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| 1 | Identification and analysis of type II TGF-β receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells显示文摘我们的以前的研究表明了那根骨头形态基因的蛋白质(BMP-9 ) 9 是最有效的 BMP 之一导致间充质的干细胞(MSC ) 的造骨细胞区别。然而,位于 MSC 的 BMP-9-induced osteogenic 区别下面的分子的机制尚待充分被阐明。在这研究,主导否定(DN ) 类型 II TGF- 受体被构造并且介绍干细胞进 C3H10T1/2,然后,在 vitro 并且在 vivo,试金被执行分析并且识别为 BMP-9-induced 要求的类型 II TGF- 受体成骨。我们发现那三 DN 类型 II TGF-受体, DN-BMPRII , DN-ActRII ,和 DN-ActRIIB ,减少的 BMP-9-induced 碱的磷酸酶(高山)活动,在有约束力的元素( SBE )控制了的 BMP-9-induced Smad 导致了减少记者活动, Smad6 和 Smad7 的减少的 BMP-9-induced 表达式,并且减少在在 vivo 的 vitro 和宫外的骨头形成的 BMP-9-induced 矿化作用,最后导致了减少的骨头群众和不成熟的成骨。这些调查结果强烈建议了那三野类型的 II TGF- 受体, BMPRII, ActRII 和 ActRIIB,可以在 C3H10T1/2 房间的 BMP-9-induced osteogenic 区别起一个功能的作用。然而, C3H10T1/2 干细胞能表示 BMPRII 和 ActRII,然而并非 ActRIIB。用 RNA 干扰(RNAi ) ,我们发现那项酶记者活动和高山活动被 BMP-9 导致了因此被禁止与一起 BMPRII 和 ActRII 击倒。一起拿,我们的结果证明 BMPRII 和 ActRII 是在 C3H10T1/2 房间的 BMP-9-induced osteogenic 区别的功能的类型 II TGF- 受体。 | Ningning Wu Yingze Zhao Yibing Yin Yan Zhang Jinyong Luo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，10： | 20 |
| 2 | Graft-accelerated virus-induced gene silencing facilitates functional genomics in rose flowers显示文摘Rose has emerged as a model ornamental plant for studies of flower development, senescence, and morphology, as well as the metabolism of floral fragrances and colors.Virus-induced gene silencing(VIGS) has long been used in functional genomics studies of rose by vacuum infiltration of cuttings or seedlings with an Agrobacterium suspension carrying TRV-derived vectors. However, VIGS in rose flowers remains a challenge because of its low efficiency and long time to establish silencing. Here we present a novel and rapid VIGS method that can be used to analyze gene function in rose,called ‘graft-accelerated VIGS', where axil ary sprouts are cut from the rose plant and vacuum infiltrated with Agrobacterium. The inoculated scions are then grafted back onto the plants to flower and silencing phenotypes can be observed within 5 weeks, post-infiltration. Using this new method, we successfully silenced expression of the RhDFR_1, RhA G, and RhNUDX_1 in rose flowers, and affected their color, petal number, as well as fragrance, respectively. This grafting method will facilitate high-throughput functional analysis of genes in rose flowers. Importantly, it may also be applied to other woody species that are not currently amenable to VIGS by conventional leaf or plantlet/seedling infiltration methods. | Huijun Yan Shaochuan Shi Nan Ma Xiaoqian Cao Hao Zhang Xianqin qiu Qigang Wang Hongying Jian Ningning Zhou Zhao Zhang Kaixue Tang | 2018 | Journal of Integrative Plant Biology2018，60，1： | 11 |
| 3 | Physiological levels of ATP negatively regulate proteasome function显示文摘由 ubiquitin-proteasome 系统的细胞内部的蛋白质降级是 ATP 依赖者,和最佳的 ATP 集中激活 proteasome 在 vitro 的功能是 ~ 100 渭 M。细胞内部的 ATP 层次在在这个范围以内的水平通常在低 millimolar 范围,而是 ATP 被显示在 vitro 禁止 proteasome peptidase 活动。这里,我们报导支持在生理的层次的细胞内部的 ATP 双向地调整的一个假设的新证据 26S proteasome 在房间的解朊的功能。首先,我们证实 ATP 在 vitro 在 26S proteasome 上施加了双向规定,与最佳的 ATP 集中(在 50 和 100 渭 M 之间) 刺激 proteasome 像糜蛋白酶的活动。第二,我们发现操作细胞内部的 ATP 层次也在有教养的房间在 proteasome 特定的蛋白质底层的层次导致了双向变化。最后,测量增加提高的细胞内部的 ATP,当减少的细胞内部的 ATP 稀释了导致房间死亡的 proteasome 抑制的能力时。这些数据强烈建议在生理的集中范围以内的内长的 ATP 能在 proteasome 活动施加否定影响,允许房间到很快,在应力下面的 ATP 减小上的 upregulate proteasome 活动调节。 | Hongbiao Huang Xiaoyan Zhang Shujue Li Ningning Liu Wen Elan Emily McDowell Ping Zhou Canguo Zhao Haiping Guo Change Zhang Changshan Yang Guangmei Wen Xiaoxian Dong Li Lu Ningfang Ma Weihua Dong Q Ping Dou Xuejun Wang Jinbao Liu | 2010 | Cell Research2010，20，12： | 4 |
