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| 1 | Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration显示文摘The host immune response effecting on biomaterials is critical to determine implant fates and bone regeneration property.Bone marrow stem cells(BMSCs)derived exosomes(Exos)contain multiple biosignal molecules and have been demonstrated to exhibit immunomodulatory functions.Herein,we develop a BMSC-derived Exos-functionalized implant to accelerate bone integration by immunoregulation.BMSC-derived Exos were reversibly incorporated on tannic acid(TA)modified sulfonated polyetheretherketone(SPEEK)via the strong interaction of TA with biomacromolecules.The slowly released Exos from SPEEK can be phagocytosed by co-cultured cells,which could efficiently improve the biocompatibilities of SPEEK.In vitro results showed the Exos loaded SPEEK promoted macrophage M2 polarization via the NF-κB pathway to enhance BMSCs osteogenic differentiation.Further in vivo rat air-pouch model and rat femoral drilling model assessment of Exos loaded SPEEK revealed efficient macrophage M2 polarization,desirable new bone formation,and satisfactory osseointegration.Thus,BMSC-derived Exos-functionalized implant exerted osteoimmunomodulation effect to promote osteogenesis. | Lei Fan Pengfei Guan Cairong Xiao Huiquan Wen Qiyou Wang Can Liu Yian Luo Limin Ma Guoxin Tan Peng Yu Lei Zhou Chengyun Ning | 2021 | Bioactive Materials2021，6，9： | 11 |
| 2 | The role played by traditional Chinese medicine in preventing and treating COVID-19 in China显示文摘Traditional Chinese medicine(TCM),an ancient system of alternative medicine,played an active role in the prevention and control of COVID-19 in China.It improved the clinical symptoms of patients,reduced the mortality rate,improved the recovery rate,and effectively relieved the operating pressure on the national medical system during critical conditions.In light of the current global pandemic,TCM-related measures might open up a new channel in the control of COVID-19 in other countries and regions.Here,we summarize the TCM-related measures that were widely used in China,including TCM guidelines,the Wuchang pattern,mobile cabin hospitals,integrated treatment of TCM and modern medicine for critical patients,and non-medicine therapy for convalescent patients,and describe how TCM effectively treated patients afflicted with the COVID-19.Effective TCM therapies could,therefore,be recommended and practiced based on the existing medical evidence from increased scientific studies. | Qingwei Li Han Wang Xiuyang Li Yujiao Zheng Yu Wei Pei Zhang Qiyou Ding Jiaran Lin Shuang Tang Yikun Zhao Linhua Zhao Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，5： | 10 |
| 3 | Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair显示文摘Growth plate cartilage has limited self-repair ability,leading to poor bone bridge formation post-injury and ultimately limb growth defects in children.The current corrective surgeries are highly invasive,and outcomes can be unpredictable.Following growth plate injury,the direct loss of extracellular matrix(ECM)coupled with further ECM depletion due to the inhibitory effects of inflammation on the cartilage matrix protein greatly hinder chondrocyte regeneration.We designed an exosome(Exo)derived from bone marrow mesenchymal stem cells(BMSCs)loaded ECM-mimic hydrogel to promote cartilage repair by directly supplementing ECM and anti-inflammatory properties.Aldehyde-functionalized chondroitin sulfate(OCS)was introduced into gelatin methacryloyl(GM)to form GMOCS hydrogel.Our results uncovered that GMOCS hydrogel could significantly promote the synthesis of ECM due to the doping of OCS.In addition,the GMOCS-Exos hydrogel could further promote the anabolism of chondrocytes by inhibiting inflammation and ultimately promote growth plate injury repair through ECM remodeling. | Pengfei Guan Can Liu Denghui Xie Shichao Mao Yuelun Ji Yongchang Lin Zheng Chen Qiyou Wang Lei Fan Yongjian Sun | 2022 | Bioactive Materials2022，7，4： | 3 |
