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| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 3 | An overview of the use of plastic-film mulching in China to increase crop yield and water-use efficiency显示文摘Since 1990,crop yields have stagnated in many parts of the world,posing a significant challenge to global food security[1].As such;innovative solutions are needed to increase the resource-use efficiency of cropping systems to produce more grains per unit area. | Dongbao Sun Haigang Li Enli Wang Wenqing He Weiping Hao Changrong Yan Yuzhong Li Xurong Mei Yanqing Zhang Zhanxiang Sun Zhikuan Jia Huaiping Zhou Tinglu Fan Xucheng Zhang Qin Liu Fengju Wang Chaochun Zhang Jianbo Shen Qingsuo Wang Fusuo Zhang | 2020 | National Science Review2020，7，10： | 19 |
| 4 | Cigarette Smoking Increases Risk for Incident Metabolic Syndrome in Chinese Men—Shanghai Diabetes Study显示文摘Objective To determine whether smoking increases the risk for developing metabolic syndrome (MetS) in Chinese men.Methods A total of 693 men with no MetS at baseline were followed for 2.9‐5.5 years.Subjects were divided into nonsmokers,ex‐smokers,and current smokers according to baseline smoking status.Results After adjusting for age,education level,alcohol intake,fasting plasma insulin,HOMA‐IR index,and BMI at baseline and weight change,current smokers were dose‐dependently associated with increased risk for developing new MetS compared with nonsmokers.The odds ratio (OR) was 2.131 (95% CI,1.264,3.592;P<0.01) for the NCEPIII definition or 3.083 (95% CI,1.807,5.295;P<0.01) for the JCDCG definition of MetS.Ex‐smokers who had quit for ≥13 years significantly decreased the risk for developing new MetS defined by the JCDCG definition.Compared with nonsmokers,current smokers were significantly associated with increased incidence of hypertriglyceridemia and low HDL‐C.Conclusion Smoking is a risk factor for developing MetS in Chinese men after adjusting for age,education level,alcohol intake,fasting plasma insulin,HOMA‐IR,BMI,and weight change.This could be due to an increased incidence of dyslipidemia.Smoking cessation for >13 years decreased the risk for developing MetS defined by the JCDCG definition. | ZHU YunXia ZHANG MingLiang HOU XuHong LU JunXi PENG LiangPu GU HuiLin WANG Chen JIA WeiPing | 2011 | Biomedical and Environmental Sciences2011，24，5： | 13 |
| 5 | Obesity in China: its characteristics, diagnostic criteria, and implications显示文摘 | Weiping Jia | 2015 | Frontiers of Medicine2015，9，2： | 13 |
| 6 | The IRE1α-XBP1 pathway regulates metabolic stressinduced compensatory proliferation of pancreatic β-cells显示文摘 | Tongfu Xu Liu Yang Cheng Yan Xiaoxia Wang Ping Huang Feng Zhao Liyun Zhao Mingliang Zhang Weiping Jia Xiangdong Wang Yong Liu | 2014 | Cell Research2014，24，9： | 8 |
| 7 | Whole-exome sequencing identifies a novel INS mutation causative of maturity-onset diabetes of the young 10显示文摘 | Jing Yan Feng Jiang Rong Zhang Tongfu Xu Zhou Zhou Wei Ren Danfeng Peng Yong Liu Cheng Hu Weiping Jia | 2017 | Journal of Molecular Cell Biology2017，9，5： | 7 |
| 8 | Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy显示文摘Objective:Hepatocellular carcinoma(HCC),the main type of liver cancer,has a high morbidity and mortality,and a poor prognosis.RNA helicase DDX5,which acts as a transcriptional co-regulator,is overexpressed in most malignant tumors and promotes cancer cell growth.Heat shock protein 90(HSP90)is an important molecular chaperone in the conformational maturation and stabilization of numerous proteins involved in cell growth or survival.Methods:DDX5 m RNA and protein expression in surgically resected HCC tissues from 24 Asian patients were detected by quantitative real-time PCR and Western blot,respectively.The interaction of DDX5-HSP90 was determined by molecular docking,immunoprecipitation,and laser scanning confocal microscopy.The autophagy signal was detected by Western blot.The cell functions and signaling pathways of DDX5 were determined in 2 HCC cell lines.Two different murine HCC xenograft models were used to determine the function of DDX5 and the therapeutic effect of an HSP90 inhibitor.Results:HSP90 interacted directly with DDX5 and inhibited DDX5 protein degradation in the AMPK/ULK1-regulated autophagy pathway.The subsequent accumulation of DDX5 protein induced the malignant phenotype of HCC by activating theβ-catenin signaling pathway.The silencing of DDX5 or treatment with HSP90 inhibitor both blocked in vivo tumor growth in a murine HCC xenograft model.High levels of HSP90 and DDX5 protein were associated with poor prognoses.Conclusions:HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation.DDX5 and HSP90 are therefore potential therapeutic targets for HCC. | Ting Zhang Xinrui Yang Wanping Xu Jing Wang Dawei Wu Zhixian Hong Shengxian Yuan Zhen Zeng Xiaodong Jia Shanshan Lu Rifaat Safadi Sen Han Zhihong Yang Leonard M.Neckers Suthat Liangpunsakul Weiping Zhou Yinying Lu | 2021 | Cancer Biology & Medicine2021，18，3： | 7 |
