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| 1 | Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells显示文摘Chemokines are involved in human hepatocellular carcinoma (HCC) carcinogenesis. However, the exact mechanism of chemokines in HCC carcinogenesis remains unknown. Here we investigated the roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in the metastasis of HCC. We found that the expression levels of CXCR4 mRNA in HCC tissues, MHCC97 cells, and HUVEC cells were 2.52 ± 1.13, 2.34 ± 1.16 and 1.63 ± 1.26, respectively and that the CXCR4 protein levels were 1.38 ± 0.13, 1.96 ± 0.32 and 1.86 ± 0.21, respectively. In contrast, CXCR4 was not detected in normal hepatic tissues. In 78 HCC patients, we also found that the concentration of CXCL12 in cancerous ascitic fluid was 783-8,364 pg/ml and that CXCL12 mRNA level in HCC metastasis portal lymph nodes was 1.21 ± 0.87 but undetectable in normal hepatic tissues. Finally we discovered that recombinant human CXCL12 could induce MHCC97 cells and HUVEC cells to migrate with chemotactic indexes (CI) of 3.9 ± 1.1 and 4.1 ± 1.6, respectively. Cancerous ascitic fluid could also induce the migration of MHCC97 cells with a CI of 1.9 ± 0.8. Thus, our data suggest that CXCR4 and CXCL12 may play an important role in the metastasis of HCC by promoting the migration of tumor cells. | Hui Liu Zeya Pan Aijun Li Siyuan Fu Yin Lei Hangyong Sun Mengchao Wu Weiping Zhou | 2008 | Cellular & Molecular Immunology2008，5，5： | 30 |
| 2 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 3 | Evaluation of mercury speciation and removal through air pollution control devices of a 190 MW boiler显示文摘Air pollution control devices(APCDs) are installed at coal-fired power plants for air pollutant regulation.Selective catalytic reduction(SCR) and wet flue gas desulfurization(FGD) systems have the co-benefits of air pollutant and mercury removal.Configuration and operational conditions of APCDs and mercury speciation affect mercury removal efficiently at coal-fired utilities.The Ontario Hydro Method(OHM) recommended by the U.S.Environmental Protection Agency(EPA) was used to determine mercury speciation simultaneously at five sampling locations through SCR-ESP-FGD at a 190 MW unit.Chlorine in coal had been suggested as a factor affecting the mercury speciation in flue gas;and low-chlorine coal was purported to produce less oxidized mercury(Hg2+) and more elemental mercury(Hg0 ) at the SCR inlet compared to higher chlorine coal.SCR could oxidize elemental mercury into oxidized mercury when SCR was in service,and oxidation efficiency reached 71.0%.Therefore,oxidized mercury removal efficiency was enhanced through a wet FGD system.In the non-ozone season,about 89.5%-96.8% of oxidized mercury was controlled,but only 54.9%-68.8% of the total mercury was captured through wet FGD.Oxidized mercury removal efficiency was 95.9%-98.0%,and there was a big difference in the total mercury removal efficiencies from 78.0% to 90.2% in the ozone season.Mercury mass balance was evaluated to validate reliability of OHM testing data,and the ratio of mercury input in the coal to mercury output at the stack was from 0.84 to 1.08. | Chengli Wu Yan Cao Zhongbing Dong Chinmin Cheng Hanxu Li Weiping Pan | 2010 | Journal of Environmental Sciences2010，22，2： | 13 |
| 4 | Early-onset diabetes:an epidemic in China显示文摘Although type 2diabetes is a disease often associated with aging,the global prevalence of early-onset diabetes has been increasing due to man's sedentary lifestyle,low-physical activity,obesity,and some non- modifiable risk factors.Many studies have found that individuals with early-onset type 2diabetes were at higher risk of developing vascular complications than those with late-onset diabetes.Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health,which results in poor glycemic control and the delayed detection of diabetes-related complications.Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2diabetes.Therefore, focusing on this particular population is critical for the government and academic societies.Screening for T2DM is imminent for young adults with a family history of diabetes,obesity,markers of insulin resistance,or alcohol consumption.More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes. | Jiemin Pan Weiping Jia | 2018 | Frontiers of Medicine2018，12，6： | 7 |
