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| 1 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 2 | Preparation and Microstructure of Green Ceramsite Made from Sewage Sludge显示文摘A pilot study was conducted to produce high performance green ceramsite by using sewage sludge, fly ash and silt. According to the theory of Riley, the proportions of raw materials were chosen to perform the sintering experiments. Thereby, the optimum proportion of sludge, fly ash and silt and sintering parameters were determined. The microstructure of the optimized mixture and the leaching of heavy metal elements were also analyzed. The lab testing results show that sintering parameters have significant impact on the performance of ceramsite. For solid waste ceramsite with high loss of ignition, inadequate pre-burning process lowers the strength and increases the water absorption. Low water absorption can be achieved by the enameled surface and closed pore structure. The high performance green ceramsite has the density grade of 700, water absorption of 6% and compressive strength of 6.6 MPa. The ceramsite is mainly composed of cristobalite and mullite. The leaching of heavy metal elements from the solid waste ceramsite are lower than the limits required by the national standard. This study shows that the utilization of solid waste ceramsite as the light weight aggregate is feasible and safe. | 柳俊哲 LIU Rui HE Zhimin BA Mingfang 李玉顺 | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，1： | 4 |
| 3 | Multi-hazard disaster scenario method and emergency management for urban resilience by integrating experiment-simulation-field data显示文摘Due to the frequent occurrence of multi-hazard disasters worldwide in recent years,effective multi-hazard sce-nario analysis is imperative for disaster rescue and emergency management.The response procedure for different single hazards were investigated and formulated before.However,the investigations of disaster scenario rarely systematically address the entire development and response process of multi-hazards,including the coupling mechanisms,evolution dynamics,scenario assessment and emergency response.To this end,this paper presents our methodology of multi-hazard disaster scenario that integrates experiment-simulation-field data,focusing on three dimensions consisting of multi-hazard coupling,structures and systems,and emergency management.The newly proposed scenario method mainly comprises three aspects:experiments and simulations,multi-hazard field investigation,scenario analysis and response.Specifically,in order to study the large-scale,high-intensity and multi-hazard coupling effects,we carried out reduced-scale experiments and field measurement experiments to develop experimental similarity theory and prototype simulations of multi-hazards.In addition,a variety of field rescue and survey equipment,such as robots,Unmanned Aerial Vehicle(UAV),and Virtual Reality/Augmented Reality(VR/AR)technologies were utilized to acquire real-time data of multi-hazard field.Furthermore,we also examine the mechanism and framework of multi-hazard scenarios to formulate the detailed procedures of man-agement and response.They are incorporated with the experiments,simulations,field data and models to con-struct a new scenario platform.The proposed scenario method was applied in a case study of the coupled wind and snow multi-hazard to verify its effectiveness.The new method contributes to the disaster relief,decision-making and emergency management for multi-hazard disaster to improve the urban resilience. | Rui Ba Qing Deng Yi Liu Rui Yang Hui Zhang | 2021 | Journal of Safety Science and Resilience2021，2，2： | 3 |
| 4 | A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis显示文摘 | Rui Liu Chunni Zhang Zhibin Hu Gou Li Cheng Wang Cuihua Yang Dingzhi Huang Xi Chen Haiyang Zhang Rui Zhuang Ting Deng Hua Liu Jingjing Yin Sufen Wang Ke Zen Yi Ba Chen-Yu Zhang | 2010 | European Journal of Cancer2010，，5： | 3 |
