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| 1 | Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。 | Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie | 2011 | Cell Research2011，21，10： | 23 |
| 2 | Efficacy and safety evaluation of icotinib in patients with advanced non-small cell lung cancer显示文摘Objective: To evaluate the efficacy and safety of icotinib hydrochloride in patients with advanced non-small cell lung cancer (NSCLC). Methods: A total of 89 patients with stage ⅢB or IV NSCLC received icotinib at a dose of 125 mg administered 3 times a day. Icotinib treatment was continued until disease progression or development of unacceptable toxicity. Results: A total of 89 patients were assessable. In patients treated with icotinib, the overall response rate (RR) was 36.0% (32/89), and the disease control rate (DCR) was 69.7% (62/89). RR and DCR were significantly improved in patients with adenocarcinoma versus non-adenocarcinoma (P<0.05). The symptom improvement rate was 57.3% (51/89), and the main symptoms improved were cough, pain, chest distress, dyspnea, and Eastern Cooperative Oncology Group performance status. The main toxic effects were rash [30/89 (33.7%)] and diarrhea [15/89 (16.9%)]. The level of toxicity was typically low. Conclusions: The use of icotinib hydrochloride in the treatment of advanced NSCLC is efficacious and safe, and its toxic effects are tolerable. | Aiqin Gu Chunlei Shi Liwen Xiong Tianqing Chu Jun Pei Baohui Han | 2013 | Chinese Journal of Cancer Research2013，25，1： | 22 |
| 3 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 4 | Deterministic secure quantum communication over a collective-noise channel显示文摘We present two deterministic secure quantum communication schemes over a collective-noise. One is used to complete the secure quantum communication against a collective-rotation noise and the other is used against a collective-dephasing noise. The two parties of quantum communication can exploit the correlation of their subsystems to check eavesdropping efficiently. Although the sender should prepare a sequence of three-photon entangled states for accomplishing secure communication against a collective noise,the two parties need only single-photon measurements,rather than Bell-state measurements,which will make our schemes convenient in practical application. | GU Bin PEI ShiXin SONG Biao ZHONG Kun | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 20 |
| 5 | EXPERIMENTAL STUDY OF FLOWFIELD STRUCTURE AROUND AN OGIVE-CYLINDER显示文摘The flowfield structure and their aerodynamic characteristics over an ogive cylinder were studied by means of flow visualization and surface pressure measurement in a water tunnel and a wind tunnel. The existence of multi asymmetric vortices over long slender bodies was experimentally confirmed at large angles of attack and in the subcritical Reynolds number range. The spatial 3 D characteristics of the multi vortices system were analyzed and a physical model was developed. The topological structure of different patterns in cross flow plane was studied and the mechanism governing the formation of asymmetric vortices and multi vortices was discussed from the viewpoint of stability of the topological structure. It was concluded that the maximum in the sectional side force distribution curve are not caused by the shedding of higher position vortex, but by the cross over to the symmetric plane of the lower position