| 5 | Highly efficient base editing in human tripronuclear zygotes显示文摘 | Changyang Zhou Meiling Zhang Yu Wei Yidi Sun Yun Sun Hong Pan Ning Yao Wanxia Zhong Yixue Li Weiping Li3 Hui Yang Zi-jiang Chen | 2017 | Protein & Cell2017，8，10： | 6 |
| 6 | Mercury transportation in soil via using gypsum from flue gas desulfurization unit in coal-fired power plant显示文摘The mercury flux in soils was investigated, which were amended by gypsums from flue gas desulphurization (FGD) units of coal- fired power plants. Studies have been carried out in confined greenhouses using FGD gypsum treated soils. Major research focus is uptakes of mercury by plants, and emission of mercury into the atmosphere under varying application rates of FGD gypsum, simulating rainfall irrigations, soils, and plants types. Higher FGD gypsum application rates generally led to higher mercury concentrations in the soils, the increased mercury emissions into the atmosphere, and the increased mercury contents in plants (especially in roots and leaves). Soil properties and plant species can play important roles in mercury transports. Some plants, such as tall fescue, were able to prevent mercury from atmospheric emission and infiltration in the soil. Mercury concentration in the stem of plants was found to be increased and then leveled off upon increasing FGD gypsum application. However, mercury in roots and leaves was generally increased upon increasing FGD gypsum application rates. Some mercury was likely absorbed by leaves of plants from emitted mercury in the atmosphere. | Kelin Wang William Orndorff Yan Cao Weiping Pan | 2013 | Journal of Environmental Sciences2013，25，9： | 4 |
| 7 | Distribution and sources of heavy metals in the sediment of Xiangshan Bay显示文摘Heavy metals in the surface sediments and sediment core from the Xiangshan Bay, a mariculture base on the coast of the East China Sea, were determined by inductively coupled plasma mass spectrometry(ICP–MS) in order to evaluate their levels and sources. The results showed that the levels of Cu, Pb, Zn, and Cr in the sediments of the bay have been generally influenced by anthropogenic inputs since the founding of the People's Republic of China. In particular, Cu and Zn were polluted to some extent, as evidenced by high enrichment factors. Organic matter, grain size, wastewater discharge, and low energy hydrodynamic environment played dominant roles in the heavy metal enrichment in the sediments. The ratio of terrigenous source to marine biogenic deposit of trace metals in the sediments was calculated, revealing that terrigenous inputs were the main source of Cu, Pb, and Zn, while biological pellets contributed much more to the enrichment of Cr and Cd. Considering the influence of biological sources on the enrichment of Cd and Cr, and the fact that the sediment has been polluted by Cu and Zn, the development of mariculture and discharge of wastewater into the Bay should be restricted. | SUN Weiping YU Jianjun XU Xiaoqun ZHANG Weiyan LIU Ruijuan PAN Jianming | 2014 | Acta Oceanologica Sinica2014，33，4： | 4 |
| 8 | 煤粉炉烟气中汞浓度测试和分布(英文)显示文摘参照美国标准实验方法(ASTM)中关于汞的OHM等速取样和化学分析法,结合汞的SCEM在线测量技术,利用一多功能流动实验室,对一满负荷运行的100MW煤粉锅炉尾部烟气系统进行了单质汞、氧化态汞和颗粒态汞的现场测试和分析.得到了空气预热器、静电除尘器前后烟气中气态、固态和烟气中总汞的浓度及其分布.结果表明烟气中气态总汞的浓度随温度的降低发生着氧化态汞向颗粒汞的转化.在ESP之后的清洁烟气中,OHM和SCEM方法的测试结果吻合较好;在含颗粒浓度较高的烟气中,2种方法存在较大的偏差,原因在于OHM取样过滤器中形成一定厚度的飞灰.该飞灰颗粒对烟气中气态汞有吸附作用并形成颗粒汞. | 段钰锋 Cao Yan Shawn Kellie Kunlei Liu John Riley Weiping Pan | 2005 | Journal of Southeast University(English Edition)2005，21，1： | 3 |
| 9 | Impact of pathological response after preoperative transcatheter arterial chemoembolization(TACE)on incidences of microvascular invasion and early tumor recurrence in hepatocellular carcinoma:a multicenter propensity score matching analysis显示文摘Background:To study the influence of pathological responses(PR)after transcatheter arterial chemoembolization(TACE)on incidences of microvascular invasion(MVI)and early recurrence in hepatocellular carcinoma(HCC)patients.Methods:Between 2013 to 2015,consecutive HCC patients who underwent liver resection with“curative”intent at three hospitals were enrolled in this study.Patients with different areas of PR after preoperative TACE were compared with those without preoperative TACE on the incidences of MVI,early recurrence rates and patterns of recurrence before and after propensity score matching(PSM).Results:Of 1,970 patients,737 patients who received preoperative TACE were divided