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| 1 | Ideotype root architecture for efficient nitrogen acquisition by maize in intensive cropping systems显示文摘The use of nitrogen(N) fertilizers has contributed to the production of a food supply sufficient for both animals and humans despite some negative environmental impact.Sustaining food production by increasing N use efficiency in intensive cropping systems has become a major concern for scientists,environmental groups,and agricultural policymakers worldwide.In high-yielding maize systems the major method of N loss is nitrate leaching.In this review paper,the characteristic of nitrate movement in the soil,N uptake by maize as well as the regulation of root growth by soil N availability are discussed.We suggest that an ideotype root architecture for efficient N acquisition in maize should include(i) deeper roots with high activity that are able to uptake nitrate before it moves downward into deep soil;(ii) vigorous lateral root growth under high N input conditions so as to increase spatial N availability in the soil;and(iii) strong response of lateral root growth to localized nitrogen supply so as to utilize unevenly distributed nitrate especially under limited N conditions. | MI GuoHua,CHEN FanJun,WU QiuPing,LAI NingWei,YUAN LiXing & ZHANG FuSuo* Key Laboratory of Plant Nutrition,MOA Key Laboratory of Plant-Soil Interaction,MOE College of Resources and Environmental Science,China Agricultural University,Beijing 100193,China | 2010 | Science China(Life Sciences)2010，53，12： | 35 |
| 2 | Natural variation in Ghd7.1 plays an important role in grain yield and adaptation in rice显示文摘 | Wenhao Yan Haiyang Liu Xiangchun Zhou Qiuping Li Jia Zhang Li Lu Touming Liu Haijun Liu Chengjun Zhang Zhanyi Zhang Guojing Shen Wen Yao Huaxia Chen Sibin Yu Weibo Xie Yongzhong Xing | 2013 | Cell Research2013，23，7： | 39 |
| 3 | Energy-Efficient Computation Offloading and Resource Allocation in Fog Computing for Internet of Everything显示文摘With the dawning of the Internet of Everything(IoE) era, more and more novel applications are being deployed. However, resource constrained devices cannot fulfill the resource-requirements of these applications. This paper investigates the computation offloading problem of the coexistence and synergy between fog computing and cloud computing in IoE by jointly optimizing the offloading decisions, the allocation of computation resource and transmit power. Specifically, we propose an energy-efficient computation offloading and resource allocation(ECORA) scheme to minimize the system cost. The simulation results verify the proposed scheme can effectively decrease the system cost by up to 50% compared with the existing schemes, especially for the scenario that the computation resource of fog computing is relatively small or the number of devices increases. | Qiuping Li Junhui Zhao Yi Gong Qingmiao Zhang | 2019 | China Communications2019，16，3： | 19 |
| 4 | Intestinal Microbiota in Early Life and Its Implications on Childhood Health显示文摘Trillions of microbes reside in the human body and participate in multiple physiological and pathophysiological processes that affect host health throughout the life cycle. The microbiome is hallmarked by distinctive compositional and functional features across different life periods.Accumulating evidence has shown that microbes residing in the human body may play fundamental roles in infant development and the maturation of the immune system. Gut microbes are thought to be essential for the facilitation of infantile and childhood development and immunity by assisting in breaking down food substances to liberate nutrients, protecting against pathogens, stimulating or modulating the immune system, and exerting control over the hypothalamic–pituitary–adrenal axis.This review aims to summarize the current understanding of the colonization and development of the gut microbiota in early life, highlighting the recent findings regarding the role of intestinal microbes in pediatric diseases. Furthermore, we also discuss the microbiota-mediated therapeutics that can reconfigure bacterial communities to treat dysbiosis. | Lu Zhuang Haihua Chen Sheng Zhang Jiahui Zhuang Qiuping Li Zhichun Feng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 16 |
