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| 1 | Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft显示文摘Polyphyllin 我(PPI ) ,从巴黎 polyphyllin 的根茎提取的小分子的单体,在以前的学习显示出强壮的 anticancer 效果。人的肺腺癌 A549 房间,人的肺有鳞的房间癌 SK-MES-1 房间,和人的肺大房间癌 H460 房间与 PPI 有教养然后对待。房间增长和 apoptosis 被 3- 测量[4,5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物试金,流动 cytometry,西方的污点分析,和 DNA 梯子。Athymic 裸体老鼠适用肿瘤与 PPI 被注射,并且肿瘤生长被记录。我们的结果证明 PPI 显著地禁止了房间衬里的三非小的房间肺癌症(NSCLC ) 的增长,与为 A549, H460,和 SK-MES-1 的 1.24, 2.40,和 2.33 g/ml 的禁止的集中(IC50 ) 房间分别地。在为 24 h 与 PPI 的 2.5 g/ml 被对待以后, A549 房间的 apoptotic 率是 39.68% ,它比控制的显著地高。肿瘤生长显著地与在裸体老鼠与 cisplatin (DDP ) 或 PBS 对待的组相比在对待 PPI 的组被禁止。在在 vitro 并且在 vivo 的 NSCLC 房间的 PPI 展览 antitumor 能力,它可能与 apoptosis 有关由 PPI 导致了。 | Minjian Kong Junqiang Fan Aiqiang Dong Haifeng Cheng Rongzhen Xu | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 15 |
| 2 | Leukemia stem cells: the root of chronic myeloid leukemia显示文摘长期的 myeloid 白血病(电流型逻辑) 是产生编码一项组成的 kinase 活动的 Bcr-Abl oncogene 的染色体 translocation 描绘的同种细胞的 myeloproliferative 混乱。尽管有在由 Bcr-Abl 酷氨酸 kinase 禁止者( TKI )在长期的阶段控制电流型逻辑的显著成功,电流型逻辑病人的一个重要比例与 TKI 对待由于 TKI 的无能开发药抵抗杀死为开始负责的白血病干细胞(最低有效字符),药抵抗,并且电流型逻辑的恶化。因此,对为治好电流型逻辑的白血病干细胞对更多的有势力和更安全的治疗有迫切需要。很多个联系最低有效字符的目标和相应发信号小径包括 CaMKII- ,为共同激活的一个批评分子的开关多重联系最低有效字符的发信号小径,在过去的十年被识别了,指向最低有效字符的各种各样的小禁止者也在开发中。增加的证据证明白血病干细胞是电流型逻辑的根,指向最低有效字符可以为电流型逻辑病人提供一种可医好的治疗选择。这评论在长期的 myeloid 白血病总结最低有效字符和它的联系目标,和潜在的临床的应用程序的分子的生物学。 | Hong Zhou | 2015 | Protein & Cell2015，6，6： | 13 |
| 3 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 4 | Reverse reconciliation for continuous variable quantum key distribution显示文摘An efficient and practical post-processing technique based on reverse reconciliation for continuous variable quantum key distribution is proposed and simulated with low-density parity check (LDPC) codes. MultiLevel Coding/ MultiStage Decoding, which fully utilizes optimization technique such as vector quantization and iterative decoding and the optimal channel coding most close to the Shannon limit, was used to realize efficient reverse reconciliation algorithm. Simulation results showed that the proposed method can improve the secure key distribution rate to 2.2 kb/s and the coding efficiency to 0.89 over 20 km in single-mode optical fiber. Moreover, there still is room for much improvement. | LU ZhiXin 1,2 , YU Li 1,2 , LI Kang 1,2 , LIU BingCan 1,2,3 , LIN JianGui 1,2 , JIAO RongZhen 1,2 & YANG BoJun 1,21 School of Science, Beijing University of Posts and Telecommunications, Beijing 100876, China 2 Key Laboratory of Information Photonics and Optical Communication, Ministry of Education, Beijing University of Posts and Telecommunications, Beijing 100876, China 3 Department of Fundamental Courses, Academy of Armored Force Engineering, Beijing 100072, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 12 |
| 5 | Anthropogenic climate change revealed by coral gray values in the South China Sea显示文摘The authors analyze the coral growth band from a colony in the northwestern South China Sea. The coral growth band can provide comprehensive environmental information on climate. The trend from the two-century-long annual density of the coral is in a good agreement with that of the global CO2 concentration. Both trends were small prior to the end of the 19th century; after that, trends became clear, more so from the 1960s to the 1990s (the end of the coral record). The overall coral density shows a steady decrease from the late 19th century to the late 20th century. Therefore, the trend from the annual density of the coral reveals the history of the anthropogenic climate change, which is coherent with instrumental and other proxy records. We propose a simple coral-based proxy for reconstructing the anthropogenic climate change over the past two centuries. | WANG Xin WANG DongXiao GAO RongZhen SUN DongHuai | 2010 | Chinese Science Bulletin2010，55，13： | 7 |