into three groups according to the areas of PR:≥90%(n=226),60-90%(n=447),and<60%(n=64).PR≥90%was an independent protective factor of incidences of MVI[odds ratio(OR),0.144;95%confidence interval(CI),0.082-0.245,P<0.001)and early recurrence(HR,0.742;95%CI,0.561-0.963,P=0.032);while PR<60%was an independent risk factor of incidences of MVI(OR,6.076;95%CI,3.004-11.728,P<0.001)and early recurrence(HR,1.428;95%CI,1.095-1.929;P=0.009).Furthermore,patients with PR<60%were significantly more likely to develop multiple intrahepatic recurrences involving multiple hepatic segments when compared with patients without preoperative TACE.Conclusions:This study indicated the area of PR after TACE was closely associated with the incidences of MVI and early tumor recurrence.Patients with PR<60%were at significantly higher risks of having more MVI,early and multiple tumor recurrences. | Yun Yang Zheng Dang Peng Lu Youwen Qian Kongying Lin Zeya Pan Wan Yee Lau Weiping Zhou | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 2 |
| 10 | Serum C-Reactive Protein and Risk of Cardiovascular Events in Middle-Aged and Older Chinese Population显示文摘 | Shan Jiang Yuqian Bao Xuhong Hou Qichen Fang Chen Wang Jiemin Pan Yuhua Zuo Wenhong Zhong Kunsan Xiang Weiping Jia | 2009 | The American Journal of Cardiology2009，，12： | 2 |
| 11 | Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women显示文摘 | Rong Yang Xiaojing Ma Xiaoping Pan Feifei Wang Yuqi Luo Chengchen Gu Yuqian Bao Weiping Jia | 2013 | Menopause: The Journal of The North American Menopause Society2013，，5： | 1 |
| 12 | Impact of reclaimed water irrigation on soil health in urban green areas显示文摘 | CHEN Weiping LU Sidan PAN Neng | 2015 | Chemosphere2015，119，： | 1 |
| 13 | Thermal analytical characterization of carbon/carbon hybrid material,apple woodceramics显示文摘 | Ozao R Nishimoto Y Pan Weiping | 2006 | Thermochimica Acta2006，440，： | 1 |
| 14 | Polycyclic aromatic hydrocarbon (PAH) emissions from a coal-fired pilot FBC system显示文摘 | Kunlei Liu Wenjun Han Weiping Pan | 2001 | Journal of Hazardous Materious2001，84，： | 1 |
| 15 | AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism显示文摘Type 2 diabetes mellitus(T2 DM) is a common metabolic disease influenced by both genetic and environmental factors. In this study, we performed an in-house genotyping and meta-analysis study using three independent GWAS datasets of T2 DM and found that rs3743121, located 1 kb downstream of AQR,was a novel susceptibility SNP associated with T2 DM. The risk allele C of rs3743121 was correlated with the increased expression of AQR in white blood cells, similar to that observed in T2 DM models. The knockdown of AQR in HepG2 facilitated the glucose uptake, decreased the expression level of PCK2,increased the phosphorylation of GSK-3β, and restored the insulin sensitivity. Furthermore, the suppression of AQR inhibited the mTOR pathway and the protein ubiquitination process. Our study suggests that AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism. | Chun Song Han Yan Hanming Wang Yan Zhang Huiqing Cao Yiqi Wan Lingbao Kong Shenghan Chen Hong Xu Bingxing Pan Jin Zhang Guohuang Fan Hongbo Xin Zicai Liang Weiping Jia Xiao-Li Tian | 2018 | Journal of Genetics and Genomics2018，45，2： | 1 |
| 16 | Investigation of chemical-looping combustion by solid fuels(2):Redox reaction kinetics and product characterization with coal,biomass,and solid waste as solid fuels and CuO as an oxygen carrier显示文摘 | Cao Yah Cascnas Bianca Pan Weiping | 2006 | Energy & Fuels2006，20，5： | 1 |
| 17 | Behavior of chloride during coal combustion in an AFBC system显示文摘 | Xie Wei Pan Weiping John T R | 1999 | Energy Fuels1999，13，3： | 1 |
| 18 | Enantioselectivity in Estrogenic Potential and Uptake of Bifenthrin显示文摘 | Lumei Wang Weiping Liu Caixia Yang Zhiyan Pan Jianying Gan Chao Xu Meirong Zhao and Daniel Schlenk | 2007 | Environmental Science & Technology2007，41，17： | 1 |
| 19 | Cluster analysis: Unsupervised learning via supervised learning with a non- convex penalty 显示文摘 | Pan Weip Shen Xiaotong Liu Binghui | 2013 | Journal of Machine Learning Research2013，14，4： | 1 |
| 20 | Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride显示文摘 | Huating Li Qichen Fang Fei Gao Jia Fan Jian Zhou Xiaoying Wang Huizhen Zhang Xiaoping Pan Yuqian Bao Kunsan Xiang Aimin Xu Weiping Jia | 2010 | Journal of Hepatology2010，，5： | 1 |
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