| 5 | Root growth in response to nitrogen supply in Chinese maize hybrids released between 1973 and 2009显示文摘Root growth has a fundamental role in nitrogen (N) use efficiency.Nevertheless,little is known about how modern breeding progress has affected root growth and its responses to N supply.The root and shoot growth of a core set of 11 representative Chinese maize (Zea mays L.) hybrids released between 1973 and 2009 were investigated under high N (4 mmol L?1,HN) and low N (0.04 mmol L?1,LN) levels in a solution culture system.Compared with LN,HN treatment decreased root dry weight (RDW),the root:shoot ratio (R/S),and the relative growth rate for root dry weight (RGRroot),but increased the total root length (TRL) and the total lateral root length (LRL).The total axial root length (ARL) per plant was reduced under HN,mostly in hybrids released before the 1990s.The number of seminal roots (SRN) was largely unaffected by different N levels.More recently released hybrids showed higher relative growth rates in the shoot under both HN and LN.However,the roots only showed increased RGR under HN treatment.Correspondingly,there was a positive linear relationship with the year of hybrid release for TRL,LRL and ARL under HN treatment.Together,these results suggest that while shoot growth of maize has improved,its root growth has only improved under high N conditions over the last 36 years of selective breeding in China.Improving root growth under LN conditions may be necessary to increase the N use efficiency of maize. | WU QiuPing CHEN FanJun CHEN YanLing YUAN LiXing ZHANG FuSuo MI GuoHua | 2011 | Science China(Life Sciences)2011，54，7： | 15 |
| 6 | Effects of narrow plant spacing on root distribution and physiological nitrogen use efficiency in summer maize显示文摘The objective of this study was to understand the effects of plant spacing on grain yield and root competition in summer maize(Zea mays L.). Maize cultivar Denghai 661 was planted in rectangular tanks(0.54 m × 0.27 m × 1.00 m) under 27 cm(normal) and 6 cm(narrow) plant spacing and treated with zero and 7.5 g nitrogen(N) per plant. Compared to normal plant spacing, narrow plant spacing generated less root biomass in the 0–20 cm zone under both N rates, slight reductions of dry root weight in the 20–40 cm and 40–70 cm zones at the mid-grain filling stage, and slight variation of dry root weights in the 70–100 cm zone during the whole growth period. Narrow plant spacing decreased root reductive activity in all root zones, especially at the grain-filling stage. Grain yield and above-ground biomass were 5.0% and 8.4% lower in the narrow plant spacing than with normal plant spacing, although narrow plant spacing significantly increased N harvest index and N use efficiency in both grain yield and biomass, and higher N translocation rates from vegetative organs. These results indicate that the reductive activity of maize roots in all soil layers and dry weights of shallow roots were significantly decreased under narrow plant spacing conditions, resulting in lower root biomass and yield reduction at maturity. Therefore, a moderately dense sowing is a basis for high yield in summer maize. | Wenshun Jiang Kongjun Wang Qiuping Wu Shuting Dong Peng Liu Jiwang Zhang | 2013 | The Crop Journal2013，1，1： | 13 |
| 7 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 8 | Oxidative stress, nutritional antioxidants and beyond显示文摘Free radical-induced oxidative stress contributes to the development of metabolic syndromes(Mets), including overweight,hyperglycemia, insulin resistance and pro-inflammatory state. Most free radicals are generated from the mitochondrial electron transport chain;under physiological conditions, their levels are maintained by efficient antioxidant systems. A variety of transcription factors have been identified and characterized that control gene expression in response to oxidative stress status.Natural antioxidant compounds have been largely studied for their strong antioxidant capacities. This review discusses the recent progress in oxidative stress and mitochondrial dysfunction in Mets and highlights the anti-Mets, anti-oxidative, and antiinflammatory effect of polyphenols as potential nutritional therapy. | Qiuping Guo Fengna Li Yehui Duan Chaoyue Wen Wenlong Wang Lingyu Zhang Ruilin Huang Yulong Yin | 2020 | Science China(Life Sciences)2020，63，6： | 10 |
