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| 1 | A Novel Load Balancing Strategy of Software-Defined Cloud/Fog Networking in the Internet of Vehicles显示文摘The Internet of Vehicles(IoV)has been widely researched in recent years,and cloud computing has been one of the key technologies in the IoV.Although cloud computing provides high performance compute,storage and networking services,the IoV still suffers with high processing latency,less mobility support and location awareness.In this paper,we integrate fog computing and software defined networking(SDN) to address those problems.Fog computing extends computing and storing to the edge of the network,which could decrease latency remarkably in addition to enable mobility support and location awareness.Meanwhile,SDN provides flexible centralized control and global knowledge to the network.In order to apply the software defined cloud/fog networking(SDCFN) architecture in the IoV effectively,we propose a novel SDN-based modified constrained optimization particle swarm optimization(MPSO-CO) algorithm which uses the reverse of the flight of mutation particles and linear decrease inertia weight to enhance the performance of constrained optimization particle swarm optimization(PSO-CO).The simulation results indicate that the SDN-based MPSO-CO algorithm could effectively decrease the latency and improve the quality of service(QoS) in the SDCFN architecture. | Xiuli He Zhiyuan Ren Chenhua Shi Jian Fang | 2016 | China Communications2016，13，S2： | 10 |
| 2 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 3 | Promoting proliferation and differentiation of BMSCs by green tea polyphenols functionalized porous calcium phosphate显示文摘In this article,we proposed a facile protocol to functionalize porous calcium phosphate ceramics(PCPC)using dietary tea polyphenols(TP).TP molecules was attracted and anchored by Ca2t ions from the surface of CPC.These TP molecules modulated the nucleation and crystallization of calcium phosphate nanorods assemblies on the surface of PCPC.Our results prove that these calcium phosphate nanorods assemblies accompanies functional groups of TP make PCPC/TP effectively promote proliferation and differentiation of bone mesenchymal stem cells(BMSCs).We inferred that these calcium phosphate nanorods assemblies might change the surface microenvironment of PCPC,which is critical to promote the proliferation and differentiation of BMSCs.Compared with naked PCPC,PCPC/TP obviously increased BMP2,ErK/MAPK and JNK/MAPK level and mineralization capacity of cells(ALP level). | Kang Zhou Xiuli Ren Mengen Zhao Xifan Mei Peng Zhang Zhenhua Chen Xiangdong Zhu | 2018 | Regenerative Biomaterials2018，5，1： | 5 |
| 4 | Synthesis and Properties of UV-curable Hyperbranched Polyurethane and Its Application in the Negative-type Photoresist显示文摘UV-curable hyperbranched polyurethane(UV-HBPU) containing carboxyl groups was synthesized from isophorone diisocyanate(IPDI), diethanolamine(DEOA), polyethylene glycol(PEG-400), hydroxyethyl acrylate(HEA), and 2,2-bis(hydroxymethyl) propionic acid(DMPA). The UV-HBPU was used as a negative-type photoresist for a printed circuit board(PCB). Fourier-transform infrared spectroscopy(FTIR) and proton nuclear magnetic resonance(1HNMR) spectroscopy of UV-HBPUs indicated that the synthesis was successful. Differential scanning calorimetry(DSC) and thermogravimetric analysis(TGA) showed that the thermal stability of the UV-HBPUs decreased as the HEA content increased. The polymer exhibited excellent photoresist properties, and the resolution of circuits based on this negative-type photoresist reached 10 μm. | 刘敬成 LIN Licheng JIA Xiuli LIU Ren ZHANG Shengwen 刘晓亚 | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，1： | 3 |
