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| 1 | Current status of cell-mediated regenerative therapies for human spinal cord injury显示文摘During the past decade, significant advances have been made in refinements for regenerative therapies following human spinal cord injury(SCI).Positive results have been achieved with different types of cells in various clinical studies of SCI.In this review, we summarize recently-completed clinical trials using cellmediated regenerative therapies for human SCI, together with ongoing trials using neural stem cells.Specifically, clinical studies published in Chinese journals are included.These studies show that current transplantation therapies are relatively safe, and have provided varying degrees of neurological recovery.However, many obstacles exist, hindering the introduction of a specifi c clinical therapy, including complications and their causes, selection of the target population, and optimization of transplantation material.Despite these and other challenges, with the collaboration of research groups and strong support from various organizations, cell-mediated regenerative therapies will open new perspectives for SCI treatment. | Tongming Zhu Qisheng Tang Huasong Gao Yiwen Shen Luping Chen Jianhong Zhu | 2014 | Neuroscience Bulletin2014，30，4： | 7 |
| 2 | Inductive heat property of Fe_3O_4 nanoparticles in AC magnetic field for local hyperthermia显示文摘Magnetite (Fe3O4) nanoparticles with different magnetic properties were prepared by coprecipitation of Fe3+ and Fe2+ with aqueous NaOH solution. The inductive heat properties of Fe3O4 nanoparticles in an alternating current (AC) magnetic field were investigated for local hyperthermia. The maximum saturation magnetization Ms of Fe3O4 nanoparticles is 65.53 emu·g-1 under the optimum conditions of Fe3+: Fe2+ molar ratio at 1.8:1. The Ms of Fe3O4 nanoparticles decreased as the Fe3+/Fe2+ molar ratio increased. But the coercivity Hc increases with the increasing of Fe3+/Fe2+ molar ratio. Exposed in the AC magnetic field for 29 min, the temperatures of physiological saline suspension containing Fe3O4 nanoparticles were 42-97.5 ℃. The inductive heat property of Fe3O4 nanoparticles in AC magnetic field decreases as Hc increases, but increases with the increasing of Ms. The Fe3O4 nanoparticles would be useful as good thermoseeds for localized hyperthermia treatment of cancers. | ZHAO Donglin ZENG Xianwei XIA Qisheng TANG Jintian | 2006 | Rare Metals2006，25，z1： | 5 |
| 3 | Intraoperative ultrasound assistance in resection of intracranial meningiomas显示文摘Objective: Intracranial meningiomas, especially those located at anterior and middle skull base, are difficult to be completely resected due to their complicated anatomy structures and adjacent vessels. It's essential to locate the tumor and its vessels precisely during operation to reduce the risk of neurological deficits. The purpose of this study was to evaluate intraoperative ultrasonography in displaying intracranial meningioma and its surrounding arteries, and evaluate its potential to improve surgical precision and minimize surgical trauma. Methods: Between December 2011 and January 2013, 20 patients with anterior and middle skull base meningioma underwent surgery with the assistance of intraoperative ultrasonography in the Neurosurgery Department of Shanghai Huashan Hospital. There were 7 male and 13 female patients, aged from 31 to 66 years old. Their sonographic features were analyzed and the advantages of intraoperative ultrasonography were discussed. Results: The border of the meningioma and its adjacent vessels could be exhibited on intraoperative ultrasonography. The sonographic visualization allowed the neurosurgeon to choose an appropriate approach before the operation. In addition, intraoperative ultrasonography could inform neurosurgeons about the location of the tumor, its relation to the surrounding arteries during the operation, thus these essential arteries could be protected carefully. Conclusions: Intraoperative ultrasonography is a useful intraoperative technique. When appropriately applied to assist surgical procedures for intracranial meningioma, it could offer very important intraoperative information (such as the tumor supplying vessels) that helps to improve surgical resection and therefore might reduce the postoperative morbidity. | Hailiang Tang Huaping Sun Liqian Xie Qisheng Tang Ye Gong Ying Mao Qing Xie Mingzhe Zheng Daijun Wang Hongda Zhu Jianhong Zhu Xiaoyuan Feng Zhenwei Yao Xiancheng Chen Liangfu Zhou | 2013 | Chinese Journal of Cancer Research2013，25，3： | 3 |
