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| 1 | Inducible Rubicon facilitates viral replication by antagonizing interferon production显示文摘The RUN domain Beclin-1-interacting cysteine-rich-containing(Rubicon)protein is involved in the maturation step of autophagy and the endocytic pathway as a Beclin-1-binding partner,but little is known regarding the role of Rubicon during viral infection.Here,we performed functional studies of the identified target in interferon(IFN)signaling pathways associated with Rubicon to elucidate the mechanisms of viral resistance to IFN.The Rubicon protein levels were elevated in peripheral blood mononuclear cells,sera and liver tissues from patients with hepatitis B virus(HBV)infection relative to those in healthy individuals.Assays of the overexpression and knockdown of Rubicon showed that Rubicon significantly promoted HBV replication.In addition,Rubicon knockdown resulted in the inhibition of enterovirus 71,influenza A virus and vesicular stomatitis virus.The expression o0f Rubicon led to the suppression of virus-induced type-I interferon(IFN-αand IFN-β)and type-III interferon(IFN-λ1).Translocation of activated IRF3 and IRF7 from the cytoplasm to the nucleus was involved in this process,and the NF-κB essential modulator(NEMO),a key factor in the IFN pathway,was the target with which Rubicon interacted.Our results reveal a previously unrecognized function of Rubicon as a virus-induced protein that binds to NEMO,leading to the inhibition of type-I interferon production.Rubicon thus functions as an important negative regulator of the innate immune response,enhances viral replication and may play a role in viral immune evasion. | Yushun Wan Wei Cao Tao Han Sheng Ren Jian Feng TieLong Chen Jun Wang Ruth Broering Mengji Lu Ying Zhu | 2017 | Cellular & Molecular Immunology2017，14，7： | 4 |
| 2 | Solvent engineering towards scalable fabrication of high-quality perovskite films for efficient solar modules显示文摘Over the last decade,remarkable progress has been made in metal halide perovskite solar cells(PSCs),which have been a focus of emerging photovoltaic techniques and show great potential for commercialization.However,the upscaling of small-area PSCs to large-area solar modules to meet the demands of practical applications remains a significant challenge.The scalable production of high-quality perovskite films by a simple,reproducible process is crucial for resolving this issue.Furthermore,the crystallization behavior in the solution-processed fabrication of perovskite films can be strongly influenced by the physicochemical properties of the precursor inks,which are significantly affected by the employed solvents and their interactions with the solutes.Thus,a comprehensive understanding of solvent engineering for fabricating perovskite films over large areas is urgently required.In this paper,we first analyze the role of solvents in the solution-processed fabrication of large-area perovskite films based on the classical crystal nucleation and growth mechanism.Recent efforts in solvent engineering to improve the quality of perovskite films for solar modules are discussed.Finally,the basic principles and future challenges of solvent system design for scalable fabrication of high-quality perovskite films for efficient solar modules are proposed. | Zhaoyi Jiang Binkai Wang Wenjun Zhang Zhichun Yang Mengjie Li Fumeng Ren Tahir Imran Zhenxing Sun Shasha Zhang Yiqiang Zhang Zhiguo Zhao Zonghao Liu Wei Chen | 2023 | Journal of Energy Chemistry2023，，5： | 4 |
| 3 | TLR7/8 signalling affects X-sperm motility via the GSK3α/β-hexokinase pathway for the efficient production of sexed dairy goat embryos显示文摘Background:Goat milk is very similar to human milk in terms of its abundant nutrients and ease of digestion.To derive greater economic benefit,farmers require more female offspring(does);however,the buck-to-doe offspring sex ratio is approximately 50%.At present,artificial insemination after the separation of X/Y sperm using flow cytometry is the primary means of controlling the sex of livestock offspring.However,flow cytometry has not been successfully utilised for the separation of X/Y sperm aimed at sexing control in dairy goats.Results:In this study,a novel,simple goat sperm sexing technology that activates the toll-like receptor 7/8(TLR7/8),thereby inhibiting X-sperm motility,was investigated.Our results showed that the TLR7/8 coding goat Xchromosome was expressed