhao JJ Roberts TM Mandel G Hannon GJ Depinho RA Chin L Elledge SJ | 2005 | Cell2005，121，： | 1 |
| 16 | Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases显示文摘 | Lijun Zheng Xiaojiang Wu Martin E. Kreis Zhen Yu Lijin Feng Chunqiu Chen Bin Xu Zhaode Bu Ziyu Li Jiafu Ji Paul Enck | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 17 | Travel Time and Distance in International Perspective: A Comparison between Nanjing (China) and the Randstad (The Netherlands)显示文摘 | Jianxi Feng Martin Dijst Jan Prillwitz Bart Wissink | 2013 | Urban Studies2013，，14： | 1 |
| 18 | Distance regularized level set evolution and its application to image segmentation 显示文摘 | Li Chun - Ming Xu Chen - Yang Gui Chang - Feng Martin D Fox | 2010 | IEEE Trans - actions on Image Processing2010，9，12： | 1 |
| 19 | Accretion in strong field gravity with eXTP显示文摘In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced 'spectral-timing-polarimetry' techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process. | Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 1 |
| 20 | Revisiting Newton’s rings with a plasmonic optical flat for high-accuracy surface inspection显示文摘Two parallel optical surfaces often exhibit colorful fringes along the lines of equal thickness because of the interference of light.This simple phenomenon allows one to observe subwavelength corrugations on a reflective surface by simply placing on it a flat reference dielectric surface,a so-called optical flat,and inspecting the resultant interference pattern.In this work,we extend this principle from dielectric surfaces to two-dimensional plasmonic nanostructures.Optical couplings between an Au nanodisk array and an Au thin film were measured quantitatively using two different techniques,namely,the classical Newton’s rings method and a closed-loop nano-positioning system.Extremely high spectral sensitivity to the inter-surface distance was observed in the near-field coupling regime,where a 1-nm change in distance could alter the resonance wavelength by almost 10 nm,440 times greater than the variation in the case without near-field coupling.With the help of a numerical fitting technique,the resonance wavelength could be determined with a precision of 0.03 nm,corresponding to a distance precision as high as 0.003 nm.Utilizing this effect,we demonstrated that a plasmonic nanodisk array can be utilized as a plasmonic optical flat,with which nanometer-deep grooves can be directly visualized using a low-cost microscope. | Yun Zheng Jie Bian Xiao-Long Wang Ju-Xiu Liu Peng Feng Hai-Xiong Ge Olivier JF Martin Wei-Hua Zhang | 2016 | Light(Science & Applications)2016，5，1： | 1 |
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