vortex. | Ph.D.Candidate:Wang Gang Fluid Mechanics Institute, Beijing University of Aeronautics and Astronautics, Beijing 100083, China,Supervisor: Deng Xue ying (Beijing University of Aeronautics and Astronautics) Members of Dissertation Defense Committee: Tong Bing gang (Graduate School of the Chinese Academy of Sciences),Chairman Gu Zhi fu (Peking University) Yang Qi de (China Aerodynamics Research and Development Center) Lv Zhi yong (Beijing University of Aeronautics and Astronautics) Liu Pei qing (Beijing University of Aeronautics and Astronautics) | 2003 | Journal of Hydrodynamics2003，15，5： | 18 |
| 6 | Long-term Efficacy of Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease: A 5-year Follow-up Study in China显示文摘 | Lu-Lu Jiang Jin-Long Liu Xiao-Li Fu Wen-Biao Xian Jing Gu Yan-Mei Liu Jing Ye Jie Chen Hao Qian Shao-Hua Xu Zhong Pei Ling Chen | 2015 | Chinese Medical Journal2015，，18： | 13 |
| 7 | Effect of oxymatrine on specific cytotoxic T lymphocyte surface programmed death receptor-1 expression in patients with chronic hepatitis B显示文摘 | GU Xi-bing YANG Xiao-juan HUA Zhong LU Zhong-hua ZHANG Bo ZHU Yin-fang WU Hang-yuan JIANG Yi-ming CHEN Hao-kun PEI Hao | 2012 | Chinese Medical Journal2012，，8： | 11 |
| 8 | Combination of mild therapeutic hypothermia and adipose-derived stem cells for ischemic brain injury显示文摘Mild therapeutic hypothermia has been shown to mitigate cerebral ischemia, reduce cerebral edema, and improve the prognosis of patients with cerebral ischemia. Adipose-derived stem cell-based therapy can decrease neuronal death and infiltration of inflammatory cells, exerting a neuroprotective effect. We hypothesized that the combination of mild therapeutic hypothermia and adipose-derived stem cells would be neuroprotective for treatment of stroke. A rat model of transient middle cerebral artery occlusion was established using the nylon monofilament method. Mild therapeutic hypothermia(33°C) was induced after 2 hours of ischemia. Adipose-derived stem cells were administered through the femoral vein during reperfusion. The severity of neurological dysfunction was measured by a modified Neurological Severity Score Scaling System. The area of the infarct lesion was determined by 2,3,5-triphenyltetrazolium chloride staining. Apoptotic neurons were detected by terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The regeneration of microvessels and changes in the glial scar were detected by immunofluorescence staining. The inflammatory responses after ischemic brain injury were evaluated by in situ staining using markers of inflammatory cells. The expression of inflammatory cytokines was measured by reverse transcription-polymerase chain reaction. Compared with mild therapeutic hypothermia or adipose-derived stem cell treatment alone, their combination substantially improved neurological deficits and decreased infarct size. They synergistically reduced the number of TUNEL-positive cells and glial fibrillary acidic protein expression, increased vascular endothelial growth factor levels, effectively reduced inflammatory cell infiltration and down-regulated the m RNA expression of the proinflammatory cytokines interleukin-1β, tumor necrosis factor-α and interleukin-6. Our findings indicate that combined treatment is a better approach for treating stroke compared with mild therapeutic hypothermia or adipose-derived stem cells alone. | Kai Zhao Rui Li Sheng Bi Yu Li Long Liu Yu-Long Jia Peng Han Chang-Cong Gu Xi-Ze Guo Wan-Ping Zhang Chun Wang Chun-Ying Pei Lin-Lu Tian Li-Xian Li | 2018 | Neural Regeneration Research2018，13，10： | 9 |
