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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Physical model test study on shear strength characteristics of slope sliding surface in Nanfen open-pit mine显示文摘A physical model for the footwall slope of Nanfen open-pit mine, China was established using a selfdeveloped deep geological engineering disaster model test system. A thermosensitive similar material,paraffin, was selected to simulate a weak structural plane in the slope to reproduce the landslide process.From an experimental perspective, the variation trend of shear strength parameters of weak structural plane and the mechanical support characteristics of NPR(negative Poisson’s ratio) anchor cable under the condition of a large landslide deformation and failure were examined. The results of this model test showed that slope failure has four distinct stages:(1) soil compaction stage,(2) crack generation stage,(3) crack propagation stage, and(4) sliding plane transfixion stage. According to the test results, the rock mechanics parameters of weak surface in the footwall slope of Nanfen open-pit mine were calculated.The cohesion is approximately 1.35×10~5 Pa, and the internal friction angle is approximately 6.33°.During slope failure, the NPR anchor cable experiences a large deformation but no damage occurs, indicating that the NPR anchor cable can be continuously monitored and reinforced during the deformation and failure of landslide. The stress characteristics of NPR anchor cables during the test are consistent with the monitoring results of Newtonian force at the landslide site, proving that NPR anchor cables are effective and reasonable in landslide monitoring and early warning. | Zhigang Tao Yu Shu Xiaojie Yang Yanyan Peng Qihang Chen Haijiang Zhang | 2020 | International Journal of Mining Science and Technology2020，30，3： | 8 |
| 3 | Roles of soluble minerals in Cd sorption onto rice straw biochar显示文摘Transforming to biochar provides an environmentally friendly approach for crop residue reutilization,which are usually applied as sorbent for heavy metal removal.As typical siliconrich material,the specific sorptive mechanisms of rice straw derived biochar(RSBC)are concerned,especially at the low concentration range which is more environmentally relevant.In the present study,Cd sorption onto RSBCs at the concentration of ≤5 mg/L was investigated.The sorptive capacity was positively correlated with the pyrolytic temperature of the biochar and the environmental pH value.Water soluble minerals of the RSBCs played the dominant roles in Cd sorption,contributing 29.2%,62.5%and 82.9%of the total sorption for RSBCs derived under 300℃,500℃and 700℃,respectively.Increased number of cations,dominantly K^(+),were exchanged during the sorption.Coprecipitation with cations and carbonates may also be contributive to the sorption.The dissolution of silicon-containing minerals was found to be declined during sorption,suggesting its involvement in the sorption process,possibly through precipitation.Whilst,the sparingly soluble silicate crystals may impose ignorable role in the sorption.Complexation with organic groups is only a minor mechanism in Cd sorption,compared to the much more dominant roles of the inorganic ashes. | Ying-heng Fei Zuannan Zhang Zhuofeng Ye Qihang Wu Ye-tao Tang Tangfu Xiao | 2022 | Journal of Environmental Sciences2022，34，3： | 4 |
| 4 | Petrology, Geochemistry and Zircon U-Pb Geochronology of the Xiangshan Group in the Eastern Hexi Corridor Belt: Implications for Provenance and Tectonic Evolution显示文摘The eastern Hexi Corridor Belt(HCB) is located in the transitional belt among the Alxa Block,the Qilian Orogenic Belt and the North China Block. Because of its unique tectonic location, the tectonic setting, provenance, and even the age of the sedimentary strata in the eastern HCB during the Early Paleozoic remain controversial. This study analyzes the provenance of the poorly studied Xiangshan Group, discusses its age of development and tectonic setting in the eastern HCB using a combination of petrological, geochemical and LA-ICP-MS U-Pb zircon dating methods. Based on the youngest age peaks and the fossil evidence, we suggest that the Xiangshan Group is Middle Cambrian to Late Ordovician in age. The complexity of the geochemical characteristics and associated diagrams suggests that the early stage of the Xiangshan