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| 1 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 2 | Serum cystatin C concentration as an independent marker for hypertensive left ventricular hypertrophy显示文摘Background Serum cystatin C levels can be used to predict morbidity and mortality in patients with cardiovascular disease. However, the clinical relevance of serum cystatin C levels in patients with hypertensive left ventricular hypertrophy (LVH) has rarely been investigated. We designed the present study to investigate whether serum cystatin C levels are associated with cardiac structural and functional alterations in hypertensive patients. Methods We enrolled 823 hypertensive patients and classified them into two groups:those with LVH (n=287) and those without LVH (n=536). All patients underwent echocardiography and serum cystatin C testing. We analyzed the relationship be-tween serum cystatin C levels and LVH. Results Serum cystatin C levels were higher in hypertensive patients with LVH than in those without LVH (P<0.05). Using linear correlation analysis, we found a positive correlation between serum cystatin C levels and interven-tricular septal thickness (r=0.247, P<0.01), posterior wall thickness (r=0.216, P<0.01), and left ventricular weight index (r=0.347, P<0.01). When analyzed by multiple linear regression, the positive correlations remained between serum cystatin C and interventricular septal thickness (β=0.167, P<0.05), posterior wall thickness (β=0.187, P<0.05), and left ventricular weight index (β=0.245, P<0.01). Con-clusion Serum cystatin C concentration is an independent marker for hypertensive LVH. | Xin Li Hang Zhu Peng Li Qian Xin Jie Liu Wei Zhang You-Hong Xing Hao Xue | 2013 | Journal of Geriatric Cardiology2013，10，3： | 21 |
| 3 | Preliminary study on proteomics of gastric carcinoma and its clinical significance显示文摘AIM: To explore the preliminary identification of serum protein pattern models that may be novel potential biomarkers in the detection of gastric cancer.METHODS: A total of 130 serum samples, including 70 from patients with gastric cancer and 60 from healthy adults, were detected by surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS). The data of spectra were analyzed by Biomarker Patterns Software (BPS). Thirty serum samples of gastric cancer patients and 30 serum samples of healthy adults were grouped into the training group to build models, and the other 70 samples were used to test and evaluate the models. The samples of the test group were judged only with their peaks'height and were separated into cancer group or healthy control group by BPS automatically and the judgments were checked with the histopathologic diagnosis of the samples.RESULTS: Sixteen mass peaks were found to be potential biomarkers with a significant level of P<0.01.Among them, nine mass peaks showed increased expression in patients with gastric cancer. Analyzed by BPS, two peaks were chosen to build the model for gastric cancer detection. The sensitivity, specificity, and accuracy of the model were 90%, 36/40, 86.7%, 26/30,and 88.6%, 62/70, respectively, which were greatly higher than those of clinically used serum biomarkers CEA (carcinoembryonic antigen), CA19-9 and CA72-4.Stage Ⅰ/Ⅱ gastric cancer samples of the test group were all judged correctly.CONCLUSION: The novel biomarkers in serum and the established model could be potentially used in the detection of gastric cancer. However, large-scale studies should be carried on to further explore the clinical impact on the model. | Hong-Gang Qian Jing-Shen Hong Ma Hua-Chong Ma Ya-Hui Su Chun-Yi Hao Bao-Cai Xing Xin-Fu Huang Cheng-Chao Shou | 2005 | World Journal of Gastroenterology2005，11，40： | 20 |