| 6 | Arbitrary focusing lens by holographic metasurface显示文摘In this paper, an ultrathin metalens has been proposed based on a holographic metasurface that consists of elongated apertures in 40 nm gold film, which exhibit intriguing properties such as on-and off-axis focusing and also can concentrate light into multiple, discrete spots for circularly polarized incident lights. First, the spatial transmission phase distributions of the designed metalens with arbitrary focusing can be obtained by computergenerated holography. Then, the discrete phase distributions can be continuously encoded by subwavelength nanoapertures with spatially varying orientations in gold film. The simulation results show that our designed metalens can work efficiently for different types of focusing. Finally, our metasurface shows superior broadband characteristics between 670 and 810 nm, and the corresponding focal lengths of the designed lenses also can be efficiently modulated with the incident lights at different wavelengths. | Rongzhen Li Zhongyi Guo Wei Wang Jingran Zhang Keya Zhou Jianlong Liu Shiliang Qu Shutian Liu Jun Gao | 2015 | Photonics Research2015，3，5： | 6 |
| 7 | Convection effect on dendritic growth using phase-field method显示文摘Phase-field model was employed to quantitatively study the effect of convection on pattern selection and growth rate of 2D and 3D dendrite tip,as well as the effect of the different convection velocity on the dendritic growth.The calculated results show that crystal is asymmetric in the priority direction of growth under flow.The dentritic growth is promoted in the upstream region and suppressed in the downstream region.Convection can cause deviation in the dendrite growth direction and the preferred direction of the columnar crystals.It has been found that both primary dendrite stem and secondary dendrite arm deflect significantly towards upstream direction,secondary dendrite arm in upstream direction is more developed than the primary dendrite in downstream direction. | Zhu Changsheng Wang Zhiping Gui Jin Xiao Rongzhen | 2010 | China Foundry2010，7，1： | 5 |
| 8 | Cloudiness regime shift during 1946—1992 recorded by coral in the South China Sea显示文摘By extracting and comparing long-term trend components of coral gray value, sea surface temperature, cloudiness, and net heat flux for the period of 1946~1992, the relationships among them are addressed. There exists a prominent regime shift in the cloudiness associated with the corresponding variabilities of sea surface temperature and net heat flux occurred in the mid-1960s, which can be successfully recorded by coral gray value, a climatic proxy. Long-term cloudiness variations in the South China Sea are completely opposite to the equatorial western Pacific in the past five decades, whereas they share a similar trend to that over Asian monsoon prevailing waters. The fact that the coral gray value is highly correlated to cloudiness provides a unique perspective on utilizing this coral to study cloudiness variations in the pre-instrumental period. | GAO Rongzhen SUN Donghuai WANG Dongxlao YANG Xiaoyi | 2005 | Acta Oceanologica Sinica2005，24，5： | 5 |
| 9 | Multi-scale variability of subsurface temperature in the South China Sea显示文摘Using Morlet wavelet transform and harmonic analysis the multi-scale variability of subsurface temperature in the South China Sea is studied by analyzing one-year (from April 1998 to April 1999) ATLAS mooring data. By wavelet transform, annual and semi-annual cycle as well as intraseasonal variations are found, with different dominance, in subsurface temperature. For annual harmonic cycle, both the downward net surface heat flux and thermocline vertical movement partially control the subsurface temperature variability. For semi-annual cycle and intraseasonal variability, the subsurface temperature variability is mainly linked to the vertical displacement of thermocline. | Gao Rongzhen(高荣珍) Zhou Faxiu(周发琇) Wang Dongxiao(王东晓) | 2002 | Acta Oceanologica Sinica2002，21，2： | 4 |
| 10 | An efficient catalytic system for the synthesis of glycerol carbonate by oxidative carbonylation of glycerol显示文摘Glycerol carbonate was synthesized by the oxidative carbonylation of glycerol catalyzed by the commercial Pd/C with the aid of NaI.High conversion of glycerol(82.2%),selectivity to glycerol carbonate(>99%),and TOF(900 h–1)were obtained under the conditions of 5 MPa(pCO:pO2=2:1),140 oC,2 h.The highly active palladium species were generated in situ by dissolution from the carbon support and stabilized by re-deposition onto the support surface after the reaction was finished.Palladium dissolution and re-deposition were crucial and inherent parts of the catalytic cycle,which involved heterogeneous reactions.This Pd/C catalyst could be recycled and efficiently reused for four times with a gradual decrease in activity.Moreover,the influences of various parameters,e.g.,types of catalysts,solvents,additives,reaction temperature,pressure,and time on the conversion of glycerol were investigated.A reaction mechanism was proposed for oxidative carbonylation of glycerol to glycerol carbonate. | WANG LiYan LIU Yan LIU ChunLing YANG RongZhen DONG WenSheng | 2013 | Science China Chemistry2013，56，10： | 4 |