| 9 | Manipulation of Band Degeneracy and Lattice Strain for Extraordinary PbTe Thermoelectrics显示文摘Maximizing band degeneracy and minimizing phonon relaxation time are proven to be successful for advancing thermoelectrics.Alloying with monotellurides has been known to be an effective approach for converging the valence bands of PbTe for electronic improvements,while the lattice thermal conductivity of the materials remains available room for being further reduced.It is recently revealed that the broadening of phonon dispersion measures the strength of phonon scattering,and lattice dislocations are particularly effective sources for such broadening through lattice strain fluctuations.In this work,a fine control of MnTe and EuTe alloying enables a significant increase in density of electron states near the valence band edge of PbTe due to involvement of multiple transporting bands,while the creation of dense in-grain dislocations leads to an effective broadening in phonon dispersion for reduced phonon lifetime due to the large strain fluctuations of dislocations as confirmed by synchrotron X-ray diffraction.The synergy of both electronic and thermal improvements successfully leads the average thermoelectric figure of merit to be higher than that ever reported for p-type PbTe at working temperatures. | Yixuan Wu Pengfei Nan Zhiwei Chen Zezhu Zeng Siqi Lin Xinyue Zhang Hongliang Dong Zhiqiang Chen Hongkai Gu Wen Li Yue Chen Binghui Ge Yanzhong Pei | 2020 | Research2020，，1： | 6 |
| 10 | A new single-cell protein from Clostridium autoethanogenum as a functional protein for largemouth bass(Micropterus salmoides)显示文摘Clostridium autoethanogenum protein(CAP)is a new single-cell protein source originating from inactivated bacteria.An in vitro digestion experiment and an 8-wk growth experiment were conducted to evaluate the molecular weight distribution of the CAP hydrolysate,and the effects of dietary CAP levels on the growth performance,plasma parameters,hepatic and intestinal health,and the diversity of gutadherent microbiota of largemouth bass(Micropterus salmoides).The fish(initial body weight of 47.99±0.01 g)were fed diets where CAP gradually replaced 0%(CAP0),12.5%(CAP12.5),25%(CAP25),37.5%(CAP37.5)and 50%(CAP50)of low-temperature steam dried anchovy fish meal(LTFM)in the diet.Results showed that the content of peptides below 1,000 Da in the CAP hydrolysate(0.56 mg/mL)was higher than that of the LTFM hydrolysate(0.48 mg/mL).Dietary CAP inclusion had no negative effect on growth performance,while whole-body lipid content significantly reduced in the CAP25 and CAP50 groups(P<0.05).The plasma alanine aminotransferase activities and triglyceride concentrations in the CAP inclusion groups were significantly lower than those in the CAP0 group(P<0.05).The plasma aspartate aminotransferase activity was significantly reduced in the CAP37.5 group(P<0.05).The richness and diversity of the gut-adhesive microbiota and the proportion of Clostridium sensu stricto 12 in the CAP50 group were significantly higher than those in the CAP0 group(P<0.05).Dietary CAP inclusion inhibited inflammatory responses by down-regulating the mRNA levels of interleukin 1b(IL1b),IL10 and transforming growth factor b1(P<0.05)in the liver.The mRNA levels of acetyl-CoA carboxylase 1 were significantly down-regulated in the CAP12.5,CAP25 and CAP37.5 groups(P<0.05),while that of fatty acid synthase was significantly down-regulated in the CAP50 group(P<0.05).These results demonstrate that dietary CAP inclusion could improve the hepatic and intestinal health of largemouth bass,and can be helpful to further develop CAP as a functional feed ingredient. | Shifeng Ma Xiaofang Liang Pei Chen Jie Wang Xu Gu Yuchang Qin Christophe Blecker Min Xue | 2022 | Animal Nutrition2022，，3： | 6 |
