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| 1 | Behaviors and kinetics of toluene adsorption-desorption on activated carbons with varying pore structure显示文摘This work was undertaken to investigate the behaviors and kinetics of toluene adsorption and desorption on activated carbons with varying pore structure. Five kinds of activated carbon from different raw materials were selected. Adsorption isotherms and breakthrough curves for toluene were measured. Langmuir and Freundlich equations were fitted to the equilibrium data, and the Freundlich equation was more suitable for simulating toluene adsorption. The process consisted of monolayer, multilayer and partial active site adsorption types. The effect of the pore structure of the activated carbons on toluene adsorption capacity was investigated. The quasi-first-order model was more suitable for describing the process than the quasi-second-order model. The adsorption data was also modeled by the internal particle diffusion model and it was found that the adsorption process could be divided into three stages. In the external surface adsorption process, the rate depended on the specific surface area. During the particle diffusion stage, pore structure and volume were the main factors affecting adsorption rate. In the final equilibrium stage, the rate was determined by the ratio of meso-and macro-pores to total pore volume. The rate over the whole adsorption process was dominated by the toluene concentration. The desorption behavior of toluene on activated carbons was investigated,and the process was divided into heat and mass transfer parts corresponding to emission and diffusion mechanisms, respectively. Physical adsorption played the main role during the adsorption process. | Xi Yang Honghong Yi Xiaolong Tang Shunzheng Zhao Zhongyu Yang Yueqiang Ma Tiecheng Feng Xiaoxu Cui | 2018 | Journal of Environmental Sciences2018，30，5： | 28 |
| 2 | Advances in optical engineering for future telescopes显示文摘Significant optical engineering advances at the University of Arizona are being made for design, fabrication, and construction of next generation astronomical telescopes. This summary review paper focuses on the technological advances in three key areas. First is the optical fabrication technique used for constructing next-generation telescope mirrors. Advances in ground-based telescope control and instrumentation comprise the second area of development. This includes active alignment of the laser truss-based Large Binocular Telescope(LBT) prime focus camera, the new MOBIUS modular cross-dispersion spectroscopy unit used at the prime focal plane of the LBT, and topological pupil segment optimization. Lastly, future space telescope concepts and enabling technologies are discussed. Among these, the Nautilus space observatory requires challenging alignment of segmented multi-order diffractive elements. The OASIS terahertz space telescope presents unique challenges for characterizing the inflatable primary mirror, and the Hyperion space telescope pushes the limits of high spectral resolution, far-UV spectroscopy. The Coronagraphic Debris and Exoplanet Exploring Pioneer(CDEEP) is a Small Satellite(Small Sat) mission concept for high-contrast imaging of circumstellar disks and exoplanets using vector vortex coronagraph. These advances in optical engineering technologies will help mankind to probe, explore, and understand the scientific beauty of our universe. | Daewook Kim Heejoo Choi Trenton Brendel Henry Quach Marcos Esparza Hyukmo Kang Yi-Ting Feng Jaren NAshcraft Xiaolong Ke Tianyi Wang Ewan SDouglas | 2021 | Opto-Electronic Advances2021，4，6： | 10 |
| 3 | Genome sequencing and phylogenetic analysis of Banna virus(genus Seadornavirus,family Reoviridae)isolated from Culicoides显示文摘In an investigation of blood-sucking insects and arboviruses, a virus(YN12243) was isolated from Culicoides samples collected in the Sino-Burmese border region of Yunnan Province, China. The virus caused cytopathic effect(CPE) in C6/36 cells and passaged stably. Polyacrylamide gel analysis showed that the genome of YN12243 was composed of 12 segments of double-stranded RNA(dsRNA), with a distribution pattern of 6-6. The nucleotide and amino acid sequences of the coding region(1.12 segments) were17,803 bp and 5,925 amino acids in length, respectively. The phylogenetic analysis of VP1 protein(RdRp) revealed that YN12243 belonged to genus Seadornavirus of family Reoviridae, and further analysis indicated that YN12243 belongs to the Banna virus(BAV) genotype A2. Additionally, YN12243 was located in the same evolutionary cluster