| 5 | The Mesenchymal Stem Cells Derived from Transgenic Mice Carrying Human Coagulation Factor Ⅷ Can Correct Phenotype in Hemophilia A Mice显示文摘Hemophilia A(HA)is an inherited X-linked recessive bleeding disorder caused by coagulant factor Ⅷ(FⅧ)deficiency.Previous studies showed that introduction of mesenchymal stem cells(MSCs)modified by FⅧ-expressing retrovirus may result in phenotypic correction of HA animals.This study aimed at the investigation of an alternative gene therapy strategy that may lead to sustained FⅧ transgene expression in HA mice.B-domain-deleted human FⅧ(hFⅧBD)vector was microinjected into single-cell embryos of wild-type mice to generate a transgenic mouse line,from which hFⅧBD-MSCs were isolated,followed by transplantation into HA mice.RT-PCR and real-time PCR analysis demonstrated the expression of hFⅧBD in multi-organs of recipient HA mice.Immunohistochemistry showed the presence of hFⅧBD positive staining in multi-organs of recipient HA mice.ELISA indicated that plasma hFⅧBD level in recipient mice reached its peak(77 ng/mL)at the 3rd week after implantation,and achieved sustained expression during the 5-week observation period.Plasma FⅧ activities of recipient HA mice increased from 0%to 32%after hFⅧBD-MSCs transplantation.APTT(activated partial thromboplastin time)value decreased in hFⅧBD-MSCs transplanted HA mice compared with untreated HA mice(45.5 s vs.91.3 s).Our study demonstrated an effective phenotypic correction in HA mice using genetically modified MSCs from hFⅧBD transgenic mice. | Qing Wang Xiuli Gong Zhijuan Gong Xiaoyie Ren Zhaorui Ren Shuzhen Huang Yitao Zeng | 2013 | Journal of Genetics and Genomics2013，40，12： | 2 |
| 6 | High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair显示文摘 | Bing Pan Baoqi Yu Hui Ren Belinda Willard Ling Pan Lingyun Zu Xiaoli Shen Yijing Ma Xiuli Li Chenguang Niu Jinge Kong Siyu Kang Y. Eugene Chen Subramaniam Pennathur Lemin Zheng | 2013 | Free Radical Biology and Medicine2013，，： | 1 |
| 7 | 4.1N suppresses hypoxia-induced epithelial-mesenchymal transition inepithelial ovarian cancer cells显示文摘 | Letian Zhang Ajin Hu Mengrui Li Hongquan Zhang Caixia Ren Xiuli An Congrong Liu | 2016 | Molecular Medicine Reports2016，，： | 1 |
| 8 | Seed germinating characteristics of 54 gramineous species in the alpine meadow on the eastern Qinghai-Tibet plateau显示文摘The germination experiment was started on March 3,2004,and seeds were collected from July to October in 2003.We analyzed the percentage of germination,days to first germination,germination period and days to 50%germination.Among the 54 examined species,26 species exceeded 80%germination,11 species exceeded 60%–80%germination,8 exceeded 40%–0%,5 exceeded 20%–40%,and 4 showed less than 20%.A principalcomponent analysis revealed that the species were distributed along two statistically independent axes,the first primarily represented the germination rate and the second represented the time of germination process.Based on scores of germination characteristics,cluster analysis of the 54 gramineous species could be divided into 4 distinct groups:rapid,slow,intermediate germinating(germination percentage>50%),and low germinating(germination percentage<50%).The meaning of different groups to the vegetation regeneration was discussed. | Haiyan BU Qingji REN Xiuli XU Kun LIU Peng JIA Shujun WEN Dashuai SUN Guozhen DU | 2008 | Frontiers in Biology2008，3，2： | 1 |
| 9 | Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats显示文摘Luteolin (3',4',5,7-tetrahydroxyflavone) has powerful anti-apoptotic and antioxidant properties. This study aimed to investigate the effects of luteolin on hyperglycemia-mediated apoptosis in the hippocampi of rats with streptozotocin-induced diabetic encephalopathy after injection into the tail veins, and the molecular mechanisms involved. Biochemistry and terminal deoxynucleotidyl transferase mediated dUTP nick end labelling detection results showed that luteolin treatment (given twice daily for 15 days) significantly inhibited hyperglycemia-mediated apoptosis, decreased malondialdehyde levels and increased glutathione levels in the hippocampi of streptozotocin-induced diabetic rats. Western blot analysis revealed that luteolin also inhibited the expression of apoptosis-related factors and cytochrome c release from mitochondria. Luteolin also improved the learning and memory abilities of rats with diabetic encephalopathy in a water maze test. Further western blot analysis revealed that luteolin treatment facilitated neuronal cell survival through activation of the phosphatidylinositol 3-kinase/Akt signaling pathway, an extracellular signal pathway involved in the suppression of cell apoptosis and promotion of cell survival. These experimental findings indicate that luteolin can inhibit apoptosis of hippocampal nerve cells in rats with diabetic encephalopathy, and that this effect is mediated by an indirect antioxidative effect, the inhibition of activation of apoptosis-related factors and the activation of phosphatidylinositol 3-kinase/Akt signal pathway. | Guiru Ren Jingjing Kong Ning Jia Xiuli Shang | 2013 | Neural Regeneration Research2013，8，12： | 1 |
