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| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | OsWRKY03, a rice transcriptional activator that functions in defense signaling pathway upstream of OsNPR1显示文摘WRKY family proteins are a class of plant specific transcription factors that involve in many stress response pathways. It has been shown that one Arabidopsis WRKY protein, AtWRKY29/22, is activated by MAP kinase signaling cascade and confers resistance to both bacterial and fungal pathogens. However, little is known about the biological roles of WRKY proteins in rice. In this study, we investigated the expression patterns of rice AtWRKY29/22 homolog, OsWRKY03, under different conditions, and also its possible role involved in plant defense. Our results showed that OsWRKY03 was up-regulated by several defense signaling molecules or different treatments. Further analysis revealed that the expres- sion of OsWRKY03 was light dependent. Transcriptional activation activity of OsWRKY03 was also demonstrated by yeast functional assay. Transient expression of OsWRKY03-GFP fusion protein in onion epidermis cells showed that OsWRKY03 was a nuclear localized protein. OsNPR1 as well as several other pathogenesis-related genes, such as OsPR1b, phenylalanine ammonia-lyase (ZB8) and peroxidase (POX22.3), were induced in OsWRKY03-overexpressing transgenic plants. These results indicated that OsWRKY03 is located upstream of OsNPR1 as a transcriptional activator in salicylic acid (SA)-dependent or jasmonic acid (JA)-dependent defense signaling cascades. | Xiao Qiang LIU Xian Quan BAI Qian QIAN Xiu Jie WANG Ming Sheng CHEN Cheng Cai CHU | 2005 | Cell Research2005，15，8： | 55 |
| 3 | Report on Childhood Obesity in China (9): Sugar-sweetened Beverages Consumption and Obesity显示文摘Objective To explore the associations between sugar-sweetened beverage (SSB) consumption and obesity as well as obesity-related cardiometabolic disorders among children in China. Methods A total of 6974 (boys 3558, girls 3412) children aged 6-13 years participated in the study. Each participant's height, weight, waist circumference, fasting glucose, triglycerides, total cholesterol, high- density lipoprotein cholesterol, and low-density lipoprotein cholesterol were measured. The type of beverage consumption was determined using a self-administered questionnaire. Results SSBs were consumed regularly by 46.1% of the children. The prevalence [adjusted odds ratio (95% confidence internal (CI)] of obesity was 7.6% [as the reference group (ref.)], 10.1% [1.36(1.07, 1.74)], and 11.6% [1.46(1.21, 1.75)], among children who regularly drank milk, other beverages and SSBs, respectively. Regularly drinking SSBs elevated the likelihood of abdominal obesity [adjusted odds ratio (95% CI): 1.36 (1.17, 1.59)]. The prevalence [adjusted odds ratio (95% CI)] of obesity among children who regularly drank sports/caloric beverages, carbonated beverages, sweet tea, and plant protein beverages was 16.8% [2.00(1.31, 3.07)], 12.7% [1.52(1.23, 1.88)], 11.5% [1.52(1.18, 1.95)], and 10.4% [1.41(1.03, 1.94)], respectively, which was higher than that of regular milk drinkers [7.6 % (ref.)]. The prevalence [adjusted odds ratio (95% CI)] of abdominal obesity among children who regularly drank sweet tea, fruit/vegetable juices, and carbonated beverages was 17.7% [1.55(1.26, 1.90)], 16.2% [1.36(1.09, 1.70)], and 15.3% [1.24(1.03, 1.50)], respectively, which was much higher than that of regular milk drinkers [12.8% (ref.)]. Conclusions Regular SSB consumption was positively related to obesity and abdominal obesity. This relationship should be investigated further using a longitudinal study design. | SHANG Xian Wen LIU Ai Ling ZHANG Qian HU Xiao Qi DU Song Ming MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin LI Ting Yu MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 23 |
