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| 1 | A long-term Global LAnd Surface Satellite(GLASS)data-set for environmental studies显示文摘Recently,five Global LAnd Surface Satellite(GLASS)products have been released:leaf area index(LAI),shortwave broadband albedo,longwave broadband emissivity,incident short radiation,and photosynthetically active radiation(PAR).The first three products cover the years 19822012(LAI)and 19812010(albedo and emissivity)at 15 km and 8-day resolutions,and the last two radiation products span the period 20082010 at 5 km and 3-h resolutions.These products have been evaluated and validated,and the preliminary results indicate that they are of higher quality and accuracy than the existing products.In particular,the first three products have much longer time series,and are therefore highly suitable for various environmental studies.This paper outlines the algorithms,product characteristics,preliminary validation results,potential applications and some examples of initial analysis of these products. | Shunlin Liang Xiang Zhao Suhong Liu Wenping Yuan Xiao Cheng Zhiqiang Xiao Xiaotong Zhang Qiang Liu Jie Cheng Hairong Tang Yonghua Qu Yancheng Bo Ying Qu Huazhong Ren Kai Yu John Townshend | 2013 | International Journal of Digital Earth2013，6，S01： | 16 |
| 2 | Radial shock wave therapy in the treatment of chronic constriction injury model in rats: a preliminary study显示文摘 | Fu Miao Cheng Hao Li Duoyi Yu Xiaotong Ji Nan Luo Fang | 2014 | Chinese Medical Journal2014，，5： | 13 |
| 3 | Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition显示文摘 | Yan Jian Xiaotong Zhao Qian Xiao Qingbo Liu Keshuo Ding Fei Yu Rui Zhang Tao Zhu Gaoxiang Ge | 2014 | Journal of Molecular Cell Biology2014，8，4： | 11 |
| 4 | MicroRNA-125b-5p inhibits proliferation and promotes adipogenic differentiation in 3T3-L1 preadipocytes显示文摘以前的证据显示了 microRNA-125b (miR-125b ) 家庭戏在癌症房间生长,开发,区别,和 apoptosis 的规定的重要角色。然而,他们是否贡献 adipocyte 区别的过程,仍然保持不清楚。在现在的学习,我们表明表示 miR-125b-5p 铺平, miR-125b 家庭的一个成员,在进成熟 adipocyte 的 3T3-L1 preadipocyte 的区别期间是戏剧性地起来调整的。进 3T3-L1 房间的 miR-125b-5p 的补充支持了由增加的类脂化合物微滴和 adipocyte 特定的分子的标记的 mRNA 层次证实了的 adipogenic 区别,包括 peroxisome 激活 proliferators 的受体, CCAAT/enhancer-binding 蛋白质,丰满的酸绑定的蛋白质 4,并且脂蛋白脂肪分解酵素,并且由 triglyceride 累积。CCK-8 试金证明 miR-125b-5p 补充显著地禁止了房间增长。流动 cytometry 分析证明 miR-125b-5p 象 mRNA 和 G1/S-related 基因的蛋白质表示一样损害了 G1/S 阶段转变,例如 Cyclin D2, Cyclin D3,和 CDK4。不过,它没在 apoptosis 上有效果。由目标基因预言,另外,我们证明 smad4 可以是在鼠标 3T3-L1 preadipocytes 的 miR-125b-5p 的一个潜在的目标,为一些 miR-125b-5p 的函数的财务。一起拿,这些数据显示 miR-125b-5p 可以在 adipocyte 区别用作一个重要积极管理者,至少部分通过下面调整的 smad4。 | Dan Ouyang Yaqiong Ye Dongguang Guo Xiaofang Yu Jian Chen Junjie Qi Xiaotong Tan Yuan Zhang Yongjiang Ma Yugu Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 9 |
| 5 | Lactate metabolism in human health and disease显示文摘The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism,as identified by studies on the Warburg effect.The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells,organs and tissues.Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019.Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation,neural excitation,inflammation and other biological processes.An indispensable substance for various physiological cellular functions,lactate plays a regulatory role in different aspects of energy metabolism and signal transduction.Therefore,a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research.This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes,as well as a comprehensive overview of the effects of lactylation in various diseases,particularly inflammation and cancer. | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 9 |
| 6 | MiR-181a-5p regulates 3T3-L1 cell adipogenesis by targeting Smad7 and Tcf7I2显示文摘 | Dan Ouyang Lifeng Xu Lihua zhang Dongguang Guo Xiaotong Tan Xiaofang Yu Junjie Qi Yaqiong Ye Qihong Liu Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 9 |
