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| 1 | Deposition of FeCoNiCrMn high entropy alloy(HEA) coating via cold spraying显示文摘High entropy alloys(HEAs) are of great interest in the community of materials science and engineering due to their unique phase structure. They are constructed with five or more principal alloying elements in equimolar or near-equimolar ratio. Therefore, HEAs can derive their performance from multiple principal elements rather than a single element. In this work, solid-state cold spraying(CS) was applied for the first time to produce FeCoNiCrMn HEA coating. The experimental results confirm that CS can be used to produce a thick HEA coating with low porosity. As a low-temperature deposition process, CS completely retained the HEA phase structure in the coating without any phase transformation. The characterization also reveals that the grains in the CSed HEA coating had experienced significant refinement as compared to those in the as-received HEA powder due the occurrence of dynamic recrystallization at the highly deformed interparticle region. Due to the increased dislocation density and grain boundaries,CSed HEA coating was much harder than the as-received powder. The tribological study shows that the CSed FeCoNiCrMn HEA coating resulted in lower wear rate than laser cladded HEA coatings. | Shuo Yin Wenya Li Bo Song Xingchen Yan Min Kuang Yaxin Xu Kui Wen Rocco Lupoi | 2019 | Journal of Materials Science & Technology2019，35，6： | 13 |
| 2 | MicroRNA-155 Regulates Inflammatory Cytokine Production in Tumor-associated Macrophages via Targeting C/EBPβ显示文摘 | Min He Zhenqun Xu Tong Ding Dong-Ming Kuang Limin Zheng | 2009 | Cellular & Molecular Immunology2009，6，5： | 12 |
| 3 | Enhanced N-doping in mesoporous carbon for efficient electrocatalytic CO2 conversion显示文摘The capability of electrocatalytic reducti on of carbon dioxide(CO2)using nitrogen(N)-doped carb on strongly depe nds on the N-dopi ng level and their types.In this work,we developed a strategy to generate mesoporous N-doped carb on frameworks with tun able configurati ons and contents of N dopants,by using a secondary doping process via the treatment of N,N-dimethylformamide(DMF)solvent.The obtained mesoporous N-doped carbon(denoted as MNC-D)served as an efficient electrocatalyst for electroreduction of CO2 to CO.A high Faradaic efficiency of^92%and a partial current density for CO of-6.8 mA·cm^-2 were achieved at a potential of-0.58 V vs.RHE.Electrochemical analyses further revealed that the active sites within the N-doped carb on catalysts were the pyridinic N and defects gen erated by the DMF treatme nt,which enhan ced the activati on and adsorpti on CO2 molecules.Our study suggests a new approach to develop efficie nt carb on-based catalysts for potential scalable CO2 reduction reaction(CO2RR)to fuels and chemicals. | Min Kuang Anxiang Guan Zhengxiang Gu Peng Han Linping Qian Gengfeng Zheng | 2019 | Nano Research2019，12，9： | 11 |
| 4 | Pathological Relationship between Intestinal Flora and Osteoarthritis and Intervention Mechanism of Chinese Medicine显示文摘Chinese medicine(CM) has a good clinical effect on osteoarthritis(OA), but the mechanism is not very clear. Evidence-based medicine researches have shown that intestinal flora plays a role in the pathogenesis and succession of OA. Intestinal flora affects the efficacy of CM, and CM can affect the balance of intestinal flora. This paper focuses on the relationship between intestinal flora, intestinal microenvironment, brain-gut axis, metabolic immunity and OA, and preliminarily expound the significance of intestinal flora in the pathogenesis of OA and the mechanism of CM intervention. The above discussion will be of great significance in the prevention and treatment of OA by CM from the perspective of intestinal flora. | WU Yong-rong KUANG Gao-yan LU Fang-guo WANG Heng-xin LU Min ZHOU Qing | 2019 | Chinese Journal of Integrative Medicine2019，25，9： | 10 |