| 11 | Design of a low-filling-factor and polarization-sensitive superconducting nanowire single photon detector with high detection efficiency显示文摘We designed a low-filling-factor and polarization-sensitive superconducting nanowire single photon detector(SNSPD), which can achieve a high absorption efficiency and counting rate simultaneously. Numerical simulations show that high absorption efficiency can be achieved by low-filling-factor SNSPDs with a silicon slot and silver reflector. The absorptance of the NbN nanowire for a transverse magnetic(TM) wave at the wavelength of 1550 nm can be 84.4% when the filling factor is only 16.5%, and the corresponding polarization extinction ratio(PER) is 562.9;the absorptance of the NbN nanowire for a transverse electric(TE) wave can be 67.0% when the filling factor is only 11.7%, and the PER is 7.4. | DEZHI LI RONGZHEN JIAO | 2019 | Photonics Research2019，7，8： | 4 |
| 12 | Ultra-thin,planar,broadband,dual-polarity plasmonic metalens显示文摘An ultrathin,planar,broadband metalens composed of metal rectangular split-ring resonators(MRSRRs) has been designed,which shows dual-polarity characteristics for different types of circularly polarized(CP) light incidence.The designed metalens can be considered as the focusing lens and the diverging lens under left-handed CP and right-handed CP light incidence,respectively.The phase discontinuity of the cross-polarized transmission light is produced by optical-axis rotation through modulating two arms’ lengths of the MRSRR.The MRSRR metalens possesses a wavelength-controllable focal length and a relatively larger chromatic aberration compared with the conventional lenses.And the focal length changes from 9 to 7 μm with incident wavelength from 740 to 950 nm.The dual-polarity flat metalens opens a door for new applications of phase discontinuity devices,and it will promote the fabricating capability of on-chip or fiber-embedded optical devices. | Wei Wang Zhongyi Guo Rongzhen Li Jingran Zhang Yi Liu Xinshun Wang and Shiliang Qu | 2015 | Photonics Research2015，3，3： | 4 |
| 13 | Intraseasonal variability of the subsurface temperature observed in the South China Sea (SCS)显示文摘Using Morlet wavelet transform we investi-gated the intraseasonal variability of the subsurface tem-perature in the SCS by analyzing ATLAS mooring data ob-tained during the South China Sea Monsoon Experiment (SCSMEX). It is found for the first time that subsurface temperature in the SCS exists intraseasonal variability, par-ticularly in winter. The strongest intraseasonal variability ranges from 50 to 100 m with its maximum amplitude about 1.0-2.0℃. The subsurface temperature intraseasonal vari-ability in the SCS is primarily induced by local wind stress curl via adjusting the vertical displacement of thermocline. It reveals the important characteristic of intraseasonal varia-tions in the SCS upper ocean vertically. | Faxiu Zhou Rongzhen Gao | 2002 | Chinese Science Bulletin2002，47，4： | 4 |
| 14 | Food synthetic biology-driven protein supply transition: From animal-derived production to microbial fermentation显示文摘Animal-derived protein production is one of the major traditional protein supply methods,which continues to face increasing challenges to satisfy global needs due to population growth,augmented individual protein consumption,and aggravated environmental pollution.Thus,ensuring a sustainable protein source is a considerable challenge.The emergence and development of food synthetic biology has enabled the establishment of cell factories that effectively synthesize proteins,which is an important way to solve the protein supply problem.This review aims to discuss the