| 4 | Evaluation of reference genes for quantitative real-time PCR analysis of gene expression during early development processes of the tongue sole(Cynoglossus semilaevis)显示文摘Differential expression of genes is crucial to growth and development of fish.To select the appropriate genes for gene normalization during Cynoglossus semilaevis early developmental process,eight candidate reference genes(ACTB,B2 M,EF1 A,GADPH,RPL7,TUBA,UBCE and 18S) were tested for their adequacy by using quantitative real-time PCR.The results showed that the expression of all the examined genes exhibited tissue dependent variations in the mature C.semilaevis.EF1 A was listed as the most stable reference among the 14 tissues by Ref Finder.Furthermore,the recommended comprehensive ranking of the stability determined by Ref Finder showed that 18 S was the most stable gene during the early developmental stages(from oosphere to 90 days old) in this study.However,when divided the Ct value data of the above mentioned early developmental stages into two separate periods(embryo and post-hatching periods),TUBA and 18 S represented the most stable references of these two developmental periods,respectively.Consequently,the reference gene should be carefully and accurately chosen even for studies of the same species at various developmental processes.The relevant data may help in selecting appropriate reference genes for m RNA expression analysis,and is of great value in the studies of fish growth and development. | MA Qian ZHUANG Zhimeng FENG Wenrong LIU Shufang TANG Qisheng | 2015 | Acta Oceanologica Sinica2015，34，10： | 3 |
| 5 | Spatial distribution and reconstruction potential of Japanese anchovy(Engraulis japonicus) based on scale deposition records in recent anaerobic sediment of the Yellow Sea and East China Sea显示文摘Many studies have revealed that anchovy has exhibited large variability in population size on decadal timescales. However, such works concerning anchovy population are mainly based on short historical catch records. In order to understand the causes of variability in fish stocks(natural and/or anthropogenic) and calibrate the error between catches and standing stocks, it is essential to develop long-term time series of fish stocks from the time when human impacts are minimal or negligible. Well preserved fish scales from sediment record are regarded as useful indicators revealing the history of fish population dynamics over the last centuries. Anchovy scales was first analyzed over the Yellow Sea and East China Sea and the largest abundance was found in the central South Yellow Sea where is regarded as the largest overwintering ground for Japanese anchovy(Engraulis japonicas). Thus in the central South Yellow Sea, two cores covering the last 150 years were collected for estimating fish scale flux. The scale deposition rate(SDR) records show that the decadal scale SDRs were obviously coherent between cores with independent chronologies. The calibration of downcore SDRs to the standing stocks of anchovy further validated that SDR is a reliable proxy to reconstruct the long-term anchovy population dynamic in the central South Yellow Sea where anoxic conditions prevail in the sediment. When assembled with other productivity proxies, it would be expected that SDR could be associated with changes in oceanic productivity and may make a contribution to determine the forcing factors and elucidate the mechanism of the process in future. | HUANG Jiansheng SUN Yao JIA Haibo YANG Qian TANG Qisheng | 2014 | Acta Oceanologica Sinica2014，33，12： | 2 |
