|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Deep learning applied to two-dimensional color Doppler flow imaging ultrasound images significantly improves diagnostic performance in the classification of breast masses:a multicenter study显示文摘Background:The current deep learning diagnosis of breast masses is mainly reflected by the diagnosis of benign and malignant lesions.In China,breast masses are divided into four categories according to the treatment method:inflammatory masses,adenosis,benign tumors,and malignant tumors.These categorizations are important for guiding clinical treatment.In this study,we aimed to develop a convolutional neural network(CNN)for classification of these four breast mass types using ultrasound(US)images.Methods:Taking breast biopsy or pathological examinations as the reference standard,CNNs were used to establish models for the four-way classification of 3623 breast cancer patients from 13 centers.The patients were randomly divided into training and test groups(n=1810 vs.n=1813).Separate models were created for two-dimensional(2D)images only,2D and color Doppler flow imaging(2D-CDFI),and 2D-CDFI and pulsed wave Doppler(2D-CDFI-PW)images.The performance of these three models was compared using sensitivity,specificity,area under receiver operating characteristic curve(AUC),positive(PPV)and negative predictive values(NPV),positive(LR+)and negative likelihood ratios(LR-),and the performance of the 2D model was further compared between masses of different sizes with above statistical indicators,between images from different hospitals with AUC,and with the performance of 37 radiologists.Results:The accuracies of the 2D,2D-CDFI,and 2D-CDFI-PW models on the test set were 87.9%,89.2%,and 88.7%,respectively.The AUCs for classification of benign tumors,malignant tumors,inflammatory masses,and adenosis were 0.90,0.91,0.90,and 0.89,respectively(95%confidence intervals[CIs],0.87-0.91,0.89-0.92,0.87-0.91,and 0.86-0.90).The 2D-CDFI model showed better accuracy(89.2%)on the test set than the 2D(87.9%)and 2D-CDFI-PW(88.7%)models.The 2D model showed accuracy of 81.7%on breast masses≤1 cm and 82.3%on breast masses>1 cm;there was a significant difference between the two groups(P<0.001).The accuracy of the CNN classifications for the test set(89.2%)was significantly higher than that of all the radiologists(30%).Conclusions:The CNN may have high accuracy for classification of US images of breast masses and perform significantly better than human radiologists.Trial registration:Chictr.org,ChiCTR1900021375;http://www.chictr.org.cn/showproj.aspx?proj=33139. | Teng-Fei Yu Wen He Cong-Gui Gan Ming-Chang Zhao Qiang Zhu Wei Zhang Hui Wang Yu-Kun Luo Fang Nie Li-Jun Yuan Yong Wang Yan-Li Guo Jian-Jun Yuan Li-Tao Ruan Yi-Cheng Wang Rui-Fang Zhang Hong-Xia Zhang Bin Ning Hai-Man Song Shuai Zheng Yi Li Yang Guang | 2021 | Chinese Medical Journal2021，，4： | 11 |
| 2 | Adiponectin protects the genioglossus of rats against chronic intermittent hypoxia-induced injury via inhibition of endoplasmic reticulum stress显示文摘 | ZHANG Xiao-feng HUANG Han-peng DING Wen-xiao DING Ning LU Gan LIU Jian-nan ZHANG Xi-long | 2013 | Chinese Medical Journal2013，，17： | 8 |
| 3 | The Cohomology of Line Bundles on Non-primary Hopf Manifolds显示文摘纸是为 cohomology 的 thecomputation 给一个基本方法的礼品的目的组织 H^q (X,Ω _ X^p (L)) ,(0 ≤ q ≤ n ) n-dimensionalnon-primary Hopf 歧管与任意的基本的组一起的 X。我们使用主要 Hopf manifolds 和与 Abelianfundamental 歧管的非主要的 Hopf 的结果组织的周 togeneralize 的方法。 | Ning GAN Xiang Yu ZHOU | 2007 | Acta Mathematica Sinica,English Series2007，23，2： | 6 |
| 4 | Adiponectin alleviates contractile dysfunction of genioglossus in rats exposed to chronic intermittent hypoxia显示文摘 | WANG Wen-jing LU Gan DING Ning, HUANG Han-peng DING Wen-xiao ZHANG Xi-long | 2013 | Chinese Medical Journal2013，，17： | 6 |