existing problems of traditional protein supply and to elucidate the feasibility of synthetic biology in the process of protein synthesis.Moreover,using artificial bioengineered milk and artificial bioengineered eggs as examples,the progress of food protein supply transition based on synthetic biology has been systematically summarized.Additionally,the future of food synthetic biology as a potential source of protein has been also discussed.By strengthening and innovating the application of food synthetic biology technologies,including genetic engineering and high-throughput screening methods,the current limitations of artificial foods for protein synthesis and production should be addressed.Therefore,the development and industrial production of new food resources should be explored to ensure safe,high-quality,and sustainable global protein supply. | Yanfeng Liu Xiaomin Dong Bin Wang Rongzhen Tian Jianghua Li Long Liu Guocheng Du Jian Chen | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 4 |
| 15 | Shp2,a novel oncogenic tyrosine phosphatase and potential therapeutic target for human leukemia显示文摘Shp2 ,由 PTPN11 基因编码了为人,是包含二N终端 Src 相同的无所不在地表示的蛋白质酷氨酸磷酸酶 2 ( SH2 )领域( N-SH2 , C-SH2 ,分别地),一个催化蛋白质酷氨酸磷酸酶( PTP )领域,并且C终端与 tyrosyl 磷酸化地点和一个prolyl富有的主题跟踪。我们 Shp2 的生物函数的理解的进步清楚地证明了 Shp2 不仅在正常造血的房间和另外的哺乳动物的房间的生物学,而且在白血病和另外的肿瘤的开发起一个重要作用。最最近,当第一 proto-oncogenethat 编码蛋白质酷氨酸磷酸酶, PTPN11 基因坚定地被建立了。在造血的系统,最如果 Shp2 的并非所有功能是充当一个积极部件,那为通过表明包含英皇家空军之阶级最低之兵, Akt 和 STAT5 的小径的规定的造血的房间的增长或幸存是必要的。 | Rongzhen Xu | 2007 | Cell Research2007，17，4： | 4 |
| 16 | Chloride Ion Transmission Model under the Drying-wetting Cycles and Its Solution显示文摘The chloride ion transmission model considering diffusion and convection was established respectively for different zones in concrete by analyzing chloride ion transmission mechanism under the dryingwetting cycles. The finite difference method was adopted to solve the model. The equation of chloride ion transmission model in the convection and diffusion zone of concrete was discreted by the group explicit scheme with right single point(GER method) and the equation in diffusion zone was discreted by FTCS difference scheme. According to relative humidity characteristics in concrete under drying-wetting cycles, the seepage velocity equation was formulated based on Kelvin Equation and Darcy's Law. The time-variant equations of chloride ion concentration of concrete surface and the boundary surface of the convection and diffusion zone were established. Based on the software MATLAB the numerical calculation was carried out by using the model and basic material parameters from the experiments. The calculation of chloride ion concentration distribution in concrete is in good agreement with the drying-wetting cycles experiments. It can be shown that the chloride ion transmission model and the seepage velocity equation are reasonable and practical. Studies have shown that the chloride ion transmission in concrete considering convection and diffusion under the drying-wetting cycles is the better correlation with the actual situation than that only considering the diffusion. | 黄滢 卫军 DONG Rongzhen ZENG Hua | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，3： | 2 |
| 17 | Kinetics, thermodynamics, and equilibrium of As(Ⅲ),Cd(Ⅱ), Cu(Ⅱ) and Pb(Ⅱ) adsorption using porous chitosan bead-supported MnFe_(2)O_(4) nanoparticles显示文摘A novel porous nanocomposite,cross-linked chitosan and polyethylene glycol(PEG) bead-supported MnFe_(2) O_(4) nanoparticles(CPM),was developed as an efficient adsorbent to remove metalloid(As(Ⅲ))and heavy metals(Cd(Ⅱ),Cu(Ⅱ),and Pb(Ⅱ)).The characteristics of CPM showed a porous structure,well dispersed MnFe_(2) O_(4),and several of hydroxyl and amino groups(-OH,-NH_(2)).Batch experiments demonstrated that the best adsorption property of As(Ⅲ),Cd(Ⅱ),Cu(Ⅱ),and Pb(Ⅱ) was achieved within 8 h with maximum adsorption capacities of 9.90,9.73,43.94,and 11.98 mg/g,respectively.Competitive and synergistic effects(particularly precipitation) were included in the co-adsorption mechanism of As(Ⅲ) and heavy metals.Thereinto,As(Ⅲ) was partly oxidized by MnFe_(2) O_(4) to As(V),and both were coordinated on MnFe_(2) O_(4) nanoparticles.Pb(Ⅱ) could also bind to MnFe_(2) O_(4) by ion exchange and