| 6 | Genetic Variation Among White Croaker Populations显示文摘To investigate the genetic structures and differentiation of different wild populations of white croaker (Pennahia argen- tata), horizontal starch gel electrophoresis was performed on 133 individuals collected from five different locations in China and Japan. The eleven enzyme systems revealed 15 loci, of which eleven were polymorphic. The percentage of polymorphic loci of white croaker populations varied from 6.67% to 53.33%; the mean observed and expected heterozygosity ranged from 0.0033 to 0.0133 and 0.0032 to 0.0191, respectively. The expected heterozygosity revealed a low genetic variability for white croaker in comparison with other marine fishes. The genetic distances between populations ranged from 0.00005 to 0.00026. A weak differentiation was observed within each clade and between clades; and no significant differences in gene frequencies among populations were observed in white croaker. Among the five populations, three Chinese populations showed more genetic diversity than that in Japanese populations. | HAN Zhiqiang GAO Tianxiang ZHUANG Zhimeng TANG Qisheng | 2008 | Journal of Ocean University of China2008，7，1： | 2 |
| 7 | Hyperthermia by a nitinol stent in an alternating magnetic field:Safety and feasibility in rabbit esophageal cancer显示文摘Hyperthermia by heating in-stent is a potentially new method to treat esophageal cancer.This study assessed the safety of heating the rabbit esophagus with a nitinol stent in an alternating magnetic field(AMF) and investigated whether this method offers a therapeutic option for esophageal cancer.Nitinol stents were placed in the cervical esophagi of healthy rabbits,which were heated in an AMF for different times at 43,46 and 50℃.The esophagi were histologically examined after a week to observe whether there was transmural necroses.Then esophageal cancer of rabbit placed nitinol stents were heated in an AMF at 46℃for 10 min.Stents were heated to a target temperature within 5 min.The highest tolerated temperature and time for the healthy rabbit esophagus was at 46℃for 10 min.Tumor growth was delayed by heating and it was statistically significant.Heating the rabbit esophageal wall at 46℃for 10 min proves to be safe and effective in delaying tumor growth. | Jumei Zhou Ning Li Qisheng Xia Lehui Du Xiaowen Wang Linyun Zhao Xufei Wang Jintian Tang | 2009 | Progress in Natural Science:Materials International2009，19，12： | 1 |
| 8 | Preparation of nanosheet Fe-ZSM-5 catalysts, and effect of Fe content on acidity, water, and sulfur resistance in the selective catalytic reduction of NO x by ammonia显示文摘 | Luoning Ma Hongxia Qu Jie Zhang Qisheng Tang Shule Zhang Qin Zhong | 2013 | Research on Chemical Intermediates2013，，9： | 1 |
| 9 | Decadal-scale variations of ecosystem productivity and control mechanisms in the Bohai Sea显示文摘 | TANG Qisheng JIN Xianshi WANG Jun | 2003 | Fish Oceanogr2003，12，45： | 1 |
| 10 | In-situ energy calibration of SSRF macromolecular crystallography beamline using powder diffraction显示文摘For X-ray powder diffraction spectra collected by an area detector of MarCCD on macromolecular crystallography beamline of SSRF,an energy calibration method was developed using LaB_6(660a) powder diffraction for in-situ rapid energy calibration of the X-rays without changing the experimental conditions.The intensity of each diffraction ring was integrated,and the accurate peak positions were fitted by Pseudo-Voigt function model.The sample's interplanar spacing for XRD analysis and the calibrated energy were obtained by the PCPDFWIN code and by fitting all the energies with the least-square method.The exposure time and the sample-to-detector distance were found no effect on accuracy of the energy calibration,and the in-situ energy calibration could be done with an accuracy of better than 0.4‰in 7-18 keV.This method is applicable to other X-ray beamlines. | Tao Shixing Zhu Jing Niu Jing Chen Mingzhi Liu Ke Wang Yu Wang Qisheng Sun Bo Huang Sheng Tang Lin He Jianhua | 2010 | Nuclear Science and Techniques2010，21，6： | 1 |
