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| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | Glycidyl methacrylate-compatibilized poly(lactic acid)/hemp hurd biocomposites: Processing, crystallization, and thermo-mechanical response显示文摘Poly(lactic acid)-based biocomposites were developed with hemp hurd(Cannabis sativa L.) with grafting-based interfacial compatibilization. Poly(lactic acid) was extruded with hemp hurd and glycidyl methacrylate as the polymer/hurd interfacial compatibilizer, and injection molded. Interfacial compatibility between poly(lactic acid) and hemp hurd increased with grafted glycidyl methacrylate in comparison to the non-compatibilized control, as corroborated by scanning electron microscopy fractography and mechanical analysis, which showed increases in the glycidyl methacrylate-grafted 20%(w/w)hemp hurd/poly(lactic acid) biocomposite, retaining 94% of the neat polymer strength, with increases in crystallinity, and showing a range of thermo-mechanical properties desirable for rigid biocomposite applications. | Belas Ahmed Khan Haining Na Venkata Chevali Philip Warner Jin Zhu Hao Wang | 2018 | Journal of Materials Science & Technology2018，34，2： | 2 |
| 3 | Staging of carcinoid tumours with 18 F-DOPA PET: a prospective, diagnostic accuracy study显示文摘 | Klaas P Koopmans Elisabeth GE de Vries Ido P Kema Philip H Elsinga Oliver C Neels Wim J Sluiter Anouk NA van der Horst-Schrivers Pieter L Jager | 2006 | Lancet Oncology2006，，9： | 1 |
| 4 | The montreal cognitive assessment, MoCA: a brief screening tool for mild cog- nitive impairment 显示文摘 | Nasreddine ZS Philips NA Bedirian V | 2005 | J Am Geriatrics Soc2005，53，4： | 1 |
| 5 | Nocturnal recovery of gastric acid secretion with twice-daily dosing of proton pump inhibitors显示文摘 | Peghini PL Philip O Kz NA | 1998 | Am J Gastroenterol1998，93，： | 1 |
| 6 | The Montreal Cognitive Assessment, Mo- CA : a brief screening tool for mild cognitive impairment显示文摘 | Nasreddine ZS Philips NA Bedirian V | 2015 | J Am Geriatrics Soc2015，53，： | 1 |
| 7 | Form deprivation myopia-elastic properties of sclera显示文摘 | Philips JR McBrien NA | 1995 | Ophthalmic Physiol Opt1995，15，5： | 1 |
| 8 | The montreal cog- nitive assessment, MoCA : a brief screening tool for mild cognitive impairment 显示文摘 | Nasreddine ZS Philips NA Bedirian V | 2005 | J Am Geriatrics Soc2005，53，： | 1 |
| 9 | Mechanism of TNFa-induced IL-la, IL- and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones显示文摘 | NA Turner RS Mughal Philip Warburton | 2007 | Cardiovasc Res2007，76，1： | 1 |
| 10 | The Montreal Cognitive Assessment,MoCA:a brief screening tool for mild cognitive impairment显示文摘 | Nasreddine ZS Philips NA Bédirian V | 2005 | J Am Geriatrics Soc2005，53，4： | 1 |
| 11 | Estimating human energy expenditure:a review of techniques with particular reference to doubly labeled water 显示文摘 | Philip NA Thomas R Klass RW | 2003 | Sports Med2003，33，9： | 1 |
| 12 | The Montreal Cognitive Assessment, MoCA:a brief screening tool for mild cognitive impairment 显示文摘 | Nasreddine ZS Philips NA Bedirian V | 2005 | J Am Geriatrics Soc2005，53，： | 1 |
| 13 | Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats显示文摘 | Philip Y. Lam Po Yee Chiu Hoi Yan Leung Na Chen Pou Kuan Leong Kam Ming Ko | 2010 | Fitoterapia2010，，8： | 1 |
| 14 | TheMontreal Cognitive Assessment, MoCA:a briefscreening tool for mild cognitive impairment显示文摘 | Nasreddine ZS Philips NA Bedirian V et a1 | 2005 | J AmGeriatr Soc2005，53，： | 1 |
| 15 | Evalua- tion of a specially designed tobacco control program to re- duce tobacco use among school children in Kerala 显示文摘 | Philip PM Parambil NA Bhaskarapillai B | 2013 | Asian Pac J Cancer Prev2013，14，6： | 1 |
| 16 | The association between body mass index processes of care, and outcomes from mechanical ventilation: A prospective cohort study显示文摘 | O'Brien JM Philips GS Mi NA | 2012 | Crit Care Med2012，40，5： | 1 |
| 17 | The Montreal cog- nitive assessment (MOCA): a brief screening tool for mild cognitive impairment 显示文摘 | Nasreddine ZS Philips NA Bedirian V | 2005 | J Am Geriatr Soc2005，53，4： | 1 |
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