| 4 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 5 | Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy显示文摘With improvements in care of at-risk neonates, more and more children survive. This makes it increasingly important to assess, soon after birth, the prognosis of children with hypoxic-ischemic encephalopathy. Computed tomography, ultrasound, and conventional magnetic resonance imaging are helpful to diagnose brain injury, but cannot quantify white matter damage. In this study, ten full-term infants without brain injury and twenty-two full-term neonates with hypoxic-ischemic encephalopathy(14 moderate cases and 8 severe cases) underwent diffusion tensor imaging to assess its feasibility in evaluating white matter damage in this condition. Results demonstrated that fractional anisotropy, voxel volume, and number of fiber bundles were different in some brain areas between infants with brain injury and those without brain injury. The correlation between fractional anisotropy values and neonatal behavioral neurological assessment scores was closest in the posterior limbs of the internal capsule. We conclude that diffusion tensor imaging can quantify white matter injury in neonates with hypoxic-ischemic encephalopathy. | Hong-xin Li Xing Feng Qian Wang Xuan Dong Min Yu Wen-juan Tu | 2017 | Neural Regeneration Research2017，12，4： | 19 |
| 6 | An HNF 1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells显示文摘 | Hui Qian Xing Deng Zhao-Wei Huang Ji Wei Chen-Hong Ding Ren-Xin Feng Xin Zeng Yue-Xiang Chen Jin Ding Lei Qiu Zhen-Lin Hu Xin Zhang Hong-Yang Wang Jun-Ping Zhang Wei-Fen Xie | 2015 | Cell Research2015，25，8： | 15 |
| 7 | Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclinl to negatively regulate antiviral innate immunity显示文摘 | Xiaojuan Chen Kai Wang Yaling Xing Jian Tu Xingxing Yang Qian Zhao Kui Li Zhongbin Chen | 2014 | Protein & Cell2014，5，12： | 14 |
| 8 | Response to Hepatocarcinoma Hca-F of Mice Immunized with Heat Shock Protein 70 from Elemene Combo Tumor Cell Vaccine显示文摘为了分析有免疫力的反应到老鼠的鼠科的 hepatocarcinoma Hca-F,与热吃惊使免疫(HSP70 ) 蛋白质 70 源于 elemene 组合肿瘤 Hca-F 的房间疫苗(EC-TCV ) , HSP70 被自动数据处理从 EC-TCV 孤立亲密关系层析。老鼠 intraperitoneally 与 HSP70 被使免疫三次,怒气房间被取样。为房间,他们对 Hca-F 的增长和 cytotoxicity 与 MTT 试金被测量,他们的显型与流动 cytometry 被分析。有 HSP70 的使免疫的鼠标的怒气房间比与 EC-TCV 使免疫的鼠标的比正常控制鼠标,而是更少的有势力的对 Hca-F 和增长展出了更多的有势力 cytotoxicity。在三个组之中,在与 HSP70 (35.5%) 使免疫的老鼠的 T 淋巴细胞的百分比在正常老鼠与 6.25% 相比是最高的,并且 28.4% 与 EC-TCV 在老鼠使免疫。从 EC-TCV 导出的 HSP70 的免疫能得到有势力免疫者反应到 Hca-F。HSP70 是对 Hca-F 导致反肿瘤免疫者回答的元素之一。细胞与分子的免疫学。2006; 3 (4 ): 291-295。 | Lianying Guo Guangxia Shi Zhihong Gao Jie Shen Rong Xing Zhenchao Qian | 2006 | Cellular & Molecular Immunology2006，3，4： | 13 |
| 9 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 10 | LEAFY HEAD2,which encodes a putative RNA-binding protein,regulates shoot development of rice显示文摘在植物的开发期间,更高的植物连续地在常规空间、时间的模式形成新叶子。有反常的叶的异种发展模式不仅提供大卓见进理解植物建筑学的规章的机制,而且充实方法到它庄稼产量能被改进的修正。这里,我们报导了米饭 leafy-head2 (lhd2 ) 的描述展览弄短的异种阶段的 plastochron,侏儒症,减少的 tiller 数字,和失败转移从对繁殖生长植物。而减少的 tiller 数字是 tiller 芽长出的抑制的后果,解剖、组织学的学习表明在 lhd2 的叶子的快速的出现从叶 primordia 的快速的开始被结果。分子、基因的分析证明 LHD2 与 67% 类似编码通常认为的 RNA 有约束力的蛋白质到玉米 TE1。染色体规模表示侧面在之间的比较野类型并且 lhd2 植物建议 LHD2 可以通过 KNOX 和荷尔蒙相关的基因调整米饭射击开发。LHD2 变化和 LHD2 的保存表示模式引起的类似的显型在在草控制时间的叶开始显示了保存机制。 | Guo Sheng Xiong Xing Ming Hu Yong Qing Jiao Yan Chun Yu Cheng Cai Chu Jia Yang Li Qian Qian Yong Hong Wang | 2006 | Cell Research2006，16，3： | 11 |
| 11 | Comparison of gut-associated and nest-associated microbial communities of a fungus-growing termite (Odontotermes yunnanensis)显示文摘 | Yan-Hua Long Lei Xie Ning Liu Xing Yan Ming-Hui Li Mei-Zhen Fan Qian Wang | 2010 | Insect Science2010，17，3： | 11 |
