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| 1 | SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts显示文摘The ongoing outbreak of Coronavirus Disease 2019(COVID-19)has become a global public health emergency.SARScoronavirus-2(SARS-CoV-2),the causative pathogen of COVID-19,is a positive-sense single-stranded RNA virus belonging to the family Coronaviridae.For RNA viruses,virus-encoded RNA helicases have long been recognized to play pivotal roles during viral life cycles by facilitating the correct folding and replication of viral RNAs.Here,our studies show that SARS-CoV-2-encoded nonstructural protein 13(nsp13)possesses the nucleoside triphosphate hydrolase(NTPase)and RNA helicase activities that can hydrolyze all types of NTPs and unwind RNA helices dependently of the presence of NTP,and further characterize the biochemical characteristics of these two enzymatic activities associated with SARS-CoV-2 nsp13.Moreover,we found that some bismuth salts could effectively inhibit both the NTPase and RNA helicase activities of SARS-CoV-2 nsp13 in a dose-dependent manner.Thus,our findings demonstrate the NTPase and helicase activities of SARS-CoV-2 nsp13,which may play an important role in SARS-CoV-2 replication and serve as a target for antivirals. | Ting Shu Muhan Huang Di Wu Yujie Ren Xueyi Zhang Yang Han Jingfang Mu Ruibing Wang Yang Qiu Ding-Yu Zhang Xi Zhou | 2020 | Virologica Sinica2020，35，3： | 11 |
| 2 | The ORF3a protein of SARS-CoV-2 induces apoptosis in cells显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused the ongoing pandemic of Coronavirus Disease 2019.SARS-CoV-2 belongs to the genus Betacoronavirus of the Coronaviridae family,which includes SARS-CoV and Middle East respiratory syndrome coronavirus.1,2 Coronavirus-encoded accessory proteins play critical roles in virus–host interactions and the modulation of host immune responses,thereby contributing to coronaviral pathogenicity via different strategies.3 However,the functions of SARS-CoV-2-encoded accessory proteins are not well understood.Apoptosis is a predominant type of programmed cell death,and has been recognized as an important host antiviral defense mechanism that controls viral infection and regulates the inflammatory response.4,5 Previous studies have reported that the SARS-CoV-encoded accessory protein ORF3a can induce apoptosis in cells,6,7 leading to the question of whether SARS-CoV-2 ORF3a also has pro-apoptotic activity.Here,we investigated the potential apoptosis-inducing activity of SARS-CoV-2 ORF3a in different cell lines and compared the pro-apoptotic activities of SARS-CoV-2 ORF3a with those of SARS-CoV ORF3a using the same system. | Yujie Ren Ting Shu Di Wu Jingfang Mu Chong Wang Muhan Huang Yang Han Xue-Yi Zhang Wei Zhou Yang Qiu Xi Zhou | 2020 | Cellular & Molecular Immunology2020，17，8： | 11 |
| 3 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 4 | Intermetallic PtBi core/ultrathin Pt shell nanoplates for efficient and I stable methanol and ethanol electro-oxidization显示文摘The development of Pt-based core/shell nanoparticles represents an emerging class of electrocatalysts for fuel cells, such as methanol oxidation reaction (MOR) and ethanol oxidation reaction (EOR). Here, we present a one-pot synthesis approach to prepare hexagonal PtBi/Pt core/shell nan ostructure composed of an in termetallic PtiBii core and an ultrathi n Pt shell with well-defined shape, size, and composition.The structure and the synergistic effect among different components enhanced their MOR and EOR performanee. The optimized Pt2Bi nanoplates exhibit excellent mass activities in both MOR (4,820 mA·mgpt^-1) and EOR (5,950 mA·mgpt^1) conducted in alkaline media, which are 6.15 times and 8.63 times higher than those of commercial Pt/C, respectively. Pt2Bi nan opiates also show superior operati on durability to commercial Pt/C. This work may inspire the rational design and synthesis of Pt-based nanoparticles with improved performance for fuel cells and other applications. | Xiaolei Yuan Xiaojing Jiang Muhan Cao Lei Chen Kaiqi Nie Yong Zhang Yong Xu Xuhui Sun Yanguang Li Qiao Zhang | 2019 | Nano Research2019，12，2： | 7 |