| 11 | Prostate cancer risk and aggressiveness associated with the CYPIB1 4326C/G (Leu432Val) polymorphism: a meta-analysis of 2788 cases and 2968 controls显示文摘为了导出在细胞色素 P450 1B1 (CYP1B1 ) 之间的协会的一个精确评价, 4326C/G 变体和前列腺癌症(PCa ) 冒险或攻击性,元分析用所有合格出版研究被执行。有 95 % 的机会比率(ORs ) ;信心间隔(CI ) 被估计与 2788 个盒子和 2968 控制在七文学研究估计协会。在全面分析,没有重要协会在 4326C/G 多型性和 PCa 风险,而是种族亚群分析的 CYP1B1 之间被发现,盒子来源分析揭示了重要协会。4326G 等位基因在亚洲人与增加的 PCa 风险显示出一个重要协会(OR=1.52, 95 %CI:1.20-1.92 ) ,并且重要协会也在异质接合体比较被观察(OR=1.40, 95 %CI:1.03-1.89 ) ,同质接合体比较(OR=2.38, 95 %CI:1.31-4.33 ) 并且在一个主导的基因模型(OR=1.52, 95 %CI:1.14-2.01 ) 。而且, 4326G 等位基因显著地也与分散的 PCa 的增加的风险被相关(OR=1.13, 95 %CI:1.04-1.24 ) ,并且重要协会在异质接合体比较被观察(OR=1.16, 95 %CI:1.02-1.33 ) ,同质接合体比较(OR=1.24, 95 %CI:1.03-1.49 ) 并且一个主导的基因模型(OR=1.19, 95 %CI:1.05-1.34 ) 。全面分析和所有亚群分析没显示出在 4326C/G 多型性和 PCa 攻击性之间的重要协会。我们的元分析证明那 CYP1B1 4326G 等位基因显著地在亚洲人并且在分散的 PCa 盒子中与增加的 PCa 风险被联系。 | Jie Yang Dong-Liang Xu Qiang Lu Zhi-Jian Han Jun Tao Pei Lu Chao Wang Xiao-Ke Di Min Gu | 2012 | Asian Journal of Andrology2012，14，4： | 5 |
| 12 | Unusual Patterns of Neural Tube Defects in a High Risk Region of Northern China显示文摘Objective To study the prevalence of different types of neural tube defects (NTDs) in Luliang Prefecture, Shanxi province, where the prevalence of NTDs is unusually high and the correlation between NTDs prevalence and patterns. Methods A surveillance population-based birth defects was performed in Luliang Prefecture, Shanxi province. Results The results of our study showed that the prevalence of NTDs was 2-fold higher in Luliang Prefecture than in other areas of Shanxi province. Unusual patterns of NTDs were found, however, multiple NTDs were relatively common in Luliang Prefecture, accounting for over 13% of all NTDs cases in China. Conclusion The prevalence of NTDs is associated with its patterns. | GONG CHEN LI-JUN PEI JIAN HUANG XIN-MING SONG LIANG-MING LIN XUE GU JIAN-XIN WU FANG WANG JI-LEI WU JIA-PENG CHEN JU-FEN LIU RUO-LEI XIN TING ZHANG XIAO-YING ZHENG | 2009 | Biomedical and Environmental Sciences2009，22，4： | 4 |
| 13 | The risks, degree of malignancy and clinical progression of prostate cancer associated with the MDM2 T309G polymorphism: a meta-analysis显示文摘为了决定风险,恶意的度和前列腺癌症(PCa ) 的临床的前进,把 2 蛋白质(MDM2 ) 与鼠标双分钟联系了 T309G 变体,元分析在所有合格出版研究上被执行。有 95 % 的机会比率(ORs ) ;信心间隔(CI ) 被估计在包括了 5151 个盒子和 1003 控制的七研究估计这些协会。在全面分析, 309G 等位基因显著地与减少的 PCa 风险被联系(OR=0.85, 95 %CI:0.74-0.97 ) ;这也是为同型结合的比较的盒子(OR=0.72, 95 %CI:0.55-0.95 ) 并且主导的基因模型(OR=0.79, 95 %CI:0.65-0.96 ) 。309G 等位基因也被发现显著地与 PCa 恶意的更低的度被联系(OR=0.85, 95 %CI:0.75-0.96 ) 在全面分析,以及在异质接合的比较(OR=0.79, 95 %CI:0.65-0.96 ) ,同型结合的比较(OR=0.76, 95 %CI:0.58-0.98 ) 并且主导的基因模型(OR=0.81, 95 %CI:0.68-0.96 ) 。而且,组织分析证明在白种人的 309G 等位基因显著地与减少的 PCa 风险被相关(OR=0.77, 95 %CI:0.61-0.96 ) ;这也是在同型结合的比较的盒子(OR=0.51, 95 %CI:0.31-0.86 ) 。组织分析也证明在白种人的 309G 变体显著地基因模型在所有与 PCa 恶意的更低的度被联系。另外,我们发现在白种人的 309G 变体显著地基因模型在所有与更慢的 PCa 临床的前进被联系。在摘要,我们的元分析证明 MDM2 309G 变体显著地在白种人与减少的 PCa 风险,更低的恶意的度和更慢临床的前进被联系,但是在亚洲人口没有明显的协会。 | Jie Yang Wen Gao Ning-Hong Song Wei Wang Jie-Xiu Zhang Pei Lu Li-Xin Hua Min Gu | 2012 | Asian Journal of Andrology2012，14，5： | 4 |