| 10 | Seismic Stability of Subsea Tunnels Subjected to Seepage显示文摘 | Xuansheng Cheng Yi Ren Xiuli Du Yida Zhang C. W. Chang-Jian A. Rodríguez-Castellanos | 2014 | The Scientific World Journal2014，，： | 1 |
| 11 | Validation of American Joint Committee on Cancer 8th edition of TNM staging in resected distal pancreatic cancer显示文摘BACKGROUND In order to improve risk stratification and clinical management of the pancreatic ductal adenocarcinoma(PDAC),the American Joint Committee on Cancer(AJCC)has published its eighth edition staging manual.Some major changes have been introduced in the new staging system for both T and N categories.Given the rarity of resectable disease,distal pancreatic cancer is likely underrepresented in the published clinical studies,and how the impact of the staging system actually reflects on to clinical outcomes remain unclear.AIM To validate the AJCC 8th edition of TNM staging in distal PDAC.METHODS A retrospective cohort study was performed in seven academic medical centers in the United States.Clinicopathological prognostic factors associated with progression-free survival(PFS)and overall survival(OS)were evaluated through univariate and multivariate analyses.RESULTS Overall,454 patients were enrolled in the study,and were divided into 2 subgroups:Invasive intraductal papillary mucinous neoplasms(IPMN)(115 cases)and non-IPMN associated adenocarcinoma(339 cases).Compared to invasive IPMN,non-IPMN associated adenocarcinomas are more common in relatively younger patients,have larger tumor size,are more likely to have positive lymph nodes,and are associated with a higher tumor(T)stage and nodal(N)stage,lymphovascular invasion,perineural invasion,tumor recurrence,and a worse PFS and OS.The cohort was predominantly categorized as stage 3 per AJCC 7th edition staging manual,and it’s more evenly distributed based on 8th edition staging manual.T and N staging of both 7th and 8th edition sufficiently stratify PFS and OS in the entire cohort,although dividing into N1 and N2 according to the 8th edition does not show additional stratification.For PDAC arising in IPMN,T staging of the 7th edition and N1/N2 staging of the 8th edition appear to further stratify PFS and OS.For PDAC without an IPMN component,T staging from both versions fails to stratify PFS and OS.CONCLUSION The AJCC 8th edition TNM staging system provides even distribution for the T staging,however,it does not provide better risk stratification than previous staging system for distal pancreatic cancer. | Feng Yin Mohammed Saad Hao Xie Jingmei Lin Christopher R Jackson Bing Ren Cynthia Lawson Dipti M Karamchandani Belen Quereda Bernabeu Wei Jiang Teena Dhir Richard Zheng Christopher W Schultz Dongwei Zhang Courtney L Thomas Xuchen Zhang Jinping Lai Michael Schild Xuefeng Zhang Xiuli Liu | 2020 | World Journal of Gastrointestinal Pharmacology and Therapeutics2020，11，2： | 1 |
| 12 | A novel multipath disjoint routing to support ad hoc wireless sensor networks显示文摘 | Ren Xiuli Yu Haibin | 2006 | Washington DC USA: IEEE Computer Society2006，2006，： | 1 |
| 13 | Organic photoresponsive materials for information storage:a review显示文摘Organic photoresponsive materials can undergo various reversible variations in certain physical and chemical properties,such as optical properties,electrochemical properties,conformation,and conductivity,upon photoirradiation.They have been widely applied in various optoelectronic fields,especially in information storage.We summarize research progress on organic photoresponsive materials for information storage.First,the design strategies and photoswitching mechanisms for various kinds of organic photoresponsive materials,including small organic molecules,metal complexes,polymers,supramolecules,and cholesteric liquid crystals,are systematically summarized.These materials exhibit reversible changes of absorption and/or emission properties in response to different wavelengths of light.Subsequently,the applications of these organic materials in information storage,such as data(re)writing and erasing,encryption and decryption,and anticounterfeiting,are introduced in detail.Finally,the current challenges and future directions in this rapidly growing research field are discussed.The review will provide important guidance on the future works about the design of excellent organic photoresponsive materials for optoelectronic applications. | Yanling Zhuang Xiuli Ren Xueting Che Shujuan Liu Wei Huang Qiang Zhao | 2021 | Advanced Photonics2021，3，1： | 1 |
