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| 1 | Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms显示文摘 | Sakai Kiyoshi Yamamoto Akihito Matsubara Kohki Nakamura Shoko Naruse Mami Yamagata Mari Sakamoto Kazuma Tauchi Ryoji Wakao Norimitsu Imagama Shiro Hibi Hideharu Kadomatsu Kenji Ishiguro Naoki Ueda Minoru | 2012 | Journal of Clinical Investigation2012，，1： | 2 |
| 2 | Genotype and phylogenetic characterization of hepatitis B virus among multi-ethnic cohort in Hawaii显示文摘AIM: Hepatitis B virus (HBV) genomes in carriers from Hawaii have not been evaluated previously. The aim of thepresent study was to evaluate the distribution of HBV genotypes and their clinical relevance in Hawaii.METHODS: Genotyping of HBV among 61 multi-ethnicc arriers in Hawaii was performed by genetic methods.Three complete genomes and 61 core promoter/precore regions of HBV were sequenced directly.RESULTS: HBV genotype distribution among the 61 carderswas 23.0% for genotype A, 14.7% for genotype B and 62.3% for genotype C. Genotypes A, B and C were obtained from the carriers whose ethnicities were Filipino and Caucasian,Southeast Asian, and various Asian and Micronesian,respectively. All cases of genotype B were composed of recombinant strains with genotype C in the precore plus core region named genotype Ba. HBeAg was detected more frequently in genotype C than in genotype B (68.4% vs 33.3%, P<0.05) and basal core promoter (BCP) mutation (T1762/A1764) was more frequently found in genotype C than in genotype B. Twelve of the 38 genotype C strains possessed C at nucleotide (nt) position 1858 (C-1858).However there was no significant difference in clinical characteristics between C-1858 and T-1858 variants. Based on complete genome sequences, phylogenetic analysis revealed one patient of Micronesian ethnicity as having C1858 clustered with two isolates from Polynesia with T-1858.In addition, two strains from Asian ethnidties were clustered with known isolates in carriers from Southeast Asia.CONCLUSION: Genotypes A, B and C are predominant types among multi-ethnic HBV carriers in Hawaii, and distribution of HBV genotypes is dependent on the ethnic background of the carriers in Hawaii. | Mayumi Sakurai Fuminaka Sugauchi Naoky Tsai Seiji Suzuki Izumi Hasegawa Kei Fujiwara Etsuro Orito Ryuzo Ueda Masashi Mizokami | 2004 | World Journal of Gastroenterology2004，10，15： | 2 |
| 3 | Multicenter phase II study of weekly paclitaxel plus S-1 combination chemotherapy in patients with advanced gastric cancer显示文摘 | Yuji Ueda Hisakazu Yamagishi Daisuke Ichikawa Kazuma Okamoto Eigo Otsuji Jun Morii Kinya Koizumi Naoki Kakihara Masataka Shimotsuma Tetsuro Yamashita Fumihiro Taniguchi Hideki Aragane Hiroshi Nishi Yoshiki Itokawa Satoshi Morita Junichi Sakamoto | 2010 | Gastric Cancer2010，，3： | 2 |
| 4 | C-reactive protein as a predictor of cardiac rupture after acute myocardial infarction显示文摘 | So Ueda Uichi Ikeda Keiji Yamamoto Masafumi Takahashi Masanori Nishinaga Naoki Nago Kazuyuki Shimada | 1996 | American Heart Journal1996，，5： | 2 |
| 5 | A case of chronic pancreatitis in which endoscopic ultrasonography was effective in the diagnosis of a pseudoaneurysm显示文摘Endoscopic ultrasonography (EUS) was performed on a patient being treated for chronic pancreatitis because a submucosal tumor was observed in the stomach during gastrointestinal endoscopy. As internal pulsa- tile blood flow on Doppler was present, the diagnosis of an aneurysm was made. The pseudoaneurysm of the left gastric artery was embolized with histoacryl and lipiodol and the splenic artery was embolized with coils at the location of the pseudoaneurysm to prevent hemorrhage. Follow up EUS confirmed the cessation of blood flow from the pseudoaneurysm. Clinicians encountering a gastric submucosal tumor-like protrusion in a patient with chronic pancreatitis should use EUS to investigate the possibility of a pseudoaneurysm, which must be treated as quickly as possible once identified. | Kazuhiro Fukatsu Kazuki Ueda Hiroki Maeda Yasunobu Yamashita Masahiro Itonaga Yoshiyuki Mori Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Izumi Inoue Takao Maekita Mikitaka Iguchi Hideyuki Tamai Jun Kato Masao Ichinose | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 2 |