| 5 | Genetic diagnosis history and osteoarticular phenotype of a nontransfusion secondary hemochromatosis显示文摘BACKGROUND It is not easy to identify the cause of various iron overload diseases because the phenotypes overlap.Therefore,it is important to perform genetic testing to determine the genetic background of patients.AIM To investigate the genetic background of a patient with hemochromatosis complicated by psoriasis on both lower extremities.METHODS Ten years ago,a 61-year-old male presented with iron overload,jaundice,hemolytic anemia and microcytic hypochromic anemia.Computed tomography of the left knee joint showed enlargement of the tibial medullary cavity and thinned bone cortices.Magnetic resonance imaging showed hepatic hemochromatosis,extensive abnormal signals from bone marrow cavities and nodular lesions in the lateral medullary cavity of the upper left lateral tibia.Single photon emission computed tomography showed radial dots of abnormal concentration in the upper end of the left tibia and radial symmetry of abnormal concentrations in joints of the extremities.The patient showed several hot spot mutations of the HFE and G6PD genes detected by next-generation sequencing,but no responsible gene mutation was found.The thalassemia gene was detected by gap-PCR.RESULTS The patient was found to carry the-α4.2 and--SEA deletion mutations of the globin gene.These two mutations are common causes of Southeast Asianα-thalassemia,but rarely cause severe widespread non-transfusion secondary hemochromatosis osteoarthropathy.The simultaneous presence of an auxiliary superposition effect of a rare missense mutation of the PIEZO1 gene(NM_001142864,c.C4748T,p.A1583V)was considered.Moreover,several rare mutations of the IFIH1,KRT8,POFUT1,FLG,KRT2,and TGM5 genes may be involved in the pathogenesis of psoriasis.CONCLUSION The selection of genetic detection methods for hemochromatosis still needs to be based on an in-depth study of the clinical manifestations of the disease. | Dan-Dan Ruan Yu-Mian Gan Tao Lu Xiao Yang Yao-Bin Zhu Qing-Hua Yu Li-Sheng Liao Ning Lin Xin Qian Jie-Wei Luo Fa-Qiang Tang | 2020 | World Journal of Clinical Cases2020，8，23： | 4 |
| 6 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 7 | Report of epibenthic macrofauna found from Haima cold seeps and adjacent deep-sea habitats,South China Sea显示文摘This work reports on a preliminary taxonomic study of epibenthic macroinvertebrates collected or observed by underwater video at the Haima cold seeps and in adjacent deep-sea habitats,including a mud volcano feld and Ganquan Plateau,during an expedition in the South China Sea by the Chinese-manned submersible Shenhai Yongshi in May 2018.A total of 41 species belonging to 6 phyla were identifed,among which 34 species were collected from the Haima cold seeps.Mollusks and crustaceans that are specialized in reducing habitats were predominant in biotopes of the Haima cold seeps,whereas sponges and cold-water corals and their commensals were prominent in communities of the mud volcano feld and the slopes of Ganquan Plateau.The distribution and faunal composition of each taxonomic group are discussed. | Dong Dong Xinzheng Li Mei Yang Lin Gong Yang Li Jixing Sui Zhibin Gan Qi Kou Ning Xiao Junlong Zhang | 2021 | Marine Life Science & Technology2021，3，1： | 3 |
| 8 | Amperometric detection of gold by differential pulse voltammetry using a DNA biosensor显示文摘A DNA biosensor with [Ru(DA-bpy)3]Cl2(DA-bpy:4,4'-diamino-2,2'-bipyridine) (RuL) as the electrochemical probe was prepared on pyrolytic graphite electrode (PGE) through the supramolecular interaction between RuL complex and DNA template. Cyclic voltammetry of RuL-DNA film showed a pair of stable and reversible peaks corresponding to the Ru(III)/Ru(II) redox potential of -0.165 V versus Ag|AgCl in pH 7.4 0.1 mol·L-1 Tris-HCl. The electron transfer was expected across the double-strand DNA by an 'electron tunneling' mechanism. When the DNA biosensor was immerged in gold (III) buffer solution, the current peak signal (I) of the RuL-DNA supramolecular depressed and △I was linear in the concentration range of Au ion from 1 × 10-7 to 2 × 10-5 mol·L-1 with a regression coefficient of 0.9879. The detection limit was 5 × 10-8 mol·L-1. The developed procedures were applied to the analysis of synthetic samples of real materials with good sensitivity and selectivity. | GAN Ning WANG Zhiying XU Weiming PAN Jianguo | 2007 | Rare Metals2007，26，2： | 2 |