in approximately 50%of round spermatids in the testis and sperm,as measured from cross-sections of the epididymis and ejaculate,respectively.Importantly,TLR7/8 was located at the tail of the Xsperm.Upon TLR7/8 activation,phosphorylated forms of glycogen synthase kinaseα/β(GSK3α/β)and nuclear factor kappa-B(NF-κB)were detected in the X-sperm,causing reduced mitochondrial activity,ATP levels,and sperm motility.High-motility Y-sperm segregated to the upper layer and the low-motility X-sperm,to the lower layer.Following in vitro fertilisation using the TLR7/8-activated sperm from the lower layer,80.52±6.75%of the embryos were XX females.The TLR7/8-activated sperm were subsequently used for in vivo embryo production via the superovulatory response;nine embryos were collected from the uterus of two does that conceived.Eight of these were XX embryos,and one was an XY embryo.Conclusions:Our study reveals a novel TLR7/8 signalling mechanism that affects X-sperm motility via the GSK3α/β-hexokinase pathway;this technique could be used to facilitate the efficient production of sexed dairy goat embryos. | Fa Ren Huaming Xi Yijie Ren Yu Li Fei Wen Ming Xian Mengjie Zhao Dawei Zhu Liqiang Wang Anmin Lei Jianhong Hu | 2022 | Journal of Animal Science and Biotechnology2022，13，2： | 2 |
| 4 | Morbidity Analysis of the Notifiable Infectious Diseases in China,2018显示文摘Introduction Notifiable infectious disease surveillance is important for understanding the trends in morbidity for certain diseases,especially detection of acute infectious disease outbreaks and changing epidemiology.A web-based reporting system was deployed in January 2004,which has improved data collection and speed tremendously.This report provides an updated analysis for reports published in 2013 and 2015.Methods Data from the National Notifiable Disease Reporting System(NNDRS)was used.The NNRDS shows data from 39 notifiable diseases split into three categories(A,B,and C)based on severity and importance.A descriptive analysis was conducted to analyze the morbidity of notifiable diseases in China.Results In 2018,the morbidity of national notifiable diseases was 559.41 per 100,000 population,an increase of 12.88% compared with the average of 2015–2017.The proportion of laboratory confirmed cases was 36.22%,which decreased 4.03% compared with the average of that in the recent three years.Diseases transmitted by direct contact/fecal–oral transmission accounted for the largest proportion,49.37% of the total reported cases,followed by the respiratory transmitted diseases,blood-borne/sexually transmitted diseases,and the zoonotic and vectorborne diseases with a proportion of 25.18%,24.60%,and 0.85%,respectively.Pathogenic descriptive analysis showed that the viral-infected cases accounted for 73.78% of the totals,followed by the bacterialinfected and parasitic diseases.Conclusion The national morbidity of notifiable infectious diseases showed increases in 2018,mostly due to higher morbidity of category C diseases,such as HFMD,infectious diarrhea,and influenza,and these diseases need to be further prioritized in disease control and prevention efforts.Laboratory confirmed cases remain low and need to be improved to improve data quality. | Shuaibing Dong Xiang Ren Cuihong Zhang Mengjie Geng Yuliang Zhu Lusha Shi Lijie Zhang Zhongjie Li Liping Wang | 2019 | China CDC weekly2019，1，4： | 2 |
| 5 | Correlation analysis of three influencing factors and the dust production rate for a free-falling particle stream显示文摘 | Mengjie Duan Yi Wang Xiaofen Ren Xinrui Qu Yingxue Cao Yang Yang Lun Nian | 2017 | Particuology2017，15，5： | 1 |
| 6 | Identification of phytochemicals from Lentinus edodes and Auricularia auricula with UPLC-Q-Exactive Orbitrap MS显示文摘Lentinus edodes and Auricularia auricula are the first and second largest edible fungi in China with high nutritional and medicinal values.Research about phytochemicals of L.edodes and A.auricula mainly focuses on polysaccharides,other phytochemicals are not fully studied.Phytochemicals of L.edodes and A.auricula were investigated by ultra-high performance liquid chromatography tandem hybrid quadrupole-orbitrap mass spectrometry(UPLC-Q-Exactive-Orbitrap MS).Twenty-three compounds were identified in L.edodes,mainly including amino acids and analogs,flavonoids,nucleosides and analogs,phenols and steroids.Twenty-nine compounds were identified in A.auricula,mainly including amino acids and analogs,nucleosides and analogs,flavonoids and phenols.There are 9 common ingredients of L.edodes and A.auricula,including 4 amino acids and analogs,2 flavonoids,2 nucleosides and analogs and 1 phenol. | Lili Cui Yuhang Liu Ming Liu Mengjie Ren Adel F.Ahmed Wenyi Kang | 2022 | Journal of Future Foods2022，2，3： | 1 |
