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| 1 | Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis显示文摘AIM: To investigate the in vivo anti-tumor effects of total polysaccharide (AP-0) isolated from Angelica sinensis (Oliv.)Diels (Danggui) on mice and thein vitro inhibitory effects of AP-0 and its sub-constituents (AP-1, AP-2 and AP-3) on invasion and metastasis of human hepatocellular carcinoma.METHODS: Three kinds of murine tumor models in vivo,sarcoma 180 (S180), leukemia L1210 and Ehrlich ascitic cancer (FAC) were employed to investigate the anti-tumor effects of AP-0. For each kind of tumor model, three experimental groups were respectively given AP-0 at doses of 30, 100 and 300 mg/kg byip once a day for 10 days.Positive control groups were respectively given Cy at a dose of 30 mg/kg for S180 and leukemia L1210, and 5-FU at a dose of 20 mg/kg for EAC. On d 11, mice bearing S180were sacrificed and the masses of tumors, spleens and thymus were weighed. The average living days of mice bearing EAC and of mice bearing L1210 were observed,and the rates of life prolongation of each treatment were calculated, respectively. The inhibitory effects of APs on hepatoma invasion and metastasis in vitro were investigated by employing human hepatocellular carcinoma cell line (HHCC) with the Matrigel invasion chamber, adhesion to extracelluler matrix and chemotatic migration tests, respectively.RESULTS: AP-0 had no obviously inhibitory effect on the growth of S180, but it could significantly decrease the thymus weights of the mice bearing S180. AP-0 could significantly reduce the production of ascitic liquids and prolong the life of mice bearing EAC. AP-0 could also increase the survival time of mice bearing L1210. AP-0 and AP-2 had significantly inhibitory effects on the invasion of HHCC into the Matrigel reconstituted basement membrane with the inhibitory rates of 56.4% and 68.3%, respectively. AP-0, AP-1, AP-2 and AP-3 could influence the adhesion of HHCC to extracellular matrix proteins (Matrigel and fibronectin) at different degrees, among them only AP-3 had significant blocking effect on the adhesion of HHCC to fibronectin with an inhibitory rate of 30.3%. AP-0, AP-1 and AP-3 could partially inhibit the chemotactic migration abilities of HHCC.CONCLUSION: The experimental findings suggest that total polysaccharide of Angelica sinensis (Oliv.) Diels (Chinese Danggui) possesses anti-tumor effects on experimental tumor models in vivo and inhibitory effects on invasion and metastasis of hepatocellular carcinoma cells in vitro. | Wen-MingZhao Zhi-NanChen PengShang Ai-RongQian Tie-HongYang MinJia Qi-BingMei Chi-HinCho | 2003 | World Journal of Gastroenterology2003，9，9： | 27 |
| 2 | Optimal p-ary Codes from One-weight Linear Codes over Zpm显示文摘 | SHI Minjia | 2013 | Chinese Journal of Electronics2013，22，4： | 9 |
| 3 | THE RANKS OF CYCLIC AND NEGACYCLIC CODES OVER THE FINITE RING R显示文摘The ranks of cyclic and negacyclic codes over the finite chain ring R as well as their minimal generating sets are defined, and then the expression forms we presented by studying the structures of cyclic and negacyclic codes over the finite chain ring R. Through the paper, it is assumed that the length of codes n can not be divided by the characteristic of R. | Zhu Shixin Shi Minjia | 2008 | Journal of Electronics(China)2008，25，1： | 9 |
| 4 | China's Regional Disparity and Its Policy Responses显示文摘中国在 3 十年的快速的经济发展的水果没越过不同区域相当被散布。在 1998 期间用从 815 汉语的一件样品的数据列出了公司—2004,我们的错误修正投资模型嘘在不同区域在公司的投资上欠不同金融限制的证据。我们主张中国的地区性的发展政策极大地作出贡献到地区性的不平等。控制升起的不平等,中国从海岸转移了它的焦点到内部区域。然而,它正在变得为市场机制现在不得不指导经济,,的政府日益困难对经济的远更大的影响比政府做。当前的领导的以民族为中心的途径意味着实质的注意在一次尝试被放在地区性的发展不同上造“一个和谐社会” . 如果为减少地区性的不同的所有措施是有效,中国需要推进广泛的改革。 | Minjia Chen Yongnian Zheng | 2008 | China & World Economy2008，16，4： | 7 |
| 5 | Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death显示文摘 | Lifeng Yuan Linhui Zhai Lili Qian De Huang Yi Ding Handan Xiang Xiaojing Liu J. Will Thompson Juan Liu Yong-Han He Xiao-Qiong Chen Jing Hu Qing-Peng Kong Minjia Tan Xiao-Fan Wang | 2018 | Cell Research2018，28，6： | 7 |