| 9 | Effects of HDAC4 on IL-1β-induced matrix metalloproteinase expression regulated partially through the WNT3A/β-catenin pathway显示文摘Background::Histone deacetylase 4(HDAC4)regulates chondrocyte hypertrophy and bone formation.The aim of the present study was to explore the effects of HDAC4 on Interleukin 1 beta(IL-1β)-induced chondrocyte extracellular matrix degradation and whether it is regulated through the WNT family member 3A(WNT3A)/β-catenin signaling pathway.Methods::Primary chondrocytes(CC)and human chondrosarcoma cells(SW1353 cells)were treated with IL-1βand the level of HDAC4 was assayed using Western blotting.Then,HDAC4 expression in the SW1353 cells was silenced using small interfering RNA to detect the effect of HDAC4 knockdown on the levels of matrix metalloproteinase 3(MMP3)and MMP13 induced by IL-1β.After transfection with HDAC4 plasmids,the overexpression efficiency was examined using Real-time quantitative polymerase chain reaction(qRT-PCR)and the levels of MMP3 and MMP13 were assayed using Western blotting.After incubation with IL-1β,the translocation ofβ-catenin into the nucleus was observed using immunofluorescence staining in SW1353 cells to investigate the activation of the WNT3A/β-catenin signaling pathway.Finally,treatment with WNT3A and transfection with glycogen synthase kinase 3 beta(GSK3β)plasmids were assessed for their effects on HDAC4 levels using Western blotting.Results::IL-1βdownregulated HDAC4 levels in chondrocytes and SW1353 cells.Furthermore,HDAC4 knockdown increased the levels of MMP3 and MMP13,which contributed to the degradation of the extracellular matrix.Overexpression of HDAC4 inhibited IL-1β-induced increases in MMP3 and MMP13.IL-1βupregulated the levels of WNT3A,and WNT3A reduced HDAC4 levels in SW1353 cells.GSK-3βrescued IL-1β-induced downregulation of HDAC4 in SW1353 cells.Conclusion::HDAC4 exerted an inhibitory effect on IL-1β-induced extracellular matrix degradation and was regulated partially by the WNT3A/β-catenin signaling pathway. | Qi Ning Ye-Hua Gan Rui-Rui Shi Juan-Hong Meng | 2021 | Chinese Medical Journal2021，，8： | 2 |
| 10 | Enhanced Crystallization Rate of Poly(L-lactide)/Hydroxyapatite-graftpoly(D-lactide) Composite with Different Processing Temperatures显示文摘Hydroxyapatite-graft-poly(D-lactide)(HA-g-PDLA)was synthesized by ring-opening polymerization with HA as initiator and stannous octanoate(Sn(Oct)2)as catalyst.Thermogravimetric analysis(TGA)and Fourier transform infrared spectroscopy(FUR)results indicate that PDLA chains are successfully grafted onto HA particles by covalent bond.Under two different processing temperatures(190 and 230℃),the effect of the grafted PDLA chains on the crystallization behavior of poly(L-lactide)/HA-g-PDLA(PLLA/HA-g-PDLA)composite was investigated in the current study,comparing to neat PLLA and its four composites(PLLA/HA,PLLA/HA-g-PLLA,PLLA/PDLA,and PLLA/HA/PDLA).The crystallization rate of PLLA/HA-g-PDLA composite is highly enhanced comparing to PLLA,PLLA/HA and PLLA/HA-g-PLLA composites in which there are no stereocomplex(SC)crystallites.In addition,when the processing temperature rises from 190℃ to 230℃,the acceleration of PLLA crystallization in PLLA/HA-g-PDLA composite is not influenced so much as other composites containing SC crystallites,such as PLLA/HA/PDLA or PLLA/PDLA.The differential scanning calorimetry(DSC)results demonstrate that even without SC crystallites,the crystallization of PLLA can still be accelerated a lot in this composite.This may be related to the interaction between the grafted PDLA chains and the amorphous PLLA chains in PLLA/HA-g-PDLA composite.The isothermal crystallization kinetics studies indicate that the nature of nucleation and crystal growth of PLLA/HAg-PDLA composite are more likely 3D crystalline growth with heterogeneous nucleation mode,which are different from PLLA or other composites.This investigation could shed new light on the application of PLLA/HA composites. | Min Wang Lei-Chu You Yu-Qi Guo Ni Jiang Zhi-Hua Gan Zhen-Bo Ning | 2020 | Chinese Journal of Polymer Science2020，38，6： | 2 |