| 5 | Petrogenesis, Tectonic Evolution and Geothermal Implications of Mesozoic Granites in the Huangshadong Geothermal Field, South China显示文摘Mesozoic multi-stage tectono-magmatic events produced widely distributed granitoids in the South China Block. Huangshadong(HSD) is located in south-eastern South China Block, where closely spaced hot springs accompany outcrops of Mesozoic granites. New data on whole-rock geochemistry, zircon U-Pb geochronology, and zircon Lu-Hf isotopes are presented, to study the petrogenesis and tectonic evolution of the granites, and to explore the relationship between granites and geothermal anomalies. Zircon U-Pb isotopes display three periods of granites in the HSD area: Indosinian(ca. 253 Ma, G4) muscovite-bearing monzonitic granite, early Yanshanian(ca. 175–155 Ma, G5 and G3) monzonitic granite and granodiorite, and late Yanshanian(ca. 140 Ma, G1 and G2) biotite monzonitic granite. In petrogenetic type, granites of the three periods are I-type granite. Among them, G1, G2, G3, and G4 are characterized by high fractionation, with high values of SiO2, alkalis, Ga/Al, and Rb/Sr, and depletion in Sr, Ba, Zr, Nb, Ti, REEs, with low(La/Yb)N, Nb/Ta, and Zr/Hf ratios and negative Eu anomalies. In terms of tectonic setting, 253 Ma G4 may be the product of partial melting of the ancient lower crust under post-orogenic extensional tectonics, as the closure of the Paleo-Tethys Ocean resulted in an intracontinental orogeny. At 175 Ma, the subduction of the Pacific Plate became the dominant tectonic system, and low-angle subduction of the Paleo-Pacific Plate facilitated partial melting of the subducted oceanic crust and basement to generate the hornblende-bearing I-type granodiorite. As the dip angle of the subducting plate increased, the continental arc tectonic setting was transformed to back-arc extension, inducing intense partial melting of the lower crust at ca. 158 Ma and resulting in the most frequent granitic magmatic activity in the South China hinterland. When slab foundering occurred at ca. 140 Ma, underplating of mantle-derived magmas caused melting of the continental crust, generating extensive highly fractionated granites in HSD. Combining the granitic evolution of HSD and adjacent areas and radioactive heat production rates, it is suggested that highly fractionated granites are connected to the enrichments in U and Th with magma evolution. The high radioactive heat derived from the Yanshanian granites is an important part of the crustal heat, which contributes significantly to the terrestrial heat flow. Drilling ZK8 reveals deep, ca. 140 Ma granite, which implies the heat source of the geothermal anomalies is mainly the concealed Yanshanian granites, combining the granite distribution on the surface. | Zhicai Xiao Shuai Wang Shihua Qi Jian Kuang Min Zhang Feng Tian Yongjie Han | 2020 | Journal of Earth Science2020，31，1： | 9 |
| 6 | Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties显示文摘Diabetes-associated periodontitis(DP)aggravates diabetic complications and increases mortality from diabetes.DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult.In this study,we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related to DP.Moreover,inhibition of CCL2 by oral administration of bindarit reduced alveolar bone loss and increased periodontal epithelial thickness by suppressing periodontal inflammation.Furthermore,bindarit suppressed the infiltration of proinflammatory monocytes and altered the inflammatory properties of macrophages in the diabetic periodontium.This finding provides a basis for the development of an effective therapeutic approach for treating DP. | Zongshan Shen Shuhong Kuang Min Zhang Xin Huang Jiayao Chen Meiliang Guan Wei Qin Hockin H.K.Xu Zhengmei Lin | 2021 | Cellular & Molecular Immunology2021，18，9： | 6 |