Group developed in a passive continental margin environment, late in the backarc basin of the eastern HCB. Based on the sandstone detrital composition, whole-rock geochemistry and detrital zircon ages, we conclude that the Xiangshan Group had an early provenance that was mainly from the Qilian Block and a late provenance from the Qilian Block and the western Alxa Block. The eastern HCB and its northern and southern blocks have similar palaeontology, lithology and basement age characteristics to the South China Block. This indicates that the eastern HCB might not have formed in the intra-continental aulacogen of the North China Block during the Early Paleozoic but has a close affinity to eastern Gondwana. | ZHAO Xiaochen LIU Chiyang WANG Jianqiang DUAN Liang ZHAO Yan ZHANG Qihang LUO Wei | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 4 |
| 5 | Surface‑Enhanced Raman Scattering Fiber Probe Based on Silver Nanocubes显示文摘Surface-enhanced Raman scattering(SERS)provides a novel method for low concentration molecular detection.The performances were highly dependent on the sizes,geometries and distributions of metal nanostructures.Here,highly sensitive SERS fber probe based on silver nanocubes(Ag NCs)was fabricated,by assembled nanostructures on planar and tapered fber tips.Ag NCs were synthesized by polyol method,and controlled by reductant content,reaction temperatures and crystal growth durations.Tapered fbers with diferent cone angles were prepared by chemical etching.The electromagnetic distribution simulation indicated that nanocubes had stronger electric feld between two cubes and vertex corners than nanosphere,under 532 nm laser excitation.The intensity could reach 53.52 V/m,for cubes with 70 nm edge length.The SERS performance of probes was characterized using crystal violet analyte.The detectable lowest concentration could reach 10^(-9) and 10^(-10) M for planar and tapered fber probes,respectively.The corresponding enhancement factor could be 9.02×10^(7) and 6.22×10^(8).The relationship between SERS peak intensities and analyte concentrations showed well linear,which indicated both fber probes could be applied for both qualitative and quantitative analysis.Furthermore,optimal cone angle of tapered fber SERS probe was 8.3°.The tapered fber SERS probes have highly sensitive activity and great potential in substance detection. | Miao Yu Qihang Tian Guangyuan He Kaimin Cui Jihong Zhang | 2021 | Advanced Fiber Materials2021，3，6： | 3 |
| 6 | Polyploidy events shaped the expansion of transcription factors in Cucurbitaceae and exploitation of genes for tendril development显示文摘Cucurbitaceae is one of the most important plant families distributed worldwide.Transcription factors(TFs)regulate plant growth at the transcription level.Here,we performed a systematic analysis of 42641 TFs from 63 families in 14 Cucurbitaceae and 10 non-cucurbit species.Whole-genome duplication(WGD)was the dominant event type in almost all Cucurbitaceae plants.The TF families were divided into 1210 orthogroups(OGs),of which,112 were unique to Cucurbitaceae.Although the loss of several gene families was detected in Cucurbitaceae,the gene families expanded in five species that experienced a WGD event comparing with grape.Our findings revealed that the recent WGD events that had occurred in Cucurbitaceae played important roles in the expansion of most TF families.The functional enrichment analysis of the genes that significantly expanded or contracted uncovered five gene families,AUX/IAA,NAC,NBS,HB,and NF-YB.Finally,we conducted a comprehensive analysis of the TCP gene family and identified 16 tendril-related(TEN)genes in 11 Cucurbitaceae species.Interestingly,the characteristic sequence changed from CNNFYFP to CNNFYLP in the TEN gene(Bhi06M000087)of Benincasa hispida.Furthermore,we identified a new characteristic sequence,YNN,which could be used for TEN gene exploitation in Cucurbitaceae.In conclusion,this study will serve as a reference for studying the relationship between gene family evolution and genome duplication.Moreover,it will provide rich genetic resources for functional Cucurbitaceae studies in the future. | Yu Zhang Yingchao Zhang Bing Li Xiao Tan Changping Zhu Tong Wu Shuyan Feng Qihang Yang Shaoqin Shen Tong Yu Zhuo Liu Xiaoming Song | 2022 | Horticultural Plant Journal2022，8，5： | 2 |