| 7 | Preparation and Hu- midity Controlling Behaviors of Sepiolite/Polyacrylic Acid (So- dium) Composite 显示文摘 | Wang Jihui Ren Shuping Guo Mengjie | 2012 | Procedia Eng2012，，27： | 1 |
| 8 | Carbon materials in electrocatalytic oxidation systems for the treatment of organic pollutants in wastewater:A review显示文摘Carbon materials are widely used as catalysts in electrocatalytic oxidative(EO)degradation of wastewater due to their large specific surface area and low cost.Carbon materials can also be used as catalyst carriers for EO reactions due to their ease of functionalization with other heteroatoms and metals/metal oxides.To improve the catalytic activity and current efficiency of carbon materials,modifying the structural and physicochemical properties of conventional carbon materials are common improvement method.This review briefly outlines the recent research progress of carbon materials in EO for organic pollutants degradation.It also discusses the modification strategies and corresponding electrocatalytic properties of various carbon materials(carbon nanomaterials and porous carbon materials),and explores the EO mechanism.Finally,some summaries of the remaining challenges and future developments of carbon materials in the field of electrocatalysis are given. | Xintong Duan Dezhang Ren Shichun Wang Mengjie Zhang Yaguang Sun Shujing Sun Zhibao Huo Nahui Zhang | 2023 | Carbon Resources Conversion2023，6，4： | 0 |
| 9 | A review of anodic catalysts and their application in(non-)Kolbe electrocatalytic decarboxylation of carboxylic acids显示文摘Biomass,as the exclusive and abundant organic resources,is considered to be the promising renewable resource.Carboxylic acids are one of the many compounds that can be obtained from raw biomass.Decarboxylation of carboxylic acids into fuels and chemicals via electrochemical method at mild reaction condition has been studied for many years.The(non-)Kolbe reaction,one of the oldest organic electrochemical reactions,is the decarboxylation of carboxylic acids to produce alkanes,alcohols,esters,etc.And electrode materials influence the production of electrocatalytic decarboxylation products from carboxylic acids.Therefore,this work mainly reviews the recent advances in applications of anodic materials for(non-)Kolbe electrocatalytic decarboxylation of carboxylic acids.It discusses the reaction mechanism of(non-)Kolbe electrolytic reaction,and the electrocatalytic oxidation of carboxylic acid using different electrodes and electrolytic systems to synthesize fuels and chemicals.Also,various types of electrode catalysts,such as Pt-based catalysts,C-based catalysts,and other catalysts,are introduced in detail.Finally,the challenges and future trends of the(non-)Kolbe reaction of carboxylic acids are presented.This review found that platinum-based electrocatalysts proved to be the most promising catalysts at present.And in recent years,a variety of synthesis methods have been developed to synthesize small size and high-performance noble metal based amorphous catalysts.Another approach is to study catalysts without platinum electricity,such as Ru,Ir,Ti and carbon materials.The review is helpful in understanding and know the anodic materials and their application in(non-)Kolbe electrocatalytic decarboxylation of carboxylic acids for the readers. | Shichun Wang Dezhang Ren Yueying Du Mengjie Zhang Nahui Zhang Yaguang Sun Zhibao Huo | 2023 | Carbon Resources Conversion2023，6，4： | 0 |
| 10 | The hidden risk of microplastic-associated pathogens in aquatic environments显示文摘Increasing studies of plastisphere have raised public concern about microplastics(MPs)as vectors for pathogens,especially in aquatic environments.However,the extent to which pathogens affect human health through MPs remains unclear,as controversies persist regarding the distinct pathogen colonization on MPs as well as the transmission routes and infection probability of MP-associated pathogens from water to humans.In this review,we critically discuss whether and how pathogens approach humans via MPs,shedding light on the potential health risks involved.Drawing on cutting-edge multidisciplinary research,we show that some MPs