| 12 | Pb isotope geochemistry of lead, zinc, gold and silver deposit clustered region, Liaodong rift zone,northeastern China显示文摘Pb isotopic analyses were reported for sulfide and hydrothermal carbonate minerals and marble of the Xiquegou lead-zinc, the Zhenzigou zinc-lead and the Gaojiapuzi silver deposits from the Qingchengzi ore field and the Beiwagou zinc-lead deposit in the west, Proterozoic Liaodong rift zone. Pb isotopic ratios of the marble from the Qingchengzi ore field range from 18.24 to 30.63 for 206 Pb/204Pb, 15.59 to 17.05 for207Pb/204Pb and 37.43 to 38.63 for 208Pb/204Pb. The marble gives a Pb-Pb isochron age of 1822±92 Ma, which is interpreted as the age of the metamorphism of the marble. Ore Pb, including Pb of sulfide and hydrothermal car- bonate minerals, from the Qingchengzi ore field shows limited variation with 206 Pb/204Pb=17.66- 17.96, 207 Pb/204Pb=15.60-15.74 and 208Pb/204Pb=37.94-38.60. In contrast, ore Pb from the Beiwagou deposit gives different Pb isotopic ratios with 206Pb/204Pb=15.68-15.81, 207 Pb/204Pb= 15.34-15.45 and 208Pb/204Pb=35.30-35.68. Pb of all deposits from the Liaodong rift zone is derived from the upper crust. Ore Pb of the Qingchengzi deposits is derived from a young upper crust. The model Th/U ratios of 4.40 to 4.74 for ore Pb are significantly different from that of 1.7 to 4.4 given by the marble of the Qingchengzi ore field, suggesting that marble is not the source of the ore Pb. Ore Pb of the Beiwagou deposit is extracted from its source and the deposit is formed at the Paleoproterozoic era. Different Pb isotopic ratios of the Qingchengzi ore field and the Beiwagou deposit are due to different ages of the deposits and suggest that the two types of deposits are derived from different sources and are possibly formed by different ore-forming processes. | CHEN Jiangfeng1, YU Gang1, XUE Chunji2, QIAN Hui1, HE Jianfeng1, XING Zhi1 & ZHANG Xun1 1. School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, China 2. Department of Geology, Chang’an University, Xi’an 710054, China | 2005 | Science China Earth Sciences2005，48，4： | 11 |
| 13 | Metabolic and pharmacokinetic studies of scutellarin in rat plasma, urine, and feces显示文摘 | Jian-feng XING Hai-sheng YOU Ya-lin DONG Jun LU Si-ying CHEN Hui-fang ZHU Qian DONG Mao-yi WANG Wei-hua DONG | 2011 | Acta Pharmacologica Sinica2011，32，5： | 11 |
| 14 | SHRIMP zircon age for a K-bentonite in the top of the Laobao Formation at the Pingyin section,Guizhou,South China显示文摘The Lower Cambrian on the Yangtze Platform in South China(internationally equivalent to the Nerreneuvian and 2nd series of the Cambrian)is valuable for understanding the early evolution of life,the global biogeochemical circles,and the major changes of the ocean.In particular,a precise radiometric calibration of the Lower Cambrian of this region is a critical realm in its multidisciplinary studies.A SHRIMP U-Pb geochronology study of the K-bentonite in the topmost Laobao Formation at the Pingyin section,Guizhou,South China yielded an age of 536±5 Ma(MSWD=0.75),suggesting that the K-bentonite here can be correlated with the intensely studied K-bentonite within the middle Zhongyicun Member(Bed 5)of the Zhujiaqing Formation at the Meishucun section in Yunnan.Such a regional correlation result reveals that the Bed 5 K-bentonite also extends into deeper-water environments rather than being deposited merely in the shallow platform interior of the Yangtze Platform.The age of the K-bentonite at the Pingyin section also implies that its overlying polymetallic Ni-Mo layer should be younger than 536±5 Ma.Hence the previous placement of the Precambrian/Cambrian boundary at this layer is inappropriate.Combined with the results of stratigraphic correlations,it is suggested that the K-bentonites in the middle Zhongyicun Member of the Zhujiaqing Formation(or the equivalents)and the base of the Shiyantou Formation(or its equivalents),together with the polymetallic Ni-Mo layer,serve as three important marker beds.Their self-consistent radiometric ages have established an improved geochronologic framework for the Lower Cambrian in South China. | ZHOU MingZhong LUO TaiYi LIU ShiRong QIAN ZhiKuan XING LeCai | 2013 | Science China Earth Sciences2013，56，10： | 10 |