| 4 | Three-dimensional human facial morphologies as robust aging markers显示文摘老化与许多复杂疾病被联系。变老的过程的可靠预言为估计联系老化的疾病的风险是重要的。然而尽管有强烈研究,到目前为止没有可靠老化标记。这里,我们由检验人的 3D 美容成像特征是否能被用作可靠老化标记处理了这个问题。我们收集了 >300 幅 3D 人美容图象和越过 17 ~ 77 年的年龄散布得好的血侧面。由分析词法侧面,我们产生了变老的人的面部 phenome 的第一张全面地图。我们鉴别量的面部特征例如眼睛斜坡,高度与年龄联系了。我们构造了一个柔韧的年龄预言者并且发现平均,一样的按年代先后的年龄的人由 ± 不同;在美容的 6 年变老,与在年龄 40 以后增加的偏差。用这个预言者,我们识别了被健康指示物的层次显著地支持的慢、快的蒸化机。尽管有在在血的面部词法特征和健康指示物之间的一种靠近的关系,面部特征比血侧面是更可靠的老化 biomarkers 并且能更好比按年代先后的年龄反映一般健康地位。 | Weiyang Chen Wei Qian Gang Wu Weizhong Chen Bo Xian Xingwei Chen Yaqiang Cao Christopher D Green Fanghong Zhao Kun Tang Jing-Dong J Han | 2015 | Cell Research2015，25，5： | 17 |
| 5 | Long-term Efficacy of Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease: A 5-year Follow-up Study in China显示文摘 | Lu-Lu Jiang Jin-Long Liu Xiao-Li Fu Wen-Biao Xian Jing Gu Yan-Mei Liu Jing Ye Jie Chen Hao Qian Shao-Hua Xu Zhong Pei Ling Chen | 2015 | Chinese Medical Journal2015，，18： | 13 |
| 6 | Effects and safety of Sinomenine in treatment of rheumatoid arthritis contrast to methotrexate: a systematic review and Meta-analysis显示文摘OBJECTIVE: To systematically evaluate the curative clinical efficacy and safety of sinomenine(SIN) in treatment of rheumatoid arthritis(RA) in comparison to methotrexate(MTX).METHODS: We searched the China National Knowledge Infrastructure Database, Chinese Biomedical Literature Database, China Science and Technology Journal Database, Wanfang Database, Pubmed and Cochrane Library electronically up to August 31,2015, without language limitation. Only randomized controlled trials(RCTs) were included. Software Review Manager 5.3 was used for Meta-analysis.RESULTS: A total of 16 eligible studies within 1500RA patients were included. The meta-analysis indicated that on basis of MTX, SIN was more effective in total effective rate(P < 0.000 01). Besides, SIN alone versus MTX also showed advantages in RA therapy(P = 0.04) Taken together, adverse events occurred less frequently in combination of SIN and MTX than MTX alone(P < 0.0001), especially in digestive system(P < 0.000 01),while occurred more in dermato mucosal system with SIN treatment versus MTX(P = 0.02), and were similar for both remedies in nervous system(P = 0.12) and hematological system(P = 0.25).CONCLUTION: Compared to MTX, SIN had better clinical efficacy and relatively fewer adverse events in treatment of RA, especially when it was used together with MTX. Due to the poor methodological quality, well-designed, multiple-center RCTs are still required to further confirm the findings. | Liu Weiwei Qian Xian Ji Wei Lu Yan Wei Gang Wang Yue | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 12 |
| 7 | Adhesion molecule and proinflammatory cytokine gene expression in hepatic sinusoidal endothelial cells following cecal ligation and puncture显示文摘INTRODUCTIONMultiple organ dysfunction syndrome (MODS) isthought to be a frequent consequence of sepsis[1-3].Despite substantial advances in our knowledge and understanding of the basic pathophysiologic mechanisms[4-7], in critically ill patients infections and sepsis are still associated with a high mortality[8,9]. | Rong Qian Wu Ying Xin Xu Xu Hua Song Li Jun Chen Xian Jun Meng Institute of Surgical Research, General Hospital of PLA, Beijing 100853, China | 2001 | World Journal of Gastroenterology2001，7，1： | 10 |