| 9 | Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway显示文摘Oxidative stress induced by free fatty acid aggravates endothelial injury,which leads to diabeti cardiovascular complications.Reduction of intracellular oxidative stress may attenuate these pathogeni processes.The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelia injury.This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation o reactive oxygen species (ROS)and further explored the underlying molecular mechanisms.We found tha resveratrol significantly reduced the PA-induced endothelial ROS levels in human aortic endothelial cells Resveratrol also induced endothelial cell autophagy,which mediated the effect of resveratrol on ROS reduction Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway.Taketogether,these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway.Thus,the induction of autophagy by resveratrol may provide a novel therapeuti candidate for cardioprotection in metabolic syndrome. | Jun Song Yeping Huang Wenjian Zheng Jing Yan Min Cheng Ruxing Zhao Li Chen Cheng Hu Weiping Jia | 2018 | Frontiers of Medicine2018，12，6： | 7 |
| 10 | miRNAs in non-alcoholic fatty liver disease显示文摘 | Zhen He Cheng Hu Weiping Jia | 2016 | Frontiers of Medicine2016，10，4： | 7 |
| 11 | Early-onset diabetes:an epidemic in China显示文摘Although type 2diabetes is a disease often associated with aging,the global prevalence of early-onset diabetes has been increasing due to man's sedentary lifestyle,low-physical activity,obesity,and some non- modifiable risk factors.Many studies have found that individuals with early-onset type 2diabetes were at higher risk of developing vascular complications than those with late-onset diabetes.Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health,which results in poor glycemic control and the delayed detection of diabetes-related complications.Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2diabetes.Therefore, focusing on this particular population is critical for the government and academic societies.Screening for T2DM is imminent for young adults with a family history of diabetes,obesity,markers of insulin resistance,or alcohol consumption.More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes. | Jiemin Pan Weiping Jia | 2018 | Frontiers of Medicine2018，12，6： | 7 |
| 12 | Altered intestinal microbiota associated with colorectal cancer显示文摘The gut microbiota plays an important role in the development and progression of colorectal cancer (CRC). To learn more about the dysbiosis of carcinogenesis, we assessed alterations in gut microbiota in patients with CRC. A total of 23 subjects were enrolled in this study: 9 had CRC (CRC group) and 14 had normal colons (normal group). The microbiome of the mucosal-luminal interface of each subject was sampled and analyzed using 16S rRNA gene amplicon sequencing. We also used Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) to predict microbial functional profiles. The microbial composition of the mucosal lumen differed between the groups, and the presence of specific bacteria may serve as a potential biomarker for colorectal carcinogenesis. We identified a significant reduction in Eubacterium, which is a butyrate-producing genera of bacteria, and a significant increase in Devosia in the gut microbiota of CRC patients. Different levels of gut microflora in healthy and CRC samples were identified. The observed abundance of bacterial species belonging to Eubacterium and Devosia may serve as a promising biomarker for the early detection of CRC. | Hong Zhang Ying Chang Qingqing Zheng Rong Zhang Cheng Hu Weiping Jia | 2019 | Frontiers of Medicine2019，13，4： | 6 |