| 7 | Removal of hexavalent chromium in aquatic solutions by pomelo peel显示文摘This study investigated the removal of hexavalent chromium(Cr(VI)) in aqueous solutions using pomelo peel(PP) and FeCl3-modified pomelo peel(FPP) as novel biomass adsorbents.Batch adsorption experiments were performed to evaluate the effects of pH,time,temperature,initial concentration,and adsorbent dose on Cr(VI) removal by PP and FPP.The results show that the maximum adsorption capacity of Cr(VI)was 21.55 mg/g for FPP and 0.57 mg/g for PP at a pH of 2.0 and a temperature of 40℃.The surface shape,microstructure,and chemical composition of FPP were analyzed with scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FTIR),and energy dispersive spectroscopy(EDS),and compared with those of PP.The results show that the adsorption performance of FPP was much better than that of PP,indicating that FPP can be an alternative high-efficiency adsorbent for Cr(VI) removal. | Qiong Wang Cong Zhou Yin-jie Kuang Zhao-hui Jiang Min Yang | 2020 | Water Science and Engineering2020，13，1： | 6 |
| 8 | Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR显示文摘Programmed cell death ligand 1(PD-L1)/programmed cell death protein 1(PD-1)cascade is an effective therapeutic target for immune checkpoint blockade(ICB)therapy.Targeting PD-L1/PD-1 axis by small-molecule drug is an attractive approach to enhance antitumor immunity.Using flow cytometry-based assay,we identify tubeimoside-1(TBM-1)as a promising antitumor immune modulator that negatively regulates PD-L1 level.TBM-1 disrupts PD-1/PD-L1 interaction and enhances the cytotoxicity of T cells toward cancer cells through decreasing the abundance of PD-L1.Furthermore,TBM-1 exerts its antitumor effect in mice bearing Lewis lung carcinoma(LLC)and B16 melanoma tumor xenograft via activating tumor-infiltrating T-cell immunity.Mechanistically,TBM-1 triggers PD-L1 lysosomal degradation in a TFEB-dependent,autophagy-independent pathway.TBM-1 selectively binds to the mammalian target of rapamycin(m TOR)kinase and suppresses the activation of m TORC1,leading to the nuclear translocation of TFEB and lysosome biogenesis.Moreover,the combination of TBM-1 and anti-CTLA-4 effectively enhances antitumor T-cell immunity and reduces immunosuppressive infiltration of myeloid-derived suppressor cells(MDSCs)and regulatory T(Treg)cells.Our findings reveal a previously unrecognized antitumor mechanism of TBM-1 and represent an alternative ICB therapeutic strategy to enhance the efficacy of cancer immunotherapy. | Xiaojia Liu Mingxiao Yin Jingwen Dong Genxiang Mao Wenjian Min Zean Kuang Peng Yang Lu Liu Na Zhang Hongbin Deng | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 5 |
| 9 | Ultimate treatment for a patient with severe traumatic brain injury without intake for 192 hours after Wenchuan massive earthquake显示文摘 | GU Jian-wen ZHOU Hu-tian YANG Tao CHENG Jing-min QU Yan LI Cui-ying LI Qing-jie LU Ji-yun CHENG Shou-long LIU Jian-jun KUANG Yong-qin HUANG Hai-dong YANG Li-bin HE Wei-qi ZHAO Kai SONG Li-xin ZHENG Xiao-dong LIU Shu-xin SUN Yan HE Hong-lian WU Jiang LIU Xu-sheng LU Min | 2009 | Chinese Medical Journal2009，，1： | 4 |
| 10 | Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium显示文摘Although mesenchymal stem cell-derived exosomes(MSC-exos)have been shown to have therapeutic effects in experimental periodontitis,their drawbacks,such as low yield and limited efficacy,have hampered their clinical application.These drawbacks can be largely reduced by replacing the traditional 2D culture system with a 3D system.However,the potential function of MSC-exos produced by 3D culture(3D-exos)in periodontitis remains elusive.This study showed that compared with MSC-exos generated via 2D culture(2D-exos),3D-exos showed enhanced anti-inflammatory effects in a ligature-induced model of periodontitis by restoring the reactive T helper 17(Th17)cell/Treg balance in inflamed periodontal tissues.Mechanistically,3D-exos exhibited greater enrichment of miR-1246,which can suppress the