| 7 | Volatile threshold switching memristor:An emerging enabler in the AIoT era显示文摘With rapid advancement and deep integration of artificial intelligence and the internet-of-things,artificial intelligence of things has emerged as a promising technology changing people’s daily life.Massive growth of data generated from the devices challenges the AIoT systems from information collection,storage,processing and communication.In the review,we introduce volatile threshold switching memristors,which can be roughly classified into three types:metallic conductive filament-based TS devices,amorphous chalcogenide-based ovonic threshold switching devices,and metal-insulator transition based TS devices.They play important roles in high-density storage,energy efficient computing and hardware security for AIoT systems.Firstly,a brief introduction is exhibited to describe the categories(materials and characteristics)of volatile TS devices.And then,switching mechanisms of the three types of TS devices are discussed and systematically summarized.After that,attention is focused on the applications in 3D cross-point memory technology with high storage-density,efficient neuromorphic computing,hardware security(true random number generators and physical unclonable functions),and others(steep subthreshold slope transistor,logic devices,etc.).Finally,the major challenges and future outlook of volatile threshold switching memristors are presented. | Wenbin Zuo Qihang Zhu Yuyang Fu Yu Zhang Tianqing Wan Yi Li Ming Xu Xiangshui Miao | 2023 | Journal of Semiconductors2023，44，5： | 1 |
| 8 | Experimental study on instability mechanism and critical intensity of rainfall of high-steep rock slopes under unsaturated conditions显示文摘Two critical factors,namely intense precipitation and intricate excavation,can trigger rock mass disasters in mining operations.In this study,an indoor rainfall system was developed to precisely regulate the flow and intensity of precipitation.A large-scale model experiment was conducted on a self-designed physical simulation experiment platform to investigate the failure and instability of high-steep rock slopes under unsaturated conditions.The real-time reproduction of the progressive failure process in high-steep rock slopes enabled the determination of the critical rainfall intensity and revealed the mechanism underlying slope instability.Experiment results indicated that rainfall may be the primary factor contributing to rock mass instability,while continuous pillar mining exacerbates the extent of rock mass failure.The critical failure stage of high-steep rock slopes occurs at a rainfall intensity of 40 mm/h,whereas a rainfall exceeding 50 mm can induce critical instability and precipitation reaching up to 60 mm will result in slope failure.The improved region growing segmentation method(IRGSM)was subsequently employed for image recognition of rock mass deformation in underground mines.Herein an error comparison with the simple linear iterative cluster(SLIC)superpixel method and the original region growing segmentation method(ORGSM)showed that the average identification error in the X and Y directions by the method was reduced significantly(1.82%and 1.80%in IRGSM;4.70%and 6.26%in SLIC;9.45%and 12.40%in ORGSM).Ultimately,the relationship between rainfall intensity and failure probability was analyzed using the Monte Carlo method.Moreover,the stability assessment criteria of rock slope under unsaturated condition were quantitatively and accurately evaluated. | Xiaoshuang Li Qihang Li Yunmin Wang Wei Liu Di Hou Wenbo Zheng Xiong Zhang | 2023 | International Journal of Mining Science and Technology2023，33，10： | 1 |
| 9 | An insight into aggregation kinetics of polystyrene nanoplastics interaction with metal cations显示文摘Once inevitably released into the aquatic environment,polystyrene nanoplastics(PS-NPs)will present complicated environmental behaviors,of which the aggregation is a key process determining their environmental fate and impact.In this study,the aggregation kinetics of different sizes(30 nm and 100 nm)of PS-NPs with metal cations(Na^(+),K^(+),Ca^(2+),Mg^(2+)and Pb^(2+))at different solution pH(3,6 and 8)were investigated.The results showed that the aggregation of PS-NPs increased with cation concentration.Taking Pb^(2+)as an example,the adsorption behavior of cations onto PS-NPs was determined by transmission electron microscopy(TEM)and energy dispersive X-ray(EDX)spectroscopy,which