| 4 | Systematic Review and Meta-analysis of Efficacy of Banxia Xiexin Decoction for Treatment of Bile Reflux Gastritis显示文摘[Objectives]The purpose was to study the clinical efficacy and safety of Banxia Xiexin decoction in treating bile reflux gastritis(BRG).[Methods]Randomized controlled trial was adopted to conduct scientific and standardized assessment on the risk of bias in the included articles.With overall effect and epigastric pain relief as indices,meta-analysis was performed,and sensitivity and safety analysis was conducted on the included literature.[Results]A total of 13 articles were included,involving a total of 1478 patients.The results of meta-analysis show that the efficacy of Banxia Xiexin decoction alone and Banxia Xiexin decoction-Western medicine combination is better than that of Western medicine alone.[Conclusions]Banxia Xiexin decoction is safe and effective in treating bile reflux gastritis.However,as the 13 articles included are all low in quality and there is a certain degree of publication bias,the objectivity of the results is affected to some extent. | Ningning ZHAO Bing WEI Shiying TANG | 2020 | Medicinal Plant2020，11，3： | 3 |
| 5 | Cleaning of South African coal using a compound dry cleaning apparatus显示文摘复合干燥清洗原则简短被描述。南非的煤上的 beneficiation 测试用模型混合物被进行干燥清洗仪器。优秀结果被获得,操作参数的最佳是坚定的。他们是:3.0 公里, 47.5 Hz 的马达频率, 50% 的空气体积, 7 掳的一个横向的角度,和一个纵的角度的一个振幅 ? 2 掳。这些条件产出包含 11% 灰和 75% 的煤生产的干净的煤。器官的效率,畏,是 95.86% 。这些结果证明南非的煤能被复合干燥清洗有效地分开,它将推广复合干燥清洗方法。 | Li Haibin Luo Zhenfu Zhao Yuemin Wu Wanchang Zhang Cuiyu Dai Ningning | 2011 | Mining Science and Technology2011，21，1： | 3 |
| 6 | Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer显示文摘Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer. | Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song Menglin Yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 7 | DEM simulation of particle flow and separation in a vibrating flip-flow screen显示文摘Vibrating flip-flow screens(VFFS)with stretchable polyurethane sieve mats have been widely used in screening fine-grained materials in recent years.In this work,the discrete element method(DEM)is used to study the screening process in VFFS to explain particle flow and separation behavior at the particle scale.Unlike traditional vibrating screens,for VFFS,the amplitude response of each point on the elastic sieve mat is different everywhere.This study measures the kinematics of the elastic sieve mat under different conditions such as different stretched lengths and material loads.To establish the elastic sieve mat model in a DEM simulation,the continuous elastic sieve mat is discretized into multiple units,and the displacement signal of each unit tested is analyzed by Fourier series.The Fourier series analysis results of each unit are used as the setting parameters for motion.In this way,the movement of the elastic sieve mat is approximately simulated,and a DEM model of VFFS is produced.Through the simulation,the flow and separation of different-sized particles in VFFS are studied,and the reasonability of the simulation is verified by a pilot-scale screening experiment.The present study demonstrates the potential of the DEM method for the analysis of screening processes in VFFS. | Chi Yu Dongdong Lin Ningning Xu Xinwen Wang Kunwei Pu Zhenghao Wang Guofeng Zhao Runhui Geng Sanpeng Gong | 2023 | Particuology2023，，2： | 2 |
| 8 | In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT显示文摘In this paper,we proposed a contrast-enhanced homemade spectral domain optical coherence tomography(SD-OCT)method for monitoring of brain microcirculation.We used the polyethylene glycol(PEG)-ylated gold nanorods(GNRs)as a contrast-enhanced agent,obtained clearly 2D and 3D OCT images of blood vessels and dynamic changes of probes in mouse blood vessels.Owing to high scattering of the PEG-GNRs,more tiny blood vessels can be imaged and the OCT signal can be enhanced by 5.87 dB after injection of PEG-GNRs for 20 min,the enhancement then declined gradually for 60 min.Our results demonstrate an effective technique for the enhanced imaging of blood vessels in vivo,especially for studies of the brain microcirculation,which could be serviced for disease mechanism research and therapeutic drug monitoring. | Shaozhuang Yang Liwei Liu Yixin Chang Ningning Zhang Kun Liu Liang Hong Bingling Chen Yue Zhao Rui Hu Junle Qu | 2019 | Journal of Innovative Optical Health Sciences2019，，1： | 2 |