| 5 | Exosomal miR-155 from gastric cancer induces cancerassociated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ显示文摘Objective:The aim of this research was to identify whether exosomes were involved in impairing adipogenesis in cancer-associated cachexia(CAC)by detecting the adipodifferentiation capacity and the expressions of adipogenic proteins in gastric cancer(GC)-associated adipocytes.Methods:Western blotting and RT-PCR were used to investigate the expressions of C/EPBβ,C/EPBα,PPARγ,and UCP1 in adipose mesenchymal stem cells(A-MSCs)to evaluate the function of exosomal miR-155.BALB/c nude mice were intravenously injected in vivo with GC exosomes with different levels of miR-155 to determine changes in adipodifferentiation of A-MSCs.Results:Exosomes derived from GC cells suppressed adipogenesis in A-MSCs as characterized by decreased lipid droplets.Similarly,A-MSCs co-cultured with GC exosomes exhibited increased ATP production through brown adipose differentiation characterized by highly dense mitochondria and enhanced UCP1 expression(P<0.05).Mechanistically,exosomal miR-155 secreted from GC cells suppressed adipogenesis and promoted brown adipose differentiation by targeting C/EPBβ,accompanied by downregulated C/EPBαand PPARγand upregulated UCP1(P<0.05).Moreover,overexpression of miR-155 in GC exosomes improved CAC in vivo,which was characterized by fat loss,suppressed expressions of C/EPBβ,C/EPBα,and PPARγin A-MSCs,and high expression of UCP1(P<0.05).Decreasing the level of miR-155 in injected GC exosomes abrogated the improved CAC effects.Conclusions:GC exosomal miR-155 suppressed adipogenesis and enhanced brown adipose differentiation in A-MSCs by targeting C/EPBβof A-MSCs,which played a crucial role in CAC. | Ying Liu Meng Wang Ting Deng Rui Liu Tao Ning Ming Bai Guoguang Ying Haiyang Zhang Yi Ba | 2022 | Cancer Biology & Medicine2022，19，9： | 3 |
| 6 | miRNA27a Is a Biomarker for Predicting Chemosensitivity and Prognosis in Metastatic or Recurrent Gastric Cancer显示文摘 | Dingzhi Huang Haiyan Wang Rui Liu Hongli Li Shaohua Ge Ming Bai Ting Deng Guangyu Yao Yi Ba | 2014 | J. Cell. Biochem2014，，3： | 2 |
| 7 | 改良FOLFIRINOX方案一线化疗中国转移性胰腺癌患者的疗效与安全性研究显示文摘背景与目的奥沙利铂(oxaliplatin)、伊立替康(irinotecan)、5-氟尿嘧啶(5-fluorouracil)和1-醛氢叶酸(l-leucovorin)联合用药(即FOLFIRINOX方案)已成为晚期胰腺癌(pancreatic cancer,PC)的一线治疗方案之一。然而,与FOLFIRINOX标准剂量相关的3级或4级不良事件的较高发生率限制了该方案在临床上的广泛应用。在本研究中,我们对改良FOLFIRINOX方案一线化疗中国转移性PC患者的疗效和安全性进行了评价。方法将组织学证实为原发转移性胰腺癌,且东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)体能状态评分为0-2的患者纳入本研究。所有患者均接受改良FOLFIRINOX方案治疗(静脉滴注奥沙利铂65 mg/m^2、伊立替康150 mg/m^2、l-醛氢叶酸200 mg/m^2、5-氟尿嘧啶2400 mg/m^2,每2周重复1次)。治疗持续12个周期,除非患者出现疾病进展(progressive disease,PD)、症状恶化的疾病稳定(stable disease,SD)、不可耐受的不良事件或要求提前终止治疗。主要终点为客观缓解率(objective response rate,ORR)。结果2012年7月至2017年4月期间,共有来自3个机构的65例患者被纳入本研究。所有患者均接受了至少1个周期化疗,化疗周期中位数为8个周期(范围:1-12个周期)。本研究中未观察到完全缓解。21(32.3%)例患者为部分缓解,27(41.5%)例表现为SD。总体人群的ORR和疾病控制率(diseasecontrol rate,DCR)分别为32.3%和73.8%。中位总生存期和无进展生存期分别为11.60[95%置信区间(confidence interval,CI):8.76-14.44]个月和5.77(95%CI:5.00-6.54)个月。主要的3级或4级不良事件包括中性粒细胞减少(12.3%)和腹泻(6.2%)。未观察到与治疗相关的死亡。结论改良FOLFIRINOX具有良好的耐受性,可作为中国转移性PC中国患者的一线治疗方案。 | Zhi‑Qiang Wang Fei Zhang Ting Deng Le Zhang Fen Feng Feng‑Hua Wang Wei Wang De‑Shen Wang Hui‑Yan Luo Rui‑Hua Xu Yi Ba Yu‑Hong Li | 2019 | 癌症2019，38，8： | 2 |
| 8 | Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer显示文摘 | Liu Rui Chen Xi Du Yiqi Yao Weiyan Shen Lin Wang Cheng Hu Zhibin Zhuang Rui Ning Guang Zhang Chunni Yuan Yaozong Li Zhaoshen Zen Ke Ba Yi Zhang Chen-Yu | 2012 | Clinical Chemistry2012，，3： | 2 |
| 9 | Change of SPARC expression after chemotherapy in gastric cancer显示文摘Objective:The expression of tumor biomarkers may change after chemotherapy. However, whether secreted protein acidic and rich in cysteine(SPARC) expression changes after chemotherapy in gastric cancer(GC) is unclear. This study investigated the influence of chemotherapy on SPARC expression in GC.Methods: Immunohistochemistry was used to analyze SPARC expression in 132 GC cases(including 54 cases with preoperative chemotherapy and 78 cases without preoperative chemotherapy). SPARC expression of postoperative specimens with and without preoperative chemotherapy was assessed to analyze the influence of chemotherapy on SPARC expression.Results: SPARC was highly expressed in GC compared with the desmoplastic