| 6 | OPTIMAL BINARY CODES FROM ONE-LEE WEIGHT CODES AND TWO-LEE WEIGHT PROJECTIVE CODES OVER Z_4显示文摘This paper investigates the structures and properties of one-Lee weight codes and two-Lee weight projective codes over Z4.The authors first give the Pless identities on the Lee weight of linear codes over Z_4.Then the authors study the necessary conditions for linear codes to have one-Lee weight and two-Lee projective weight respectively,the construction methods of one-Lee weight and two-Lee weight projective codes over Z4 are also given.Finally,the authors recall the weight-preserving Gray map from(Z_4~n,Lee weight)to(F_2^(2n),Hamming weight),and produce a family of binary optimal oneweight linear codes and a family of optimal binary two-weight projective linear codes,which reach the Plotkin bound and the Griesmer bound. | SHI Minjia WANG Yu | 2014 | Journal of Systems Science & Complexity2014，27，4： | 6 |
| 7 | GOOD p-ARY QUASIC-CYCLIC CODES FROM CYCLIC CODES OVER F_p+vF_p显示文摘This paper introduces a Gray map from(Fp + uFp)n to Fp2n,and describes the relationship between codes over Fp + vFp and their Gray images.The authors prove that every cyclic code of arbitrary length n over Fp + vFp is principal,and determine its generator polynomial as well as the number of cyclic codes.Moreover,the authors obtain many best-known p-ary quasic-cyclic codes in terms of their parameters via the Gray map. | Minjia SHI Shanlin YANG Shixin ZHU | 2012 | Journal of Systems Science & Complexity2012，25，2： | 5 |
| 8 | Optimal p-Ary Codes from One-Weight and Two-Weight Codes over IF_p+ vIF_p显示文摘This paper is devoted to determining the structures and properties of one-Lee weight codes and two-Lee weight projective codes Ck1,k2,k3 over p IF+ v IFp with type p2k1pk2pk3. The authors introduce a distance-preserving Gray map from( IFp + v IFp)nto2np. By the Gray map, the authors construct a family of optimal one-Hamming weight p-ary linear codes from one-Lee weight codes over IFp+ v IFp, which attain the Plotkin bound and the Griesmer bound. The authors also obtain a class of optimal p-ary linear codes from two-Lee weight projective codes over IFp + vIFp, which meet the Griesmer bound. | SHI Minjia SOL Patrick | 2015 | Journal of Systems Science & Complexity2015，28，3： | 3 |
| 9 | Optimal p-ary Codes from Constacyclic Codes over a Non-chain Ring R显示文摘This paper is devoted to the study of constacyclic codes over a non-chain ring R. The generator polynomials of all constacyclic codes over R are characterized and their dual codes are also determined. We also introduce a Gray map. It is proved that the image of a v-constacyclic code of length n over R under the Gray map is a cyclic code of length 2n over a field with p elements,where p is odd prime. Moreover, we obtain a substantial number of optimal p-ary linear(cyclic) codes, in terms of their parameters, via the Gray map. | SHI Minjia | 2014 | Chinese Journal of Electronics2014，23，4： | 3 |
| 10 | CYCLIC CODES OVER THE RING Z(_P^2) OF LENGTH p^e显示文摘The study of cyclic codes over rings has generated a lot of public interest.In this paper,we study cyclic codes and their dual codes over the ring Z P2 of length pe,and find a set of generators for these codes.The ranks and minimal generator sets of these codes are studied as well,which play an important role in decoding and determining the distance distribution of codes. | Shi Minjia Zhu Shixin | 2008 | Journal of Electronics(China)2008，25，5： | 3 |
| 11 | Construction of One-Lee Weight and Two-Lee Weight Codes over IF_p+vIF_p显示文摘This paper is devoted to the construction of one-Lee weight codes and two-Lee weight codes over IF_p+vIF_p(v^2=v) with type p^(2 k_1)p^(k2)p^(k3) based on two different distance-preserving Gray maps from((IF_p+vIF_p)~n, Lee weight) to(IF_p^(2 n), Hamming weight), where p is a prime. Moreover, the authors prove that the obtained two-Lee weight codes are projective only when p=2. | SHI Minjia LUO Yong SOLE Patrick | 2017 | Journal of Systems Science & Complexity2017，30，2： | 2 |
| 12 | Identification of two novel mutations in the GALNT3 gene in a Chinese family with hyperphosphatemic familial tumoral calcinosis显示文摘Hyperphosphatemic familial tumoral calcinosis(HFTC) is a rare, autosomal recessive genetic disease.This disease is characterized by the progressive calcification of soft tissues leading to symptoms of pressure and hyperphosphatemia but normal concentrations of serum calcium with or without an elevation of1,25-dihydroxyvitamin D3 levels.HFTC is caused by loss-of-function mutations in the GALNT3, FGF23 or KL genes. Here, we identified two novel mutations in the GALNT3 gene in a Chinese family with HFTC.Identification of a novel genotype in HFTC provides clues for understanding the phenotype–genotype relationships in HFTC and may assist not only in the clinical diagnosis of HFTC but also in the interpretation of the genetic information used for prenatal diagnosis and genetic counseling. | Lihao Sun Lin Zhao Lianiun Du Peipei Zhang Minjia Zhang Min Li Tingting Liu Lei Ye Bei Tao Hongyan Zhao Jianmin Liu Xiaoyi Ding | 2016 | Bone Research2016，4，4： | 2 |