| 5 | SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells显示文摘Dear Editor,Coronaviruses (Co Vs) are large enveloped non-segmented positive-strand RNA viruses that broadly distribute among humans and other animal species, including bats, mice and birds. SARS-Co V-2 infections can cause diseases, named the 2019 novel coronavirus disease (COVID-19). The symptoms of COVID-19 range from mild symptoms to severe respiratory syndromes, including pneumonia, and even death(Chen et al., 2020b;Jiang and Shi, 2020;Xia et al., 2020). | Jingfang Mu Jiuyue Xu Leike Zhang Ting Shu Di Wu Muhan Huang Yujie Ren Xufang Li Qing Geng Yi Xu Yang Qiu Xi Zhou | 2020 | Science China(Life Sciences)2020，63，9： | 5 |
| 6 | The treatment of black-odorous water using tower bipolar electro-flocculation including the removal of phosphorus,turbidity,sulfion,and oxygen enrichment显示文摘The large amount of municipal wastewater discharged into urban rivers sometimes exceeds the rivers’self-purification capacity leading to black-odorous polluted water.Electro-flocculation has emerged as a powerful remediation technology.Electro-flocculation in a bubble column tower with a bipolar electrode(BPE)was tested in an attempt to overcome the high resistance and weak gas-floatation observed with a monopolar electrode(MPE)in treating such water.The BPE reactor tested had a Ti/Ta2O_(5)-IrO_(2)anode and a graphite cathode with an iron or aluminum bipolar electrode suspended between them.It was tested for its ability to reduce turbidity,phosphate and sulphion and to increase the concentration of dissolved oxygen.The inclusion of the bipolar electrode was found to distinctly improved the system’s conductivity.The system’s electro-flocculation and electrical floatation removed turbidity,phosphate and sulphion completely,and the dissolved oxygen level improved from 0.29 to 6.28 mg/L.An aluminum bipolar electrode performed better than an iron one.Changes in the structure of the microbial community confirmed a significant improvement in water quality. | Huan He Qinjin Yu Chaochao Lai Chen Zhang Muhan Liu Bin Huang Hongping Pu Xuejun Pan | 2021 | Frontiers of Environmental Science & Engineering2021，15，2： | 5 |
| 7 | Porous Pt nanoframes decorated with Bi(OH)3 as highly efficient and stable electrocatalyst for ethanol oxidation reaction显示文摘High-quality Pt-based catalysts are highly desirable for ethanol oxidation reaction(EOR),which is of critical importance for the commercial applications of direct ethanol fuel cells(DEFCs).However,most of the Pt-based catalysts have suffered from high cost and low operation durability.Herein a two-step method has been developed to synthesize porous Pt nanoframes decorated with Bi(OH)3,which show excellent catalytic activity and operation durability in both alkaline and acidic media.For example,the nanoframes show a mass activity of 6.87 A·mgPt−1 in alkaline media,which is 13.5-fold higher than that of commercial Pt/C.More importantly,the catalyst can be reactivated simply,which shows negligible activity loss after running for 180,000 s.Further in situ attenuated total reflection-infrared(ATR-IR)absorption spectroscopy and CO-stripping experiments indicate that surface Bi(OH)3 species can greatly facilitate the formation of adsorbed OH species and subsequently remove carbonaceous poison,resulting in a significantly enhanced stability towards EOR.This work may favor the tailoring of desired electrocatalysts with high activity and durability for future commercial application of DEFCs. | Xiaolei Yuan Bei Jiang Muhan Cao Congyang Zhang Xiaozhi Liu Qinghua Zhang Fenglei Lyu Lin Gu Qiao Zhang | 2020 | Nano Research2020，13，1： | 3 |
| 8 | AI Enabled Wireless Communications with Real Channel Measurements:Channel Feedback显示文摘Artificial intelligence(AI)has shown great potential in wireless communications.AI-empowered communication algorithms have beaten many traditional algorithms through simulations.However,the existing works just use the simulated datasets to train and test the algorithms,which can not represent the power of AI in practical communication systems.Therefore,Peng Cheng Laboratory holds an AI competition,National Artificial Intelligence Competition(NAIC):AI+wireless communications,in which one of the topics is AI-empowered channel feedback system design using practical measurements.In this paper,we give a baseline neural network design,QuanCsiNet,for this competition,and the details of the channel measurements.QuanCsiNet shows excellent performance on channel feedback and the complexity of the neural networks is also given. | Jiajia Guo Xiangyi Li Muhan Chen Peiwen Jiang Tingting Yang Weiming Duan Haowen Wang Shi Jin Quan Yu | 2020 | Journal of Communications and Information Networks2020，5，3： | 2 |