expression of Nfat5,a key factor that mediates Th17 cell polarization in a sequence-dependent manner.Furthermore,we found that recovery of the Th17 cell/Treg balance in the inflamed periodontium by the local injection of 3D-exos attenuated experimental colitis.Our study not only showed that by restoring the Th17 cell/Treg balance through the miR-1246/Nfat5 axis,the 3D culture system improved the function of MSC-exos in the treatment of periodontitis,but also it provided a basis for treating inflammatory bowel disease(IBD)by restoring immune responses in the inflamed periodontium. | Yong Zhang Jiayao Chen Haijun Fu Shuhong Kuang Feng He Min Zhang Zongshan Shen Wei Qin Zhengmei Lin Shuheng Huang | 2021 | International Journal of Oral Science2021，13，4： | 4 |
| 11 | Simultaneous determination of 35 constituents and elucidation of effective constituents in a multi-herb Chinese medicine formula Xiaoer-Feire-Kechuan显示文摘Xiaoer-Feire-Kechuan(XFK) is an 11-herb Chinese medicine formula to treat cough and pulmonary inflammation.The complicated composition rendered its chemical analysis and effective-component elucidation.In this study,we combined quantitative analysis and bioactivity test to reveal the antiinflammatory constituents of XFK.First,UPLC-DAD and UHPLC/Q-Orbitrap-MS methods were established and validated to quantify 35 analytes(covering 9 out of 11 herbs) in different XFK formulations.Parallel reaction monitoring mode built in Q-Orbitrap-MS was used to improve the sensitivity and selectivity.Then,anti-inflammatory activities of the 35 analytes were analyzed using in vitro COX-2 inhibition assay.Finally,major analytes forsythosides H,I,A(8-10),and baicalin(15)(total contents varied from 21.79 to 91.20 mg/dose in different formulations) with significant activities(inhibitory rate ≥ 80%) were proposed as the anti-inflammatory constituents of XFK.The present study provided an effective strategy to discover effective constituents of multi-herb formulas. | Zhanpeng Shang Lulu Xu Yi Kuang Yan Lin Shuang Liu Long Sun Tao Bo Min Ye Xue Qiao | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 4 |
| 12 | Diagnostic Utility of Diffusion-weighted Magnetic Resonance Imaging in Differentiating Small Solid Renal Tumors (≤4 cm) at 3.0T Magnetic Resonance Imaging显示文摘 | Han-Mei Zhang Ying-Hua Wu Qi Gan Xiao Lyu Xiang-Lan Zhu Min Kuang Rong-Bo Liu Zi-Xing Huang ang Yuan Xi-Jiao Liu Bin Song | 2015 | Chinese Medical Journal2015，，11： | 4 |
| 13 | GLOBAL STABILITY OF ENDEMIC EQUILIBRIUM POINT OF BASIC VIRUS INFECTION MODEL WITH APPLICATION TO HBV INFECTION显示文摘 | Yu ZHENG Lequan MIN Yu JI Yongmei SU Yang KUANG | 2010 | Journal of Systems Science & Complexity2010，23，6： | 4 |
| 14 | The membrane lipid metabolism in horticultural products suffering chilling injury显示文摘Horticultural commodities suffer chilling injury following exposure to extremely low temperatures,which results in visible symptoms and considerable quality loss.Therefore,it is of significance to understand the mechanism of this physiological disorder and to develop effective strategies to control it.Chilling stress causes alteration in structure and function of the plasma membrane,which is assumed to be the primary event in response to cold stress.During this process,the membrane lipid metabolism plays a pivotal role in membrane fluidity and stability.In this review,we summarized the possible roles of membrane lipid metabolism in the development of chilling injury,having the potential for developing effective strategies to alleviate chilling injury in horticultural products under refrigerated storage in practice. | Shu-min Liang Jian-fei Kuang Shu-juan Ji Qin-fang Chen Wei Deng Ting Min Wei Shan Jian-ye Chen Wang-jin Lu | 2020 | Food Quality and Safety2020，4，1： | 3 |