| 9 | Genetic diversity,population structure,and relationships of apricot(Prunus)based on restriction site-associated DNA sequencing显示文摘Single-nucleotide polymorphisms(SNPs)are the most abundant form of genomic polymorphisms and are widely used in population genetics research.Here,high-throughput sequencing was used to examine the genome-level diversity,population structure,and relationships of apricot,which are important for germplasm conservation and molecular breeding.Restriction site-associated DNA sequencing(RAD-seq)was adopted to sequence 168 Prunus spp.accessions distributed in five ecological groups,including 74 accessions of cultivated Prunus armeniaca L.and 94 accessions of wild apricots(P.armeniaca L.and Prunus sibirica L.),which generated 417,961 high-quality SNPs.We used cluster,genetic structure,and principal component analyses to examine the genetic diversities and genetic relationships of the 168 accessions.The Dzhungar-Ili ecological group accessions showed the highest genetic diversity in terms of private allele number,observed heterozygosity,and nucleotide diversity.We speculate that the Central Asian ecological group accessions were domesticated from the Dzhungar-Ili ecological group accessions.The population structure and gene flow of the North China and European ecological group accessions suggested a genetic background of P.sibirica.We argue that the two groups should be considered hybrid swarms connected to P.sibirica by continuous and extensive gene flow.P.armeniaca originated in Northwest China(Ili Valley),subsequently spread throughout Central Asia,and eventually spread to Europe.In addition,selective sweep signatures in P.armeniaca during domestication from wild to cultivated apricots,combined with differentially expressed genes,underlie distinct fruit traits,including sugars,aromas,organic acids,and carotenoids.This study provides substantive and valuable genomic resources that will significantly advance apricot improvement and effective utilization. | Wenwen Li Liqiang Liu Yanan Wang Qiuping Zhang Guoquan Fan Shikui Zhang Yatong Wang Kang Liao | 2020 | Horticulture Research2020，7，1： | 9 |
| 10 | G protein-coupled receptor 183 facilitates endothelial-to- hematopoietic transition via Notch1 inhibition显示文摘 | Panpan Zhang Qiuping He Dongbo Chen Weixiao Liu Lu Wang Chunxia Zhang Dongyuan Ma Wei Li Bing Liu Feng Liu | 2015 | Cell Research2015，25，10： | 7 |
| 11 | Modeling and Analysis of a Micromotor with an Electrostatically Levitated Rotor显示文摘The modeling and evaluation of a prototype rotary micromotor where the annular rotor is supported electrostatically in five degrees of freedom is presented in order to study the behavior of this levitated micromotor and further optimize the device geometry.The analytical torque model is obtained based on the principle of a planar variable-capacitance electrostatic motor while the viscous damping caused by air film between the stator and rotor is derived using laminar Couette flow model.Simulation results of the closed-loop drive motor, based on the developed dynamic model after eliminating mechanical friction torque via electrostatic suspension, are presented.The effects of the high-voltage drive, required for rotation of the rotor, on overload capacity and suspension stiffness of the electrostatic bearing system are also analytically evaluated in an effort to determine allowable drive voltage and attainable rotor speed in operation.The analytical results show that maximum speed of the micromotor is limited mainly by viscous drag torque and stiffness of the bearing system.Therefore, it is expected to operate the device in vacuum so as to increase the rotor speed significantly, especially for those electrostatically levitated micromotors to be used as an angular rate micro-gyroscope. | HAN Fengtian WU Qiuping ZHANG Rong | 2009 | Chinese Journal of Mechanical Engineering2009，22，1： | 5 |
| 12 | Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets显示文摘Background: Oxidative stress is a key factor that influences piglets' health. Taurine plays an imperative role in keeping the biological system from damage. This study was conducted to investigate the protective effect of taurine against muscle injury due to the secondary effect of diquat toxicity.Results: Our study found that taurine effectively and dose-dependently alleviated the diquat toxicity induced rise of feed/gain, with a concurrent improvement of carcass lean percentage. The plasma content of taurine was considerably increased in a dose-dependent manner. Consequently, dietary taurine efficiently improved the activity of plasma antioxidant enzymes. Furthermore, taurine attenuated muscle damage by restoring mitochondrial micromorphology, suppressing protein degradation and reducing the percentage of apoptotic cells in the skeletal muscle. Taurine supplementation also suppressed the genes expression levels of the antioxidant-, mitochondrial biogenesis-, and muscle atrophy-related genes in the skeletal muscle of piglets with oxidative stress.Conclusions: These results showed that the dose of 0.60% taurine supplementation in the diet could attenuate skeletal muscle injury induced by diquat toxicity. It is suggested that taurine could be a potential nutritional intervention strategy to improve growth performance. | Chaoyue Wen Fengna Li Qiuping Guo Lingyu Zhang Yehui Duan Wenlong Wang Jianzhong Li Shanping He Wen Chen Yulong Yin | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 5 |