| 11 | Roadway layout for recycling residual coal pillar in room-and-pillar mining of thick coal seam显示文摘In the context of a room-and-pillar mining gob in Shanxi province in China,this paper numerically investigates the stress distribution and deformation rules of roadway surrounding rocks at various locations of residual coal pillars in room-and-pillar mining gobs using software FLAC3 D.It is found that the concentrated stress beneath coal pillars distributes in a shape of ellipse.A reasonable roadway layout is then proposed.In this design,it is indicated that roadways should be designed to avoid the supporting zones of pillars with increasing compression and take into account the roof falling and crushing in the upper gob.According to the surrounding rock deformation characteristics and mining roadway locations as well as the supporting principles of timely support,rock reinforcing,piecewise management and suiting local conditions,a new asymmetric shield supporting plan is proposed.The field surveying results show that this supporting plan can effectively control the roadway rock deformation,thus guarantee the safe and smooth construction of roadways. | Jin Gan Wang Lianguo Zhang Jihua Hu Minjun Duan Ning | 2015 | International Journal of Mining Science and Technology2015，25，5： | 2 |
| 12 | Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo显示文摘Antrodia cinnamomea is extensively used as a traditional medicine to prevention and treatment of liver cancer.However,its comprehensive chemical fingerprint is uncertain,and the mechanisms,especially the potential therapeutic target for anti-hepatocellular carcinoma(HCC)are still unclear.Using UPLC-Q-TOF/MS,139 chemical components were identified in A.cinnamomea dropping pills(ACDPs).Based on these chemical components,network pharmacology demonstrated that the targets of active components were significantly enriched in the pathways in cancer,which were closely related with cell proliferation regulation.Next,HCC data was downloaded from Gene Expression Omnibus database(GEO).The Cancer Genome Atlas(TCGA)and Dis Ge NET were analyzed by bioinformatics,and 79 biomarkers were obtained.Furtherly,nine targets of ACDP active components were revealed,and they were significantly enriched in PI3 K/AKT and cell cycle signaling pathways.The affinity between these targets and their corresponding active ingredients was predicted by molecular docking.Finally,in vivo and in vitro experiments showed that ACDPs could reduce the activity of PI3 K/AKT signaling pathway and downregulate the expression of cell cycle-related proteins,contributing to the decreased growth of liver cancer.Altogether,PI3 K/AKT-cell cycle appears as the significant central node in anti-liver cancer of A.Cinnamomea. | Yan Zhang Pin Lv Junmei Ma Ning Chen Huishan Guo Yan Chen Xiaoruo Gan Rong Wang Xuqiang Liu Sufang Fan Bin Cong Wenyi Kang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 13 | Drug repositioning of disulfiram induces endometrioid epithelial ovarian cancer cell death via the both apoptosis and cuproptosis pathways显示文摘Various therapeutic strategies have been developed to overcome ovarian cancer.However,the prognoses resulting from these strategies are still unclear.In the present work,we screened 54 small molecule compounds approved by the FDA to identify novel agents that could inhibit the viability of human epithelial ovarian cancer cells.Among these,we identified disulfiram(DSF),an old alcohol-abuse drug,as a potential inducer of cell death in ovarian cancer.Mechanistically,DSF treatment significantly reduced the expression of the anti-apoptosis marker Bcell lymphoma/leukemia-2(Bcl-2)and increase the expression of the apoptotic molecules Bcl2 associated X(Bax)and cleaved caspase-3 to promote human epithelial ovarian cancer cell apoptosis.Furthermore,DSF is a newly identified effective copper ionophore,thus the combination of DSF and copper was used to reduce ovarian cancer viability than DSF single treatment.Combination treatment with DSF and copper also led to the reduced expression of ferredoxin 1 and loss of Fe-S cluster proteins(biomarkers of cuproptosis).In vivo,DSF and copper gluconate significantly decreased the tumor volume and increased the survival rate in a murine ovarian cancer xenograft model.Thus,the role of DSF revealed its potential for used as a viable therapeutic agent for the ovarian cancer. | YAPING GAN TING LIU WEIFENG FENG LIANG WANG LI LI YINGXIA NING | 2023 | Oncology Research2023，31，3： | 2 |