| 9 | Post-mortem tissue proteomics reveals the pathogenesis of multi-organ injuries of COVID-19显示文摘Multi-organ injuries are a major complication of severe Coronavirus Disease 2019(COVID-19).However,its pathogenesis is barely understood.Herein;we profile host responses to fatal SARS-CoV-2 infection by performing quantitative proteomics of 19 post-mortem samples of 8 different organs or tissues,including lungs,liver,intestine,kidney;spleen,brain,heart and muscle,from 3 deceased COVID-19 victims during the first wave of the pandemic(Supplementary Fig.S1A and B,Tables SI-S3). | Yang Qiu Di Wu Wanshan Ning Jiqian Xu Ting Shu Muhan Huang Rong Chen Jiancheng Zhang Yang Han Qingyu Yang Ruiting Li Xiaobo Yang Yaxin Wang Xiaojing Zou Shangwen Pan Chaolin Huang Yu Xue You Shang Xi Zhou | 2021 | National Science Review2021，8，11： | 1 |
| 10 | LncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBL-mediated degradation of β-catenin显示文摘LncMIR31HG acts as a host gene for miR-31,also known as LncHIFCAR(long non-coding HIF-1 co-activating RNA),whose deregulation has been reported to promote the development of various human cancers,including lung cancer,colorectal cancer,etc.1,2 However,the biological functions and molecular mechanisms of MIR31HG in gastric cancer are unclear. | Wen Peng Jiayi Zhang Shenghao Wang Feng Wang a Kun Wang Rui Geng Xiangfei Ding Jingping Zhang Biao Li Xiaoxue Ke Muhan Lü Hongjuan Cui | 2023 | Genes & Diseases2023，10，3： | 1 |
| 11 | Linear probe endobronchial ultrasound bronchoscopy with guided transbronchial needle aspiration (EBUS-TBNA) in the evaluation of mediastinal and hilar pathology: introducing the procedure to a teaching institution显示文摘 | MUHANNED A H YASER E S KATHLEEN E | 2013 | Lung2013，191，1： | 1 |
| 12 | Changes in actomyosin dissociation and endogenous enzyme activities during heating and their relationship with duck meat tenderness显示文摘 | Daoying Wang Han Dong Muhan Zhang Fang Liu Huan Bian Yongzhi Zhu Weimin Xu | 2013 | Food Chemistry2013，，2： | 1 |
| 13 | Effects of different cooking regimes on the microstructure and tenderness of duck breast muscle显示文摘 | Chao Li Daoying Wang Han Dong Weimin Xu Feng Gao Guanghong Zhou Muhan Zhang | 2012 | Food Agric2012，，8： | 1 |
| 14 | Out-of-Band Measurement of LED-based Solar Blind UV Filters 显示文摘 | CUI Muhan ZHOU Yue CHEN Xue | 2014 | Journal of the OpticalSoeiety of Korea(S1226-4776)2014，18，： | 1 |
| 15 | Pleuropericarditis in a Patient with Inflammatory Bowel Disease: A Case Presentation and Review of the Literature显示文摘 | Muhanned Abu-Hijleh Samuel Evans Bassam Aswad | 2010 | Lung2010，，6： | 1 |
| 16 | Cooperative interactions among CTA^+, Br^-and Ag^+ during seeded growth of gold nanorods显示文摘我们在由第四级的铵卤化物和钠油酸盐(NaOL ) 组成的二进制表面活化剂混合物在 Au nanorods (AuNRs ) 的形成机制上执行了全面研究。我们在指导 AuNRs 的各向异性的生长作为关键成分识别 cetyltrimethyl 铵(CTA )-Br-Ag+ 建筑群。在我们推进的 CTA +, Br -和 Ag +,之中基于合作相互作用的改进理解乐意地表明那 AgBr ,它是由 cetyltrimethyl 铵溴化物( CTAB )或 cetyltrimethyl 铵氯化物( CTAC )的 solubilized 微粒,能为 AuNRs 的准备作为 Ag +和 Br -的联合来源被采用。高质量的 AuNRs 的生长能在极其低的溴化物内容(0.1 公里) 下面在 15 min 以内被完成。 | Yong Xu Lei Chen Xingchen Ye Xuchun Wang Jiaqi Yu Yang Zhao Muhan Cao Zhouhui Xia Baoquan Sun Qiao Zhang | 2017 | Nano Research2017，10，6： | 1 |
| 17 | Decreased Expression of FOXJ1 is a Potential Prognostic Predictor for Progression and Poor Survival of Gastric Cancer显示文摘 | Jing Wang Xiqiang Cai Limin Xia Jinfeng Zhou Jing Xin Muhan Liu Xin Shang Jian Liu Xiaowei Li Zhangqian Chen Yongzhan Nie Daiming Fan | 2015 | Annals of Surgical Oncology2015，，2： | 1 |
| 18 | Removel of phenol from agueous solutions by adsorption onto polymeric adsorbents 显示文摘 | Muhanned A Hararah | 2010 | Journal of Applied Poly- mer Science2010，，117： | 1 |
| 19 | Synthesis and characterization of nano-engineered thermoelectric skutterudite via solution chemistry route显示文摘 | Wang M Zhang Y Muhanned M | 1999 | Nanostructured Mater1999，12，： | 1 |
| 20 | A highly loaded and dispersed Ni2 P/SiO2 catalyst for the hydrotreating reactions 显示文摘 | ZHAOYu XUE Mingwei CAO Muhan | 2011 | Applied Catalysis B: Environmental2011，104，34： | 1 |
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