| 9 | Comparisons of stable isotopic fractionation in winter and summer at Baishui Glacier No.1,Mt.Yulong,China显示文摘Based on the data of δ18O in surface snow, snow pits, meltwater and the glacier-fed river water at Baishui Glacier No.1, Mt. Yulong, the isotopic fractionation behaviors in the typical monsoonal temperate glacier system in winter and summer were compared. The results indicate that the isotopic fractionation degree in summer is greater than that in winter, suggesting that the snow/ice melting is more intense in summer. Moreover, whenever it is in winter or summer, from surface snow to meltwater, and to glacier-fed river water, the gradient of δ18O with altitude gradually increases. This shows that the degree of isotopic fractionation gradually strengthens when surface snow is being converted into meltwater and finally into glacial river water, which suggests that the influence of post-depositional processes on δ18O gradient in the monsoonal temperate glacier region differs spatially. | PANG Hongxi HE Yuanqing LU Aigang ZHAO Jingdong NING Baoying YUAN Lingling SONG Bo ZHANG Ningning | 2006 | Journal of Geographical Sciences2006，16，3： | 2 |
| 10 | Trace determination and characterization of ginsenosides in rat plasma through magnetic dispersive solid-phase extraction based on core-shell polydopamine-coated magnetic nanoparticles显示文摘Enrichment of trace bioactive constituents and metabolites from complex biological samples is challenging.This study presented a one-pot synthesis of magnetic polydopamine nanoparticles(Fe3O4@-SiO2@PDA NPs)with multiple recognition sites for the magnetic dispersive solid-phase extraction(MDSPE)of ginsenosides from rat plasma treated with white ginseng.The extracted ginsenosides were characterized by combining an ultra-high-performance liquid chromatography coupled to a highresolution mass spectrometry with supplemental UNIFI libraries.Response surface methodology was statistically used to optimize the extraction procedure of the ginsenosides.The reusability of Fe3O4@-SiO2@PDA NPs was also examined and the results showed that the recovery rate exceeded 80%after recycling 6 times.Furthermore,the proposed method showed greater enrichment efficiency and could rapidly determine and characterize 23 ginsenoside prototypes and metabolites from plasma.In comparison,conventional methanol method can only detect 8 ginsenosides from the same plasma samples.The proposed approach can provide methodological reference for the trace determination and characterization of different bioactive ingredients and metabolites of traditional Chinese medicines and food. | Ningning Zhao Shu Liu Junpeng Xing Zifeng Pi Fengrui Song Zhiqiang Liu | 2020 | Journal of Pharmaceutical Analysis2020，10，1： | 1 |
| 11 | Iron regulation by hepcidin显示文摘 | Zhao Ningning Zhang An-Sheng Enns Caroline A | 2013 | Journal of Clinical Investigation2013，，6： | 1 |
| 12 | Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line 显示文摘 | WANG Ningning ZHAO Lijun WU Linan | 2013 | Asian pacific journal of cancer prevention2013，10，9： | 1 |
| 13 | An analytical poroelastic model for laboratorial mechanical testing of the articular cartilage (AC)显示文摘The articular cartilage(AC) can be seen as a biphasic poroelastic material.The cartilage deformation under compression mainly leads to an interstitial fluid flow in the porous solid phase.In this paper,an analytical poroelastic model for the AC under laboratorial mechanical testing is developed.The solutions of interstitial fluid pressure and velocity are obtained.The results show the following facts.(i) Both the pressure and fluid velocity amplitudes are proportional to the strain loading amplitude.