| 13 | Flexible organic thin-film transistors based on poly(3-hexylthiophene) films for nitrogen dioxide detection显示文摘Flexible nitrogen dioxide(NO_2) gas sensors based on organic thin-film transistors(OTFTs) were developed in this work, in which conductive indium tin oxide(ITO) coated polyethylene naphthalene-2,6-dicarboxylate(PEN) was designed for the flexible substrates, and poly methyl methacrylate(PMMA) and poly(3-hexylthiophene)(P3HT) was spin-coated as the gate dielectric layer and spray-deposited as the active layer, respectively. The effects of PMMA concentrations and P3HT solution volume on performances of flexible OTFTs were systematically investigated. The results showed that the optimized flexible OTFT exhibited high field-effect mobility(9.51×10^(–3) cm^2/(V s) at a gate bias of –50 V) and excellent response characteristics,including high sensitivity(up to 0.169 ppm^(–1)), good repeatability and selectivity. The flexibility of the developed OTFT sensor was also investigated, and the results showed that the electrical and gas-sensing properties were affected by the bending cycles,thus further work should be done for improving the flexibility of the sensor. This work provides an effective approach in developing high performance flexible OTFT NO_2 gas sensor. | YANG Jing XIE GuangZhong SU YuanJie ZHANG QiuPing DU HongFei TAI HuiLing DU XiaoSong JIANG YaDong | 2018 | Science China(Technological Sciences)2018，61，11： | 3 |
| 14 | Comparisons of carcass traits,meat quality,and serum metabolome between Shaziling and Yorkshire pigs显示文摘This study aims to compare the meat quality of Shaziling and Yorkshire pigs and to find the potential indicator in serum for superior meat quality.Six Shaziling and Yorkshire pigs at 30,60,90,150,210,and 300 d of age were selected to examine carcass traits,meat quality,and serum metabolome.The results showed that the body weight,carcass length,and loin eye area of Shaziling pigs at 150,210,and 300 d of age were significantly lower than those of Yorkshire pigs(P<0.05).Shaziling pigs at 150 and 300 d of age had significantly lower backfat thickness than Yorkshire pigs(P<0.05).Compared with Yorkshire pigs,Shaziling pigs at all 6 ages had a lower lean percentage and a higher fat percentage(P<0.05).At 60,90,and 150 d of age,the post-mortem pH-decline,b*value(yellowness),and drip loss of Shaziling pigs were significantly lower than those of Yorkshire pigs(P<0.05).Moreover,at 150 d of age,Shaziling pigs had significantly higher a^(*)value(redness)and intramuscular fat(IMF)content than Yorkshire pigs(P<0.05).Correlation analysis between the top 40 metabolites and phenotypes indicated that L-carnitine had positive correlations with fat percentage,pH24h,and IMF content,but had negative correlations with lean percentage,L^(*)value(lightness),and b^(*)value(P<0.05).Serum L-carnitine content,fat percentage,pH24h,and IMF content all decreased first and then increased as the pigs grew,which verified the positive correlations between L-carnitine and these phenotypes.In conclusion,Shaziling pigs have a slower growth rate but a better meat quality than Yorkshire pigs.The meat quality of Shaziling pigs is the best from 150 to 210 d of age.This study suggests that a higher serum L-carnitine content is a promising indicator for better meat quality. | Bo Song Changbing Zheng Jie Zheng Shiyu Zhang Yinzhao Zhong Qiuping Guo Fengna Li Cimin Long Kang Xu Yehui Duan Yulong Yin | 2022 | Animal Nutrition2022，，1： | 3 |