| 7 | Effects of dietary protein levels on the long-term growth response and fitting growth models of gibel carp(Carassius auratus gibelio)显示文摘A 41-wk growth trial was conducted to evaluate the effects of dietary protein levels on the long-term growth response and fitting growth models of gibel carp(Carassius auratus gibelio) with an initial body weight of 1.85 ± 0.17 g. The dietary protein levels were designed at 320(P32), 360(P36). 400(P40).and 440 g/kg(P44), respectively. The growth curves of the gibel carp for each group were fitted and analyzed with four nonlinear regression models(Gompertz. logistic. von Bertalanffy and Richards). The final body weights(mean ± SD) of the fish were 226 ± 6.231 ± 7.242 ± 2, and 236 ± 2 g for P32, P36, P40,and P44. respectively. Feed conversion ratio of P40 and P44 groups was significantly lower than that of P32 and P36 groups(P < 0.05). Productive protein value of P44 group was significantly lower than that of P32 and P36 groups, but not different from that of P40 group(P > 0.05). The growth response of the gibel carp for each group was the best fitted by Richards model with the lowest Chi^2, residual sum of squares and residual variance, then Gompertz and von Bertalanffy growth models, but the logistic model did not fit the data well justified by Chi^2 values. The optimal protein level(400 g/kg) prolonged the stage of fast growth and predicted the highest asymptotic weight, which was close to the harvest size in practice. | Biao Yun Xiaotong Yu Min Xue Ying Liu Jia Wang Xiufeng Wu Fang Han Xufang Liang | 2015 | Animal Nutrition2015，，2： | 4 |
| 8 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 9 | Hd1,Ghd7,and DTH8 synergistically determine the rice heading date and yield-related agronomic traits显示文摘Heading date determines the seasonal and regional adaptation of rice(Oryza sativa L.)varieties and is mainly controlled by photoperiod sensitivity(PS).The core heading date genes Hd1,Ghd7,DTH8,and PRR37 act synergistically in regulating the PS.In this study,we systematically analyze the heading date,PS,and agronomic traits of eight homozygous lines with various combinations of Hd1,Ghd7,and DTH8 alleles in the prr37 background under long-day(LD)and short-day(SD)conditions,respectively.We find that Hd1 alone promotes heading,regardless of the day length.However,under LDs,Hd1 suppresses flowering,in coordination with functional Ghd7 or with Ghd7 and DTH8.These loci cooperate to negatively regulate the Ehd1-Hd3 a/RFT1 pathway and delay heading.Under SDs,Hd1 competes with various heading suppressors to promote heading.Therefore,the dual function of Hd1 is vital for PS.The lines carrying Hd1 alone show reduced plant height with fewer primary and secondary branches in panicles.Lines carrying Ghd7 and DTH8(with hd1)show delayed heading and improve agronomic traits.Overall,our results reveal the regulation of rice PS flowering by the core heading date genes and their effects on agronomic traits,providing valuable information for the selection of rice varieties for adaptation to different light and temperature conditions. | Kangli Sun Minghui Huang Wubei Zong Dongdong Xiao Chen Lei Yanqiu Luo Yingang Song Shengting Li Yu Hao Wanni Luo Bingqun Xu Xiaotong Guo Guangliang Wei Letian Chen Yao-Guang Liu Jingxin Guo | 2022 | Journal of Genetics and Genomics2022，49，5： | 4 |
| 10 | Effects of “Bioactive” amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks显示文摘Feed intake control is vital to ensuring optimal nutrition and achieving full potential for growth and development in poultry. The aim of the present study was to investigate the effects of L-leucine, L-glutamate, L-tryptophan and L-arginine on feed intake and the mRNA expression levels of hypothalamic Neuropeptide involved in feed intake regulation in broiler chicks. Leucine, glutamate, tryptophan or arginine was intra-cerebroventricularly (ICV) administrated to 4d-old broiler chicks respectively and