demonstrated Pb^(2+)could be adhered onto the surface of PS-NPs with the effect of charge neutralization.The critical coagulation concentrations(CCC)of smaller PS-NPs were higher than that of larger PS-NPs for monovalent cations,whereas a different pattern is observed for divalent cations.It was suggested that there were other factors that DLVO theory does not consider affect the stability of NPs with different particle sizes.In addition,it should be noted that PS-NPs had the capacity of adsorbing large amounts of heavy metal cations and carried them transport to a long distance,and the corresponding ecological risks need to further elucidate. | Yucheng Zhang Xiaotong Su Nora FYTam Xiaolan Lao Meiling Zhong Qihang Wu Huifang Lei Zihui Chen Zhang Li Jie Fu | 2022 | Chinese Chemical Letters2022，33，12： | 1 |
| 10 | A Through-Intact-Skull(TIS)chronic window technique for cortical structure and function observation in mice显示文摘Modern optical imaging techniques provide powerful tools for observing cortical structure and functions at high resolutions.Various skull windows have been established for different applications of cortical imaging,and each has its advantages and limitations.Most critical of the limitations,none of the current skull windows is suitable for observing the responses to some acute craniocerebral injuries on a large scale and at high resolution.Here,we developed a“Through-Intact-Skull(TIS)window”that enables the observation of an immune response on a bilateral cortical scale and at single-cell resolution after traumatic brain injury without affecting the pathological environment of the brain.The TIS window also has the advantages of craniotomy-freeness,centimeter-field of view,synaptic resolution,large imaging depth,long-term observation capability,and suitability for awake mice.Therefore,the TIS window is a promising new approach for intravital cortical microscopy in basic research in neuroscience. | Dongyu Li Zhengwu Hu Hequn Zhang Qihang Yang Liang Zhu Yin Liu Tingting Yu Jingtan Zhu Jiamin Wu Jing He Peng Fei Wang Xi Jun Qian Dan Zhu | 2022 | eLight2022，2，1： | 1 |
| 11 | VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway显示文摘Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases. | Chunsik Lee Rongyuan Chen Guangli Sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li Weiwei Lu Wei Chen Juanxi Liu Jiaxin Hu Qihang Sun Weisi Lu Lekun Fang Shasha Wang Haiqing Kuang Yihan Zhang Geng Tian Jia Mi Bi-Ang Kang Masashi Narazaki Aaron Prodeus Luc Schoonjans David MOrnitz Jean Gariepy Guy Eelen Mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio Mora Jin Yao Chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 12 | Machine learning-based detection of cervical spondylotic myelopathy using multiple gait parameters显示文摘Cervical spondylotic myelopathy(CSM)is the main cause of adult spinal cord dysfunction,mostly appearing in middle-aged and elderly patients.Currently,the diagnosis of this condition depends mainly on the available imaging tools such as X-ray,computed tomography and magnetic resonance imaging(MRI),of which MRI is the gold standard for clinical diagnosis.However,MRI data cannot clearly demonstrate the dynamic characteristics of CSM,and the overall process is far from costefficient.Therefore,this study proposes a new method using multiple gait parameters and shallow classifiers to dynamically detect the occurrence of CSM.In the present study,45 patients with CSM and 45 age-matched asymptomatic healthy controls(HCs)were recruited,and a three-dimensional(3D)motion capture system was utilized to capture the locomotion data.Furthermore,63 spatiotemporal,kinematic,and nonlinear parameters were extracted,including lower limb joint angles in the sagittal,coronal,and transverse planes.Then,the Shapley Additive exPlanations(SHAP)value was utilized for feature selection and reduction of the dimensionality of features,and five traditional shallow classifiers,including support vector machine(SVM),logistic regression(LR),k-nearest neighbor(KNN),decision tree(DT),and random forest(RF),were used to classify gait patterns between CSM patients and HCs.On the basis of the 10-fold cross-validation method,the highest average accuracy was achieved by SVM(95.56%).Our results demonstrated that the proposed method could effectively detect CSM and thus serve as an automated auxiliary tool for the clinical diagnosis of CSM. | Xinyu Ji Wei Zeng Qihang Dai Yuyan Zhang Shaoyi Du Bing Ji | 2023 | Biomimetic Intelligence & Robotics2023，3，2： | 0 |
