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| 1 | Effects of Chinese herbs on salivary fluid secretion by isolated and perfused rat submandibular glands显示文摘AIM:To determine whether Chinese herbs (CHs) relieve xerostomia (dry mouth) by increasing salivary secretion.METHODS: The submandibular glands of Wistar rats were surgically isolated and perfused arterially with buffered salt solution. After control perfusion, recording started 5 min prior to the start of stimulation. After fluid secretion was induced by 0.2 μmol/L carbamylcholine (CCh) in the perfusate for 10 min, Chinese herb (CH) was added in the perfusion for 5 min. CCh was then overloaded at 0.2 μmol/L in the perfusion for 20 min. The volume of salivary fluid secretion was recorded by a computer-controlled balance system.RESULTS: Saliva secretion formed an initial ephemeral peak at 30 s followed by a gradual increase to a sustained level. CH alone induced no or little saliva in all types of CH selected. During perfusion with CH,overloading of CCh promoted fluid secretion in 15 of 20 CHs. This promotion was classified into four patterns, which were eventually related to the categories of CH: Overall sustained phase was continuously raised (Yin-nourishing, fluid production-promoting and heat-clearing agents); The sustained secretion rose to reach a maximum then decreased (Qi-enhancing agent); Sustained secretion rose to reach the highest maximum and was then sustained with a slight decline (swelling-reducing, phlegm-resolving and pus-expelling agents); Stimulation of salivary secretion without any added stimulants. Addition of CCh raised the fluid secretion to reach the highest maximum then sharply decreased to a lower sustained level (blood activating agent).CONCLUSION: The present findings lead to the conclusion that various CHs have different promotional effects directly on the salivary gland. | Masataka Murakami Mu-Xin Wei Wei Ding Qian-De Zhang | 2009 | World Journal of Gastroenterology2009，15，31： | 9 |
| 2 | Benefits of nucleos(t)ide analog treatments for hepatitis B virus-related cirrhosis显示文摘Chronic hepatitis B infection induces progressive liver disease. Before nucleos(t)ide analogs(NUCs) became established as a safe and effective treatment for hepatitis B,it was difficult to suppress the activity of the hepatitis B virus(HBV). Currently,many patients withhepatitis or cirrhosis associated with HBV are treated with NUCs for an extended period of time,and the effects,benefits,and limitations of these treatments have been apparent. This article reviews HBV-related cirrhosis,its natural course and survival,histological improvement after NUC treatments,treatment effects for decompensated cirrhosis,the incidence of hepatocellular carcinoma(HCC) after NUC treatments,and the efficacy of NUC treatments before and after the treatment of patients for HBV-related HCC. Of particular interest are the histological improvements,including regression of fibrosis,that have been achieved with NUC treatments. Liver function of patients with decompensated cirrhosis has significantly improved regardless of the type of NUC applied,and treatment with NUCs has reduced the incidence of HCC in cirrhotic patients. However,cirrhosis remains the strongest risk factor for HCC occurrence following NUC treatments,and the long-term cumulative incidence of HCC after NUC treatments remains high. When recurrence does occur,it is important to reconsider the treatment modality according to the degree of improved liver function that was achieved. | Koichi Honda Masataka Seike Kazunari Murakami | 2015 | World Journal of Hepatology2015，7，22： | 9 |
| 3 | Mechanism involved in Danshen-induced fluid secretion in salivary glands显示文摘AIM:Danshen's capability to induce salivary fluid secretion and its mechanisms were studied to determine if it could improve xerostomia.METHODS:Submandibular glands were isolated from male Wistar rats under systemic anesthesia with pentobarbital sodium.The artery was cannulated and vascularly perfused at a constant rate.The excretory duct was also cannulated and the secreted saliva was weighed in a cup on an electronic balance.The weight of the accumulated saliva was measured every 3 s and the salivary flow rate was calculated.In addition,the arterio-venous difference