electrostatic attraction.Furthermore,Cd(Ⅱ) and Cu(Ⅱ) tended to be coordinated on chitosan.Therefore,CPM can serve as a remediation material for water and soil co-contaminated with As(Ⅲ) and heavy metals. | Hongxia Li Hongbing Ji Xinglan Cui Xiaokui Che Qidong Zhang Juan Zhong Rongzhen Jin Lei Wang Yi Luo | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 18 | TGF-β-induced CD4+FoxP3+regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model显示文摘CD4^(+)FOXP3^(+)Treg cells are central to the maintenance of self-tolerance and can be defective in autoimmunity.In autoimmune rheumatic diseases,dysfunctional self-tolerance,is to a large extent,caused by insufficient Treg-cell activity.Although nTregs have therapeutic effects in vivo,their relative scarcity and slow rate of in vitro expansion hinder the application of nTreg therapy.It was previously reported that EVs contribute significantly to the suppressive function of FOXP3^(+)Treg cells.Considering that the stability and plasticity of nTregs remain major challenges in vivo,we established EVs derived from in vitro TGF-β-induced Treg cells(iTreg-EVs)and assessed their functions in a murine model of autoimmune arthritis.The results demonstrated that iTreg-EVs preferentially homed to the pathological joint and efficiently prevented the imbalance in Th17/Treg cells in arthritic mice.Furthermore,we found that miR-449a-5p mediated Notch1 expression modulation and that miR-449a-5p knockdown abolished the effects of iTreg-EVs on effector T cells and regulatory T cells in vitro and in vivo.Taken together,our results show that iTreg-EVs control the inflammatory responses of recipient T cells through miR-449a-5p-dependent modulation of Notch1 and ameliorate the development and severity of arthritis,which may provide a potential cell-free strategy based on manipulating iTreg-EVs to prevent autoimmune arthritis. | Jingrong Chen Feng Huang Yuluan Hou Xiaorong Lin Rongzhen Liang Xiaojiang Hu Jun Zhao Julie Wang Nancy Olsen Song Guo Zheng | 2021 | Cellular & Molecular Immunology2021，18，11： | 2 |
| 19 | The mechanical properties of co-continuous Si 3 N 4 /Al composites manufactured by squeeze casting显示文摘 | Yuan Lu Jianfeng Yang Weizhong Lu Rongzhen Liu Guanjun Qiao Chonggao Bao | 2010 | Materials Science & Engineering A2010，，23： | 2 |
| 20 | The coral grayness in northern South China Sea and its description of interdecadal variation of precipitation in south China显示文摘The interdecadal variation of coral grayness in northern South China Sea (SCS) is studied using the annual mean coral grayness in northern SCS from 1789 to 1992 and annual precipitation at Guangzhou from 1908 to 1992 by Singular Spectrum Analysis (SSA), correlation analysis, Mann-Kendall’s abrupt change analysis and composite analysis. The interdecadal variation of south China precipitation as reflected by the series of Guangzhou precipitation rebuilt with the coral grayness is discussed. The results show that the variation of coral grayness in SCS has significant terms of tendency, much-weighted interdecadal variation and weak interannual variation. There was a century-scale abrupt change of coral grayness at the end of the 1880s that changed from positive anomalies to negative anomalies. The global field of SST difference corresponding to the point of abrupt change was negative anomalies over the SCS and neighboring northern Indian Ocean, most of central and western Pacific Ocean and coastal areas of the northern Atlantic Ocean. The large-scale distribution of SST anomalies is concomitant with the century-scale abrupt change of coral grayness in SCS. Negative correlation exists between the coralgrayness in SCS and precipitation in Guangzhou on the interdecadal scale and the interdecadal precipitation in Guangzhou as reflected by the interdecadaldata of SCS coral grayness shows that the interdecadal variation of south China precipitation changes significantly from phase to phase. The current study aims at contributing in the effort of identifying alternative indexes for climate change in south China on the interdecadal scale and beyond. | GU Dejun WANG Dongxiao SUN Donghuai GAO Rongzhen JI Zhongping | 2006 | Chinese Science Bulletin2006，51，B12： | 2 |
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