stroma surrounding tumor cells and noncancerous tissues. High SPARC expression was correlated with invasion depth, lymph node, and TNM stage. After chemotherapy, a lower proportion of high SPARC expression was observed in patients with preoperative chemotherapy than in the controls. For 54 patients with preoperative chemotherapy, gross type, histology, depth of invasion, lymph node, TNM stage, and SPARC expression were related to overall survival. Further multivariate analysis showed that lymph node, histology, and SPARC expression after chemotherapy were independent prognostic factors.Conclusion: SPARC expression may change after chemotherapy in GC. SPARC expression should be reassessed for patients with GC after chemotherapy. | Yong-Yin Gao Ru-Bing Han Xia Wang Shao-Hua Ge Hong-Li Li Ting Deng Rui Liu Ming Bai Li-Kun Zhou Xin-Yuan Zhang Yi Ba Ding-Zhi Huang | 2015 | Cancer Biology & Medicine2015，12，1： | 2 |
| 10 | Synthesis of ethyltert-butylether from tert-butyl alcohol and ethanol on Strong acid cation-exchange resins 显示文摘 | Yang bo lun Yang san ba Yao rui qing | 2000 | Reactive and Functional Polymers2000，44，2： | 1 |
| 11 | A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis显示文摘 | Rui Liu Chunni Zhang Zhibin Hu Gou Li Cheng Wang Cuihua Yang Dingzhi Huang Xi Chen Haiyang Zhang Rui Zhuang Ting Deng Hua Liu Jingjing Yin Sufen Wang Ke Zen Yi Ba Chen-Yu Zhang | 2010 | European Journal of Cancer2010，，5： | 1 |
| 12 | Effects of Mg Incorporation on Microstructure and Optical Properties of ZnO Thin Films Prepared by Sol-gel Method显示文摘Well-crystallized MgZnO alloy thin films with hexagonal wurtzite structure were fabricated by sol-gel method. With the band gap increases, the surface roughness and the grain size reduces. It is worth noting that the intensity of the band-edge luminescence of Mg doped films enhances with the increase of the Mg content. The microstructure and photoluminescence mechanism have been discussed based on X-ray diffraction patterns, atomic force microscopy images, ultraviolet-visible absorption spectra, photoluminescence spectra and Fourier transform infrared spectra. | Rui Ding Chunxiang Xu Baoxiang Gu Zengliang Shi Haitao Wang Long Ba Zhongdang Xiao | 2010 | Journal of Materials Science & Technology2010，26，7： | 1 |
| 13 | Toripalimab combined with targeted therapy and chemotherapy achieves pathologic complete response in gastric carcinoma:A case report显示文摘BACKGROUND Neoadjuvant or perioperative chemotherapy combined with surgery can reduce postoperative recurrence and improve the long-term survival rate of patients with locally advanced resectable gastric carcinoma.Nivolumab combined with chemotherapy has been recommended by the National Comprehensive Cancer Network guidelines as a first-line therapy for advanced gastric carcinoma/adenocarcinoma of the gastroesophageal junction and serves as the basis for immunotherapy combined with chemotherapy to become a neoadjuvant therapy.Herein,we report a case in which pathologic complete response was achieved by neoadjuvant administration of toripalimab,Herceptin,and docetaxel,oxaliplatin,calcium folinate,and fluorouracil(FLOT)chemotherapy followed by surgery for human epidermal growth factor receptor 2(HER2)-and programmed deathligand 1(PD-L1)-positive locally advanced gastric carcinoma.We hope that this case will shed some light on neoadjuvant therapy for gastric carcinoma.CASE SUMMARY The patient was diagnosed with locally advanced adenocarcinoma of the cardia.Immunohistochemistry of the baseline tissues suggested that the tissues were HER2-(fluorescent in situ hybridization)and PD-L1-positive(combined positive score=1).The patient underwent surgery following a four-cycle neoadjuvant therapy comprising Herceptin,toripalimab,and FLOT chemotherapy.The postoperative pathological findings showed mild atypical hyperplasia of the local glands with chronic mucosal inflammation(proximal stomach),no clear residual tumor(tumor regression grade 0),no regional lymph node metastasis,and negative upper and lower cut ends.The levels of tumor markers were reduced to normal levels after re-examination.With good postoperative recovery,the