| 6 | The Effect of Fatigue Property on Fine Particle Peening显示文摘 | Naoki Ueda | 1999 | Japan PAKARAYIZINGU Technical Review1999，，12： | 1 |
| 7 | Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori?associatedchronic atrophic gastritis: A follow?up study of patients with endoscopicallyresected colorectal neoplasia显示文摘 | Izumi Inoue Jun Kato Noriko Yoshimura Yoshimasa Maeda Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Takao Maekita Kazuki Ueda Mikitaka Iguchi Hideyuki Tamai Mitsuhiro Fujishiro Nobutake Yamamichi Tatsuya Takeshita Masao Ichinose | 2013 | Molecular and Clinical Oncology2013，，1： | 1 |
| 8 | Changes in fructooligosaccaride composition and related enzyme activities of burdock root during low-temperature storage显示文摘 | Yoshihiro Imahori Naoki Kitamura Shizuka Kobayashi Takanobu Takihara Kimiko Ose Yoshinori Ueda | 2009 | Postharvest Biology and Technology2009，，1： | 1 |
| 9 | Significant elevation of serum interleukin-18 levels in patients with acute pancreatitis显示文摘 | Takashi Ueda Yoshifumi Takeyama Takeo Yasuda Naoki Matsumura Hidehiro Sawa Takahiro Nakajima Tetsuo Ajiki Yasuhiro Fujino Yasuyuki Suzuki Yoshikazu Kuroda | 2006 | Journal of Gastroenterology2006，，2： | 1 |
| 10 | Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease显示文摘 | Tomoko Hatta Yasunari Fujinaga Masumi Kadoya Hitoshi Ueda Hiroaki Murayama Masahiro Kurozumi Kazuhiko Ueda Michiharu Komatsu Tadanobu Nagaya Satoru Joshita Ryo Kodama Eiji Tanaka Tsuyoshi Uehara Kenji Sano Naoki Tanaka | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 11 | Prediction of early death in severe acute pancreatitis显示文摘 | Makoto Shinzeki Takashi Ueda Yoshifumi Takeyama Takeo Yasuda Naoki Matsumura Hidehiro Sawa Takahiro Nakajima Ippei Matsumoto Tsunenori Fujita Tetsuo Ajiki Yasuhiro Fujino Yoshikazu Kuroda | 2008 | Journal of Gastroenterology2008，，： | 1 |
| 12 | Prevention of postoperative complications in skull base surgery for nasal or paranasal sinus carcinoma invading the skull base显示文摘 | Shigeru Nishizawa Naoki Yokota Tetsuo Yokoyama Hiroyuki Mukodaka Takahiro Watanabe Tomoyuki Hoshino Yoshio Ueda | 2001 | Journal of Clinical Neuroscience2001，，4： | 1 |
| 13 | Japanese apricot improves symptoms of gastrointestinal dysmotility associated with gastroesophageal reflux disease显示文摘AIM: To investigate the effects of Japanese apricot(JA) consumption on gastroesophageal reflux disease(GERD)-related symptoms.METHODS: Participants included individuals living in Minabe-cho,a well-known JA-growing region,who received specific medical check-ups by the local community health service in 2010.GERD-related symptoms were examined in 1303 Japanese individuals using a validated questionnaire,the Frequency Scale for Symptoms of GERD(FSSG),which consists of 7 questions associated with acid reflux symptoms and 5 questions asking about gastrointestinal dysmotility symptoms.Each question was answered using a 4-point scale,with higher scores indicating more severe GERDrelated symptoms.Subjects were divided into two groups according to their intake of dried and pickled JA: daily intake(≥ 1 JA daily)(392 subjects) and none oroccasional intake(< 1 JA daily)(911 subjects).FSSG scores were compared between subjects who consumed JA daily and those who did not.Next,subjects were stratified by age,gender and Helicobacter pylori(H.pylori) status for subanalyses.RESULTS: Those who ate JA daily were significantly older than those who did not(60.6 ± 10.5 years vs 56.0 ± 11.0 years,P < 0.001).Total FSSG scores were significantly lower in subjects with daily