| 15 | Complications and management of penile augmentation with hyaluronic acid injection显示文摘Hyaluronic acid injection is becoming a popular way for penile augmentation.However,only few studies and follow-ups have investigated the various complications of hyaluronic acid injection and their corresponding management.In this study,a total of 230 patients who had penile augmentation with hyaluronic acid injection from January 2018 to December 2019 were examined on follow-up for penile girth,complications,and their corresponding management.At 1-month,3-month,and 6-month postoperative follow-ups,the penile circumference had increased by 2.66±1.24 cm,2.28±1.02 cm,and 1.80±0.83 cm,respectively.During the entire 6-month follow-up,4.3%had complications such as subcutaneous bleeding,subcutaneous nodules,and infection.There were no systemic or local allergic reactions among all the patients.All complications were treated accordingly,and no further deterioration or severe sequelae were observed.Although complications of hyaluronic acid injections are mild and rare,these may affect the patient's satisfaction postoperatively.Preoperative redundant prepuce may increase the incidence of penile edema or postoperative gel migration.Standardization of the surgery protocol and elucidation of the effects of other injection parameters are still lacking.Nevertheless,it still highlights the importance of preoperative preparation and surgical technique. | Yuan Quan Zi-Rui Gao Xiang Dai Ling Kuang Min Zhang Qing Li Tao Xu Xiao-Wei Zhang | 2021 | Asian Journal of Andrology2021，23，4： | 3 |
| 16 | Effect of Al_(2)O_(3)/CaO on the melting and mineral transformation of Ningdong coal ash显示文摘Coal ash melting characteristics has a direct impact on the smooth operation of entrained gasifier.Mineral conversion of coal ash is very significant to be investigated,because the mineral can affect the melting temperature and viscosity under high temperature conditions.In this paper,the effects of different Al2O3/CaO on the mineral conversion,melting temperature and viscosity of Ningdong coal ash are studied by the combination of experiment and simulation.The trend of melting temperature decreases firstly and rises with increasing Al_(2)O_(3)/CaO.The ashmelting point reached to the lowestwhen the ratio is 1.23.XRD and Factsage software are used to analyze crystallization behavior of samples.The results showthat the content of anorthite,albite and corundumincreases and subsequently decreases,while the content of mullite decreases firstly and then rises with increasing Al_(2)O_(3)/CaO.High content with CaO can contribute to form albite and anorthite of low-melting.Besides,high content with Al_(2)O_(3) can tend to produce mullite of high-melting.The results of experimental and simulation are basically the same,which lays a foundation for the melting characteristics of Ningdong coal ash and can provide technical support for the smooth operation of the entrained-gasifier. | Feng Wang Min Yao Haoyong Kan Jianping Kuang Ping Li Jiashuo Zhang Yixin Zhang | 2020 | Chinese Journal of Chemical Engineering2020，28，12： | 3 |
| 17 | Crustal Thermo-Structure and Geothermal Implication of the Huangshadong Geothermal Field in Guangdong Province显示文摘Dense distribution of granites and surrounding hot springs, the high anomalous heating rates of geothermal fluids and the high geothermal gradients in shallow crust in Southeast China are revealed by previous geothermal explorations. However, there have always been debates on the genesis of geothermal anomalies of Southeast China. It is imperative to look into the genesis mechanism of geothermal anomalies through selecting a typical geothermal field, and constructing fine crustal thermostructure. In this study, in-depth excavation is implemented for the previous data of geophysical exploration and deep drilling exploration in the Huangshadong area. We synthetically analyze the results of radioactive heat productions(RHPs), thermophysical properties of rocks and audio-frequency magnetotellurics(AMT) sounding. This study concludes that the coefficient of