| 14 | Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis显示文摘Iloperidone 是被 CYP2D6, CYP3A4,和 cytosolic 酶主要使产生代射变化的不正常的抑制精神的药。以前的研究证明 CYP2D6 的广泛、差的 metabolizers 展出 iloperidone 和它的代谢物的不同血浆集中。这研究的目的是开发一个父母代谢物人口 pharmacokinetic (PPK ) 模型确定在中国精神分裂症 patients.Methods 的 iloperidone 和它的代谢物的 pharmacokinetics 上的 CYP2D6 *10 等位基因的效果:七十个中国精神分裂症病人被注册,从谁有限的血样品在 d 上被收集 15 (0 h ) 并且 d 28 (在药管理以后的 0, 4 和 12 h ) 。iloperidone 和它的代谢物 M 1(P-88 ) 和 M 2(P-95 ) 的血浆集中同时用验证 HPLCMS 试金被检测。CYP2D6 *10 (rs1065852 ) genotyping 被执行。一个 PPK 模型用 NONMEM 软件(版本 7.2 ) 从病人基于数据被开发。有一阶的吸收和消除的一个一个分隔空间模型被用来描述与 iloperidone 和它的 metabolites.Results 有关的 pharmacokinetic 数据:有 CYP2D6 *10 T/T 遗传型的病人与 C/C 或 C/T 遗传型比病人有 iloperidone 和 M 1, 的显著地更高的集中和 M 2 的更低的集中。CYP2D6 *10 遗传型为 iloperidone 的转变影响了消除常数到代谢物 M 1(K 23) 和 M 2(K 24) 。有 T/T 遗传型的病人的 K 23 价值是与 C/C 或 C/T 遗传型象病人的一样大的 1.34 褶层。分别地,有 C/T 和 T/T 遗传型的病人的 K 24 价值是 0.693-fold, 和 0.492 褶层象有 C/C genotype.Conclusion 的病人的一样低:CYP2D6 *10 变化在中国精神分裂症病人影响 iloperidone 和它的代谢物的 pharmacokinetics,建议为有 CYP2D6 *10 变化的病人的 iloperidone 的临床的剂量需要被优化。 | Qi PEI Lu HUANG Jie HUANG Jing-kai GU Yun KUANG Xiao-cong ZUO Jun-jie DING Hong-yi TAN Cheng-xian GUO Shi-kun LIU Guo-ping YANG | 2016 | Acta Pharmacologica Sinica2016，37，11： | 4 |
| 15 | An overview on the designs of distributed observers in LTI multi-agent systems显示文摘With the rapid development of information technologies and cloud computing, sensor networks play an increasingly important role in our society. Over the past few decades, distributed observer theory has attracted unprecedented attention due to its wide potential applications in different areas. Meanwhile, various approaches and algorithms have been proposed and investigated. The design of distributed observers is one of the frontier topics of system and control research, which has the significant theoretical values and broad application prospects. This paper attempts to review the representative models and the corresponding approaches for distributed observer design in linear time-invariant(LTI) systems. Firstly, the research backgrounds and main advances of distributed observer designs are briefly reviewed. Then, recent results of distributed observer designs for discrete-time and continuous-time LTI multi-agent systems(MASs) are introduced in detail, respectively. Finally, the prospects and the future work directions of the design of distributed observers are put forward. The main purpose of this paper is to promote the emerging topic on the designs of distributed observers, with focuses on the interdisciplinary interest from technological sciences. | PEI YingQing GU HaiBo LIU KeXin LU JinHu | 2021 | Science China(Technological Sciences)2021，64，11： | 3 |
| 16 | Bilateral adrenocortical adenomas causing adrenocorticotropic hormone-independent Cushing's syndrome: A case report and review of the literature显示文摘BACKGROUND Adrenocorticotropic hormone(ACTH)-independent Cushing's syndrome(CS) is mostly due to unilateral tumors, with bilateral tumors rarely reported. Its common causes include primary pigmented nodular adrenocortical disease,ACTH-independent macronodular adrenal hyperplasia, and bilateral adrenocortical adenomas(BAAs) or carcinomas. BAAs causing ACTHindependent CS are rare; up to now, fewer than 40 BAA cases have been reported. The accurate diagnosis and evaluation of BAAs are critical for determining optimal treatment