JA intake than in those with none or only occasional intake(2.13 ± 3.14 vs 2.70 ± 3.82,P = 0.005).In particular,subjects who consumed JA daily showed significantly improved FSSG dysmotility scores compared with subjects who did not(1.05 ± 1.58 vs 1.46 ± 2.11,P < 0.001).In contrast,the FSSG reflux score did not differ between subjects with and without daily intake of JA(1.08 ± 1.90 vs 1.24 ± 2.11,P = 0.177).Subanalysis indicated that improvement in dysmotility by JA intake was specifically observed in non-elderly(1.24 ± 1.68 vs 1.62 ± 2.22,P = 0.005) and H.pylori-negative subjects(0.99 ± 1.58 vs 1.57 ± 2.06,P < 0.001).GERD patients(total FSSG score ≥ 8) were less frequently observed among subjects with daily intake of JA as compared to those without daily intake of JA(6.1% vs 9.7%,P = 0.040).CONCLUSION: Daily JA intake may improve digestive dysmotility symptoms,resulting in relief of GERD symptoms.The effect is more obvious in non-elderly and H.pylori-negative subjects. | Takao Maekita Jun Kato Shotaro Enomoto Takeichi Yoshida Hirotoshi Utsunomiya Hideyuki Hayashi Toshiko Hanamitsu Izumi Inoue Yoshimasa Maeda Kosaku Moribata Yosuke Muraki Naoki Shingaki Hisanobu Deguchi Kazuki Ueda Mikitaka Iguchi Hideyuki Tamai Masao Ichinose | 2015 | World Journal of Gastroenterology2015，21，26： | 1 |
| 14 | 在屏蔽胃的 mucosal 瘤形成的 Transnasal 和标准 transoral 内视镜检查法显示文摘 AIM: To compare the diagnostic performances of transnasal and standard transoral esophagogastroduodenoscopy (EGD) in gastric cancer screening of asymptomatic healthy subjects. METHODS: Between January 2006 and March 2010, atotal of 3324 subjects underwent examination of the upper gastrointestinal tract by EGD for cancer screening, with 1382 subjects (41.6%) screened by transnasal EGD and the remaining 1942 subjects (58.4%) by standard transoral EGD. Clinical profiles of the screened subjects, detection rates of gastric neoplasia and histopathology of the detected neoplasias were compared between groups according to the stage of Helicobacter pylori (H. pylori )-related chronic gastritis. RESULTS: Clinical profiles of subjects did not differ significantly between the two EGD groups, except that there were significantly more men in the transnasal EGD group. During the study period, 55 cases of gastric mucosal neoplasias were detected. Of these, 23 cases were detected by transnasal EGD and 32 cases by standard transoral EGD. The detection rate for gastric mucosal neoplasia in the transnasal EGD group was thus 1.66%, compared to 1.65% in the standard transoral EGD group, with no significant difference between the two groups. Detection rates using the two endoscopies were likewise comparable, regardless of H. pylori infection. However, detection rates when screening subjects without extensive chronic atrophic gastritis (CAG) were significantly higher with standard transoral EGD (0.70%) than with transnasal EGD (0.12%, P < 0.05). In particular, standard transoral EGD was far better for detecting neoplasia in subjects with H. pylorirelated non-atrophic gastritis, with a detection rate of 3.11% compared to 0.53% using transnasal EGD (P < 0.05). In the screening of subjects with extensive CAG, no significant differences in detection of neoplasia were evident between the two endoscopies, although the mean size of detected cancers was significantly smaller and the percentage of early cancers was significantly higher with standard transoral EGD. CONCLUSION: These results strongly suggest that the diagnostic performance of transnasal endoscopy issuboptimal for cancer screening, particularly in subjects with H. pylori-related non-atrophic gastritis. | Hiroya Nakata Shotaro Enomoto Takao Maekita Izumi Inoue Kazuki Ueda Hisanobu Deguchi Naoki Shingaki Kosaku Moribata Yoshimasa Maeda Yoshiyuki Mori Mikitaka Iguchi Hideyuki Tamai Hiroya Nakata Nobutake Yamamichi Mitsuhiro Fujishiro Jun Kato Masao Ichinose | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，8： | 1 |