| 11 | Management strategies of marine food resources under multiple stressors with particular reference of the Yellow Sea large marine ecosystem显示文摘In this study two main management strategies are discussed:one is to develop resource conservationbased capture fisheries,and the other is to develop environmentally friendly aquaculture.During the resource recovery period,the development of environmentally friendly aquaculture should be encouraged,especially in integrated multi-trophic aquaculture,which is adaptive,efficient and sustainable.For future development and better understanding the ecosystem,it is necessary to further strengthen basic research. | Qisheng TANG | 2014 | Frontiers of Agricultural Science and Engineering2014，1，1： | 1 |
| 12 | A kinetic model for thermally induced hydrogen and carbon isotope fractionation of individual n -alkanes in crude oil显示文摘 | Yongchun Tang Yongsong Huang Geoffrey S. Ellis Yi Wang Paul G. Kralert Bruno Gillaizeau Qisheng Ma Rong Hwang | 2005 | Geochimica et Cosmochimica Acta2005，，： | 1 |
| 13 | Long-term environmental changes and the responses of the ecosystems in the Bohai Sea during 1960–1996显示文摘 | Xiuren Ning Chuanlan Lin Jilan Su Chenggang Liu Qiang Hao Fengfeng Le Qisheng Tang | 2010 | Deep-Sea Research Part II2010，，11： | 1 |
| 14 | Shellfish and seaweed mariculture increase atmospheric CO2 absorption by coastal ecosystems 显示文摘 | TANG Qisheng ZHANG Jihong FANG Jianguang | 2011 | Mar Ecol Prog Ser2011，424，： | 1 |
| 15 | co-Condensation Synthesis of Salicylaldimine Calcium Complex Containing Mesoporous Silica Nanoparticles as Carriers for Drug Release显示文摘 | TANG Duihai ZHANG Weiran WANG Yifan MIAO Jing QIAO Zhen'an HUO Qisheng ZHANG Lirong | 2014 | Chemical Research in Chinese Universities2014，30，4： | 0 |
| 16 | BCNU/PLGA microspheres:a promising strategy for the treatment of gliomas in mice显示文摘Objective:To investigate the effects of BCNU/PLGA microspheres on tumor growth,apoptosis and chemotherapy resistance in a C57BL/6 mice orthotopic brain glioma model using GL261 cell line.Methods:BCNU/PLGA sustained-release microspheres were prepared by the water-in-oil-in-water emulsion technique.GL261 cells were intracranially injected into C57BL/6 mouse by using the stereotactic technology.A total of 60 tumor-bearing mice were randomly and equally divided into three groups:untreated control,PLGA treated,BCNU/PLGA treated.Magnetic resonance imaging(MRI) was taken to evaluate tumor volume.BCNU/PLGA sustained-release wafers were implanted in the treatment group two weeks after inoculation.Survival time and quality were observed.Specimens were harvested,and immunohistochemical staining was used to check the expression of Bax,Bcl-2,and O6-methylguanine-DNA methyltransferase(MGMT).Statistical methods was used for analysis of relevant data.Results:BCNU/PLGA sustained-release wafers were fabricated and implanted successfully.There is statistical difference of survival time between the BCNU/PLGA treated group and control groups(P<0.05).MRI scan showed inhibitory effect of BCNU/PLGA on tumor growth.Compared to the group A and B,BCNU/PLGA decreased the expression of apoptosis related gene Bcl-2(P<0.05),but did not elevate the expression level of Bax(P>0.05),with the ratio of Bax/Bcl-2 increased.For MGMT protein expression,no statistically significant change was found in treated group(P>0.05).Conclusions:Local implantation of BCNU/PLGA microspheres improved the survival quality and time of GL261 glioma-bearing mice significantly,inhibited the tumor proliferation,induced more cell apoptosis,and did not increase the chemotherapy resistance. | Tongming Zhu Yiwen Shen Qisheng Tang Luping Chen Huasong Gao Jianhong Zhu | 2014 | Chinese Journal of Cancer Research2014，26，1： | 0 |
| 17 | The influence of main ecological and environmental factors on the energy budget of Schlegel' s black rockfish Sebastes schlegeli显示文摘在在 1998 ~ 的 Huanghai 海渔业 ResearchInstitute 的 Maidao 生态的实验室 2000 ,连续流动彻底地方法被采用决定精力预算部件和Schlegel' s 黑人各种栖于礁石中的鱼类的模型在下面不同生态并且环境因素例如温度,食物种类,身体团和喂的水平,等等。测试鱼的身体团从 21.2 ~ 224.5 g 。特定的生长率趋于转换有温度的变化增加的“ U ”。生态的变换效率显示出象温度和喂的水平上升的一样的趋势。仅仅特定的生长率趋于速度有喂的上升的增长铺平。从上述量的关系,当喂喂的率和最佳的 17.5 和 16.2 ℃,和维护被评为 0,最大、最佳的生长温度能被获得。8% 和 4。1% 身体质量。特定的生长率和生态的换算系数与身体团增长显示出一个速度的减少趋势。缩放 Thesmall 的鱼食物对与缩放 thesmall 的虾食物比较的喂的水平增加更有益,它导致了生长,新陈代谢和排泄的增加,但是没在生态的换算系数上有重要影响。所有能显然温度,喂的水平,身体团和食物种类改变精力预算模型。分配增长率精力趋于沿着“ U ”随温度和喂的水平的增加弄弯,并且随身体团增加,而是新陈代谢精力的分配的率减少的 invert 变化,排泄精力是相当反向的。这些关系能是描述为二次的份量上或力量功能曲线。如果证明真到另外的水兵的上述关系钓鱼,精力预算的建立在不同条件下面一样的鱼当模特儿能大部分被简化。 | SUN Yao ZHENG Bing ZHANG Bo TANG Qisheng | 2007 | Acta Oceanologica Sinica2007，26，3： | 0 |