| 15 | Prediction Model of Coal Reservoir Pressure and its Implication for the Law of Coal Reservoir Depressurization显示文摘The main methods of coalbed methane(CBM)development are drainage and depressurization,and a precise prediction of coal reservoir pressure is thus crucial for the evaluation of reservoir potentials and the formulation of reasonable development plans.This work established a new reservoir pressure prediction model based on the material balance equation(MBE)of coal reservoir,which considers the self-regulating effects of coal reservoirs and the dynamic change of equivalent drainage area(EDA).According to the proposed model,the reservoir pressure can be predicted based on reservoir condition data and the actual production data of a single well.Compared with traditional reservoir pressure prediction models which regard EDA as a fixed value,the proposed model can better predict the average pressure of reservoirs.Moreover,orthogonal experiments were designed to evaluate the sensitivity of reservoir parameters on the reservoir pressure prediction results of this proposed model.The results show that the saturation of irreducible water is the most sensitive parameter,followed by Langmuir volume and reservoir porosity,and Langmuir pressure is the least sensitive parameter.In addition,the pressure drop of reservoirs is negatively correlated with the saturation of irreducible water and the Langmuir volume,while it is positively correlated with porosity.This work analyzed the reservoir pressure drop characteristics of the CBM wells in the Shizhuangnan Block of the Qinshui Basin,and the results show that the CBM reservoir depressurization can be divided into three types,i.e.,rapidly drop type,medium-term stability type,and slowly drop type.The drainage features of wells were reasonably interpreted based on the comprehensive analysis of the reservoir depressurization type;the latter was coupled to the corresponding permeability dynamic change characteristics,eventually proving the applicability of the proposed model. | YAN Xinlu ZHANG Songhang TANG Shuheng LI Zhongcheng WANG Kaifeng YI Yongxiang DANG Feng HU Qiuping | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 2 |
| 16 | PpTCP18 is upregulated by lncRNA5 and controls branch number in peach (Prunus persica) through positive feedback regulation of strigolactone biosynthesis显示文摘Branch number is an important agronomic trait in peach(Prunus persica)trees because plant architecture affects fruit yield and quality.Although breeders can select varieties with different tree architecture,the biological mechanisms underlying architecture remain largely unclear.In this study,a pillar peach(‘Zhaoshouhong’)and a standard peach(‘Okubo’)were compared.‘Zhaoshouhong’was found to have significantly fewer secondary branches than‘Okubo’.Treatment with the synthetic strigolactone(SL)GR24 decreased branch number.Transcriptome analysis indicated that PpTCP18(a homologous gene of Arabidopsis thaliana BRC1)expression was negatively correlated with strigolactone synthesis gene expression,indicating that PpTCP18 may play an important role in peach branching.Yeast one-hybrid,electrophoretic mobility shift,dual-luciferase assays and PpTCP18-knockdown in peach leaf buds indicated that PpTCP18 could increase expression of PpLBO1,PpMAX1,and PpMAX4.Furthermore,transgenic Arabidopsis plants overexpressing PpTCP18 clearly exhibited reduced primary rosette-leaf branches.Moreover,lncRNA sequencing and transient expression analysis revealed that lncRNA5 targeted PpTCP18,significantly increasing PpTCP18 expression.These results provide insights into the mRNA and lncRNA network in the peach SL signaling pathway and indicate that PpTCP18,a transcription factor downstream of SL signaling,is involved in positive feedback regulation of SL biosynthesis.This role of PpTCP18 may represent a novel mechanism in peach branching regulation.Our study improves current understanding of the mechanisms underlying peach branching and provides theoretical support for genetic improvement of peach tree architecture. | Xiaobei Wang Qiuping Wang Lixia Yan Yuhang Hao Xiaodong Lian Haipeng Zhang Xianbo Zheng Jun Cheng Wei Wang Langlang Zhang Xia Ye Jidong Li Bin Tan Jiancan Feng | 2023 | Horticulture Research2023，10，1： | 2 |
| 17 | Capacitive sensor interface for an electrostatically levitated micromotor 显示文摘 | Han Fengtian Wu Qiuping Zhang Rang | 2009 | IEEE Transactions on Instrumentation and Measurement2009，58，10： | 1 |