| 8 | Infection within 2 weeks before liver transplantation closely related to prognosis of posttransplant infection:A single-center retrospective observational study in China显示文摘Background:Infections still represent the main factors influencing morbidity and mortality following liver transplantation.This study aimed to evaluate the incidence and risk factors for infection and survival after liver transplantation.Methods:We retrospectively examined medical records in 210 liver recipients who underwent liver transplantation between April 2015 and October 2017 in our hospital.Clinical manifestations and results of pathogen detection test were used to define infection.We analyzed the prevalence,risk factors and prognosis of patients with infection.Results:The median follow-up was 214 days;the incidence of infection after liver transplantation was 46.7%(n=98)which included pneumonia(43.4%),biliary tract infection(21.9%),peritonitis(21.4%)and bloodstream infection(7.6%).Among the pathogens in pneumonia,the most frequently isolated was Acinetobacter baumanii(23.5%)and Klebsiella pneumoniae(21.2%).Model for end-stage liver disease(MELD)score(OR=1.083,95%CI:1.045–1.123;P<0.001),biliary complication(OR=4.725,95%CI:1.119–19.947;P=0.035)and duration of drainage tube(OR=1.040,95%CI:1.007–1.074;P=0.017)were independent risk factors for posttransplant infection.All-cause mortality was 11.0%(n=23).The prognostic factors for postoperative infection in liver recipients were prior-transplant infection,especially pneumonia within 2 weeks before transplantation.Kaplan-Meier curves of survival showed that recipients within 2 weeks prior infection had a significantly lower cumulative survival rate compared with those without infection(65.2%vs.90.0%;hazard ratio:4.480;P<0.001).Conclusions:Infection,especially pneumonia within 2 weeks before transplantation,complication with impaired renal function and MELD score after 7 days of transplantation was an independent prognostic factor for postoperative infection in liver transplant recipients. | Yue Ying Rui-Dong Li Jing-Wen Ai Yi-Min Zhu Xian Zhou Yi-Yi Qian Xin-Chang Chen Xu-Yang Wang Hao-Cheng Zhang Yang Li Shan-Shan Weng Yi-Qi Yu Yi-Feng Tao Yu-Xian Huang Zheng-Xin Wang Wen-Hong Zhang | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，4： | 7 |
| 9 | Adverse Effects of Exposure to Fine Particulate Matters and Ozone on Gestational Hypertension显示文摘Gestational hypertension(GH)is a common complication during pregnancy.GH is regarded as a potential public health challenge for pregnant women and infants.Limited evidence has linked ambient air pollution to an increased GH risk.However,most of the studies were conducted in developed countries,with inconsistent results obtained.The present study was performed to explore whether exposure to particulate matters with an aerodynamic diameter≤2.5(PM2.5)and ozone(O3)was related to elevated odds of GH in a Chinese population.This population-based cohort study involved 38115 pregnant women in Wuhan,China.All information was collected from the Wuhan Maternal and Child Health Management Information System,using standardized quality control.The daily air pollutant data for PM2.5 and O3 were obtained from the 20 monitoring stations of the Wuhan Environmental Monitoring Center during 2014.The nearest monitor approach was applied to individual exposure assessment of PM2.5 and O3 for each participant.After adjusting for major confounders and other air pollutants,a 10μg/m^3 increase in PM25 and O3 concentrations was found to correlate to a 1.14-fold[95%confidence interval(95%CI):1.09,1.20]and a 1.05-fold(95%CI:1.02,1.07)increase in GH risk,respectively.Additionally,stronger relationships between GH risk and PM25 and O3 exposure were observed in women who conceived in winter and summer,respectively.These findings suggest that air pollutants may contribute to the development of GH. | Rong YANG Dan LUO Yi-ming ZHANG Ke HU Zheng-min QIAN Li-qin HU Long-jiao SHEN Hong XIAN Juliet Iwelunmor Su-rong MEI | 2019 | Current Medical Science2019，39，6： | 7 |
| 10 | Poly(ADP-ribosyl)ation of Apoptosis Antagonizing Transcription Factor Involved in Hydroquinone-Induced DNA Damage Response显示文摘The molecular mechanism of DNA damage induced by hydroquinone(HQ)remains unclear.Poly(ADP-ribose)polymerase-1(PARP-1)usually works as a DNA damage sensor,and hence,it is possible that PARP-1 is involved in the DNA damage response induced by HQ.In TK6 cells treated with HQ,PARP activity as well as the expression of apoptosis antagonizing | ling xiao xuan liu jia xian yun lin du yu jun chen shao qian chen jia long tang huan wen liu lin hua | 2016 | Biomedical and Environmental Sciences2016，29，1： | 6 |