| 13 | Skew Cyclic Codes over a Non-chain Ring显示文摘We study skew cyclic codes over a nonchain ring,which generalizes our previous results in IEICE Trans.on Fundamentals of Electronic Communications and Computer Sciences,2015.We describe generator polynomials of skew cyclic codes over this ring and investigate the structural properties of skew cyclic codes over the ring by a decomposition theorem.The generator polynomial of the dual code of a skew cyclic code are obtained.Moreover,the idempotent generators of skew cyclic codes are considered.Some examples are also presented to illustrate the discussed results. | SHI Minjia YAO Ting SOLE Patrick | 2017 | Chinese Journal of Electronics2017，26，3： | 2 |
| 14 | PC-407 inhibited proliferation and induced apoptosis in human colon cancer SW-1116 cells显示文摘AIM: To study whether PC-407 [4-[5-naphthyl-3- (trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide] inhibits cell viability and induces apoptosis in human colon cancer SW-1116 cells. METHODS: Inhibition of SW-1116 proliferation was measured by MTT assay. Morphological assessment of apoptosis was performed with fluorescence microscope and electron microscope. DNA fragmentation was visualized by agarose gel electrophoresis.The amount of apoptotic cells was measured by flow cytometry. RESULTS: PC-407 inhibited SW-1116 cell proliferation in a concentration-dependent manner after 3 d of treatment, and the IC5o for PC-407 inhibition of cell number was 16.67±0.17μmol/L. After incubation of SW-1116 cells with PC-407 20μmol/L for 24 h, morphological changes of typical apoptosis were observed by AO/EB staining or transmission electron microscopy. Flow cytometry analysis showed that PC-407 induced apoptosis in SW-1116 cells in a time- and concentration-dependant manner. The agarose gel electrophoresis of DNA revealed a 'ladder' pattern 48 h later. CONCLUSION: PC-407 inhibited proliferation and induced apoptosis in the human colon cancer SW-1116 cell line. | Li-liHAO Qi-bingMEI Bang-leZHANG MinJIA Xiao-qiangLI FengZHANG | 2004 | Acta Pharmacologica Sinica2004，25，11： | 2 |
| 15 | CD14 macrophage and IL-10 levels in the peripheral blood of breast cancer patients and their diagnostic value显示文摘Objective To explore the correlation between macrophages and interleukin-10(IL-10 in the peripheral blood of breast cancer(BC)patients and the diagnostic value of joint detection.Methods BC patients(n=50)and healthy controls(n=40)were prospectively recruited.The percentage of circulating cluster of differentiation 14(CD 14)macrophage cells was analyzed by flow cytometry,and an enzyme-linked immunosorbent assay(ELISA)was used to detect IL-10 expression levels.Receiver operating characteristic(ROC)curves were used to verify the diagnostic value of the models based on the expression of CD14 macrophage cell populations and IL-10.In addition,the association between model expression and clinicopathological characteristics was investigated.Another 30 patients with BC and 30 with benign breast disease were selected to validate the IL-10 and CD14 macrophage joint detection model using the same method.Results CD14 macrophage and IL-10 expression levels in BC patients were higher than those in healthy controls(P<0.05).The ROC curve showed that the area under the curve(AUC)of CD14+macrophages combined with IL-10 was 0.830,the sensitivity was 72.0%,and the specificity was 87.5%.Its diagnostic efficiency was better than all other single and joint detections.Correlation analysis of clinicopathological features showed that IL-10 and CD14+macrophage joint detection was significantly correlated with tumor size,tumor-node-metastasis(TNM)stage,and lymph node,estrogen receptor(ER),and Ki-67 expression(P<0.05).The validation analysis results were consistent with the test results.Conclusion Peripheral blood macrophages can be an independent diagnostic marker for BC.Joint detection of CD14-macrophages and IL-10 suggests poor prognosis,which has unlimited potential to guide BC development and provides a new theory for studying tumor-associated macrophages in BC. | Mengting Dong Jiayu Sheng Chunyang Li Patiguli·JIAPAER Xiaofei Li Minjia Yuan Xiaohong Xue Ke Jiang | 2022 | Oncology and Translational Medicine2022，8，4： | 2 |