| 14 | Influence of kaolinite and montmorillonite on benzo[a]pyrene biodegradation by Paracoccus aminovorans HPD-2 and the underlying interface interaction mechanisms显示文摘Clay minerals play an important role in biogeochemical cycling.Here,kaolinite and montmorillonite,the two most abundant and widespread clay minerals with typical layered structures,were selected to investigate and compare their effects on the biodegradation of benzo[a]pyrene(BaP)by Paracoccus aminovorans HPD-2 and to investigate the underlying interface mechanisms.Overall,the BaP degradation efficiency was significantly higher 7 d after montmorillonite addition,reaching 68.9%(P<0.05),when compared with that of the control without addition of clay minerals(CK,61.4%);however,the addition of kaolinite significantly reduced the BaP degradation efficiency to 45.8%.This suggests that kaolinite inhibits BaP degradation by inhibiting the growth of strain HPD-2,or its strong hydrophobicity and readily agglomerates in the degradation system,resulting in a decrease in the bio-accessibility of BaP to strain HPD-2.Montmorillonite may buffer some unfavorable factors,and cells may be fixed on the surface of montmorillonite colloidal particles across energy barriers.Furthermore,the adsorption of BaP on montmorillonite may be weakened after swelling,reducing the effect on the bio-accessibility of BaP,thus promoting the biodegradation of BaP by strain HPD-2.The experimental results indicate that differential bacterial growth,BaP bio-accessibility,interface interaction,and the buffering effect may explain the differential effects of the different minerals on polycyclic aromatic hydrocarbon biodegradation.These observations improve our understanding of the mechanisms by which clay minerals,organic pollutants,and degrading bacteria interact during the biodegradation process and provide a theoretical basis for increasing the biodegradation of soil pollutants by native microorganisms under field conditions. | Xinhong GAN Ying TENG Jian XU Ning ZHANG Wenjie REN Ling ZHAO Peter CHRISTIE Yongming LUO | 2022 | Pedosphere2022，32，2： | 2 |
| 15 | A simple procedure to prepare spherical α-alumina powders显示文摘 | Liu H Y Ning G L Gan Zh H e t al | 2009 | Materials Research Bulletin2009，44，4： | 1 |
| 16 | A DisposableOrganophosphorus Pesticides Enzyme Biosensor Basedon Magnetic Composite Nano-Particles Modified ScreenPrinted Carbon Electrode显示文摘 | GAN Ning YANG Xin XIE Donghua | 2010 | Sensors2010，10，： | 1 |
| 17 | A novel sandwich-type noncompetitive immunoassay of diethylstilbestrol using fl-cyclodextrin modified electrode and polymer-enzyme labels 显示文摘 | YAN Zhong-dan XIONG Ping GAN Ning | 2015 | Journal of Electroanalytical Chemistry2015，736，： | 1 |
| 18 | Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study): A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study显示文摘 | Zhou Zhiguang Xiang Yufei Ji Linong Jia Weiping Ning Guang Huang Gan Yang Lin Lin Jian Liu Zhenqi Hagopian William A Leslie R David | 2013 | Diabetes2013，，2： | 1 |
| 19 | The sandwich-type electrochemiluminescence immunosensor for alpha-fe- toprotein based on enrichment by Fe3O4-Au magnetic nano probes and signal amplification by CdS-Au composite nanopar- ticles labeled anti-AFP 显示文摘 | ZHOU Hankun GAN Ning LI Tianhua | 2012 | Anal Chim Acta2012，746，9： | 1 |
| 20 | A simple procedure to prepare spherical alpha alumina powders显示文摘 | Liu H Y Ning G L Gan Z H | 2009 | Mater Res Bull2009，44，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员