| 11 | Traditional Chinese medicine compound ShengJinRunZaoYangXue granules for treatment of primary Sjogren's syndrome: a randomized, double-blind, placebo-controlled clinical trial显示文摘 | Hu Wei Qian Xian Guo Feng Zhang Miaojia Lyu Chengyin Tao Juan Gao Zhong'en Zhou Zhengqiu | 2014 | Chinese Medical Journal2014，，15： | 5 |
| 12 | Efficacy of fire needle on acute gouty arthritis induced by monosodium urate in rats显示文摘OBJECTIVE:To explore the therapeutic effect and inflammatory mechanism of fire needles on gouty arthritis.METHODS:Sixty male Sprague-Dawley rats were divided into four groups,that is,control group,the model group,the colchicine group,and the fire needle treatment group.Acute gouty arthritis was prepared by injection of monosodium urate in the ankle joint.The inflammation-related protein[toll-like receptor 4(TLR4),pyrin domain-containing protein 3(NLRP3),interleukin(IL)-1β,myeloid differentiation factor 88(My D88),nuclear factorkappa B(NF-κB),phosphorylated NF-κB(p-NF-κB),caspase-1,and p-caspase-1]in swollen tissues,the inflammation-related m RNAs indicators(TLR4,NLRP3,NF-κB,and caspase-1)and the inflammatory factors[IL-1β,IL-6,IL-8,tumor necrosis factor-α(TNF-α),and C-reactive protein(CRP)]in the serum were detected by Western blot,real-time quantitative polymerase chain reaction,and enzyme-linked immunosorbent assay,respectively.RESULTS:The fire needle treatment could reduce joint swelling,increase mechanical pain threshold and decrease the inflammation index score in the fire needle treatment group.It could also significantly decreased the protein expression of IL-1β,TLR4,My D88,p-NF-κB and NLRP3 in joint tissue,markedly downregulated the m RNA levels of TLR4 and NLRP3 in joint tissue,and significantly reduce serum levels of IL-1β,IL-6,IL-8,TNF-α,and CRP.CONCLUSION:The fire needle treatment had positive effect of treating gouty arthritis,and its underlying mechanism might be associated with NF-κB activation and related inflammatory response. | CHEN Hua ZHOU Gexuan HE Xiaojin GUO Feng CHEN Jianmei QIAN Xian | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 4 |
| 13 | Comparison study of slag corrosion resistance of MgO–MgAl_(2)O_(4),MgO–CaO and MgO–C refractories under electromagnetic field显示文摘To illuminate the corrosion behavior of MgO-based refractories under electromagnetic field(EMF),herein,the slag corrosion and penetration resistance of MgO–MgAl_(2)O_(4),MgO–CaO,and MgO–C refractories were investigated using the rotary immersion slag resistance test at 1873 K for 1 h.The results showed that the order of the good slag resistance of as-tested refractories was MgO–C>MgO–CaO>MgO–MgAl_(2)O_(4).The EMF accelerated the corrosion and penetration of slag to the refractories,which caused the molten slag to be easier into the refractories by natural convection and Marangoni effect.In addition,the MgO–C refractories did not show an overwhelming advantage in slag resistance because EMF impeded the formation of the dense protection layer.Consequently,in view of the present results,the MgO–C refractories are still the most promising slag line material for refining furnace among MgO–MgAl_(2)O_(4),MgO–CaO,and MgO–C refractories. | Xin‑ming Ren Bei‑yue Ma Shi‑ming Li Hong‑xia Li Guo‑qi Liu Wen‑gang Yang Fan Qian Shi‑xian Zhao Jing‑kun Yu | 2021 | Journal of Iron and Steel Research(International)2021，28，1： | 4 |