| 13 | Effects and mechanisms of berberine in diabetes treatment显示文摘Berberine from Rhizoma Coptidis is an oral hypoglycemic agent with anti-dyslipidemia and anti-obesity activities.Its metabolic activity of regulating blood glucose and lipids has been widely studied and evidenced in patients and various animal models.Berberine is known as an AMP-activated protein kinase(A MPK)activator.Its insulin-independent hypoglycemic effect is.related to inhibition of mitochondrial function,stimulation of glycolysis and activation of AMPK pathway.Additionally,berberine may also act as an x-glucosidase inhibitor.In the newly-diagnosed type 2 diabetic patients,berberine is able to lower blood insulin level via enhancing insulin sensitivity.However,in patients with poorβ-cell function,berberine may improve insulin secretion via resuscitating exhausted islets.Furthermore,berberine may have extra beneficial effects on diabetic cardiovascular complications due to its cholesterol-lowering,anti arrhythmias and nitric oxide(NO)inducing properties.The antioxidant and aldose reductase inhibitory activities of berberine may be useful in alleviating dia betic nephropathy.Although evidence from animal and human studies consistently supports the therapeutic activities of berberine,large-scale multicenter trials are still necessary to evaluate the efficacy of berberine on diabetes and its related complications. | Jun Yin Jianping Ye Weiping Jia | 2012 | Acta Pharmaceutica Sinica B2012，2，4： | 5 |
| 14 | Regulation of microbiota–GLP1 axis by sennoside A in diet-induced obese mice显示文摘Sennoside A(SA) is a bioactive component of Chinese herbal medicines with an activity of irritant laxative, which is often used in the treatment of constipation and obesity. However, its activity remains unknown in the regulation of insulin sensitivity. In this study, the impact of SA on insulin sensitivity was tested in high fat diet(HFD)-induced obese mice through dietary supplementation. At a dosage of 30 mg/kg/day, SA improved insulin sensitivity in the mice after 8-week treatment as indicated by HOMA-IR(homeostatic model assessment for insulin resistance) and glucose tolerance test(GTT). SA restored plasma level of glucagon-like peptide 1(GLP1) by 90% and mRNA expression of Glp1 by 80% in the large intestine of HFD mice. In the mechanism, SA restored the gut microbiota profile, short chain fatty acids(SCFAs), and mucosal structure in the colon. A mitochondrial stress was observed in the enterocytes of HFD mice with ATP elevation, structural damage, and complex dysfunction. The mitochondrial response was induced in enterocytes by the dietary fat as the same responses were induced by palmitic acid in the cell culture. The mitochondrial response was inhibited in HFD mice by SA treatment. These data suggest that SA may restore the function of microbiota–GLP1 axis to improve glucose metabolism in the obese mice. | Jiamei Le Xiaoying Zhang Weiping Jia Yong Zhang Juntao Luo Yongning Sun Jianping Ye | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 15 | Flexible heteroatom-doped porous carbon nanofiber cages for electrode scaffolds显示文摘Porous carbon nanofibers(PCNFs)with rich functionalities and high surface areas are important electrode scaffolds to load active materials,but increasing their pore volumes and strength simultaneously is a challenge.Here,we report a scalable method to fabricate B-F-N triply doped PCNF cages with high porosity of greater than 92.8%and small bending stiffness of 10 mN by electrospinning the mixed sol of poly(tetrafluoroethylene),poly(vinyl alcohol),boric acid,and carbon nanotubes(CNTs)followed by pyrolysis.The macromicro dual-phase separation creates well-controlled macropores(>60 nm)and meso-micropores with large pore volumes(0.55 cm3/g)on carbon nanofibers,while the interior CNTs can cushion the applied stress and render the PCNF films with superior flexibility.Fabricated symmetrical supercapacitors with the PCNF cages exhibit high gravimetric capacitance of 164 F/g at 20 mV/s and 92.5%capacity retention after 20000 cycles at 2 A/g.The reported approach allows the green synthesis of a new PCNF scaffold material with properties appealing for applications. | Weiping Cai Yuanyuan Zhang Yongtang Jia Jianhua Yan | 2020 | Carbon Energy2020，2，3： | 4 |