(ii) Both the amplitudes of pore fluid pressure and velocity in the AC depend more on the loading amplitude than on the frequency.Thus,in order to obtain the considerable fluid stimulus for the AC cell responses,the most effective way is to increase the loading amplitude rather than the frequency.(iii) Both the interstitial fluid pressure and velocity are strongly affected by permeability variations.This model can be used in experimental tests of the parameters of AC or other poroelastic materials,and in research of mechanotransduction and injury mechanism involved interstitial fluid flow. | Xiaogang WU Kuijun CHEN Zhaowei WANG Ningning WANG Teng ZHAO Yanan XUE Yanqin WANG Weiyi CHEN | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，6： | 1 |
| 14 | Replication,pathogenicity,and transmission of SARS-CoV-2 in minks显示文摘Minks are raised in many countries and have transmitted severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)to humans.However,the biologic properties of SARS-CoV-2 in minks are largely unknown.Here,we investigated and found that SARS-CoV-2 replicates efficiently in both the upper and lower respiratory tracts,and transmits efficiently in minks via respiratory droplets;pulmonary lesions caused by SARS-CoV-2 in minks are similar to those seen in humans with COVID-19.We further found that a spike protein-based subunit vaccine largely prevented SARS-CoV-2 replication and lung damage caused by SARS-CoV-2 infection in minks.Our study indicates that minks are a useful animal model for evaluating the efficacy of drugs or vaccines against COVID-19 and that vaccination is a potential strategy to prevent minks from transmitting SARS-CoV-2. | Lei Shuai Gongxun Zhong Quan Yuan Zhiyuan Wen Chong Wang Xijun He Renqiang Liu Jinliang Wang Qinjian Zhao Yuxiu Liu Ningning Huo Junhua Deng Jingjing Bai Hongchao Wu Yuntao Guan Jianzhong Shi Kegong Tian Ningshao Xia Hualan Chen Zhigao Bu | 2021 | National Science Review2021，8，3： | 1 |
| 15 | Systematic Review and Meta-analysis of Tanshinone Capsule in the Treatment of Polycystic Ovary Syndrome显示文摘[Objectives]To study the efficacy and safety of tanshinone capsule in the treatment of polycystic ovary syndrome(PCOS).[Methods]A randomized controlled trial or semi-randomized controlled trial of tanshinone capsule in the treatment of polycystic ovary syndrome was included.Two researchers screened the retrieved literature,extracted the data,assessed the risk of bias of the included literature,and then carried out meta-analysis.[Results]A total of 5 articles were included,involving 350 patients.The results of meta-analysis showed that compared with the control group,tanshinone capsule could reduce total cholesterol[MD=-0.73,95%CI(-0.86,-0.60),P<0.00001],triglyceride[MD=-0.40,95%CI(-0.57,-0.23),P<0.00001],low density lipoprotein cholesterol[MD=-0.47,95%CI(-0.73,-0.53),P<0.00001],follicle stimulating hormone[MD=-0.63,95%CI(-0.73,-0.53),P<0.00001],increase high density lipoprotein cholesterol[MD=0.28,95%CI(0.20,0.35),P<0.00001],the effective rate(P=0.06)and luteinizing hormone(P=0.07)in the treatment of polycystic ovary syndrome.[Conclusions]Tanshinone capsule could effectively improve the level of lipid metabolism and follicle stimulating hormone in patients with polycystic ovary syndrome. | Bing WEI Yi ZHANG Ningning ZHAO Shiying TANG | 2020 | Medicinal Plant2020，11，2： | 1 |
| 16 | Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy显示文摘Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized treatment.We examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative CRT.Methods:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were included.All patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were evaluated.Clinicopathological factors related to long-term prognosis were analyzed using univariate and multivariate analyses.The down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term outcomes.Results:The median follow-up period for survivors was 30 months.The area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and ypN0.Decision curve analysis further affirmed that DDS had the largest net benefit.The DDS cut-off value was 4.pCR and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS. | Ning Li Xin Wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin | 2021 | Chinese Journal of Cancer Research2021，33，4： | 1 |