| 13 | Intrinsic magnetic topological materials显示文摘Topological states of matter possess bulk electronic structures categorized by topological invariants and edge/surface states due to the bulk-boundary correspondence. Topological materials hold great potential in the development of dissipationless spintronics, information storage and quantum computation, particularly if combined with magnetic order intrinsically or extrinsically. Here, we review the recent progress in the exploration of intrinsic magnetic topological materials, including but not limited to magnetic topological insulators, magnetic topological metals, and magnetic Weyl semimetals. We pay special attention to their characteristic band features such as the gap of topological surface state, gapped Dirac cone induced by magnetization (either bulk or surface), Weyl nodal point/line and Fermi arc, as well as the exotic transport responses resulting from such band features. We conclude with a brief envision for experimental explorations of new physics or effects by incorporating other orders in intrinsic magnetic topological materials. | Yuan Wang Fayuan Zhang Meng Zeng Hongyi Sun Zhanyang Hao Yongqing Cai Hongtao Rong Chengcheng Zhang Cai Liu Xiaoming Ma Le Wang Shu Guo Junhao Lin Qihang Liu Chang Liu Chaoyu Chen | 2023 | Frontiers of physics2023，18，2： | 0 |
| 14 | One step hot-pressing method for hybrid Li metal anode of solid-state lithium metal batteries显示文摘Safety issues induced by infinite anode volume change and uncontrolled lithium(Li)dendrite growth have become the biggest obstacle to the practical application of Li metal batteries.In addition,the tra-ditional rolling method makes it difficult to manufacture thin Li foil with high mechanical strength and low Li content.Herein,a three-dimensional(3D)lithophilic carbon paper/copper(Cu)current collector hybrid anode with ultra-low Li metal content is prepared by a hot-pressing method.The highly re-versible and stable lithiophilic layer LiC_(x) formed in situ by heating/pressing treatment provides abun-dant nucleation sites and reduces the Li nucleation overpotential,thereby effectively suppressing Li den-drite growth.Moreover,the volume change and pulverization problems of Li metal anode during depo-sition/stripping also can be accommodated by the 3D skeleton.The optimization effect has been directly confirmed by in-situ optical and ex-situ scanning electron microscope observation.Therefore,highly sta-ble performance(158.4 mA h g^(-1) at 2 C after 200 cycles with a capacity retention of 95.24%)in Li@LCP-Cu||NCM811 coin cell can be achieved.Furthermore,the solid-state battery assembled with the hybrid anode,poly(vinylidene fluoride)(PVDF)-based polymer electrolyte and polyethylene oxide(PEO)interface functional layer also exhibits the best electrochemical and safety performance,which also proves that the Li@LCP-Cu anode has great potential for application in solid-state batteries. | Kaiming Wang Yifei Chen Liang Zhang Qihang Zhang Zhi Cheng Yining Su Fei Shen Xiaogang Han | 2023 | Journal of Materials Science & Technology2023，，22： | 0 |
| 15 | On the topological surface states of the intrinsic magnetic topological insulator Mn-Bi-Te family显示文摘We review recent progress in the electronic structure study of intrinsic magnetic topological insulators(MnBi_(2)Te_(4))·(Bi_(2)Te_(3))n(n=0,1,2,3)family.Specifically,we focus on the ubiquitously(nearly)gapless behavior of the topological Dirac surface state observed by photoemission spectroscopy,even though a large Dirac gap is expected because of surface ferromagnetic order.The dichotomy between experiment and theory concerning this gap behavior is perhaps the most critical and puzzling question in this frontier.We discuss various proposals accounting for the lack of magnetic effect on the topological Dirac surface state,which are mainly categorized into two pictures,magnetic reconfiguration and topological surface state redistribution.Band engineering towards opening a magnetic gap of topological surface states provides great opportunities to realize quantized topological transport and axion electrodynamics at higher temperatures. | Yuan Wang Xiao-Ming Ma Zhanyang Hao Yongqing Cai Hongtao Rong Fayuan Zhang Weizhao Chen Chengcheng Zhang Junhao Lin Yue Zhao Chang Liu Qihang Liu Chaoyu Chen | 2024 | National Science Review2024，11，2： | 0 |