options. Adrenal vein sampling(AVS) is a good way to diagnose ACTH-independent CS.CASE SUMMARY A 31-year-old woman had a typical appearance of CS. The oral glucose tolerance test showed impaired glucose tolerance and obviously increased insulin and Cpeptide levels. Her baseline serum cortisol and urine free cortisol were elevated and did not show either a circadian rhythm or suppression with dexamethasone administration. The peripheral 1-deamino-8-D-arginine-vasopressin(DDVAP)stimulation test showed a delay of the peak level, which was 1.05 times as high as the baseline level. Bilateral AVS results suggested the possibility of BAAs.Abdominal computed tomography showed bilateral adrenal adenomas with atrophic adrenal glands(right: 3.1 cm × 2.0 cm × 1.9 cm; left: 2.2 cm × 1.9 cm × 2.1 cm). Magnetic resonance imaging of the pituitary gland demonstrated normal findings. A left adenomectomy by retroperitoneoscopy was performed first,followed by resection of the right-side adrenal mass 3 mo later. Biopsy results of both adenomas showed cortical tumors. Evaluations of ACTH and cortisol showed a significant decrease after left adenomectomy but could still not be suppressed, and the circadian rhythm was absent. Following bilateral adenomectomy, this patient has been administered with prednisone until now,all of her symptoms were alleviated, and she had normal blood pressure without edema in either of her lower extremities.CONCLUSION BAAs causing ACTH-independent CS are rare. AVS is of great significance for obtaining information on the functional state of BAAs before surgery. | Yu-Lin Gu Wei-Jun Gu Jing-Tao Dou Zhao-Hui Lv Jie Li Sai-Chun Zhang Guo-Qing Yang Qing-Hua Guo Jian-Ming Ba Li Zang Nan Jin Jin Du Yu Pei Yi-Ming Mu | 2019 | World Journal of Clinical Cases2019，7，8： | 3 |
| 17 | Intestinal dysbiosis exacerbates the pathogenesis of psoriasis-like phenotype through changes in fatty acid metabolism显示文摘The intestinal microbiota has been associated with host immunity as well as psoriasis;however,the mechanism of intestinal microbiota regulating psoriasis needs to be demonstrated systematically.Here,we sought to examine its role and mechanism of action in the pathogenesis of psoriasis.We found that the severity of psoriasis-like skin phenotype was accompanied by changes in the composition of the intestinal microbiota.We performed co-housing and fecal microbial transplantation(FMT)experiments using the K14-VEGF transgenic mouse model of psoriasis and demonstrated that the transfer of intestinal microbiota from mice with severe psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms,including increasing the infiltration and differentiation of Th17,and increased the abundance of Prevotella,while decreasing that of Parabacteroides distasonis,in the colon.These alterations affected fatty acid metabolism,increasing the abundance of oleic and stearic acids.Meanwhile,gentamicin treatment significantly reduced the abundance of Prevotella and alleviated the psoriasis-like symptoms in both K14-VEGF mice and imiquimod(IMQ)-induced psoriasis-like mice.Indeed,administration of oleic and stearic acids exacerbated psoriasis-like symptoms and increased Th17 and monocyte-derived dendritic cell infiltration in the skin lesion areas in vivo,as well as increased the secretion of IL-23 by stimulating DCs in vitro.At last,we found that,treatment of PDE-4 inhibitor alleviated psoriasis-like phenotype of K14-VEGF mice accompanied