| 18 | Enhancing Photovoltaic Performance of Ladder-Type Heteroarene-Based Electron Acceptors by Modulating Molecular Packing显示文摘Comprehensive Summary,The development of novel building blocks with sp3-hybridized-carbon-free conjugated skeletons is important to further advance and enrich nonfullerene acceptors(NFAs),but this remains a challenge due to the lack of strategies to effectively modulate the aggregation behavior of resulting NFAs.Herein,two novel nitrogen-bridged octacyclic ladder-type heteroarenes end-capped with thiophene rings(BTPS)or selenophene rings(BTPSe)are designed and synthesized as the donor cores for constructing NFAs(MQX-2 and MQX-4).It is found that replacing the sulfur atoms(MQX-2)at the outer positions of the heteroarene core with selenium atoms(MQX-4)can effectively modulate the molecular packing mode of the NFAs.The incorporation of selenium atoms induces stronger O···Se noncovalent interaction than O···S,thus promoting the formation of mixed H/J-type aggregates in MQX-4.Benefiting from more electron hopping channels,MQX-4 exhibits higher electron transport(more than 1-fold enhancement)and photovoltaic properties compared to MQX-2,which forms only H-type aggregates. | Hongxin Tao Changquan Tang Yunlong Ma Shu-Quan Zhang Ruochuan Liao Qisheng Tu Qingdong Zheng | 2023 | Chinese Journal of Chemistry2023，41，17： | 0 |
| 19 | Stereopure AIMer:A Promising RNA Base-editing Tool for Monogenic Neurological Diseases显示文摘The continuous development of various gene therapies has brought new light to the treatment of genetic diseases.Among them,therapies targeting monogenic diseases are relatively progressive and promising due to the explicit and clear pathogenesis.The discovery and development of clustered regularly interspaced short palindromic repeats/associated nuclease(CRISPR/Cas)and related technologies was undoubtedly an extraordinary leap forward for gene therapy. | Jingyu Yu Tianwen Li Kezhu Chen Qisheng Tang Jianhong Zhu | 2023 | Neuroscience Bulletin2023，39，2： | 0 |
| 20 | RR-1 cuticular protein TcCPR69 is required for growth and metamorphosis in Tribolium castaneum显示文摘Cuticle is not only critical for protecting insects from noxious stimuli but is also involved in a variety of metabolic activities.Cuticular proteins(CPs)affect cuticle structure and mechanical properties during insect growth,reproduction,and environmental adaptation.Here,we describe the identification and characterization of a member of the RR-1 subfamily of CPs with an R&R consensus(CPR)in Tribolium castaneum(TcCPR69).Although it was previously reported to be highly expressed in the wings,we found that knocking down TcCPR69 by RNA interference(RNAi)did not cause obvious wing abnormalities but markedly disrupted the growth and metamorphosis of beetles with 100%cumulative mortality;additionally,the chitin content of the pharate adult was decreased and the new abdominal cuticle was significantly thinner before molting.TcCPR69 showed chitin-binding ability and the expression levels of key genes involved in chitin metabolism(trehalase[TcTRE],chitin synthase[TcCHSA and TcCHSB],and chitinase[TcCHT5 and TcCHT10])were also decreased by TcCPR69 knockdown.TcCPR69 gene expression peaked shortly after molting and was increased 2.61 fold at 12 h after 20-hydroxyecdysone(20E)injection.This was reversed by RNAi of the ecdysone-related genes ecdysone receptor(TcECR)and fushi tarazu transcription factor 1(TcFTZ-F1).These results indicate that TcCPR69 is positively regulated by 20E signaling to contribute to cuticle formation and maintain chitin accumulation during the growth and metamorphosis of beetles. | Jia Xie Guifang Peng Miao Wang Qisheng Zhong Xiaowen Song Jingxiu Bi Jing Tang Fan Feng Han Gao Bin Li | 2022 | Insect Science2022，29，6： | 0 |
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