| 17 | Effects of desalted duck egg white peptides and their products on calcium absorption in rats 显示文摘 | Ningning Zhao Jun Hu Tao Hou | 2014 | Journal of Functional Foods2014，8，5： | 1 |
| 18 | Flexible multilayer lead-free film capacitor with high energy storage performances via heterostructure engineering显示文摘The immense potential of flexible energy storage materials applied in wearable electronic devices hasstimulated a lot of science researches on manufacturing technology and performance optimization.Herein, an all-inorganic flexible ferroelectric film with multilayer heterostructure is prepared based onMn doped Bi0.5Na0.5TiO_(3)eBiNi0.5Zr0.5O_(3) (Mn:BNT-BNZ) and Bi0.5Na0.5TiO_(3)eBiZn0.5Zr0.5O_(3) (BNT-BZZ)relaxor ferroelectrics. A win-win situation of breakdown strength and polarization is achieved in theMn:BNT-BNZ/BNT-BZZ multilayer film with the stacking period N - 3, of which energy density and ef-ficiency reach 80.4 J/cm3 and 62.0% respectively. It is proposed that the excellent energy storage per-formances are attributed to the synergistic effect of the electric field amplification effect, interfaceblocking effect and the polarization coupling effect based on the multilayer heterostructure. Moreover,the flexible ferroelectric film exhibits outstanding temperature (25e205 - C), frequency (0.5e5 kHz)stability and antifatigue property (1 108 cycles), and can well maintain stable performance at differenttensile/compressive bending radii (10e5 mm) and even after 104 bending cycles with a fixed bendingradius of 3 mm. This work opens up a promising route to the development of flexible energy storagematerials. | Ningning Sun Jinhua Du Ye Zhao Chunxiao Lu Pei Han Yong Li Qiwei Zhang Xihong Hao | 2022 | Journal of Materiomics2022，8，4： | 1 |
| 19 | Sanggenon C decreases tumor cell viability associated with proteasome inhibition显示文摘 | Protein tyrosine phosphatase 1B Bioorganic & Medicinal Chemistry HUANG Hongbiao LIU Ningning ZHAO Kai | 2011 | Frontiers in Bioscience2011，3，： | 1 |
| 20 | Effects of Dihydromyricetin Extracted from Ampelopsis grossedentata on Visceral Organ Indexes and Intestinal Digestive Enzyme Activities of Chickens显示文摘To provide a reference basis for reasonable development and utilization of Ampelopsis grossedentata resource and its application in production,we added 0.025%,0.05% and 0.1% dihydromyricetin(DMY)extracted from A.grossedentata into the basal diets of Yaoshan chickens,and studied the effects of DMY on visceral organ indexes and digestive enzyme activities of 40-day-old healthy Yaoshan chickens.Supplementation of DMY in basal diets influenced visceral organ weight,organ index,length and digestive enzyme activity of small intestine of chickens.Among them,0.05% DMY was the most appropriate volume for supplementation.Compared with control group(without DMY),0.05% DMY reduced lung weight and index(P>0.05),significantly reduced liver weight(P<0.05),extremely reduced stomach weight and stomach index(P<0.01),increased activity of amylase in small intestine(P>0.05),significantly increased length of small intestine and activity of protease(P<0.05).Supplementation of 0.05% DMY reduced the visceral organ weight and organ index,enhanced digestion and absorption ability of gastrointestinal tract,thereby improving feed utilization rate and promoting the growth of chickens. | Dai Qing Yu Jianping Yu Lina Han Ningning Xu Yuan Zhao Hui | 2016 | Animal Husbandry and Feed Science2016，8，3： | 1 |
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