as BAV strains isolated from different mosquito species, suggesting that the BAV isolated from Culicoides does not have species barriers. These results indicate that Culicoides can also be a vector for BAV. In view of the hematophagous habits of Culicoides on cattle, horses, deer, and other large animals, as well as the possibility of spreading and causing a variety of animal arboviral diseases, it is important to improve infection detection and monitor the BAV in large livestock. | Song Song Yuanyuan Li Shihong Fu Wenwen Lei Xiaofang Guo Yun Feng Xiaoyan Gao Xiaolong Li Zhonghua Yang Ziqian Xu Ying He Huanyu Wang Hongning Zhou Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 8 |
| 4 | Service-oriented manufacturing:A literature review and future research directions显示文摘This study presents a systematic review of the literature on service-oriented manufacturing(SOM).Specifically,we focus on the impact of SOM on firm operating decisions,which distinguishes this work from previous reviews.This study proposes a classification framework for SOM research based on product flow,from its design to its final disposal.Although SOM has been studied for many years,most related research remains conceptual.Our criterion for choosing papers is that they must be relevant to practical problems.This review aims to provide readers a guide that will facilitate their search for papers in their field of interest.More importantly,we hope that this review can provide insightful managerial implications for SOM. | Zhong-Zhong JIANG Guangqi FENG Zelong YI Xiaolong GUO | 2022 | Frontiers of Engineering Management2022，9，1： | 6 |
| 5 | Attenuated phenotypes and analysis of a herpes simplex virus 1strain with partial deletion of the UL7, UL41 and LAT genes显示文摘We previously constructed a herpes simplex virus 1(HSV-1) UL7 mutant virus(M1) and showed that a partial deletion mutation of the UL7 gene led to a lower proliferative rate and an attenuated phenotype. Using the M1 mutant, we further modified the UL41 gene, which encodes another tegument protein, and the latency-associated transcript(LAT) gene. Observations of the resulting mutants with modified UL7 and UL41(M2) or UL7, UL41 and LAT(M3) genes indicated attenuated phenotypes, with lower proliferative ratios in various cells, non-lethal infections in mice and lower viral loads in nervous tissues compared with the wild-type strain. Furthermore, no LAT stable intron could be detected in the trigeminal ganglion of M3-infected animals. The results obtained with the three HSV-1 mutants indicate that the M3 mutant is an attenuated strain with low pathogenicity during both acute and latent infections. Together, the results support the use of the M3 mutant as a candidate for the development of an HSV-1 vaccine. | Xingli Xu Yingqiu Guo Shengtao Fan Pingfang Cui Min Feng Lichun Wang Ying Zhang Yun Liao Xiaolong Zhang Qihan Li | 2017 | Virologica Sinica2017，32，5： | 6 |
| 6 | Pharmacological Activation of RXR-a Promotes Hematoma Absorption via a PPAR-y-dependent Pathway After Intracerebral Hemorrhage显示文摘Endogenously eliminating the hematoma is a favorable strategy in addressing intracerebral hemorrhage(ICH).This study sought to determine the role of retinoid X receptor-ot(RXR-a)in the context of hematoma absorption after ICH.Our results showed that pharmacologically activating RXR-a with bexarotene significantly accelerated hematoma clearance and alleviated neurological dysfunction after ICH.RXR-ot was expressed in microglia/macro-phages,neurons,and astrocytes.Mechanistically,bexarotene promoted the nuclear translocation of RXR-a and PPAR-y,as well as reducing neuroinflammation by modulating microglia/macrophage reprograming from the Ml into the M2 phenotype.Furthermore,all the beneficial effects of RXR-a in ICH were reversed by the PPAR-y inhibitor GW9662.In conclusion,the pharmacological activation of RXR-a confers robust neuroprotection against ICH by accelerating hematoma clearance and repolarizing microglia/macrophages towards the M2 phenotype through PPAR-y-related mechanisms.Our data support the notion that RXR-ot might be a promising therapeutic target for ICH. | Chaoran Xu Huaijun Chen Shengjun Zhou Chenjun Sun Xiaolong Xia Yucong Peng Jianfeng Zhuang Xiongjie Fu Hanhai Zeng Hang Zhou Yang Cao Qian Yu Yin Li Libin Hu Guoyang Zhou Feng Yan Gao Chen Jianru Li | 2021 | Neuroscience Bulletin2021，37，10： | 4 |
