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| 1 | p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo显示文摘Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. | Limin Liu Peng Zhang Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun | 2019 | Journal of Molecular Cell Biology2019，11，5： | 18 |
| 2 | Clinical phenotype network: the underlying mechanism for perso- nalized diagnosis and treatment of traditional Chinese medicine显示文摘繁体中文药(TCM ) 在个性化的药的一个典型纲要调查临床的诊断和治疗整齐,它意味着有一样的疾病的个性化的病人将从不同 TCM 医生获得不同诊断和最佳的治疗。这个原则被 TCM 临床的专业人员认出并且粘住几千年了。然而,个性化的药不是的 TCM 的内在的机制到目前为止充分调查了并且仍然保持未知。这份报纸讨论 TCM 的框架在经典文学并且在真实世界的临床的背景的个性化的药,并且调查 TCM 的内在的机制从网络药的观点的个性化的药。在失眠上基于 246 个设计得好的门诊病人记录,由评估表明观察的个人偏爱和植物药方的偏爱,我们注意了每张植物药方的重要类似和每相遇的症状类似。为了调查 TCM 的内在的机制,个性化药,我们构造了一个临床的显型网络(CPN ) ,在哪个临床的显型实体喜欢症状并且诊断作为连接表现为在这些实体之间的节点和关联。这 CPN 被用来调查症候群和症状的同现的混杂的边界。小世界的拓扑的特征与高聚类结构在 CPN 被注意,它在 TCM 的合理性上提供卓见个性化的诊断和处理。这个网络上的调查将帮助我们在 TCM 的内在的机制上获得理解个性化的药并且将为 TCM 的精炼建议一个新观点个性化的临床的技巧。 | Xuezhong Zhou Yubing Li Yonghong Peng Jingqing HU Runshun Zhang Liyun He Yinghui Wang Lijie Jiang Shiyan Yan Peng Li Qi Xie Baoyan Liu | 2014 | Frontiers of Medicine2014，8，3： | 7 |
| 3 | Implementation of regional Acute Stroke Care Map increases thrombolysis rates for acute ischaemic stroke in Chinese urban area in only 3 months显示文摘Background The rate of intravenous thrombolysis for acute ischaemic stroke remains low in China.We investigated whether the implementation of a citywide Acute Stroke Care Map(ASCaM)is associated with an improvement of acute stroke care quality in a Chinese urban area.Methods The ASCaM comprises 10 improvement strategies and has been implemented through a network consisting of 20 tertiary hospitals.We identified 7827 patients with ischaemic stroke admitted from April to October 2017,and 506 patients underwent thrombolysis were finally included for analysis.Results Compared with‘pre-ASCaM period’,we observed an increased rate of administration of tissue plasminogen activator within 4.5 hours(65.4% vs 54.5%;adjusted OR,1.724;95% CI 1.21 to 2.45;p=0.003)during‘ASCaM period’.In multivariate analysis models,‘ASCaM period’was associated with a significant reduction in onset-to door time(114.1±55.7 vs 135.7±58.4 min,p=0.0002)and onset-to needle time(ONT)(169.2±58.1 vs 195.6±59.3 min,p<0.0001).Yet no change was found in door-to needle time.Clinical outcomes such as symptomatic intracranial haemorrhage,favourable functional outcome(modified Rankin Scale≤2)and in-hospital mortality remained unchanged.Conclusion The implementation of ASCaM was significantly associated with increased rates of intravenous thrombolysis and shorter ONT.The ASCaM may,in proof-of principle,serve as a model to reduce treatment delay and increase thrombolysis rates in Chinese urban areas and possibly other highly populated Asian regions. | Yi Sui Jianfeng Luo Chunyao Dong Liqiang Zheng Weijin Zhao Yao Zhang Ying Xian Huaguang Zheng Bernard Yan Mark Parsons Li Ren Ying Xiao Haoyue Zhu Lijie Ren Qi Fang Yi Yang Weidong Liu Bing Xu | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 4 | Effects of Zr,Ti and Sc additions on the microstructure and mechanical properties of Al-0.4Cu-0.14Si-0.05Mg-0.2Fe alloys显示文摘The evolution of microstructure and mechanical properties of Al-0.4 Cu-0.14 Si-0.05 Mg-0.2 Fe(wt.