| 16 | Facile shape and size-controlled growth of uniform magnetite and hematite nanocrystals with tunable properties显示文摘Monodispersed magnetite Fe3O4 and hematite α-Fe2O3 nanocrystals have been grown in co-solvents of alcohol and water. Either the shape or the size of the nanocrystals could be easily controlled. Both the phases and nanostructures have been characterized by powder X-ray diffraction patterns and electron microscopy. The magnetic and catalytic properties of these products were investigated and compared with each other. The obtained results clearly demonstrate that these iron oxide nanocrystals are soft ferromagnetic at room temperature and α-Fe2O3 has a more effective catalytic property on the thermal decomposition of ammonium perchlorate than Fe3O4. Based on the experimental data, it is proposed that the magnetic and catalytic properties of these nanocrystals are dependent not only on the size and shape, but also on the surface structure of the nanocrystals. The nanoplates with significant anisotropic nanostructure demonstrate a highly enhanced performance as compared to nanoparticles. | CHEN LiQiao LIU WeiPing CHEN JiaLin YANG XianFeng LIU Jia FU XiongHui WU MingMei | 2011 | Science China Chemistry2011，54，6： | 4 |
| 17 | Radiation segmentectomy for hepatic malignancies: Indications, devices,dosimetry, procedure, clinical outcomes, and toxicity of yttrium-90 microspheres显示文摘Radiation segmentectomy(RS) is a new approach to90 Y radioembolization that has been designed to increase the safety and efficacy of radioembolization in patients with unresectable hepatic malignancies. With this technique,high doses(>190 Gy) of radiation are delivered to the tumor through radioembolization performed in a segmental fashion, potentially increasing the radiation dose to the tumor while minimizing injury to the liver parenchyma. The aim of this review is to provide a summary of the indications, device choice, dosimetry, procedure, clinical outcomes, and toxicity of RS based on the clinical series currently available. | Zhongzhi Jia Caoye Wang Ricardo Paz-Fumagalli Weiping Wang | 2019 | Journal of Interventional Medicine2019，2，1： | 3 |
| 18 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 19 | A proposed direct measurement of cross section at Gamow window for key reaction 19F(p,α) 16O in Asymptotic Giant Branch stars with a planned accelerator in CJPL显示文摘In 2014, the National Natural Science Foundation of China(NSFC) approved the Jinping Underground Nuclear Astrophysics laboratory(JUNA) project, which aims at direct cross-section measurements of four key stellar nuclear reactions right down to the Gamow windows. In order to solve the observed fluorine overabundances in Asymptotic Giant Branch(AGB) stars, measuring the key ^(19)F( p,α)^(16)O reaction at effective burning energies(i.e., at Gamow window) is established as one of the scientific research sub-projects. The present paper describes this sub-project in details, including motivation, status, experimental setup, yield and background estimation, aboveground test, as well as other relevant reactions. | JianJun He ShiWei Xu ShaoBo Ma Jun Hu LiYong Zhang ChangBo Fu NingTao Zhang Gang Lian Jun Su YunJu Li ShengQuan Yan YangPing Shen SuQing Hou BaoLu Jia Tao Zhang XiaoPeng Zhang Bing Guo Shigeru Kubono WeiPing Liu | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，5： | 3 |
| 20 | A Privacy Protection Strategy for Source Location in WSN Based on Angle and Dynamical Adjustment of Node Emission Radius显示文摘We propose two novel methods to improve the source location privacy security protection and the node energy utilization in Wireless sensor networks(WSN).A privacy preservation protocol for source location in WSN based on angles(APS) and an Enhanced protocol for source location(EAPS),which dynamically adjusts emission radius during routing.The APS protocol produces geographically dispersed phantom source nodes and utilizes the energy from the energy-abundant regions to make the routing path versatile among the entire network.In the EAPS protocol,according to the number of its own adjacent nodes,residual energy and the distance to the base station,a node adjusts its radius adaptively.Experiments show that the two novel protocols can improve the security and take advantage of the residual energy in the network balance the network life and energy consumption in comparison with the existing routing protocols based on the phantom sources. | JIA Zongpu WEI Xiaojuan GUO Hairu PENG Weiping SONG Cheng | 2017 | Chinese Journal of Electronics2017，26，5： | 3 |
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