| 15 | A new dynamic pushback control method for reducing fuel-burn costs: Using predicted taxi-out time显示文摘Long departure-taxi-out time leads to significant airport surface congestion, fuel-burn costs, and excessive emissions of greenhouse gases. To reduce these undesirable effects, a Predicted taxi-out time-based Dynamic Pushback Control(PDPC) method is proposed. The implementation of this method requires two steps: first, the taxi-out times for aircraft are predicted by the leastsquares support-vector regression approach of which the parameters are optimized by an introduced improved Firefly algorithm. Then, a dynamic pushback control model equipped with a linear gate-hold penalty function is built, along with a proposed iterative taxiway queue-threshold optimization algorithm for solving the model. A case study with data obtained from Beijing International airport(PEK) is presented. The taxi-out time prediction model achieves predictive accuracy within 3 min and 5 min by 84.71% and 95.66%, respectively. The results of the proposed pushback method show that total operation cost and fuel-burn cost achieve a 14.0% and 21.1%reduction, respectively, as compared to the traditional K-control policy.(3) From the perspective of implementation, using PDPC policy can significantly reduce the queue length in taxiway and taxi-out time. The total operation cost and fuel-burn cost can be curtailed by 37.2% and 52.1%,respectively, as compared to the non-enforcement of any pushback control mechanism. These results show that the proposed pushback control model can reduce fuel-burn costs and airport surface congestion effectively. | Guan LIAN Yaping ZHANG Zhiwei XING Qian LUO Shaowu CHENG | 2019 | Chinese Journal of Aeronautics2019，32，3： | 10 |
| 16 | Creation of Triple Hierarchical Micro-Meso-Macroporous N-doped Carbon Shells with Hollow Cores Toward the Electrocatalytic Oxygen Reduction Reaction显示文摘A series of triple hierarchical micro-mesomacroporous N-doped carbon shells with hollow cores have been successfully prepared via etching N-doped hollow carbon spheres with CO_2 at high temperatures.The surface areas, total pore volumes and microporepercentages of the CO_2-activated samples evidently increase with increasing activation temperature from 800 to950 °C, while the N contents show a contrary trend from7.6 to 3.8 at%. The pyridinic and graphitic nitrogen groups are dominant among various N-containing groups in the samples. The 950 °C-activated sample(CANHCS-950) has the largest surface area(2072 m^2 g^(-1)), pore volume(1.96 cm^3 g^(-1)), hierarchical micro-mesopore distributions(1.2, 2.6 and 6.2 nm), hollow macropore cores(*91 nm)and highest relative content of pyridinic and graphitic N groups. This triple micro-meso-macropore system could synergistically enhance the activity because macropores could store up the reactant, mesopores could reduce the transport resistance of the reactants to the active sites, and micropores could be in favor of the accumulation of ions.Therefore, the CANHCS-950 with optimized structure shows the optimal and comparable oxygen reduction reaction(ORR) activity but superior methanol tolerance and long-term durability to commercial Pt/C with a 4 e--dominant transfer pathway in alkaline media. These excellent properties in combination with good stability and recyclability make CANHCSs among the most promising metal-free ORR electrocatalysts reported so far in practical applications. | Ruohao Xing Tingsheng Zhou Yao Zhou Ruguang Ma Qian Liu Jun Luo Jiacheng Wang | 2018 | Nano-Micro Letters2018，10，1： | 9 |