| 4 | Incorporating catechol into electroactive polypyrrole nanowires on titanium to promote hydroxyapatite formation显示文摘To improve the osteointegration property of biomedical titanium,nano-architectured electroactive coating was synthesized through the electrochemical polymerization of dopamine and pyrrole.The highly binding affinity of Ca2t to the catechol moiety of doped dopamine enabled efficient interaction between polypyrrole/polydopamine nanowires and mineral ions.The results indicate that the PPy/PDA nanowires preserved its efficient electro-activity and accelerated the hydroxyapatite deposition in a simulated body fluid.The PPy/PDA nanowires coating could be applied to promote the osteointegration of titanium implant. | Zhengao Wang Jinquan Zeng Guoxin Tan Jingwen Liao Lei Zhou Junqi Chen Peng Yu Qiyou Wang Chengyun Ning | 2018 | Bioactive Materials2018，3，1： | 1 |
| 5 | Free-standing phosphorous-doped molybdenum nitride in 3D carbon nanosheet towards hydrogen evolution at all pH values显示文摘Highly efficient electrocatalysts towards hydrogen evolution reaction(HER) with large current density at all-pH values are critical for the sustainable hydrogen production. Herein, we report a free-standing HER electrode, phosphorous-doped molybdenum nitride nanoparticles embedded in 3-dimentional carbon nanosheet matrix(P-Mo2N-CNS) fabricated via one-step carbonization and in-situ formation. The asprepared catalyst shows free-standing architecture with interconnected porous microstructure. P-doped Mo2N nanoparticles with an average diameter of 4.4 nm are well embedded in the 3-dimentional vertical carbon nanosheets matrix. Remarkable electrocatalytic HER performance is observed in alkaline, neutral and acidic media at large current densities. The overpotential of P-Mo2N-CNS to drive a current density of 100 mA cm-2 in 0.5 M H2SO4 and 1.0 M PBS is only 181 and 221 mV, respectively. In particular, the current density reaches up to 1000 mA cm-2 at a low overpotential of 256 mV in 1.0 M KOH, much better than that of the commercial Pt/C catalyst. Density functional theory calculations suggest the optimized H sorption kinetics on Mo2N after P doping, elucidating the superior activity. | Qiyou Wang Yan Zhang Wenpeng Ni Yi Zhang Tian Sun Jiaheng Zhang Junfei Duan Yang Gao Shiguo Zhang | 2020 | Journal of Energy Chemistry2020，29，11： | 1 |
| 6 | Numerical Simulation of Aerodynamic Characteristics of Helicopter Rotor with Tip Slots显示文摘Effects of tip slots on the aerodynamic characteristics of helicopter rotor were investigated numerically by solving three-dimensional Navier-Stokes equations based on unstructured overset grids algorithm.Improved delayed detached eddy simulation (IDDES) based on the Spalart-Allmaras turbulence model and adaptive grid refinement technique were employed.Several slots in the rotor blade tip were designed on the base of Caradonna-Tung rotor to study the effect of tip slots.Numerical results show that tip slots are able to introduce the airflow from the leading edge and turn it in the spanwise direction to be ejected out of the face at the rotor blade tip,which can reduce the strength of the rotor blade tip vortex and accelerate the dissipation process.Although tip slots may lead to the decrease of airfoils' lift coefficient at the root of the rotor blade,it can increase the lift coefficient of airfoils at the rotor blade tip,so the lift of the rotor with tip slots is almost the same as that of the rotor without tip slots.In addition,tip slots can also reduce the intensity of the tip shock wave,which is beneficial to reduce the wave drag of the rotor. | Chen Rongqian Wang Xu Cheng Qiyou Zhu Chengxiang You Yancheng | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，6： | 1 |
| 7 | Studies on dietary phosphorus requirement of juvenile Siberian sturgeon显示文摘 | Xu Qiyou Xu Hong Wang Chang’an | 2011 | Journal of Applied Ichthyology2011，27，： | 1 |