| 15 | Overexpression of eukaryotic elongation factor eEF2 in gastrointestinalcancers and its involvement in G2/M progression in the cell cycle显示文摘 | Junya Nakamura Sayaka Aoyagi Isamu Nanchi Shin-Ichi Nakatsuka Erika Hirata Shohei Shibata Mari Fukuda Yumiko Yamamoto Ikuyo Fukuda Naoya Tatsumi Tazu Ueda Fumihiro Fujiki Masaya Nomura Sumiyuki Nishida Toshiaki Shirakata Naoki Hosen Akihoro Tsuboi Yoshihi | 2009 | International Journal of Oncology2009，，： | 1 |
| 16 | Elevation of plasma tissue factor levels in patients with severe acute pancreatitis显示文摘 | Hidehiro Sawa Takashi Ueda Yoshifumi Takeyama Takeo Yasuda Naoki Matsumura Takahiro Nakajima Tetsuo Ajiki Yasuhiro Fujino Yasuyuki Suzuki Yoshikazu Kuroda | 2006 | Journal of Gastroenterology2006，，6： | 1 |
| 17 | Biological and clinical implications of retinoic acid-responsive genes in human hepatocellular carcinoma cells显示文摘 | Keita Kanki Yuji Akechi Chisa Ueda Hiroyuki Tsuchiya Hiroki Shimizu Naoki Ishijima Kan Toriguchi Etsuro Hatano Kanenori Endo Yasuaki Hirooka Goshi Shiota | 2013 | Journal of Hepatology2013，，： | 1 |
| 18 | Multicenter phase II study of weekly paclitaxel plus S-1 combination chemotherapy in patients with advanced gastric cancer显示文摘 | Yuji Ueda Hisakazu Yamagishi Daisuke Ichikawa Kazuma Okamoto Eigo Otsuji Jun Morii Kinya Koizumi Naoki Kakihara Masataka Shimotsuma Tetsuro Yamashita Fumihiro Taniguchi Hideki Aragane Hiroshi Nishi Yoshiki Itokawa Satoshi Morita Junichi Sakamoto | 2010 | Gastric Cancer2010，，3： | 1 |
| 19 | hepatocellular 癌的 Ultrasonogram 在 radiofrequency 脱离以后与结果被联系显示文摘 AIM:To investigate the association between B-mode ultrasound classification of small hepatocellular carcinoma(HCC) and outcome after radiofrequency ablation(RFA).METHODS:Ninety-seven cases of HCC treated using RFA between April 2001 and March 2006 were reviewed.Ultrasound images were classified as follows:type 1,with halo(n=29);and type 2,without halo(n=68).Type 2 was further categorized into three subgroups:type 2a,homogenous hyperechoic(n=9);type 2b,hypoechoic with smooth margins(n=43);and type 2c(n=16),hypoechoic with irregular or unclear margins.Patients with type 2a HCC were excluded from analysis due to the small number of cases.RESULTS:Two year recurrence rates for type 2b,type 1 and type 2c were 26%,42% and 69%,respectively,with significant differences between type 2b and type 2c(P<0.01),and between type 1 and type 2c(P<0.05).Five year survival rates were 89%,43% and 65%,respectively.Survival was significantly longer for type 2b than for other types(type 1 vs type 2b,P<0.01;type 2b vs type 2c,P<0.05).On univariate analysis,factors contributing to recurrence were number of tumors,tumor stage,serum level of lens culinaris agglutinin-reactive alpha-fetoprotein and ultrasound classification(P<0.05).Factors contributing to survival were tumor stage and ultrasound classification(P<0.05).Multivariate analysis identified ultrasound classification as the only factor independently associated with both recurrence and survival(P<0.05).CONCLUSION:B-mode ultrasound classification of small HCC is a predictive factor for outcome after RFA. | Kosaku Moribata Hideyuki Tamai Naoki Shingaki Yoshiyuki Mori Tatsuya Shiraki Shotaro Enomoto Hisanobu Deguchi Kazuki Ueda Izumi Inoue Takao Maekita Mikitaka Iguchi Masao Ichinose | 2012 | World Journal of Hepatology2012，4，12： | 1 |
| 20 | Clinical Significance of Computed Tomographic Assessment and Anatomic Features of the Inferior Alveolar Canal as Risk Factors for Injury of the Inferior Alveolar Nerve at Third Molar Surgery显示文摘 | Megumi Ueda Kenji Nakamori Kaori Shiratori Tomohiro Igarashi Takanori Sasaki Naoki Anbo Takeshi Kaneko Naohiro Suzuki Hironari Dehari Tomoko Sonoda Hiroyoshi Hiratsuka | 2012 | Journal of Oral and Maxillofacial Surgery2012，，3： | 1 |
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