four-cycle preoperative chemotherapy was continued at the same dosage as that previously administered.After the treatment,the patient was monitored every 3 mo with a follow-up of 12 mo(4 times).As of February 27,2022,he was in a good condition without disease progression.The clinical trial registration number is E2019401.CONCLUSION There are many ongoing studies on neoadjuvant immunotherapy combined with chemotherapy or radiotherapy;however,most of these studies are phase II studies with small cohorts.According to the results of some current studies,these combined regimens have shown promising results in terms of efficacy and safety.However,the clinical efficacy and safety of the neoadjuvant therapies used in these combined regimens need to be confirmed by additional prospective phase III clinical trials,and further exploration of molecular markers for effective populations is required. | Rui Liu Xia Wang Zhi Ji Ting Deng Hong-Li Li Yan-Hui Zhang Yu-Chong Yang Shao-Hua Ge Le Zhang Ming Bai Tao Ning Yi Ba | 2022 | World Journal of Clinical Cases2022，10，18： | 1 |
| 14 | Preventive and control system for the life cycle of a pandemic显示文摘Herein,a matching method for varied epidemic phase characteristics and appropriate strategies is presented,aiming at the complexities of the novel coronavirus disease 2019 pandemic and the hysteresis of strategies.The classical diffusion dynamic models of the epidemic spread are compared.Furthermore,the Bass diffusion model is selected to study more characteristics of an epidemic,such as the diversities in regional internal and external infection rates.Thereafter,the classical division method vis-à-vis a pandemic life cycle is improved.A specific approach is proposed to portray more detailed characteristics of the pandemic by dividing it into more phases.Next,a four-level epidemic prevention and control measure system is concretized.The applicable phases and strategic effectiveness of each measure are integrated into the different phases of the pandemic life cycle.Finally,the matching method is applied to analyze two cases of the spread of the outbreak in cities and significant events.The findings provide a certain reference for the effectiveness of the matching method in the post-peak epidemic period. | Chenyang Wang Rui Ba Ranpeng Wang Hui Zhang | 2022 | Journal of Safety Science and Resilience2022，3，4： | 0 |
| 15 | Rethinking the urban resilience:Extension and connotation显示文摘In recent years,urban resilience has attracted increasing attention from researchers and managers from the international community at the national,regional,and urban levels.Numerous multi-dimensional and cross-disciplinary investigations,campaigns,and outlines have significantly promoted the development goal of re-silience in cities worldwide.However,the existing definitions and interpretations of urban resilience still call for a more comprehensive,systematic,and exhaustive analysis as urbanization accelerates and the complex risks of various safety events increase.To this end,we rethink the extension and connotation of urban resilience based on a review and analysis of critical hotspots,realistic demand,and development trends.A conceptual classification with three aspects and three typical tiers of urban resilience is proposed,which further promotes a new definition and interpretation by incorporating the resilience extension of urban systems.In addition,the six-dimensional characteristics are extracted to furnish the urban resilience connotation,and four-stage improvement measures are introduced accordingly.In addition,the newly developed urban resilience is applied to a case analysis of a large-scale disaster,which demonstrates the necessity and significance of this study.The new extension and connotation investigation will be helpful for the improvement and implementation of urban resilience,thereby guiding the construction of resilient cities. | Rui Ba Chenyang Wang Luyao Kou Xiaojing Guo Hui Zhang | 2022 | Journal of Safety Science and Resilience2022，3，4： | 0 |