the feed intake were recorded at various time points. Quantitative PCR was performed to determine the hypothalamic mRNA expression levels of Neuropeptide Y (NPY), agouti related protein (AgRP), pro-opiomelanocortin (POMC), melanocortin receptor 4 (MC4R) and corticotrophin releasing factor (CRF). Our results showed that ICV administration of L-leucine (0.15 or 1.5 μmol) significantly (P<0.05) increased feed intake up to 2 h post-administration period and elevated both hypothalamic NPY and AgRP mRNA expression levels. In contrast, ICV administration of L-glutamate (1.6μmol) significantly (P<0.05) decreased feed intake 0.25, 0.5 and 2 h post-injection, and increased hypothalamic CRF and MC4R mRNA expression levels. Meanwhile, both L-tryptophan (10 or 100μg) and L-arginine (20 or 200μg) had no significant effect on feed intake. These findings suggested that L-leucine and L-glutamate could act within the hypothalamus to influence food intake, and that both orexigenic and anorexigenic Neuropeptide genes might contribute directly to these effects. | Songbo Wang Paul Khondowe Shengfeng Chen Jianjian Yu Gang Shu Xiaotong Zhu Lina Wang Ping Gao Qianyun Xi Yongliang Zhang Qingyan Jiang | 2012 | Journal of Animal Science and Biotechnology2012，3，4： | 3 |
| 11 | Recent developments and progress of inorganic photo-stimulated phosphors显示文摘Photo-stimulated luminescence(PSL) is the process in which trapped charges are released by photons and produce luminescence through recombination. The variegated optical characteristics of photostimulated phosphors(PSPs) have drawn increasing attention and a large body of work encompassing mechanism and application of PSPs has been addressed. The optical data storage capacity resulting from abundant defect states enables PSPs to be applied to information storage. Moreover, PSPs provide potential application for anti-counterfeiting, as color changes due to the tunneling process. Recently, near infrared(NIR) light PSPs have been developed, exhibiting enormous potential for in vivo bio-imaging, as the stable and high noise-signal ratio characteristic of PSL. In this review, we devote to introducing the development and process of PSPs, and the challenge and future advance have also been demonstrated. | Xiaotong Fan Zhichao Liu Xiuxia Yang Wenbo Chen Wei Zeng Shuyu Tian Xue Yu Jianbei Qiu Xuhui Xu | 2019 | Journal of Rare Earths2019，37，7： | 2 |
| 12 | MicroRNA-181a-5p enhances cell proliferation in medullary thymic epithelial cells via regulating TGF-β signaling显示文摘在从不同年龄的老鼠的胸腺纸巾的 miRNAs 的表示侧面在我们的以前的学习被表明了。在 miRNA 表达式侧面的综合分析以后,我们证明 miR-181a-5p 的表达式显著地在 thymic 被减少从 10- 的上皮的房间(侦探) 到 19-month-old 鼠标当与那相比在从 1-month-old 的侦探由量的反向的 transcriptase 聚合酶的鼠标锁住反应时。我们在侦探假设了那 miR-181a-5p 可能通过调整一些基因或发信号的小径与年龄相关的胸腺复杂物被联系。测试这个假设,老鼠髓的 thymic 上皮的房间(MTEC1 ) 被使用。有 miR-181a-5p 的 Transfection 模仿支持了 MTEC1 房间的增长,但是没影响 apoptosis。效果被颠倒 miR-181a-5p 的表示什么时候在 MTEC1 房间被压制。而且,转变生长因素贝它受体(Tgfbr1 ) 我被酶试金作为 miR-181a-5p 的一个直接目标证实。而且,它被发现 miR-181a-5p 的那 overexpression 下面调整 Smad3 的 phosphorylation 并且堵住了发信号的转变生长因素贝它的激活。不过,一相反地,关联在 Tgfbr1 的表示之间被观察,在侦探的 miR-181a-5p 源于不同年龄的老鼠。一起,我们提供 miR-181a-5p 可以是在侦探,和表示的增长的一个重要内长的管理者的证据在侦探的 miR-181a-5p 的层次可以与年龄相关的胸腺复杂物被联系。 | Dongguang Guo Yaqiong Ye Junjie Qi Lihua Zhang Lifeng Xu Xiaotong Tan Xiaofang Yu Qihong Liu Jilong Liu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 2 |