| 7 | Development of automatic counting system for urediospores of wheat stripe rust based on image processing显示文摘To realize automatic counting of urediospores of Puccinia striiformis f.sp.tritici(Pst)(causal agent of wheat stripe rust),an automatic counting system for urediospores of wheat stripe rust pathogen based on image processing was developed using MATLAB GUIDE platform in combination with Local C Compiler(LCC).The system is independent of the MATLAB environment and can be run on a computer without the MATLAB software.Using this system,automatic counting of Pst urediospores in a microscopic image can be implemented via image processing technologies including image scaling,clustering segmentation,morphological modification,watershed transformation,connected region labeling,etc.Structure design of the automatic counting system,the key algorithms used in the system and realization of the main functions of the system were described in detail.Spore counting tests were conducted using microscopic digital images of Pst urediospores and the high accuracies more than 95%were obtained.The results indicated that it is feasible to count Pst urediospores automatically using the developed system based on image processing. | Li Xiaolong Ma Zhanhong Fernando Bienvenido Qin Feng Wang Haiguang José Antonio Alvarez-Bermejo | 2017 | International Journal of Agricultural and Biological Engineering2017，10，5： | 4 |
| 8 | Synthesis and structures of two supramolecular complexes constructed via hydrogen bond linking显示文摘Two supramolecular complexes,[Ni(rac-L)]3[CrO4]2[ClO4]2-4H2O (1) and [meso-H2L]0.5[VO3]-0.16H2O (2) (L= 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetra-decane),have been prepared in an aqueous solu-tion,and detected by elemental analysis,IR,TG,and single crystal X-ray diffraction analyses. Com-pound 1 shows a one-dimensional hexagonal prism formed by the hydrogen bonding interactions between the secondary amines of rac-L and CrO42-anion/water molecules. Compound 2 displays a three-dimensional structure constructed by the hydrogen bond linking the helical chains of [VO3]nn-to the secondary amines of meso-L to generate 1D hexagon-shaped channels,and the channels are oc-cupied by guest water molecules. | OU GuangChuan JIANG Long FENG XiaoLong LU TongBu | 2009 | Science China Chemistry2009，52，4： | 4 |
| 9 | Prussian blue nanoparticle-loaded microbubbles for photothermally enhanced gene delivery through ultrasound-targeted microbubble destruction显示文摘By adsorbing chitosan(CS)-functionalized Prussian blue(PB) nanoparticles(CS/PB NPs) complexing DNA onto the surface of gas encapsulated microbubbles(MBs), a multifunctional gene delivery system of MBs@CS/PB/DNA was fabricated for photothermally enhanced gene transfection through ultrasound-targeted microbubble destruction. CS/PB NPs of(2.69 ± 0.49) nm could complex DNA effectively when the mass ratio was2:1. It was found that MBs@CS/PB/DNA could enhance ultrasound imaging greatly both in vitro and in vivo. In addition, MBs@CS/PB/DNA could be disrupted by applying a higher-intensity ultrasound irradiation to release CS/PB/DNA, which could effectively transform the nearinfrared(NIR) light into heat to assist the uptake of CS/PB/DNA by cells. With the aid of ultrasound irradiation and NIR light irradiation, the gene transfection efficiency was significantly enhanced to(43.08 ± 1.13) %, much higher than polyethylenimine. Moreover, MBs@CS/PB/DNA showed excellent biocompatibility, encouraging the further exploration of MBs@CS/PB/DNA to be a platform for combined ultrasound image, photothermal therapy, drug delivery, and gene therapy. | Xiaoda Li Xiuli Yue Jinrui Wang Xiaolong Liang Lijia Jing Li Lin Yongbo Yang Shanshan Feng Yajun Qian Zhifei Dai | 2016 | Science Bulletin2016，61，2： | 4 |
| 10 | Influence of external electric field on piezotronic effect in ZnO nanowires显示文摘In this work, the piezotronic effect is investigated for the first time in external electric fields ranging from 0 V·cm-I to 2,000 V·cm-1 by using n-type ZnO nanowires supported by a flexible substrate. In the presence of an external electric field, the Schottky barrier height (SBH) is lowered by the image force, allowing more free carriers to pass through the metal-semiconductor junction and enhancing the screening effect on positive piezoelectric polarization charges. As the strength of the external electric field increases, the piezotronic effect is significantly suppressed and the metal-semiconductor contact finally exhibits Ohmic behavior. The experimental results show that devices can be classified into three groups, corresponding to low, moderate, and high carrier densities of the nanowires used. This work not only helps us to explicate the basic physical mechanism of the piezotronic effect in a harsh environment in an electric field but also provides guidelines for future design and fabrication of piezotronic devices. | Fei Xue Limin Zhang Xiaolong Feng Guofeng Hu Feng Ru Fan Xiaonan Wen Li Zheng Zhong Lin Wang | 2015 | Nano Research2015，8，7： | 4 |