| 16 | Cathodic corrosion as a facile and universal method for the preparation of supported metal single atoms显示文摘Top-down strategy has been generally adopted for preparation of metal single atom catalysts(SACs)due to the simplified synthetic process,metal economics,and scalability characteristics.Herein,we propose a general top-down route to convert metal nanoparticles into uniformly dispersed metal single atoms in mild electrochemical environment via a facile cathodic corrosion process.Within the synthetic process,Pt nanoparticles precursors are transformed into migrating Pt single atoms(Pt1)driven by a high negative potential;and subsequently these mobile Pt atoms are trapped and stabilized by N coordination sites of N-doped carbon paper(NCP).The as-prepared Pt1/NCP electrodes exhibit a superior catalytic activity toward hydrogen evolution reaction(HER)with a low overpotential of 0.022 V at 10 mA/cm^(2)and a low Tafel slope of 28.5 mV/dec as well as a long-term durability.Notably,the proposed electrochemical atomic migration strategy shows a promising generality for fabricating other metal single atoms(e.g.,Pd,Ir,Cu),which may open a new avenue for metallic SACs preparation. | Rui Li Jingsong Xu Qingkai Zhao Wensheng Ren Rongguang Zeng Qifa Pan Xiayan Yan Jingwen Ba Tao Tang Wenhua Luo | 2022 | Nano Research2022，15，3： | 0 |
| 17 | Effects of Zr Content on the Microstructures and Tensile Properties of Ti-3Al-8V-6Cr-4Mo-xZr Alloys显示文摘The microstructural evolution and tensile properties of Ti-3Al-8V-6Cr-4Mo-xZr(x = 0,2,4 and 6) titanium alloys were investigated.The precipitated phases and tensile fracture morphologies were observed using scanning electron microscopy and transmission electron microscopy.Experimental results show that the presence of trace impurity Si and the addition of Zr induce the formation of(TiZr)_6Si_3 silicides.The quantity of silicides increases with Zr content increasing.The dispersed silicides refined the grain size of β Zr-containing alloys,and the grain size decreases significantly with Zr content increasing.Accompanying these microstructural changes,the strength of the alloys is enhanced gradually with the increase of Zr content,which is attributed to the combination of precipitation strengthening and grain refinement. | Hong-Bo Ba Li-Min Dong Zhi-Qiang Zhang Dong-Sheng Xu Rui Yang | 2016 | Acta Metallurgica Sinica(English Letters)2016，29，8： | 0 |
| 18 | Advances in medical treatment of advanced hepatobiliary and pancreatic cancer in 2022显示文摘This article summarizes the drug therapy progress of advanced hepatocellularcarcinoma, biliary tract cancer, and pancreatic cancer in 2022, includingchemotherapy, molecular targeted therapy, and immunotherapy, to providereference information for current clinical treatment and future clinicalresearch, and to better improve prognosis and quality of life in patients withhepatobiliary and pancreatic cancer. | Le Zhang Rui Liu Ting Deng Yi Ba | 2023 | Cancer Innovation2023，2，1： | 0 |
| 19 | Platinum single atom catalysts for hydrogen isotope separation during hydrogen evolution reaction显示文摘Electrolysis of water is widely used for hydrogen isotope separation and the development of hydrogen evolution reaction(HER)catalysts with high selectivity and activity is of key importance.Herein,we propose single atom catalysts(SACs)as promising catalysts for efficient hydrogen isotope separation.Pt SACs and Pt nanoparticles(NPs)have been fabricated on nanoarray-structured nitrogen-doped graphite foil(NGF)substrate by a polyol reduction method.The as prepared Pt1/NGF electrode exhibits high activity and selectivity toward HER with a low overpotential of 0.022 V at 10 mA·cm^(-2) and a high separation factor of 6.83 for hydrogen and deuterium separation,much better than Pt NPs counterpart.Density functional theory(DFT)calculations ascribe the high activity and selectivity to the constructed Pt-N_(2)C_(2) structure.This work develops a new opportunity for the design and application of high-efficiency and stable SACs toward hydrogen isotope separation by electrolysis of water. | Jingsong Xu Rui Li Xiayan Yan Qingkai Zhao Rongguang Zeng Jingwen Ba Qifa Pan Xin Xiang Daqiao Meng | 2022 | Nano Research2022，15，5： | 0 |
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