| 13 | Geometric Characteristics of Tropical Cyclone Eyes before Landfall in South China Based on Ground-Based Radar Observations显示文摘The geometric characteristics of tropical cyclone(TC) eyes before landfall in South China are examined using groundbased radar reflectivity. It is found that the median and mean eye area decrease with TC intensity, except for the severe typhoon category, and the eye size increases with height. The increasing rate of eye size is relatively greater in upper layers.Moreover, the ratio of eye size change in the vertical direction does not correlate with TC intensity. No relationship is presented between the ratio of eye size change in the vertical direction and the vertical wind shear. No relationship between the vertical change in eye size and the eye size at a certain level is found, inconsistent with other studies. No relationship exists between the vertical change in eye size and the intensity tendency. The eye roundness values range mainly from 0.5 to 0.7, and more intense TCs generally have eyes that are more circular. | Xiaotong ZHU Qingqing LI Jinhua YU Dan WU Kai YAO | 2018 | Advances in Atmospheric Sciences2018，35，5： | 2 |
| 14 | A Biodegradable Shape Memory Nanocomposite with Excellent Magnetism Sensitivity显示文摘 | Xiongjun Yu Shaobing Zhou Xiaotong Zheng | 2009 | Nanotechnology2009，20，： | 1 |
| 15 | Optical frequency synthesizer referenced to an ytterbium optical clock显示文摘Optical clocks with an unprecedented accuracy of 10-18 promise innovations in precision spectroscopy and measurement. To harness the full power of optical clocks, we need optical frequency synthesizers(OFSs) to accurately convert the stabilities and accuracies of optical clocks to other desired frequencies. This work demonstrates such an OFS referenced to an ytterbium optical clock. The OFS is based on an optical frequency comb phase-locked to a commercial rubidium microwave clock;in this way most combs can operate robustly. Despite comb frequency instability at 10^(-11), the synthesis noise and uncertainty reach 6 × 10^(-18)(1 s) and 5 × 10^(-21), respectively, facilitating frequency synthesis of the best optical clocks. In the OFS, the coherence of the OFS internal oscillator at 1064 nm is accurately transferred to a 578 nm laser for resolving the hertz-level-linewidth ytterbium clock transition(unaffected by megahertz-linewidth comb lines) and faithfully referencing the OFS to an ytterbium optical clock. | YUAN YAO BO LI GUANG YANG XIAOTONG CHEN YAQIN HAO HONGFU YU YANYI JIANG LONGSHENG MA | 2021 | Photonics Research2021，9，2： | 1 |
| 16 | An electrocatalyst with anti-oxidized capability for overall water splitting显示文摘 | Chang Yu Huawei Huang Si Zhou Xiaotong Han Changtai Zhao Juan Yang Shaofeng Li Wei Guo Bowen An Jijun Zhao Jieshan Qiu | 2018 | Nano Research2018，11，6： | 1 |
| 17 | Tauroursodeoxycholic acid(TUDCA)improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets显示文摘Background:Tauroursodeoxycholic acid(TUDCA),a hydrophilic bile acid,is the main medicinal component of bear bile and is commonly used to treat a variety of hepatobiliary diseases.Meanwhile,TUDCA has been shown to modulate the intestinal barrier function and alleviate DSS-induced colitis in mice.However,the effect of TUDCA on the intestinal barrier of weaned piglets remains largely unclear.Methods:The weaned piglets and porcine IPEC-J2 intestinal epithelial cells were used to investigate the effects of TUDCA on intestinal barrier function in weaned piglets and explore the possible underlying mechanisms.In vivo,72 healthy weaned piglets were randomly allocated into 2 groups according to their gender and body weight,and piglets were fed the basal diet with 0(control,CON)and 200 mg/kg TUDCA for 30 d,respectively.Three female and three male piglets reflecting the average bodyweight were slaughtered in each group and samples were collected.In vitro,IPEC-J2 cells were subjected to 100μmol/L TUDCA to explore the possible underlying mechanisms.Results:Our results demonstrated that dietary TUDCA supplementation significantly reduced the diarrhea incidence of weaned piglets,possibly attributing to the TUDCA-enhanced intestinal barrier function and immunity.In addition,TUDCA supplementation altered serum metabolites and the relative abundance of certain gut bacteria,which might contribute to the improved intestinal barrier function.Furthermore,the in-vitro results showed that TUDCA improved the E.coli-induced epithelial barrier impairment of IPEC-J2 cells and increased