| 16 | The Fabrication and SERS Performance of Multi-layer Hollow Au-Ag Alloy Nano Urchins Structure-based SERS Fiber Probe显示文摘Novel hollow Au Ag alloy nano urchins were synthesized via Ag seeds growth method,and self-assembly coated on the wall and end-tip of silica fiber for fiber probe fabrication.The nano urchins homogeneously distributed on fiber surface because of fiber silanization.The sizes and tip sharpness of the nano-urchins could be controlled by Ag seeds.The elements distribution analysis indicated there was high Ag content in tip-top for better surface enhance Raman scattering performance.The detectable concentration could be as low as 10-8 M using crystal violet molecules as analyte.Moreover,the fiber probes were stable in air,due to Au in the alloy.This fiber probe could be used for low content single molecular analysis. | HAO Zhenbang TIAN Qihang CAO Shiyi HAN Xiaoyu ZHANG Jihong XIE Jun ZHAO Xiujian | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，2： | 0 |
| 17 | Diagnostic and classification value of immune-related lncRNAs in dilated cardiomyopathy显示文摘Background:Various physiological mechanisms are linked to dilated cardiomyopathy(DCM)development,including oxidative stress,immune irregularities,inflammation,fibrosis,and genetic changes.However,precise molecular drivers of DCM,especially regarding abnormal immune responses,remain unclear.This study investigates immune-related long non-coding RNAs(lncRNAs)in DCM’s diagnostic and therapeutic potential.Methods:GSE141910,GSE135055,and GSE165303 datasets were acquired from the GEO database.LASSO,SVM-RFE,and random forest algorithms identified DCM-associated immune-related lncRNAs.Diagnostic capabilities were assessed by Nomogram and receiver operating characteristic(ROC)curves.Multivariate linear regression explored lncRNA correlations with ejection fraction.Single-sample gene set enrichment analysis(ssGSEA)gauged immune cell infiltration/functions.Functional enrichment analyses were performed using Gene set variation analysis(GSVA),gene ontology(GO),and the Kyoto Encyclopedia of Genes and Genomes(KEGG).Consensus clustering categorized DCM cases.Results:Ten immune-related lncRNAs emerged:C10orf71-AS1,FHAD1-AS1,SCIRT,FNDC1-AS1,MELTFAS1,LOC101928834,GDNF-AS1,DCXR-DT,C3orf36,and LOC107985323.These lncRNAs,tied to immunomodulation,showed promising DCM diagnostic accuracy.Adjusted for confounders,they independently correlated with ejection fraction.Using lncRNA expression,DCM patients were grouped into subtypes.Subtype C1 displayed a higher level of immune cell infiltration and immune checkpoint expression compared to subtype C2,emphasizing the variations in the immune microenvironment.Conclusion:This study identifies ten immune-related lncRNAs for further exploration in DCM diagnosis and subtyping.Based on expression patterns,we propose two potential DCM subtypes.Notably,findings are preliminary and hypothesis-generating,demanding validation and further investigation.This research provides insights into DCM diagnosis and classification. | CONGCHEN BAI QIHANG KONG HAO TANG SHUWEN ZHANG JUNTENG ZHOU XIAOJING LIU | 2023 | BIOCELL2023，47，11： | 0 |
| 18 | Minimizing interfacial energy losses in inverted perovskite solar cells by a dipolar stereochemical 2D perovskite interface显示文摘Inverted perovskite solar cells(PSCs) have attracted broad research and industrial interest owing to their suppressed hysteresis,cost-effectiveness,and easy-fabrication.However,the issue of non-radiative recombination losses at the n-type interface between the perovskite and fullerene has impeded further improvement of photovoltaic performance.Here,we modify the n-type interface of FAPbI_(3) perovskite films by constructing a stereochemical two-dimensional(2D) perovskite interlayer,in which the organic cations comprise both pyridine and ammonium groups.The pyridine N donor can create stable bonding with the surface-uncoordinated Pb on the perovskite,thereby passivating the shallow-level defects and enhancing the air stability of the film.Furthermore,the pyridine N donor also offers a positive polar interface to decrease the surface work function of the perovskite film,enabling n-type modification.Ultimately,we employ a p-i-n photovoltaic(PV) device with the positive dipole interlayer at