| 14 | Landscape planning and ecology construction of wetland comprehensive protected area system in the Sanjiang Plain显示文摘Wetland is one of the richest biodiversity areas in the earth. The main purpose of establishing wetland protected area is to protect biodiversity, and the protection of ecosystem diversity and landscape diversity is the key to protect biodiversity. In order to protect regional ecosystem and landscape, it is a good way to establish wetland comprehensive protected area which connected wetland nature reserves by habitat corridors. The Sanjiang Plain as a study area, its landscape evaluation index system on wetland protected area was studied, and some problems on landscape planning and ecology construction were further approached in this paper.It showed that establishing wetland comprehensive protected area is very important to protect regional wetlands, to maintain ecological balance, and to improve the sustainable development of agriculture and industry in this region. | LIU Hong\|yu, LU Xian\|guo, LIU Zhen\|qian (Changchun Institute of Geography, Chinese Academy of Sciences, Changchun 130021, China) | 2000 | Journal of Environmental Sciences2000，12，3： | 3 |
| 15 | Ceramide from sphingomyelin hydrolysis differentially mediates mitogen-activated protein kinases (MAPKs) activation following cerebral ischemia in rat hippocampal CA1 subregion显示文摘Objective:To explore the role that ceramide plays in the activation of mitogen-activated protein kinases (MAPKs) during cerebral ischemia and reperfusion. Methods: Rats were subjected to ischemia by the four-vessel occlusion (4-VO) method. The sphingomyelinase inhibitor TPCK was administered to the CA1 subregion of the rat hippocampus before inducing ischemia. Western blot was used to examine the activity of extracellular-signal regulated kinase (ERK) and c-Jun N-terminal protein kinase (JNK) using antibodies against ERK, JNK and diphosphorylated ERK and JNK. Results: At 1h reperfusion post-ischemia, JNK reached its peak activity while ERK was undergoing a sharp inactivation (P<0.05). The level of diphosphorylated JNK was significantly reduced but the sharp inactivation of ERK was visibly reversed (P<0.05) by the sphingomyelinase inhibitor. Conclusion: The ceramide signaling pathway is up-regulated through sphingomyelin hydrolysis in brain ischemia, promoting JNK activation and suppressing ERK activation, culminating in the ischemic lesion. | Xian Sun | 2010 | The Journal of Biomedical Research2010，24，2： | 3 |
| 16 | Efficacy and mechanism of anti-vascular endothelial growth factor drugs for diabetic macular edema patients显示文摘BACKGROUND Diabetes is a serious public health concern in China,with 30%of patients developing retinopathy,and diabetic macular edema(DME)having the biggest impact on vision.High blood glucose level can cause retinal cell hypoxia,thus promoting vascular endothelial growth factor(VEGF)formation and increasing vascular permeability,which induces DME.Moreover,cell hypoxia can accelerate the rate of apoptosis,which leads to the aging of patients.In severe cases,optic cell apoptosis or retinal fibrosis and permanent blindness may occur.AIM To investigate and compare the efficacy,mechanism,and differences between two anti-VEGF drugs(Compaq and ranibizumab)in DME patients.METHODS Ninety-six patients with DME who attended our hospital from April 2018 to February 2020 were included and randomly divided into two groups(Compaq group and ranibizumab group).The groups received vitreal cavity injections of 0.5 mg Compaq and 0.5 mg ranibizumab,respectively,once a month.The best corrected visual acuity(BCVA),intraocular pressure(IOP),macular retinal thickness(CMT),macular choroidal thickness(SFCT),foveal no perfusion area(FAZ),superficial capillary density,deep capillary density,treatment effect,and adverse reactions were compared before and after treatment and between the two groups.RESULTS Before treatment and 1-mo post-treatment,there was no statistically significant difference in the estimated BCVA in both groups(P>0.05).BCVA decreased in the Compaq group 3 mo after treatment,and the