in the partial oxygen pressure was measured as an indicator of oxygen consumption.In order to assess the mechanism involved in Dansheninduced fluid secretion,either ouabain(an inhibitor of Na+/K+ ATPase) or bumetanide(an inhibitor of NKCC1) was additionally applied during the Danshen stimulation.In order to examine the involvement of the main membrane receptors,atropine was added to block the M3 muscarinic receptors,or phentolamine was added to block the α1 adrenergic receptors.In order to examine the requirement for extracellular Ca2+,Danshen was applied during the perfusion with nominal Ca2+ free solution.RESULTS:Although Danshen induced salivary fluid secretion,88.7 ± 12.8 μL/g-min,n = 9,(the highest value around 20 min from start of DS perfusion was significantly high vs 32.5 ± 5.3 μL/g-min by carbamylcholine,P = 0.00093 by t-test) in the submandibular glands,the time course of that secretion differed from that induced by carbamylcholine.There was a latency associated with the fluid secretion induced by Danshen,followed by a gradual increasein the secretion to its highest value,which was in turn followed by a slow decline to a near zero level.The application of either ouabain or bumetanide inhibited the fluid secretion by 85% or 93%,and suppressed the oxygen consumption by 49% or 66%,respectively.These results indicated that Danshen activates Na+/K+ ATPase and NKCC1 to maintain Cl- release and K+ release for fluid secretion.Neither atropine or phentolamine inhibited the fluid secretion induced by Danshen(263% ± 63% vs 309% ± 45%,227% ± 63% vs 309% ± 45%,P = 0.899,0.626 > 0.05 respectively,by ANOVA).Accordingly,Danshen does not bind with M3 or α1 receptors.These characteristics suggested that the mechanism involved in DS-induced salivary fluid secretion could be different from that induced by carbamylcholine.Carbamylcholine activates the M3 receptor to release inositol trisphosphate(IP3) and quickly releases Ca2+ from the calcium stores.The elevation of [Ca2+]i induces chloride release and quick osmosis,resulting in an onset of fluid secretion.An increase in [Ca2+]i is essential for the activation of the luminal Cl- and basolateral K+ channels.The nominal removal of extracellular Ca2+ totally abolished the fluid secretion induced by Danshen(1.8 ± 0.8 μL/g-min vs 101.9 ± 17.2 μL/g-min,P = 0.00023 < 0.01,by t-test),suggesting the involvement of Ca2+ in the activation of these channels.Therefore,IP3-store Ca2+ release signalling may not be involved in the secretion induced by Danshen,but rather,there may be a distinct signalling process.CONCLUSION:The present findings suggest that Danshen can be used in the treatment of xerostomia,to avoid the systemic side effects associated with muscarinic drugs. | Fei Wei Mu-Xin Wei Masataka Murakami | 2015 | World Journal of Gastroenterology2015，21，5： | 9 |
| 4 | Imaging appearances and management of isolated spontaneous dissection of the superior mesenteric artery显示文摘 | Ichiro Sakamoto Yoji Ogawa Eijun Sueyoshi Kenichiro Fukui Tomonori Murakami Masataka Uetani | 2007 | European Journal of Radiology2007，，1： | 3 |
| 5 | Effects of Chinese herbson salivary fluid secretion of rat submandibular gland 显示文摘 | Murakami Masataka WEIMu - xin | 2007 | The Journal of Physiological Science2007，，57： | 1 |
| 6 | Small cell carcinoma of the lung metastatic to the palatine tonsil显示文摘 | YASUO HISA NORIO YASUDA MASATAKA MURAKAMI | 1997 | Otolaryngology - Head and Neck Surgery1997，，： | 1 |
| 7 | Characteristics of neurokinin A-induced salivary fluid secretion in perfused rat submandibular gland显示文摘 | Bing Qi Takanori Narita Keitaro Satoh Ming-Yu Guo Osamu Katsumata-Kato Masataka Murakami Junko Fujita-Yoshigaki Hiroshi Sugiya | 2010 | Archives of Oral Biology2010，，10： | 1 |
| 8 | Imaging appearances and management of isolated spontaneous dissection of the superior mesenteric artery显示文摘 | Ichiro Sakamoto Yoji Ogawa Eijun Sueyoshi Kenichiro Fukui Tomonori Murakami Masataka Uetani | 2007 | European Journal of Radiology2007，，1： | 1 |
| 9 | Magnetic resonance imaging of the temporomandibular joint in the rat compared with low-powered light microscopy显示文摘 | Kaori Satoh Keitaro Satoh Yoshie Imaizumi Mika Yokoi Toshirou Kondoh Masataka Murakami Yoshiteru Seo | 2011 | Archives of Oral Biology2011，，11： | 1 |