| 11 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 12 | Simulation of the Pressure-Sensitive Seepage Fracture Network in Oil Reservoirs with Multi-Group Fractures显示文摘Stress sensitivity is a very important index to understand the seepage characteristics of a reservoir.In this study,dedicated experiments and theoretical arguments based on the visualization of porous media are used to assess the effects of the fracture angle,spacing,and relevant elastic parameters on the principal value of the permeability tensor.The fracture apertures at different angles show different change rates,which influence the relative permeability for different sets of fractures.Furthermore,under the same pressure condition,the fractures with different angles show different degrees of deformation so that the principal value direction of permeability rotates.This phenomenon leads to a variation in the water seepage direction in typical water-injection applications,thereby hindering the expected exploitation effect of the original well network.Overall,the research findings in this paper can be used as guidance to improve the effectiveness of water injection exploitation in the oil field industry. | Yueli Feng Yuetian Liu Jian Chen Xiaolong Mao | 2022 | Fluid Dynamics & Materials Processing2022，18，2： | 3 |
| 13 | Effects of Thermal and Hydric Conditions on Egg Incubation and Hatchling Phenotypes in Two Phrynocephalus Lizards显示文摘Flexible-shelled eggs of the lizards Phrynocephalus przewalskii and P. versicolor were incubated under different thermal and hydric conditions to elicit the effects of incubation environment on hatching success, embryonic development and duration as well as hatchling phenotypes. Embryogenesis of the two species was not sensitive to changes in the hydric environment except P. przewalskii incubated in 30°C group. Temperature significantly altered the duration of embryogenesis, with cooler temperatures leading to a longer incubation period. Hatching success was greater at 26 and 30°C than at 34°C. The hatchlings incubated at 26 and 30°C had longer snout-vent length, larger body mass, and better locomotor performance than those incubated at 34°C. Compared to P. przewalskii, P. versicolor had a shorter incubation period and yielded smaller hatchlings, which then had a higher survival rate in cooler and drier habitats. We conclude that an incubation temperature of 30°C would produce the best balance among developmental rate, hatching success, and post-hatching performance. We speculate that the upper temperature limit for incubation of P. versicolor eggs may be slightly higher than 34°C. | Xiaolong TANG Feng YUE Ming MA Ningbo WANG Jianzheng HE Qiang CHEN | 2012 | Asian Herpetological Research2012，3，3： | 3 |
| 14 | Investigation of Swelling and Dissolution Process of Natural Rubber in Aromatic Oil显示文摘Aromatic oil has been used to promote the properties of crumb rubber modified asphalt which is an ideal method to deal with the resource utilization of waste rubber tires and by-product of refinery. Furfural extract oil(FEO) was separated into the light fraction and the heavy fraction. Swelling and dissolution process of natural rubber sheet in these three oil samples was investigated to shed light on the interaction mechanism. Crumb rubber also interacted on FEO and asphalt respectively. Energy dispersive spectrometer(EDS), thermo-gravimetric analysis(TGA) and scanning electron microscope(SEM) were used to characterize the chemical and structural properties of processed rubber. The chemical composition of processed oils and asphalt was investigated by using the hydrocarbon group analysis(SARA) and gel permeation chromatography. The results revealed that the swelling rate and mass loss of rubber in oils were much higher than those in asphalt and rose with an increasing processing temperature. The heavy fraction of FEO had more diffusion and dissolving capability than the light fraction, whilst compatibility was observed between the heavy fraction and the light fraction. Selective absorption was not observed in the study and detachment of dissolved rubber was disseminated from the outside to the inside. The cross-linking degree of the residue rubber was unchanged with the processing time, and sulfur predominantly remained in the undissolved rubber. Dissolution of crumbed rubber in oils was attributed to devulcanization, while that in the asphalt was mainly attributed to depolymerization. | Wang Feng Kuang Minming Li Guanlong Zhou Xiaolong Li Chenglie | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，3： | 3 |