| 8 | The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies显示文摘Dear Editor, Many forms of sight-threatening diseases, including retinitis pigmentosa (RP) and age-related macular degeneration (AMD), are caused by the dysfunction, degeneration and loss of the retinal pigment epithelium (RPE)(Strauss, 2005). RPE cell transplantation may potentially recover or halt disease progression, in which human embryonic stem cells (hESCs) could serve as an unlimited donor source for RPE differentiation, and a few clinical trials have shown the safety and effective of transplantation of hESCs-derived RPE (hESC-RPE) for AMD patients (Schwartz et al., 2012;Schwartz etal., 2015;Song etal., 2015;da Cruz et al., 2018;Kashani et al., 2018;Liu et al., 2018). | Lei Wang Wei Wu Qi Gu Zengping Liu Qiyou Li Zhongwen Li Jinhui Fang Wenjing Liu Jun Wu Ying Zhang Liu Wang Haiwei Xu Wei Li Baoyang Hu Qi Zhou Zhengqin Yin Jie Hao | 2019 | Protein & Cell2019，10，6： | 1 |
| 9 | Ecological Environment Change in North Slope of Qilianshan Mountains显示文摘Based on meteorological,hydrological, forest,and grassland data collected by location observation,remote sensing,field surveys and relevant literature during 1956 to 2009,the ecological environment change in northern slope of the Qilianshan Mountains was analyzed synthetically using regression and correlation analyses.The results showed that the temperature had an annual variation rate of 0.033 4℃·a-1 in northern slope of the Qilianshan Mountains since 1960,and exhibited a raising trend,especially since 1987.The annual variation rate of annual precipitation was 0.570 2 mm·a-1,indicating that the precipitation tended to increase.The climate had changed from arid to humid in this region since 1976.From 1956 to 2006,the glacier area of six inland river basin(Shiyanghe river,Heihe river, Beidahe river,Shulehe river,Danghe river and Halternhe river) and Datonghe river basin in northern slope of Qilianshan mountains decreased by 17.7%. Thickness of the glacier reduced about 5-20 m,and the snow line rose about 100-140 m.The Glacier ice reserves in inland river basin of Hexi decreased by 11.4%.From 1972 to 2007,27 glaciers in the eastern section of the Qilianshan Mountains disappeared.From 1956 to 2009,the runoff change in the northern slope of the Qilianshan Mountains was different in different regions.The runoff was reduced significantly in Shiyanghe river basin, increased slightly in Heihe river basin,and increased obviously in Shulehe river basin.From 1958 to 1988, the area of deforestation and farming was more than 10.0 million ha,and the forest area was reduced 0.6 million ha.Since the Qilianshan Mountain Nature Reserve was established in 1989, the forest was restoring gradually because of continual protection and cultivating,and the forest area was increased 9.4 million ha from 1989 to 2008. Due to human interference,especially over-grazing impact,the quality of the wood-land,shrub-land and grass-land in northern slope of the Qilianshan Mountains were in a degraded condition,which resulted in serious harm of forest pests,decrease of shrubbery snow and water-retention capacity and exacerbation of soil erosion.The ecological environment in northern slope of the Qilianshan Mountains was improved in certain regions,but deteriorated in overall region,and the protection and management are needed to be strengthened. | Wang Youkui Jia Wenxiong Liu Chaohai Chen Wen Zhao Chengzhang Wang Qiyou Wang Jie | 2012 | Chinese Forestry Science and Technology2012，11，3： | 1 |