| 10 | Small cell carcinoma of the lung metastatic to the palatine tonsil显示文摘 | Yasuo Hisa Norio Yasuda Masataka Murakami | | 0，，： | 1 |
| 11 | Long term persistence of NS5A inhibitor‐resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy显示文摘 | Satoshi Yoshimi Michio Imamura Eisuke Murakami Nobuhiko Hiraga Masataka Tsuge Yoshiiku Kawakami Hiroshi Aikata Hiromi Abe C. Nelson Hayes Tamito Sasaki Hidenori Ochi Kazuaki Chayama | 2015 | J. Med. Virol2015，，11： | 1 |
| 12 | Effect of aging on nitric oxide production by rat alveolar macrophages显示文摘 | Eiko Koike Takahiro Kobayashi Katsumi Mochitate Masataka Murakami | 1999 | Experimental Gerontology1999，，7： | 1 |
| 13 | Percutaneous Radiofrequency Ablation and Transcatheter Arterial Chemoembolization for Hypervascular Hepatocellular Carcinoma: Rate and Risk Factors for Local Recurrence显示文摘 | Tomonori Murakami Hideki Ishimaru Ichiro Sakamoto Masataka Uetani Yohjiro Matsuoka Manabu Daikoku Sumihisa Honda Takeshi Koshiishi Toshifumi Fujimoto | 2007 | CardioVascular and Interventional Radiology2007，，4： | 1 |
| 14 | Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy显示文摘AIM:To identify factors that influence long-term liver function following radiofrequency ablation(RFA)in patients with viral hepatitis-related hepatocellular carcinoma.METHODS:A total of 123 patients with hepatitis B virus-or hepatitis C virus-related hepatocellular carcinoma(HCC)(n=12 and n=111,respectively)were enrolled.Cumulative rates of worsening Child-Pugh(CP)scores(defined as a 2-point increase)were examined.RESULTS:CP score worsening was confirmed in 22patients over a mean follow-up period of 43.8±26.3mo.Multivariate analysis identified CP class,platelet count,and aspartate aminotransferase levels as significant predictors of a worsening CP score(P=0.000,P=0.011 and P=0.024,respectively).In contrast,repeated RFA was not identified as a risk factor for liver function deterioration.CONCLUSION:Long-term liver function following RFA was dependent on liver functional reserve,the degreeof fibrosis present,and the activity of the hepatitis condition for this cohort.Therefore,in order to maintain liver function for an extended period following RFA,suppression of viral hepatitis activity is important even after the treatment of HCC. | Koichi Honda Masataka Seike Junya Oribe Mizuki Endo Mie Arakawa Hiroki Syo Masao Iwao Masanori Tokoro Junko Nishimura Tetsu Mori Tsutomu Yamashita Satoshi Fukuchi Toyokichi Muro Kazunari Murakami | 2016 | World Journal of Hepatology2016，8，13： | 1 |
| 15 | Should emergency surgical intervention be performed for an octogenarian with type A acute aortic dissection?显示文摘 | Mitsumasa Hata Akira Sezai Tetsuya Niino Masataka Yoda Satoshi Unosawa Nobuyuki Furukawa Shunji Osaka Tomohiko Murakami Kazutomo Minami | 2008 | The Journal of Thoracic and Cardiovascular Surgery2008，，5： | 1 |
| 16 | Using NOAA AVHRR Data to Assess Flood Damage in China显示文摘 | Quan Wang Masataka Watanabe Seiji Hayashi Shogo Murakami | 2003 | Environmental Monitoring and Assessment2003，，2： | 1 |
| 17 | Prooxidant action of xanthurenic acid and quinoline compounds: Role of transition metals in the generation of reactive oxygen species and enhanced formation of 8-hydroxy-2′-deoxyguanosine in DNA?显示文摘 | Keiko Murakami Miyako Haneda Masataka Yoshino | 2006 | BioMetals2006，，4： | 1 |
| 18 | Percutaneous Radiofrequency Ablation and Transcatheter Arterial Chemoembolization for Hypervascular Hepatocellular Carcinoma: Rate and Risk Factors for Local Recurrence显示文摘 | Tomonori Murakami Hideki Ishimaru Ichiro Sakamoto Masataka Uetani Yohjiro Matsuoka Manabu Daikoku Sumihisa Honda Takeshi Koshiishi Toshifumi Fujimoto | 2007 | CardioVascular and Interventional Radiology2007，，4： | 1 |
| 19 | Conformational changes in seventeen cystine disulfide bridges of bovine serum albumin proved by Raman spectroscopy显示文摘 | Koji Nakamura Seiichi Era Yukihiro Ozaki Masaru Sogami Tomoya Hayashi Masataka Murakami | 1997 | FEBS Letters1997，，3： | 1 |
| 20 | Imaging appearances and management of isolated spontaneous dissection of the superior mesenteric artery显示文摘 | Ichiro Sakamoto Yoji Ogawa Eijun Sueyoshi Kenichiro Fukui Tomonori Murakami Masataka Uetani | 2007 | European Journal of Radiology2007，，1： | 1 |
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