%)alloys, micro-alloyed with Zr, Ti and Sc, were investigated. The addition of 0.2%Zr to base alloy accelerates the precipitation of Si-rich nano-phase in α-Al matrix, which plays an important role in improving the mechanical properties of an alloy. The tensile strength increases from 102 MPa for the base alloy to 113 MPa for the Zr-modified alloy. Adding 0.2%Zr + 0.2%Ti to base alloy effectively refines a-Al grain size and accelerates the precipitation of Si and Cu elements, leading to heavy segregation at grain boundary.By further adding 0.2%Sc to Zr + Ti modified alloy, the segregation of Si and Cu elements is suppressed and more Si and Cu precipitates appeared in α-Al matrix. Accompanied with the formation of coherent Al_3Sc phase, the tensile strength increases from 108 MPa for the Zr + Ti modified alloy to 152 MPa for the Sc-modified alloy. Due to excellent thermal stability of Al_3Sc phase, the Sc-modified alloy exhibits obvious precipitation hardening behavior at 350℃, and the tensile strength increases to 203 MPa after holding at 350 ℃ for 200 h. | Jian Feng Bing Ye Lijie Zuo Ruijuan Qi Qudong Wang Haiyan Jiang Rong Huang Wenjiang Ding Jie Yao Chuntao Wang | 2018 | Journal of Materials Science & Technology2018，34，12： | 3 |
| 5 | Difficult and complicated oral ulceration:an expert consensus guideline for diagnosis显示文摘The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists.The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases screening.Not only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis. | Xin Zeng Xin Jin Liang Zhong Gang Zhou Ming Zhong Wenmei Wang Yuan Fan Qing Liu Xiangmin Qi Xiaobing Guan Zhimin Yan Xuemin Shen Yingfang Wu Lijie Fan Zhi Wang Yuan He Hongxia Dan Jiantang Yang Hui Wang Dongjuan Liu Hui Feng Kai Jiao Qianming Chen | 2022 | International Journal of Oral Science2022，14，2： | 2 |
| 6 | An Outbreak of SARS-CoV-2 Omicron Subvariant BA.2.76 in an Outdoor Park—Chongqing Municipality,China,August 2022显示文摘Summary What is already known about this topic?Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron subvariant has a stronger transmission capacity and faster transmission speed than the previous strain. | Li Qi Wenge Tang Ju Wang Yu Xiong Yi Yuan Baisong Li Lin Yang Tingting Li Lianjian Yang Xiaoyuan Su Qin Li Lijie Zhang | 2022 | China CDC weekly2022，4，46： | 1 |
| 7 | Property-Structure Relationship of Nanoscale Ionic Materials Based on Multiwalled Carbon Nanotubes显示文摘 | Li Qi Dong Lijie Jingfei Fang Chuanxi Xiong | 2010 | ACSNano2010，4，： | 1 |
| 8 | A Carbon Black Derivative with Liquid Behavior显示文摘 | Li Qi Dong Lijie Liu Yun Xie Haian Xiong Chuanxi | 2011 | Carbon2011，49，： | 1 |
| 9 | CmRCD1 represses flowering by directly interacting with CmBBX8 in summer chrysanthemum显示文摘The CmBBX8-CmFTL1 regulatory module is a key determinant in the transition from vegetative growth to reproductive development in summer-flowering chrysanthemum.However,the detailed regulatory mechanism of CmBBX8-mediated flowering remains elusive.In this study,we revealed that RADICAL-INDUCED CELL DEATH 1(CmRCD1)physically associated with CmBBX8 through bimolecular fluorescence complementation(BiFC),pulldown and Coimmunoprecipitation(CoIP)assays.Furthermore,the RCD1-SRO1-TAF4(RST)domain of CmRCD1 and the B-box of CmBBX8 mediated their interaction.In addition,Luciferase(LUC)assays and electrophoretic mobility shift assay(EMSAs)showed that CmRCD1 repressed the transcriptional activity of CmBBX8 and interfered with its binding to the CmFTL1 promoter,thereby leading to delayed flowering in the summer chrysanthemum‘Yuuka’.These results provide insight into the molecular framework of CmRCD1-CmBBX8-mediated flowering in chrysanthemum. | Lijun Wang Hua Cheng Qi Wang Chaona Si Yiman Yang Yao Yu Lijie Zhou Lian Ding Aiping Song Dongqing Xu Sumei Chen Weimin Fang Fadi Chen Jiafu Jiang | 2021 | Horticulture Research2021，8，1： | 1 |
| 10 | Property-Structure Relationship of Nanoscale Ionic Materials based on Multiwalled Carbon Nanotubes显示文摘 | Li Qi Dong Lijie FANF Jingfei | 2010 | ACS Nano2010，4，5： | 1 |
| 11 | Solvent-free Fluids based on Rhombohedral Nanoparticles of Calcium Carbonate显示文摘 | Li Qi Dong Lijie Deng Wei | 2009 | Journal of the American Chemical Society2009，131，9： | 1 |