| 17 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 18 | Effects of five-year intensive multifactorial intervention on the serum amyloid A and macroangiopathy in patients with short-duration type 2 diabetes meUitus显示文摘背景 A 集中的 multifactorial 干预的五年的后续学习被承担估计淀粉的 A ( SAA )铺平的传播浆液和动脉粥样硬化的发生的变化(作为)在有短持续时间的类型的病人没有 maoroangiopathy 的 2 糖尿病 mellitus ( T2DM ),并且集中的 multifactorial 干预是否能与短持续时间的 T2DM 在 150 个病人之中阻止或至少推迟 macroangiopathy.Methods 的 occurence , 75 被分配收到常规门诊病人 | DU Jian-ling LIU Jian-feng MEN Li-li YAO Jun-jie SUN Li-peng SUN Guo-hua SONG Gui-rong YANG Yu BAI Ran XING Qian LI Chang-chen SUN Chang-kai | 2009 | Chinese Medical Journal2009，，21： | 9 |
| 19 | Characterization and Fine Mapping of a Novel Rice Narrow Leaf Mutant nal9显示文摘A narrow leaf mutant was isolated from transgenic rice(Oryza sativa L.)lines carrying a T-DNA insertion.The mutant is characterized by narrow leaves during its whole growth period,and was named nal9(narrow leaf 9).The mutant also has other phenotypes,such as light green leaves at the seedling stage,reduced plant height,a small panicle and increased tillering.Genetic analysis revealed that the mutation is controlled by a single recessive gene.A hygromycin resistance assay showed that the mutation was not caused by T-DNA insertion,so a map-based cloning strategy was employed to isolate the nal9 gene.The mutant individuals from the F2generations of a cross between the nal9 mutant and Longtepu were used for mapping.With 24 F2mutants,the nal9 gene was preliminarily mapped near the marker RM156 on the chromosome 3.New INDEL markers were then designed based on the sequence differences between japonica and indica at the region near RM156.The nal9 gene was fnally located in a 69.3 kb region between the markers V239B and V239G within BAC OJ1212_C05 by chromosome walking.Sequence and expression analysis showed that an ATP-dependent Clp protease proteolytic subunit gene(ClpP)was most likely to be the nal9 gene.Furthermore,the nal9 mutation was rescued by transformation of the ClpP cDNA driven by the 35S promoter.Accordingly,the ClpP gene was identifed as the NAL9 gene.Our results provide a basis for functional studies of NAL9 in future work. | Wei Li Chao Wu Guocheng Hu Li Xing Wenjing Qian Huamin Si Zongxiu Sun Xingchun Wang Yaping Fu Wenzhen Liu | 2013 | Journal of Integrative Plant Biology2013，55，11： | 8 |
| 20 | LSECtin on tumor-associated macrophages enhances breast cancer sternness via interaction with its receptor BTN3A3显示文摘Macrophages have bee n suggested to con tribute to con structing a cancer stem cell(CSC)niche.However,whether and how macrophages regulate the activity of CSCs through juxtacrine signaling are poorly understood.Here we report LSECtin,a transmembrane protein highly expressed on tumor-associated macrophages(TAMs),enhances sternness of breast cancer cells(BCCs).We identified BTN3A3,a B7 family member with previously unknown functions as the receptor for LSECtin on BCCs responsible for stemness-promoting effect of LSECtin.In mice bearing human tumor xenografts,either macrophage-specific ablation of LSECtin or silencing of BTN3A3 in BCCs decreased CSC frequency and tumor growth.Admixture of LSECtin-positive macrophages increased the tumorigenic activity of BCCs dependent on BTN3A3.Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 mAb has a therapeutic effect on breast cancer.These findings define a juxtacrine signaling mechanism by which TAMs promote cancer stemness.Targeting this axis in the CSC niche may provide potential therapies to breast cancer. | Di Liu Qian Lu Xing Wang Jun Wang Ning Lu Zefei Jiang Xiaopeng Hao Jianbin Li Jing Liu Pengbo Cao Guilin Peng Yuandong Tao Dianyuan Zhao Fuchu He Li Tang | 2019 | Cell Research2019，29，5： | 8 |
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