| 15 | Development of Mn-Si-MEL as a bi-functional adsorption-catalytic oxidation material for VOCs elimination显示文摘Mn-Si-MEL zeolite was developed as a bi-functional adsorption-catalytic oxidation material for volatile organic compounds(VOCs)elimination due to its good hydrophobicity&good organophileproperty brought by the substitution of Mn for Al in zeolite and the superior catalytic oxidation property endowed by the existence of Mn species.Various Mn-Si-MEL samples were obtained by introducing Mn to MEL crystallization system via different ways.It was found the incorporated Mn ways have a significant effect on the behavior of Mn being involved in the crystallization of MEL and finally influenced the distribution of Mn in zeolite as well the physicochemical properties of product zeolite.The seeding method(MnS2(Seed))is favorable for the good incorporation and uniform distribution of Mn in zeolite while both recrystallization method(Mn-S2(RC))and direct synthesis method(Mn-S2(DH))are favorable for obtaining more reducible Mn species and surface adsorbed oxygen species.The Mn amount incorporated into zeolite follows Mn-S2(RC)(1.96 wt%)>Mn-S2(Seed)(1.07 wt%)≈Mn-S2(DH)(0.97 wt%),the adsorption capacity of various samples follows Mn-S2(Seed)(83.3μmol/g)≈Mn-S2(RC)(82.1μmol/g)>Mn-S2(DH)(76.1μmol/g),while the catalytic oxidation ability of three samples follows Mn-S2(RC)≈Mn-S2(DH)>Mn-S2(Seed).Furthermore,Mn-S2(RC)which exhibits both superior adsorption capacity and catalytic oxidation ability shows good hydrophobicity and superior recyclability,demonstrating its great potential to be applied in the VOCs elimination by an enrichment-degradation route. | Qingjun Yu Yongchao Feng Jinghui Wei Xiaolong Tang Honghong Yi | 2022 | Chinese Chemical Letters2022，33，6： | 2 |
| 16 | Investigation of ion-atom collision dynamics through imaging techniques显示文摘The principle and technique details of recoil ion momentum imaging are discussed and summarized. The recoil ion momentum spectroscopy built at the Institute of Modern Physics (Lanzhou) is presented. The first results obtained at the setup are analyzed. For 30 keV He2+ on He collision, it is found that the capture of single electron occurs dominantly into the first excited states, and the related scattering angle results show that the ground state capture occurs at large impact parameters, while the capture into excited states occurs at small impact parameters. The results manifest the collision dynamics for the sub-femto-second process can be studied through the techniques uniquely. Finally, the future possibilities of applications of the recoil ion momentum spectroscopy in other fields are outlined. | MA XinWen ZHU XiaoLong LIU HuiPing LI Bin ZHANG ShaoFeng CAO ShiPing FENG WenTian XU ShenYue | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，7： | 2 |
| 17 | Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis显示文摘Dear Editor Cardiovascular disease(CVD)is the leading cause of death around the world(Truelsen,et al.,2015).Atherosclerosis,the dominant underlying cause of CVD,is a chronic inflam-matory disease characterized by lipid accumulation and immune cell infiltration in plaques and vessels(Weber,et al.,1950).The immune microenvironment is critical for the development of atherosclerosis.Homocysteine(Hcy)is an intermediate product of methionine metabolism,and its ele-vation in plasma(>15μmol/L),known as hyperhomocys-teinemia(HHcy),is an independent risk factor for atherosclerosis.HHcy is more common in Asia because of genetic factors and dietary habits(Huo,et al.,2015).folic acid supplement is one of the most important way to treat HHcy in clinic.Although HHcy potentiates atherosclerosis mainly through endothelial injury and inflammatory activa-tion(Luo,et al.,2016),a comprehensive understanding of the immune microenvironment and potential mechanisms in HHcy-accelerated atherosclerotic aortas(HHcy-AA)is still lacking. | Xiaolong Ma Jiacheng Deng Lulu Han Yuwei Song Yutong Miao Xing Du Guohui Dang Dongmin Yang Bitao Zhong Changtao Jiang Wei Kong Qingbo Xu Juan Feng Xian Wang | 2022 | Protein & Cell2022，13，7： | 2 |