| 16 | Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network显示文摘Objective:Drug repurposing,the application of existing therapeutics to new indications,holds promise in achieving rapid clinical effects at a much lower cost than that of de novo drug development.The aim of our study was to perform a more comprehensive drug repurposing prediction of diseases,particularly cancers.Methods:Here,by targeting 4,096 human diseases,including 384 cancers,we propose a greedy computational model based on a heterogeneous multilayer network for the repurposing of 1,419 existing drugs in Drug Bank.We performed additional experimental validation for the dominant repurposed drugs in cancer.Results:The overall performance of the model was well supported by cross-validation and literature mining.Focusing on the top-ranked repurposed drugs in cancers,we verified the anticancer effects of 5 repurposed drugs widely used clinically in drug sensitivity experiments.Because of the distinctive antitumor effects of nifedipine(an antihypertensive agent)and nortriptyline(an antidepressant drug)in prostate cancer,we further explored their underlying mechanisms by using quantitative proteomics.Our analysis revealed that both nifedipine and nortriptyline affected the cancer-related pathways of DNA replication,the cell cycle,and RNA transport.Moreover,in vivo experiments demonstrated that nifedipine and nortriptyline significantly inhibited the growth of prostate tumors in a xenograft model.Conclusions:Our predicted results,which have been released in a public database named The Predictive Database for Drug Repurposing(PAD),provide an informative resource for discovering and ranking drugs that may potentially be repurposed for cancer treatment and determining new therapeutic effects of existing drugs. | Xi Cheng Wensi Zhao Mengdi Zhu Bo Wang Xuege Wang Xiaoyun Yang Yuqi Huang Minjia Tan Jing Li | 2022 | Cancer Biology & Medicine2022，19，1： | 2 |
| 17 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 18 | Preparation of polyaniline coating on a stainless-steel wire using electroplating and its application to the determination of six aromatic amines using headspace solid-phase microextraction 显示文摘 | Huang Minjia Tai Chao Zhou Qunfang Jiang Guibin | 2004 | Journal of Chromatography A2004，，1048： | 1 |
| 19 | Phosphoproteomics Reveals the AMPK Substrate Network in Response to DNA Damage and Histone Acetylation显示文摘AMP-activated protein kinase(AMPK)is a conserved energy sensor that plays roles in diverse biological processes via phosphorylating various substrates.Emerging studies have demonstrated the regulatory roles of AMPK in DNA repair,but the underlying mechanisms remain to be fully understood.Herein,using mass spectrometry-based proteomic technologies,we systematically investigate the regulatory network of AMPK in DNA damage response(DDR).Our system-wide phosphoproteome study uncovers a variety of newly-identified potential substrates involved in diverse biological processes,whereas our system-wide histone modification analysis reveals a link between AMPK and histone acetylation.Together with these findings,we discover that AMPK promotes apoptosis by phosphorylating apoptosis-stimulating of p53 protein 2(ASPP2)in an irradiation(IR)-dependent manner and regulates histone acetylation by phosphorylating histone deacetylase 9(HDAC9)in an IR-independent manner.Besides,we reveal that disrupting the histone acetylation by the bromodomain BRD4 inhibitor JQ-1 enhances the sensitivity of AMPKdeficient cells to IR.Therefore,our study has provided a resource to investigate the interplay between phosphorylation and histone acetylation underlying the regulatory network of AMPK,which could be beneficial to understand the exact role of AMPK in DDR. | Yuejing Jiang Xiaoji Cong Shangwen Jiang Ying Dong Lei Zhao Yi Zang Minjia Tan Jia Li | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 1 |
| 20 | Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes显示文摘Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). | Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengke KMa Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang | 2021 | Protein & Cell2021，12，6： | 1 |
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