difference was statistically significant(P<0.05).Before treatment,and 1 mo and 3 mo post-treatment,there was no statistically significant difference in the estimated IOP in either group(P>0.05).Before treatment and 1-mo post-treatment,there was no statistically significant difference in the estimated CMT,SFCT,or FAZ in either group(P>0.05).CMT and SFCT values decreased in the Compaq group 3 mo post-treatment,and the difference was statistically significant(P<0.05).Before treatment,and 1 mo and 3 mo post-treatment,there were no statistically significant differences in vascular density in the shallow or deep capillary plexi of the fovea,parafovea,or overall macular area between the two groups(P>0.05).Marked efficient,effective,and invalid rates were 70.83%and 52.08%,27.08%and 39.58%,and 2.08%and 8.33%in the Compaq and ranibizumab groups,respectively.The differences between the two groups were statistically significant(P<0.05).CONCLUSION Anti-VEGF drugs can effectively improve CMT and SFCT,without affecting microcirculation,thus providing an effective and safe treatment for patients with DME. | Yun-Fei Li Qian Ren Chao-Hui Sun Li Li Hai-Dong Lian Rui-Xue Sun Xian Su Hua Yu | 2022 | World Journal of Diabetes2022，13，7： | 3 |
| 17 | First light for the sodium laser guide star adaptive optics system on the Lijiang 1.8 m telescope显示文摘A first generation sodium Laser Guide Star Adaptive Optics System(LGS-AOS) was developed and integrated into the Lijiang 1.8 m telescope in 2013. The LGS-AOS has three sub-systems:(1) a 20 W long pulsed sodium laser,(2) a 300-millimeter-diameter laser launch telescope, and(3) a 37-element compact adaptive optics system. On 2014 January 25, we obtained high resolution images of an mV8.18 star,HIP 43963, during the first light of the LGS-AOS. In this paper, the sodium laser, the laser launch telescope,the compact adaptive optics system and the first light results will be presented. | Kai Wei Min Li Shan-Qiu Chen Yong Bo Feng Chen Jun-Wei Zuo Qi Bian Ji Yao Lu-Chun Zhou Lin Wei Dong-Hong Chen Yang Gao KaiJin Xiao-Lin Dai Han-Chu Fu Chang Xu Zhi-Chao Wang Xiang-Hui Xue Xue-Wu Chen Xian-Mei Qian Yu Zhou Hao Xian Qin-Jun Peng Chang-Hui Rao Zu-Yan Xu Yu-Dong Zhang | 2016 | Research in Astronomy and Astrophysics2016，16，12： | 2 |
| 18 | Decomposition of Transformer Oil Under Ultrasonic Irradiation During Degassing Process显示文摘In the degassing process of transformer oil with ultrasonic waves, decomposition of the oil was observed. Light hydrocarbons, including methane, ethane, ethylene, acetylene, propane etc, were found to be released continuously from the oil into headspace within a closed vial placed in an ultrasonic field. The gases came from decomposition of hydrocarbon molecules under cavitation effect. | Xiao Zheng LAN, Ya Feng GUAN, Dao Qian ZHU, Zhi Cheng TAN*, Li Xian SUN Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 | 2002 | Chinese Chemical Letters2002，13，11： | 2 |
| 19 | The Helicobacter pylori Protein CagM is Located in the Transmembrane Channel That is Required for CagA Translocation显示文摘 | Feng Ling Xiaochun Wang DongFang Dai Min Yu Cheng Chen Jingyi Qian Chang Liu Yuanyuan Zhang Jie Ding Xian Wei Guan Shihe Shao | 2013 | Current Microbiology2013，，5： | 2 |
| 20 | Optimal model establishment of whole-process management data for CAR-T therapy in China—how should this be done?显示文摘Chimeric antigen receptor(CAR)T-cell therapy utilizes patients’own T lymphocytes that are engineered to attack cancer cells[1,2,3].With the US Food and Drug Administration(FDA)approval of four CD19-and one BCMA-targeted CAR therapy for B cell malignancies[4,5],CAR T-cell therapy has finally reached the status of a medicinal product. | Xiaolei Li Hanren Dai Xian Li Ping Li Wenbin Qian Aibin Liang Weidong Han | 2022 | Cellular & Molecular Immunology2022，19，1： | 2 |
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