| 18 | Research Progress on the Effect of Aflatoxin on Poultry Immunization显示文摘Aflatoxins( AFs) are a major pollution source of grain pollution and are secondary metabolites produced by Aspergillus flavus and A.parasiticus,which are one of the most toxic and carcinogenic substances.Feeding animals with aflatoxin-contaminated food can cause toxicosis,acute liver injury or liver cancer in animals,and also can cause multiple organ damage,decline in production performance and disease resistance,even death,which brings great economic losses to animal husbandry.In addition,AFs can do great harm to the human body.When the body ingests large amounts of AFs,it may suffer from acute poisoning and acute liver damage; and AFs can cause chronic poisoning of the body with continuous intake of trace AFs.This paper briefly analyzed the effect of AFs on the structure and function of poultry immune organs,immune gene expression,immunosuppression and so on. | Xiaolong YU Xinmiao HE Wentao WANG Yanzhong FENG Heshu CHEN Ming TIAN Di LIU | 2018 | Agricultural Biotechnology2018，7，6： | 2 |
| 19 | HIF-1α与VEGF及MVD在食管鳞癌组织中的表达及意义(英文)显示文摘Objective:To investigate the correlations among the expressions of hypoxia-inducible factor-1α(HIF-1α),vas-cular endothelial cell growth factor(VEGF) and microvessel density(MVD),and their relationships to the clinicopathologic characteristics of esophageal squamous cell carcinomas(ESCC).Methods:The expressions of HIF-1α,VEGF and MVD were detected by immunohistochemical method in 45 cases of ESCC,30 intraepithelial neoplasia and 35 normal esophageal mucosal epithelia tissues.The correlations among the expressions of HIF-1a,VEGF and MVD,and their relationships to the clinicopathologic features of ESCC were analyzed.Results:The rate of positive expression of HIF-1α and VEGF which were 80% and 84% in ESCC were significantly higher than those in intraepithelial neoplasia and normal esophageal mucosal epi-thelium tissues (P < 0.01) and so did the MVD value which was 71.10 ± 15.02 in ESCC(P < 0.01).The expression of HIF-1α and VEGF were positively correlated with the depth of tumor invasion,lymph node metastasis and TNM staging of ESCC.The expressions of HIF-1α were positively correlated with the expressions of VEGF and the value of MVD.Conclusion:Overexpression of HIF-1α is found in ESCC.HIF-1α may induce the angiogenesis in ESCC by upregulating the transcription of VEGF gene.It may play an important role in the carcinogenesis and aggression in ESCC,HIF-1α,VEGF and MVD may be a useful marker for evaluating the biological behaviors of ESCC. | Feng Liu Xiaolong Yang Boying Ding Gang Ren Rongfu Gong | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，4： | 2 |
| 20 | B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis显示文摘Hyperhomocysteinemia(HHcy)is a risk factor for chronic kidney diseases(CKDs)that affects about 85%CKD patients.HHcy stimulates B cells to secrete pathological antibodies,although it is unknown whether this pathway mediates kidney injury.In HHcytreated 2-kidney,1-clip(2K1C)hypertensive murine model,HHcy-activated B cells secreted anti-beta 2 glycoprotein I(β2GPI)antibodies that deposited in glomerular endothelial cells(GECs),exacerbating glomerulosclerosis and reducing renal function.Mechanistically,HHcy 2K1C mice increased phosphatidylethanolamine(PE)(18:0/20:4,18:0/22:6,16:0/20:4)in kidney tissue,as determined by lipidomics.GECs oxidative lipidomics validated the increase of oxidized phospholipids upon Hcy-activated B cells culture medium(Hcy-B CM)treatment,including PE(18:0/20:4+3[O],PE(18:0a/22:4+1[O],PE(18:0/22:4+2[O]and PE(18:0/22:4+3[O]).PE synthases ethanolamine kinase 2(etnk2)and ethanolamine-phosphate cytidylyltransferase 2(pcyt2)were increased in the kidney GECs of HHcy 2K1C mice and facilitated polyunsaturated PE synthesis to act as lipid peroxidation substrates.In HHcy 2K1C mice and Hcy-B CM-treated GECs,the oxidative environment induced by iron accumulation and the insufficient clearance of lipid peroxides caused by transferrin receptor(TFR)elevation and down-regulation of SLC7A11/glutathione peroxidase 4(GPX4)contributed to GECs ferroptosis of the kidneys.In vivo,pharmacological depletion of B cells or inhibition of ferroptosis mitigated the HHcy-aggravated hypertensive renal injury.Consequently,our findings uncovered a novel mechanism by which B cell-derived pathogenic anti-β2GPI IgG generated by HHcy exacerbated hypertensive kidney damage by inducing GECs ferroptosis.Targeting B cells or ferroptosis may be viable therapeutic strategies for ameliorating lipid peroxidative renal injury in HHcy patients with hypertensive nephropathy. | Xing Du Xiaolong Ma Ying Tan Fangyu Shao Chun Li Yang Zhao Yutong Miao Lulu Han Guohui Dang Yuwei Song Dongmin Yang Zhenling Deng Yue Wang Changtao Jiang Wei Kong Juan Feng Xian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
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