| 12 | Property-Structure Relationship of Nanoscale Ionic Materials Based on Multiwalled Carbon Nanotubes显示文摘 | Qi Li Lijie Dong Jingfei Fang Chuanxi Xiong | | 0，，10： | 1 |
| 13 | Parametric sensitivity analysis of the importance measure显示文摘 | Lijie Cui Zhenzhou Lu Qi Wang | 2011 | Mechanical Systems and Signal Processing2011，，： | 1 |
| 14 | Property-structure relationship of nanoscale ionic materials based on multi walled carbon nanotubes显示文摘 | Li Qi Dong Lijie Fang Jingfei | 2010 | ACS Nano2010，4，10： | 1 |
| 15 | Perfluorinated compounds in surface waters and WWTPs in Shenyang, China: Mass flows and source analysis显示文摘 | Hongwen Sun Fasong Li Tao Zhang Xianzhong Zhang Na He Qi Song Lijie Zhao Lina Sun Tieheng Sun | 2011 | Water Research2011，，15： | 1 |
| 16 | Perfluorinated compounds in surface waters and WWTPs in Shenyang, China: Mass flows and source analysis显示文摘 | Hongwen Sun Fasong Li Tao Zhang Xianzhong Zhang Na He Qi Song Lijie Zhao Lina Sun Tieheng Sun | 2011 | Water Research2011，，15： | 1 |
| 17 | Concentration and size distribution of total airborne microbes in hazy and foggy weather 显示文摘 | DONG Lijie QI Jianhua SHAO Congcong | 2016 | Science of the Total Environment2016，541，： | 1 |
| 18 | Preliminary Study on the Relationship between the M_s8.0 Wenchuan Earthquake of 2008 and the Anomalies of Earth Resistivity Observed at Qingdao Seismic Station显示文摘Near-surface earth resistivity and underground water level anomalies were recorded at Qingdao seismic observatory of Shandong Province before and after the MS8.0 Wenchuan Earthquake of May 12,2008.The observed data of earth resistivity at the observatory revealed that the underground water level dropped and the resistivity increased.It is postulated that in the special tectonic setting at Qingdao observatory,the variation of stress and strain caused the change of water level beneath the station,thus,leading to the variation of earth resistivity.The relationship between the variation of stress field and the change of earth resistivity before earthquake is analyzed. | Zhang Jihong Zhao Guoze Wang Jinsheng Tang Tingmei Qi Lijie | 2011 | Earthquake Research in China2011，25，2： | 0 |
| 19 | A Classical Chiral Invariant Theory Method of N-N Interaction显示文摘Within the framework of meson exchange theory,the N-N interaction is derived by a classical field method from a chiral σ-ω model.The nuclear potential derived is similar to the ordinary one boson exchange potential. | QI Lijie HE Guozhu | 1991 | Chinese Physics Letters1991，8，9： | 0 |
| 20 | Four-inch high quality crack-free AlN layer grown on a hightemperature annealed AlN template by MOCVD显示文摘In this work,based on physical vapor deposition and high-temperature annealing(HTA),the 4-inch crack-free high-quality AlN template is initialized.Benefiting from the crystal recrystallization during the HTA process,the FWHMs of X-ray rocking curves for(002)and(102)planes are encouragingly decreased to 62 and 282 arcsec,respectively.On such an AlN template,an ultra-thin AlN with a thickness of~700 nm grown by MOCVD shows good quality,thus avoiding the epitaxial lateral over-growth(ELOG)process in which 3-4μm AlN is essential to obtain the flat surface and high crystalline quality.The 4-inch scaled wafer provides an avenue to match UVC-LED with the fabrication process of traditional GaN-based blue LED,therefore significantly improving yields and decreasing cost. | Shangfeng Liu Ye Yuan Shanshan Sheng Tao Wang Jin Zhang Lijie Huang Xiaohu Zhang Junjie Kang Wei Luo Yongde Li Houjin Wang Weiyun Wang Chuan Xiao Yaoping Liu Qi Wang Xinqiang Wang | 2021 | Journal of Semiconductors2021，42，12： | 0 |
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