| 14 | One-step rapid synthesis,crystal structure and 3.3 microseconds long excited-state lifetime of Pd1Ag28 nanocluster显示文摘Doping foreign atom(s)in metal nanoclusters is an effective strategy to engineer the properties and functionalities of metal nanoclusters.However,until now,to dope Pd atom into Ag nanoclusters remains a huge challenge.Here we develop a one-step rapid method to synthesize the Pd-doped Ag nanocluster with high yield.The prepared Pd1Ag28 nanocluster was characterized by mass spectroscopy,X-ray photoelectron spectroscopy,X-ray crystallography,fluorescence spectroscopy,ultraviolet-visible absorption spectroscopy and transient absorption spectroscopy.The nanocluster exhibits a perfect face-centered cubic(FCC)kernel structure with a tetrahedron-like shell.Of note,Pd1Ag28 nanocluster had an unexpectedly long excited-state lifetime of 3.3 microseconds,which is the longest excited-state lifetime for Ag-based nanoclusters S0 far.Meanwhile,the excellent near-infrared luminescence indicated the nanocluster has the potential in fluorescent bio-imaging.Besides,it was revealed that Pd1Ag28 nanocluster could be transformed into Au1Ag28 nanocluster via ion exchange reaction of AuPPhzCl with Pd1Ag28 nanocluster.This work provides an efficient synthetic protocol of alloy nanoclusters and wil contribute to study the effect of foreign atom on the properties of metal nanoclusters. | Xinzhang Lin Hengjiang Cong Keju Sun Xuemei Fu Wanchao Kang Xiuli Wang Shengye Jin Ren'an Wu Chao Liu Jiahui Huang | 2020 | Nano Research2020，13，2： | 1 |
| 15 | The New Mode of Sustainable Development for China—Low Carbon Economy显示文摘This paper talks about low-carbon economy,a new mode of sustainable development in China.At first,the strategic significance to develop low-carbon economy from the angle of energy shortages and climate change is analyzed through relevant figures.And then on the base of China's reality,many measures such as human capital,laws and regulations,and life-styles should be paid more attention in developing the low-carbon economy. | Wang Xiuli Jiang Xuemin Ren Long | 2010 | 科技信息2010，，8： | 0 |
| 16 | An improved evaluation of the neutron background in the PandaX-Ⅱ experiment显示文摘In dark matter direct detection experiments,neutron is a serious source of background,which can mimic the dark matter-nucleus scattering signals.In this paper,we present an improved evaluation of the neutron background in the PandaX-II dark matter experiment by a novel approach.Instead of fully relying on the Monte Carlo simulation,the overall neutron background is determined from the neutron-induced high energy signals in the data.In addition,the probability of producing a dark-matter-like background per neutron is evaluated with a complete Monte Carlo generator,where the correlated emission of neutron(s)andγ(s)in the(α,n)reactions and spontaneous fissions is taken into consideration.With this method,the neutron backgrounds in the Run 9(26-ton-day)and Run 10(28-ton-day)data sets of PandaX-II are estimated to be(0.66±0.24)and(0.47±0.25)events,respectively. | QiuHong Wang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui YingJie Fan DeQing Fang ChangBo Fu LiSheng Geng Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo Ke Han ChangDa He Di Huang Yan Huang YanLin Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju YiHui Lai Kun Liang HuaXuan Liu JiangLai Liu WenBo Ma YuGang Ma YaJun Mao Yue Meng Parinya Namwongsa KaiXiang Ni JinHua Ning XuYang Ning XiangXiang Ren ChangSong Shang Lin Si AnDi Tan AnQing Wang HongWei Wang Meng Wang SiGuang Wang XiuLi Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu Jumin Yuan Dan Zhang HongGuang Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