radioactive heat generation(RHG) of crustal rocks and conduction heat of concealed granites is the main formation mechanism of geothermal anomalies of South China, where occurs a Great Granite Province. There is a regional indicating implication for the genesis of geothermal anomalies, taking the Huangshadong geothermal field as a typical example. It is also an important reference to guide the exploration, evaluation, development and utilization of geothermal resources in this region. | Zhicai Xiao Shuai Wang Shihua Qi Jian Kuang Min Zhang Hailong Li | 2023 | Journal of Earth Science2023，34，1： | 2 |
| 18 | Is High Serum Uric Acid a Risk Marker or a Target for Treatment? Examination of its Independent Effect in a Large Cohort With Low Cardiovascular Risk显示文摘 | Chi Pang Wen Ting-Yuan David Cheng Hui Ting Chan Min Kuang Tsai Wen-Shen Isabella Chung Shan Pou Tsai Mark L. Wahlqvist Yi Chen Yang Shiuan Be Wu Po Huang Chiang Sung Feng Wen | 2010 | American Journal of Kidney Diseases2010，，2： | 2 |
| 19 | Upwelling of Mantle-derived Material in Southeast China:Evidence from Noble Gas Isotopes显示文摘Shallow groundwater collected in Chaozhou,Huizhou,and Guangzhou allowed testing of concentrations and the isotope ratios of noble gases.Based on the calculated noble gas temperature(NGT)and the ratio of noble gas isotopes,the recharge temperature,recharge source,and residence time of groundwater can be calculated.In addition,the contribution of noble gas components from different sources to the sample components can be assessed.In the Huizhou area,according to the 1/Xe vs.Ne/Xe and NGT data,the shallow sandstone-confined water samples in the Shiba area and the unconfined water samples of the Huangshadong are in different temperature ranges,indicating that they have different recharge sources,both in time or space.The He components in the samples are calculated to obtain the content of radiogenic ^(4)He in the crust and to simulate the groundwater ages.The noble gas isotope ratios show the addition of mantle components into the basalt aquifers and sandstone aquifers in Chaozhou and Huizhou.Except for atmospheric and crustal sources,there is a certain proportion of mantle-derived components in the shallow underground cold water in Huizhou and Chaozhou.The noble gases in the Chaozhou groundwater have an obvious mantle signature,allowing speculation that there is a deep fluid carrying mantle characteristics.This upwelling of mantle-derived material might be caused by the India-Eurasia collision or that between the Philippine Sea Plate and the Eurasian Plate. | WANG Shuai KUANG Jian HUANG Xuelian ZHANG Hongyan ZHANG Min QI Shihua HAN Yongjie XIAO Zhicai WANG Siqi TANG Ling | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 2 |
| 20 | Chinese clinical practice guidelines for ultrasound-guided irreversible electroporation of liver cancer(version 2022)显示文摘Introduction Liver cancer remains a global health challenge,and its incidence is increasing worldwide.It is estimated that by 2025,more than one million individuals will be affected by liver cancer annually[1,2].In recent years,ablation has become a widely accepted treatment option for patients with primary and secondary liver malignancies[3].The commonly used ablation method for liver cancer is thermal ablation,including radiofrequency ablation. | Min Xu Li-Ting Xie Yue-Yong Xiao Ping Liang Qi-Yu Zhao Zhong-Min Wang Wei-Lu Chai Ying-Tian Wei Lin-Feng Xu Xiao-Kun Hu Ming Kuang Li-Zhi Niu Chen-Guo Yao Hai-Ying Kong Guo Tian Xiao-Yan Xie Xin-Wu Cui Dong Xu Jun Zhao Tian-An Jiang The Interventional Diagnosis and Treatment Group of the Ultrasonic Medicine Branch of Chinese Medical Association,The Nanoknife Tumor Ablation Society of the Interventional Minimally Invasive Therapy Special Committee of China Medicine Education Association | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，5： | 2 |
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