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| 1 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 2 | C.elegans as a model system for Parkinson disease显示文摘Parkinson disease(PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra. Although investigation in mammalian animal models of PD has enhanced our understanding of PD, the complexity of the mammalian nervous system and our inability to visualize DA neurons in vivo restricts the advances in elucidating the molecular mechanisms of PD. Conservation between C. elegans and mammals in genomic, biosynthetic and metabolic pathways as well as the advantages of observing DA neurons morphology in vivo and the ease of transgenic and genetic manipulation make C. elegans an excellent model organism for PD. | Pu PU,Wei-Dong LE State Key Laboratory of Medical Genomics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine Institute of Health Sciences,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences-Shanghai Jiao Tong University School of Medicine,Shanghai 200031,China | 2006 | Neuroscience Bulletin2006，22，2： | 2 |
| 3 | Environment-friendly surface cleaning using micro-nano bubbles显示文摘Cleaning a surface using a solution containing a large number of micro to nano scale bubbles has significant advantage regarding environmental protection.This review first briefly introduces the cleaning mechanism of micro-nano bubbles(MNBs),including physical and chemical effects.Then the applications of MNBs in cleaning of metal parts,precision parts,cultural relics or food are introduced.After that,coupled cleaning method of ultrasound and bubbles is introduced.Finally,the characterization methods for the cleaning effect are introduced,which mainly focuses on the changes of physico-chemical properties(mass or cleaning area,infiltration,colony number and light scattering intensity)of the cleaned parts or that(like conductivity)of the solvent.It is believed that MNBs technology will be applied in a broader range of surface cleaning applications. | Nuo Jin Fenghua Zhang Yan Cui Le Sun Haoxiang Gao Ziang Pu Weimin Yang | 2022 | Particuology2022，20，7： | 2 |
| 4 | Regulation of the formation of tumor cell pseudopodia by the Na^+/H^+ exchanger NHE1 显示文摘 | Lagana A Vadnais J Le PU | 2000 | J Cell Science2000，113，： | 1 |
| 5 | Methylation profiling of benign and malignant breast lesions and its application to cytopathology显示文摘 | Pu RT Laitala LE Alli PM | 2003 | Mod Pathol2003，16，11： | 1 |
| 6 | Integration of high-throughput phenotyping,GWAS,and predictive models reveals the genetic architecture of plant height in maize显示文摘Plant height(PH)is an essential trait in maize(Zea mays)that is tightly associated with planting density,biomass,lodging resistance,and grain yield in the field.Dissecting the dynamics of maize plant architecture will be beneficial for ideotype-based maize breeding and prediction,as the genetic basis controlling PH in maize remains largely unknown.In this study,we developed an automated high-throughput phenotyping platform(HTP)to systematically and noninvasively quantify 77 image-based traits(i-traits)and 20 field traits(f-traits)for 228 maize inbred lines across all developmental stages.Time-resolved i-traits with novel digital phenotypes and complex correlations with agronomic traits were characterized to reveal the dynamics of maize growth.An i-trait-based genome-wide association study identified 4945 traitassociated SNPs,2603 genetic loci,and 1974 corresponding candidate genes.We found that rapid growth of maize plants occurs mainly at two developmental stages,stage 2(S2)to S3 and S5 to S6,accounting for the final PH indicators.By integrating the PH-association network with the transcriptome profiles of specific internodes,we revealed 13 hub genes that may play vital roles during rapid growth.The candidate genes and novel i-traits identified at multiple growth stages may be used as potential indicators for final PH in maize.One candidate gene,ZmVATE,was functionally validated and shown to regulate PH-related traits in maize using genetic mutation.Furthermore,machine learning was used to build predictive models for final PH based on i-traits,and their performancewas assessed across developmental stages.Moderate,strong,and very strong correlations between predictions and experimental datasets were achieved from the early S4(tenth-leaf)stage.Colletively,our study provides a valuable tool for dissecting the spatiotemporal formation of specific internodes and the genetic architecture of PH,as well as resources and predictive models that are useful for molecular design breeding and predicting maize varieties with ideal plant architectures. | Weixuan Wang Weijun Guo Liang Le Jia Yu Yue Wu Dongwei Li Yifan Wang Huan Wang Xiaoduo Lu Hong Qiao Xiaofeng Gu Jian Tian Chunyi Zhang Li Pu | 2023 | Molecular Plant2023，16，2： | 1 |
| 7 | Caveolin-1 is a negative reg- ulator of caveolae-mediated endocytosis to the endoplasmic reticu- lum显示文摘 | Le PU Guay G Altschuler Y | 2002 | J Biol Chem2002，277，5： | 1 |
| 8 | Methylation profiling of benign and malignant breast lesions and its application to cytopathology显示文摘 | Pu RT Laitala LE Alli PM | 2003 | Mod Pathol2003，16，11： | 1 |
| 9 | Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1显示文摘 | Vadnais J Le PU | 2000 | J Cell Sci2000，113，20： | 1 |
| 10 | Methylation profiling of benign and malignant breast lesions and its application to cytopathology显示文摘 | Pu RT Laitala LE Alli PM | 2003 | Mod Pathol2003，16，11： | 1 |
| 11 | Caveolae/raft-dependent endocytosis 显示文摘 | Nabi IR Le PU | 2003 | J Cell Biol2003，161，4： | 1 |
| 12 | DRR drives brain cancer invasion by regulating cytoskeletal-focal adhesion dynamics显示文摘 | PU Le A Angers-Loustau RMW de Oliveira | 2010 | Oncogene2010，29，： | 1 |
| 13 | Increased beta - actinexpression in an invasive moloney sarcoma virus - transformed MD-CK cell variant concentrates to the tips of multiple pseudopodia显示文摘 | Le PU Nguyen TN Drolet - Savoie P | 1998 | Cancer Res1998，58，8： | 1 |
| 14 | Localization of autocrine motility factor receptor to caveolae and clathrin-independent internalization of its ligand to smooth endoplasmic reticulum显示文摘 | Benlimame N Le PU Nabi IR | 1998 | Mol Biol Cell1998，9，7： | 1 |
| 15 | Methylation profiling of benign and malignant breast lesions and its application to cytopathology显示文摘 | Pu RT Laitala LE Alli PM | 2003 | Mod Pathol2003，16，11： | 1 |
| 16 | Methylation profiling of urothelial carcinoma in bladder biopsy and urine 显示文摘 | Pu RT Laitala LE Clark DP | 2011 | Acta Cytol2011，50，5： | 1 |
| 17 | Regulation of the formation of tumor cell pseudopodia by the Na+/H+ exchanger NHEI显示文摘 | Lagana A Vadnais J Le PU | 2000 | J Cell Sci2000，113，20： | 1 |
| 18 | Methylation profiling of urothelial carcinoma in bladder biopsy and urine显示文摘 | Pu RT Laitala LE Clark DP | 2006 | Acta Cytol2006，50，5： | 1 |
| 19 | Regulation of the formation of tumor cell pseudopodia by the Na( + )/H( + ) exchanger NHE1 显示文摘 | Lagana A Vadnais J Le PU | 2000 | J Cell Sci2000，113，： | 1 |
| 20 | Regulation of the formation of tumor cell pseudopodia by the Na^+/H^+ exchanger NHEI显示文摘 | LAGANA A VADNAIS J LE PU | 2000 | J Cell Sci2000，113，： | 1 |
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