| 17 | Constraining self-interacting dark matter with the full dataset of PandaX-II显示文摘Self-interacting dark matter(SIDM)is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of galaxies.Many SIDM models predict the existence of a light force carrier that mediates strong dark matter self-interactions.If the mediator couples to the standard model particles,it could produce characteristic signals in dark matter direct detection experiments.We report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment,basing on a total exposure of 132 tonne-days.No significant excess over background is found,and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling strength.We further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe,and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator. | Jijun Yang Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Shengming He Di Huang Yan Huang Ran Huo Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Qing Lin Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Nasir Shaheed Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang QiuHong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Yong Yang Chunxu Yu Hai-Bo Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，11： | 0 |
| 18 | Electrospinning of antibacterial and anti-inflammatory Ag@hesperidin core-shell nanoparticles into nanofibers used for promoting infected wound healing显示文摘Bacterial infection and excessive inflammation are still the main obstacles to wound repair.Thus,antibacterial and antiinflammation nanomaterials are always attracting for infected wound healing.In this work,ultra-uniform(-20 nm)and colloidally stable Ag nanoparticles(Ag-Hes NPs)with core-shell structure were prepared by using hesperidin as reducing and capping agent.The obtained Ag-Hes NPs present effective antibacterial properties on both Staphylococcus aureus and Escherichia coli.Ag-Hes NPs also got high 1,1-diphenyl-1-picrylhydrazyl scavenging capability of 69%.Under the package of polyvinyl alcohol and sodium alginate,Ag-Hes NPs were encapsulated into electro spun nanofibers to form hydrogel(Ag-Hes@H).This strategy provides a moisture environment which could enrich and release Ag-Hes NPs gradually.Cell experiments and animal wound healing investigation proved that Ag-Hes@H could promote the proliferation and migration of human umbilical vein endothelial cells and accelerate infected wound healing.Meanwhile,Ag-Hes@H significantly reduced the expression of inflammatory cytokines,including IL-6,MMP9 and TNF-α.Immunohistochemistry data further suggested that Ag-Hes@H accelerated wound closure by promoting collagen deposition and skin cell proliferation.The designed antibacterial and anti-inflammatory Ag-Hes@H has great potential for promoting infected wound healing. | Xiuli Ren Yanan Hu Linna Chang Shibo Xu Xifan Mei Zhenhua Chen | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 19 | Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector显示文摘Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release. | Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou | 2023 | Research2023，，2： | 0 |
| 20 | Preparation of EGCG decorated,injectable extracellular vesicles for cartilage repair in rat arthritis显示文摘Arthritis is a kind of chronic inflammatory autoimmune disease,which can destroy joint cartilage and bone,leading to joint pain,joint swelling,and limited mobility.Traditional therapies have many side effects or focus too much on anti-inflammation while neglecting joint repair.In this experiment,we combined Epigallocatechin gallate(EGCG)with extracellular vesicles derived from macrophages to treat rheumatoid arthritis.Sustained-release resulted in a significant decrease in chondrocyte expression of hypoxia-inducible factor 1-alpha,a decrease in apoptosis-related proteins Cytochrome C,Caspase-3,Caspase-9,and Bax.Molecular biological analysis showed that extracellular vesicles-encapsulated EGCG(EVs-EGCG)more significantly upregulated type II collagen expression by about 1.8-fold than EGCG alone,which was more beneficial for arthritis repair.Animal experiments revealed that these EGCG-coated extracellular vesicles significantly reduced swelling,decreased synovial hyperplasia,repaired cartilage,and attenuated arthritis-related pathology scores in arthritic rats.Measurement data showed that EVs-EGCG treatment reduced joint swelling by approximately 39.5%in rheumatoid rats.In vitro studies have shown that this EVs-EGCG can increase the expression of cartilage type II collagen and reduce apoptosis of chondrocytes.Moreover,it was demonstrated in vivo experiments to reduce cartilage destruction in rheumatoid arthritis rats,providing a solution for the treatment of rheumatoid arthritis. | Changwei Song Shibo Xu Linna Chang Xingjun Zhao Xifan Mei Xiuli Ren Zhenhua Chen | 2021 | Regenerative Biomaterials2021，8，6： | 0 |
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