| 18 | Fiber guiding at the Dirac frequency beyond photonic bandgaps显示文摘Light trapping within waveguides is a key practice of modern optics,both scientifically and technologically.Photonic crystal fibers traditionally rely on total internal reflection(index-guiding fibers)or a photonic bandgap(photonic-bandgap fibers)to achieve field confinement.Here,we report the discovery of a new light trapping within fibers by the so-called Dirac point of photonic band structures.Our analysis reveals that the Dirac point can establish suppression of radiation losses and consequently a novel guided mode for propagation in photonic crystal fibers.What is known as the Dirac point is a conical singularity of a photonic band structure where wave motion obeys the famous Dirac equation.We find the unexpected phenomenon of wave localization at this point beyond photonic bandgaps.This guiding relies on the Dirac point rather than total internal reflection or photonic bandgaps,thus providing a sort of advancement in conceptual understanding over the traditional fiber guiding.The result presented here demonstrates the discovery of a new type of photonic crystal fibers,with unique characteristics that could lead to new applications in fiber sensors and lasers.The Dirac equation is a special symbol of relativistic quantum mechanics.Because of the similarity between band structures of a solid and a photonic crystal,the discovery of the Dirac-point-induced wave trapping in photonic crystals could provide novel insights into many relativistic quantum effects of the transport phenomena of photons,phonons,and electrons. | Kang Xie Wei Zhang Allan D Boardman Haiming Jiang Zhijia Hu Yong Liu Ming Xie Qiuping Mao Lei Hu Qian Li Tianyu Yang Fei Wen Erlei Wang | 2015 | Light(Science & Applications)2015，4，1： | 1 |
| 19 | Adsorption behaviors of gas molecules on the surface of ZnO nanocrystals under UV irradiation显示文摘A UV-activated room temperature chemiresistive gas sensor based on ZnO nanocrystals film was fabricated. Its gas sensing properties under various conditions were also investigated in detail. The results shed new insight into the adsorption behaviors of gas molecules on the surface of ZnO nanocrystals under UV irradiation. The chemisorbed oxygen species(O^-2(ads)(hv)) induced by UV light govern the adsorption and desorption ways of other gas molecules on the surface of ZnO nanocrystals, which is dependent on the electron affinity of gas molecules. Gas molecules with higher electron affinity than oxygen molecules can be adsorbed on the surface by the competitive adsorption way, extracting electrons from the surface. Gas molecules with lower electron affinity than oxygen molecules are attracted by the adsorbed O^-2(ads)(hv)layer, releasing electrons to the surface. These processes can influence the gas sensing properties of the sensor. Our findings will pave the way for the fundamental understanding and design of UV-activated gas sensor in the future. | ZHANG QiuPing XIE GuangZhong DU HongFei YANG Jing SU YuanJie TAI HuiLing XU Ming ZHAO Kang | 2019 | Science China(Technological Sciences)2019，62，12： | 1 |
| 20 | Association of immunoglobulin G4-related disease with a family history of malignancy:A retrospective study of 168 cases显示文摘Objective:Immunoglobulin G4-related disease(IgG4-RD)is a systemic immune-mediated fibroinflammatory condition.Previous studies have indicated relationships between malignancy and autoimmunity.This retrospective cohort study aimed to determine IgG4-RD incidence and clinical features in patients with a family history of malignancy.Methods:To analyze the relationship between IgG4-RD and family history of malignancy,we reviewed IgG4-RD patients with a family history of malignancy diagnosed in various departments in West China Hospital,Sichuan University from December 2012 to September 2019.Clinical data and laboratory features were compared between IgG4-RD patients with and without a family history of malignancy.Results:Among 168 enrolled patients with IgG4-RD,22(13.1%)had a family history of malignancy.The most frequently involved system in family members with malignancy was the digestive system(38.5%).Among patients with a family history of malignancy,the most frequently involved organs in IgG4-RD were the pancreas(31.9%)and lymph nodes(31.9%).Age at symptom onset was older in IgG4-RD patients with a family history of malignancy than in patients without a family history of malignancy(50–59 years:36.3%vs.16.4%,p=0.0393).Hemoglobin(p=0.0172)and albumin(p=0.0247)levels were higher and globulin(p=0.0232)levels were lower in patients with a family history of malignancy.Conclusions:Our findings suggest that a family history of malignancy may be associated with IgG4-RD development.We hypothesize that genetic susceptibility may be involved in the pathogenesis of IgG4-RD. | Diping Hu Yanhong Li Yu Zhou Yubin Luo Lu Cheng Chunyu Tan Qiuping Zhang Yi Zhao Yi Liu | 2021 | Rheumatology & Autoimmunity2021，1，2： | 1 |
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