perovskite/fullerene contact and achieve remarkable photoelectric conversion efficiency(PCE) of 22.0%. | Junjie Qian Jingjing He Qihang Zhang Chenyue Zhu Shilin Chen Zhanpeng Wei Xuesong Leng Ziren Zhou Benben Shen Yu Peng Qiang Niu Shuang Yang Yu Hou | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 19 | The ionome and proteome landscape of aging in laying hens and relation to egg white quality显示文摘The ionome is essential for maintaining body function and health status by participating in diverse key biological processes.Nevertheless, the distribution and utilization of ionome among different organs and how aging impacts the ionome leading to a decline in egg white quality remain unknown. Thus, we used inductively coupled plasma mass spectrometry(ICP-MS) to analyze 35 elements and their isotopic contents in eight organs of laying hens at 35, 72, and 100 weeks. Moreover, the magnum proteome, amino acids in egg white, and egg white quality were analyzed in laying hens at three different ages using 4D proteomics techniques, an amino acid analyzer, and an egg quality analyzer. Across the organs, we identified varying distribution patterns among macroelements(Mg24, Ca43/44, K39, and P31), transition metals(Zn64/66, Cu63/65, Fe56/57, and Mn55), and toxic elements(Pb208, Ba137, and Sr86). We observed an organ-specific aging pattern characterized by the accumulation of toxic elements(Pb208, Ba137, and Sr86) and calcification in the small intestine. Additionally, a decrease in the utilization of essential trace elements selenium(Se78/82) and manganese(Mn55) was noted in the oviduct. By analyzing ionome in tandem with egg quality, egg white amino acids, and proteome, we unveiled that the reduction of selenium and manganese concentrations in the magnum during the aging process affected amino acid metabolism, particularly tryptophan metabolism, thereby inhibiting the amino acid synthesis in the magnum. Furthermore, it accelerated the senescence of magnum cells through necroptosis activation, leading to a decline in the albumen secretion function of the magnum and subsequently reducing egg white quality.Overall, this study provides insights into the evolution of 35 elements and their isotopes across 8 organs of laying hens with age.It also reveals the elemental composition, interactions, and utilization patterns of these organs, as well as their correlation with egg white quality. The present study highlights the significance of ionome and offers a comprehensive perspective on the selection of ionome for regulating the aging of laying hens. | Guang Li Yuqing Feng Jian Cui Qihang Hou Tanfang Li Meiting Jia Zhengtian lv Qiuyu Jiang Ying Wang Ming Zhang Lin Wang Zengpeng Lv Junyou Li Yuming Guo Bingkun Zhang | 2023 | Science China(Life Sciences)2023，66，9： | 0 |
| 20 | Bilayer tellurene-metal interfaces显示文摘Tellurene, an emerging two-dimensional chain-like semiconductor, stands out for its high switch ratio, carrier mobility and excellent stability in air. Directly contacting the 2D semiconductor materials with metal electrodes is a feasible doping means to inject carriers. However, Schottky barrier often arises at the metal–semiconductors interface, impeding the transport of carriers. Herein, we investigate the interfacial properties of BL tellurene by contacting with various metals including graphene by using ab initio calculations and quantum transport simulations. Vertical Schottky barriers take place in Ag, Al, Au and Cu electrodes according to the maintenance of the noncontact tellurene layer band structure. Besides, a p-type vertical Schottky contact is formed due to the van der Waals interaction for graphene electrode. As for the lateral direction, p-type Schottky contacts take shape for bulk metal electrodes(hole Schottky barrier heights(SBHs) ranging from 0.19 to 0.35 eV). Strong Fermi level pinning takes place with a pinning factor of 0.02. Notably, a desirable p-type quasi-Ohmic contact is developed for graphene electrode with a hole SBH of 0.08 eV. Our work sheds light on the interfacial properties of BL tellurene based transistors and could guide the experimental selections on electrodes. | Hua Pang Jiahuan Yan Jie Yang Shiqi Liu Yuanyuan Pan Xiuying Zhang Bowen Shi Hao Tang Jinbo Yang Qihang Liu Lianqiang Xu Yangyang Wang Jing Lv | 2019 | Journal of Semiconductors2019，40，6： | 0 |
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