by the recovery of intestinal microbiota,including the decrease of Prevotella and increase of Parabacteroides distasonis.Overall,our findings reveal that the intestinal microbiota modulates host metabolism and psoriasis-like skin inflammation in mice,suggesting a new target for the clinical diagnosis and treatment of psoriasis. | Qixiang Zhao Jiadong Yu Hong Zhou Xiaoyan Wang Chen Zhang Jing Hu Yawen Hu Huaping Zheng Fanlian Zeng Chengcheng Yue Linna Gu Zhen Wang Fulei Zhao Pei Zhou Haozhou Zhang Nongyu Huang Wenling Wu Yifan Zhou Jiong Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 2 |
| 18 | Dynamic Matching-Based Spectrum Detection in Cognitive Radio Networks显示文摘Cognitive Radio Network provides an opportunity to reduce the spectrum resource crisis by allowing secondary users to access the idle spectrum allocated to primary users. The precondition of spectrum sharing is to obtain the Spectrum Availability Information(SAI). Energy detection is a typical technology to get SAI. With the mobility of primary users, the energy received by secondary users varies greatly with the distance from the target primary users. Most of the existing energy detection algorithms that use fixed thresholds are not suitable. We propose a Dynamic Matching-Based Spectrum Detection(DMBSD) scheme which can detect sensing data, reduce the impact of malicious data and make final sensing results more accurate with dynamic threshold setting and data matching. Simulation results show that the proposed scheme can detect tempered data, and increase detection probability by decreasing false alarm probability and missed detection probability. | Yu Gu Qingqi Pei Hongning Li | 2019 | China Communications2019，16，4： | 2 |
| 19 | Origin of High Efficiency and Long-Term Stability in Ionic Liquid Perovskite Photovoltaic显示文摘Environment-friendly protic amine carboxylic acid ionic liquids(ILs)as solvents is a significant breakthrough with respect to traditional highly coordinating and toxic solvents in achieving efficient and stable perovskite solar cells(PSCs)with a simple one-step air processing and without an antisolvent treatment approach.However,it remains mysterious for the improved efficiency and stability of PSCs without any passivation strategy.Here,we unambiguously demonstrate that the three functions of solvents,additive,and passivation are present for protic amine carboxylic acid ILs.We found that the ILs have the capability to dissolve a series of perovskite precursors,induce oriented crystallization,and chemically passivate the grain boundaries.This is attributed to the unique molecular structure of ILs with carbonyl and amine groups,allowing for strong interaction with perovskite precursors by forming C=O…Pb chelate bonds and N-H…I hydrogen bonds in both solution and film.This finding is generic in nature with extension to a wide range of IL-based perovskite optoelectronics. | Lingfeng Chao Tingting Niu Hao Gu Yingguo Yang Qi Wei Yingdong Xia Wei Hui Shouwei Zuo Zhaohua Zhu Chengjie Pei Xiaodong Li Jing Zhang Junfeng Fang Guichuan Xing Hai Li Xiao Huang Xingyu Gao Chenxin Ran Lin Song Li Fu Yonghua Chen Wei Huang | 2020 | Research2020，，1： | 2 |
| 20 | Effect of interface defects on shear strength and fluid channeling at cement–interlayer interface显示文摘 | Jun Gu Pei Zhong Chun Shao Shaohui Bai Hui Zhang Ke Li | 2012 | Journal of Petroleum Science and Engineering2012，，： | 1 |
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