| 10 | Supported ionic liquid phase-boosted highly active and durable electrocatalysts towards hydrogen evolution reaction in acidic electrolyte显示文摘Platinum is generally known as the most effective electrocatalyst for hydrogen evolution reaction because it can greatly lower the overpotential and accelerate the reaction kinetics,while its commercial potential always suffers from scarcity,high cost,low utilization,and poor durability particularly in acidic electrolytes.We herein demonstrate a facile method to improve the hydrogen evolution performance of Pt-based electrocatalysts by simply decorating the-state-of-the-art and commercially available Pt/C with hydrophobic protic([DBU][NTf2])or aprotic([BMIm][NTf2])ionic liquid.The current densities of[BMIm]@Pt/C and[DBU-H]@Pt/C with 10% ionic liquid at an overpotential of 40 mV are 2.81 and 4.15 times,respectively,higher than that of the pristine Pt/C.More importantly,ionic liquid-decoration significantly improves the long-term stability of Pt nanoparticles.After 8 h of chronoamperometric measurements,[DBU-H]@Pt/C and[BMIm]@Pt/C can still retain 83.7% and 78.3% of their original activity,respectively,which is much higher than that of the pristine Pt/C(24.4%).The improved performance of Pt/C decorated with ionic liquid is considered to arise from the improved proton conductivity(particularly for protic ionic liquid)and hydrophobic microenvironment created by the supported ionic liquid phase.The presence of ionic liquid layer not only de-coordinates H+from hydronium ions nearby the Pt nanoparticles,but it also protects Pt nanoparticles from dissolution in the acidic media. | Qiyou Wang Yang Gao Zhongyun Ma Yan Zhang Wenpeng Ni Hussein AYounus Ce Zhang Zhengjian Chen Shiguo Zhang | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 11 | An ultra-porous g-C_(3)N_(4) micro-tube coupled with MXene(Ti_(3)C_(2)TX)nanosheets for efficient degradation of organics under natural sunlight显示文摘It remains as a challenge for realizing efficient photo-responsive catalysts towards largescale degradation of organic pollutants under natural sunlight.This work reports a new pore engineering strategy for creating ultra-porous g-C_(3)N_(4) micro-tubes with an unprecedentedly high specific surface area of 152.96 m^(2)/g.This is mainly associated with releasing internal vapor pressure in the autoclave where the hydrothermal treatment of the urea/melamine mixture is processed.Supported by microscopic observation,porosity measurement and spectroscopic characterization,it is found that releasing the pressure at halfway of hydrothermal process is vital for forming exfoliated rod-like precursors and the de-aggregation of these rods presents substantial benefits on the production of mesopores on g-C_(3)N_(4) microtubes during the calcination of precursors.This offers a large number of reactive sites required by photocatalytic reaction.Coupling these micro-tubes with Ti_(3)C_(2)T_(X) nanosheets via electrostatic interaction yields a 1D/2D heterojunction with a close interfacial contact.The addition of metallically conductive Ti_(3)C_(2)T_(X) nanosheets accelerates the separation between electrons and holes,and also enhances the light absorption.All these merits of structural design lead to forming a group of highly efficient catalysts demonstrating an excellent photocatalytic degradation rate of k=0.0560 min^(-1)for RhB dyes under 100 mW/cm~2 visible light radiation that micks sunlight outdoors.This laboratory valuation is further supported by an outdoor test that shows a fast degradation rate of 0.0744 min^(-1)under natural sunlight. | Zongyang Ya Qiyou Wang Jingjin Cai Peng Wang Xinyu Jiang Zhiyin Cai Shanglin Xiang Tingwei Wang Dongyu Cai | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 12 | Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus显示文摘Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are lacking.Here,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to DM.Analysis of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT groups.In addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM. | Boxun Zhang Xuan Zhang Zhen Luo Jixiang Ren Xiaotong Yu Haiyan Zhao Yitian Wang Wenhui Zhang Weiwei Tian Xiuxiu Wei Qiyou Ding Haoyu Yang Zishan Jin Xiaolin Tong Jun Wang Linhua Zhao | 2024 | Journal of Genetics and Genomics2024，51，1： | 0 |
| 13 | The Coastline Landscape——The Starting Point for the Design of Haikou's City Image and the Leading Role Played in Environmental System of the City | Wang Qiyou | 1994 | China City Planning Review1994，11，1： | 0 |
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