may facilitate the growth and long-range transmission of specific pathogens in aquatic environments,ultimately increasing the risk of infection in humans.We identify MP-and pathogen-rich settings,such as wastewater treatment plants,aquaculture farms,and swimming pools,as possible sites for human exposure to MP-associated pathogens.This review emphasizes the need for further research and targeted interventions to better understand and mitigate the potential health risks associated with MP-mediated pathogen transmission. | Huan Zhong Mengjie Wu Christian Sonne Su Shiung Lam Raymond W.M.Kwong Yuelu Jiang Xiaoli Zhao Xuemei Sun Xuxiang Zhang Chengjun Li Yuanyuan Li Guangbo Qu Feng Jiang Huahong Shi Rong Ji Hongqiang Ren | 2023 | Eco-Environment & Health2023，2，3： | 0 |
| 11 | A review:the mechanism of plant-derived polysaccharides on osteoblasts and osteoclasts显示文摘Bone loss and deterioration of bone microarchitecture would increase the bone fragility and fracture risk,leading to the osteoporosis.More and more evidences proved that plant-derived polysaccharides could have a remarkable influence on osteoblasts and osteoclasts,exerting anti-osteoporosis effects.According to the previous research,the extract of Cibotium barumoz,Achyranthes bidentata,Curculigo orchioides,Epimedium brevicornum,Angelica sinensis,Polygonatum sibiricum,Dendrobium officinale,Morinda officinalis,Nelumbo mucifera,Diospyros kaki,Hordeum vulgare,Cistanche deserticola,Commiphora Myrrha and other plant-derived polysaccharides could benefit to the osteoblasts and osteoclasts.The essential mechanisms are mainly related to the activation or inhibition of many factors,including runt-related transcription factor 2(Runx2),B-catenin,osterix(Osx),activator protein-1(AP-1),osteocalcin(OCN/BGP),alkaline phosphatase(ALP),osteopontin(OPN),bone morphogenetic protein(BMP),phosphatidylinositol 3-kinase(PI3K)/C-Jun N-terminal kinase(JNK)/extracellular regulated protein kinase(ERK),osteoprotegerin(OPG),receptor activator of nuclear factor-kB(RANK),monocyte/macrophage colony-stimulating factor(M-CSF),tumor necrosis factor receptor-associated factor 6(TRAF-6),receptor activator of nuclear factor(NF)-KB ligand(RANKL),nuclear factor of activated T cells 1(NFATc1),c-Fos,matrix metallopeptidase-9(MMP-9),glycogen synthase kinase 3β(GSK3B)/B-catenin,nuclear factor E2-related factor 2(Nf2),as well as these related pathways,such as Wnt/p-catenin,BMP-2/SMAD1/5/8,PI3K/AKT,OPG/RANKL/RANK,NF-κB,MAPKs,etc.These plant-derived polysaccharides could improve the dynamic balance of bone formation and resorption through promoting the differentiation and maturation of osteoblast or inhibiting its formation.The reviewed plant-derived polysaccharides and their regulating mechanisms on the osteoclasts and osteoblasts provide the evidences for the development of osteoporosis therapeutics. | Mengjie Ren Adel F.Ahmed Meng Li Menghan Li Zhiruo Yan Jinmei Wang | 2024 | Journal of Future Foods2024，4，3： | 0 |
| 12 | Step-edge controlled fast growth of wafer-scale MoSe_(2)films by MOCVD显示文摘Two-dimensional(2D)transition metal dichalcogenides(TMDCs),due to their unique physical properties,have a wide range of applications in the next generation of electronics,optoelectronics,and valleytronics.Large-scale preparation of high-quality TMDCs films is critical to realize these potential applications.Here we report a study on metal-organic chemical vapor deposition(MOCVD)growth of wafer-scale MoSe_(2)films guided by the crystalline step edges of miscut sapphire wafers.We established that the nucleation density and growth rate of MoSe_(2)films were positively correlated with the step-edge density and negatively with the growth temperature.At a certain temperature,the MoSe_(2)domains on the substrate with high step-edge density grow faster than that with low density.As a result,wafer-scale and continuous MoSe_(2)films can be formed in a short duration(30 min).The MoSe_(2)films are of high crystalline quality,as confirmed by systematic Raman and photoluminescence(PL)measurements.The results provide an important methodology for the rapid growth of wafer-scale TMDCs,which may promote the application of 2D semiconductors. | Rui Ji Jing Liao Lintao Li Rongji Wen Mengjie Liu Yifeng Ren Jianghua Wu Yunrui Song Minru Qi Zhixing Qiao Liwei Liu Chengbing Qin Yu Deng Yongtao Tian Suotang Jia Yufeng Hao | 2023 | Nano Research2023，16，7： | 0 |
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