Takeda G-coupled protein receptor 5(TGR5)protein expression.However,knockdown of TGR5 and inhibition of myosin light chain kinase(MLCK)pathway abolished the TUDCA-improved epithelial barrier impairment in E.coli-treated IPEC-J2 cells,indicating the involvement of TGR5-MLCK in this process.Conclusions:These findings showed that TUDCA improved intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets,suggesting the potential application of TUDCA in improving gut health in piglet production. | Min Song Fenglin Zhang Yiming Fu Xin Yi Shengchun Feng Zhichang Liu Dun Deng Qiang Yang Miao Yu Canjun Zhu Xiaotong Zhu Lina Wang Ping Gao Gang Shu Xianyong Ma Qingyan Jiang Songbo Wang | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 1 |
| 18 | Salicylaldehyde fluorescein hydrazone: a colorimetric logic chemosensor for pH and Cu(II)显示文摘 | Xiaotong Chen Zifan Li Yu Xiang Aijun Tong | 2008 | Tetrahedron Letters2008，，32： | 1 |
| 19 | Enhancement of red upconversion emission intensity of Ho^(3+) ions in NaLuF4:Yb^(3+)/Ho^(3+)/Ce^(3+)@NaLuF_(4) core-shell nanoparticles显示文摘The red upconversion emission of Ho^(3+)ions,in the optical window of biological tissue,exhibits excellent prospects in biological applications.This study aims to enhance the red upconversion emission intensity of Ho^(3+)ions in NaLuF_(4):20%Yb^(3+)/2%Ho^(3+)/12%Ce^(3+) nanoparticles through building different core–shell structures with different excitation wavelengths.A significantly enhanced red upconversion emission with a higher red-to-green ratio was successfully obtained in NaLuF_(4):20%Yb^(3+)/2%Ho^(3+)/12%Ce^(3+)@NaLuF_(4) core–shell nanoparticles by introducing the Yb^(3+)and Yb^(3+)/Nd^(3+)ions into the NaLuF_(4) shell,with enhancement of the red emission occurring when Yb^(3+)and Nd^(3+)ions in the shell transfer more excitation energy to the Ho^(3+)ions.Investigation of the red emission enhancement mechanism is based on spectral characteristics and lifetimes.We examined the synergistic effect of dual-wavelength co-excitation NaLuF_(4):20%Yb^(3+)/2%Ho^(3+)/12%Ce^(3+)@NaLuF_(4):10%Yb^(3+)/15%Nd^(3+)core–shell nanoparticles to establish optimal excitation conditions.It is hoped that this method,using red upconversion emission core–shell nanoparticles with multi-mode excitation,can provide new ways to expand the applications of rare-earth luminescent materials in biomedicine and anti-counterfeiting. | Wei Gao Xiaotong Cheng Yu Xing Shanshan Han Binhui Chen Qingyan Han Xuewen Yan Jihong Liu Lin Liu Jun Dong | 2022 | Journal of Rare Earths2022，40，4： | 1 |
| 20 | Visible-blind short-wavelength infrared photodetector with high responsivity based on hyperdoped silicon显示文摘Developing a low-cost, room-temperature operated and complementary metal-oxide-semiconductor(CMOS)compatible visible-blind short-wavelength infrared(SWIR) silicon photodetector is of interest for security,telecommunications, and environmental sensing. Here, we present a silver-supersaturated silicon(Si:Ag)-based photodetector that exhibits a visible-blind and highly enhanced sub-bandgap photoresponse. The visible-blind response is caused by the strong surface-recombination-induced quenching of charge collection for short-wavelength excitation, and the enhanced sub-bandgap response is attributed to the deep-level electrontraps-induced band-bending and two-stage carrier excitation. The responsivity of the Si:Ag photodetector reaches 504 mA · W^(-1) at 1310 nm and 65 m A · W^(-1) at 1550 nm under-3 V bias, which stands on the stage as the highest level in the hyperdoped silicon devices previously reported. The high performance and mechanism understanding clearly demonstrate that the hyperdoped silicon shows great potential for use in optical interconnect and power-monitoring applications. | XIAODONG QIU ZIJING WANG XIAOTONG HOU XUEGONG YU DEREN YANG | 2019 | Photonics Research2019，7，3： | 1 |
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