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| 1 | Epidemiology of Diabetes in Adults Aged 35 and Older from Shanghai,China显示文摘Objective This study aimed to investigate the epidemiology of diabetes in adults from Shanghai, aged 35 and older, in 2013. Methods We estimated the diabetes prevalence in a representative sample of 18,736 adults who were selected through a multistage stratified cluster sampling process. A standard questionnaire containing questions about demographic characteristics and lifestyle factors was distributed. After an overnight fast of at least 10 hours, a venous blood sample was collected from each participant. For each patient without a history of diabetes, another blood sample was drawn 120 min after an oral glucose tolerance test to identify undiagnosed diabetes and prediabetic condition. Results Among Shanghai residents aged 35 and above, the overall weighted prevalence of diabetes was 17.6% [95% confidence interval(CI): 16.4%-18.8%]. The prevalences were 19.3% in men and 15.8% in women as well as 19.1%, 15.4%, and 16.1% in urban, suburban, and rural residents, respectively. In addition, the weighted prevalence of prediabetes was 16.5%(95% CI: 15.3%-17.8%), with the prevalences of 16.5% in men, 16.6% in women, 15.2% in urban residents, 18.0% in suburban residents, and 18.5% in rural residents. Among all patients with diabetes, 68.1%(95% CI: 64.3%-71.6%) were aware of their status, 63.5%(95% CI: 60.0%-66.9%) received diabetes treatment, but only 35.1%(95% CI: 32.4%-37.8%) had adequate glycemic control. Conclusion In Shanghai, diabetes and prediabetes are highly prevalent. However, 1/3rd of diabetes cases are undiagnosed, and the rate of glycemic control is low. | RUAN Ye YAN Qing Hua XU Ji Ying YANG Qun Di YAO Hai Hong LI Rui SHI Yan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 22 |
| 2 | Central Nervous System Involvement in 179 Chinese Children with Hemophagocytic Lymphohistiocytosis显示文摘 | Yun-Ze Zhao Qing Zhang Zhi-Gang Li Li Zhang Hong-Yun Lian Hong-Hao Ma Dong Wang Xiao-Xi Zhao Tian-You Wang Rui Zhang | 2018 | Chinese Medical Journal2018，，15： | 17 |
| 3 | Two surgical procedures for esophagogastric variceal bleeding in patients with portal hypertension显示文摘AIM:To determine the clinical value of a splenorenal shunt plus pericardial devascularization(PCVD)in portal hypertension(PHT)patients with variceal bleeding.METHODS:From January 2008 to November 2012,290 patients with cirrhotic portal hypertension were treated surgically in our department for the prevention of gastroesophageal variceal bleeding:207 patients received a routine PCVD procedure(PCVD group),and83 patients received a PCVD plus a splenorenal shunt procedure(combined group).Changes in hemodynamic parameters,rebleeding,encephalopathy,portal vein thrombosis,and mortality were analyzed.RESULTS:The free portal pressure decreased to 21.43±4.35 mmHg in the combined group compared with24.61±5.42 mmHg in the PCVD group(P<0.05).The changes in hemodynamic parameters were more significant in the combined group(P<0.05).The long-term rebleeding rate was 7.22%in the combined group,which was lower than that in the PCVD group(14.93%),(P<0.05).CONCLUSION:Devascularization plus splenorenal shunt is an effective and safe strategy to control esophagogastric variceal bleeding in PHT.It should be recommended as a first-line treatment for preventing bleeding in PHT patients when surgical interventions are considered. | Lin Yang Li-Juan Yuan Rui Dong Ji-Kai Yin Qing Wang Tao Li Jiang-Bin Li Xi-Lin Du Jian-Guo Lu | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 4 | Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis显示文摘Systemic chemotherapy is the basic palliative treatment for metastatic nasopharyngeal carcinoma(NPC); however, it is not known whether locoregional radiotherapy targeting the primary tumor and regional lymph nodes affects the survival of patients with metastatic NPC. Therefore, we aimed to retrospectively evaluate the benefits of locoregional radiotherapy. A total of 408 patients with metastatic NPC were included in this study. The mortality risks of the patients undergoing supportive treatment and those undergoing chemotherapy were compared with that of patients undergoing locoregional radiotherapy delivered alone or in combination with chemotherapy. Univariate and multivariate analyses were conducted. The contributions of independent factors were assessed after adjustment for covariates with significant prognostic associations (P<0.05). Both locoregional radiotherapy and systemic chemotherapy were identified as significant independent prognostic factors of overall survival(OS). The mortality risk was similar in the group undergoing locoregional radiotherapy alone and the group undergoing systemic chemotherapy alone [multi-adjusted hazard ratio(HR)=0.9, P=0.529]; this risk was 60% lower than that of the group undergoing supportive treatment(HR=0.4, P=0.004) and 130% higher than that of the group undergoing both systemic chemotherapy and locoregional radiotherapy(HR=2.3, P<0.001). In conclusion, locoregional radiotherapy, particularly when combined with systemic chemotherapy, is associated with improved survival of patients with metastatic NPC. | Ming-Yuan Chen Rou Jiang Ling Guo Xiong Zou Qing Liu Rui Sun Fang Qiu Zhong-Jun Xia Hui-Qiang Huang Li Zhang Ming-Huang Hong Hai-Qiang Mai Chao-Nan Qian | 2013 | Chinese Journal of Cancer2013，32，11： | 13 |
| 5 | Treatment of hepatoma with liposome-encapsulated adriamycin administered into hepatic artery of rats显示文摘瞄准:加空白与 adriamycin 答案(FADM ) 和 adriamycin 比较在肝细胞瘤上观察包含 liposome 的 adriamycin (LADM ) 的治疗学的效果脂肪一些(ADM + BL ) 管理了进老鼠的肝的动脉。方法:LADM 被 pH 准备坡度驱动的方法。生理盐水, FADM (2 mg/kg ) , ADM+BL (2 mg/kg ) ,和 LADM (2 mg/kg ) 在忍受肝 W256 癌肉瘤的老鼠经由肝的动脉被注射,它随机被划分成四个组。治疗学的效果以生存时间,肿瘤增大比率,和肿瘤坏死度被评估。差别与 ANOVA 和 Dunnett 测试和木头等级测试被决定。结果:比作 FADM 或 ADM + BL, LADM 生产了更重要的肿瘤抑制(肿瘤体积比率:1.243 +/- 0.523 对 1.883 +/- 0.708, 1.847 +/- 0.661, P <
0.01 ) ,并且更广泛的肿瘤坏死。增加的寿命在与 FADM 或 ADM+BL 相比收到 LADM 的老鼠显著地被延长(231.48 对 74.66, 94.70 )(P <
0.05 ) 。结论:肝细胞瘤上的 adriamycin 的反癌症功效能被 liposomal 封装强烈通过肝的动脉的管理改进。 | Dong-Sheng Sun Jiang-Hao Chen Rui Ling Qing Yao Ling Wang Zhong Ma Yu Li | 2006 | World Journal of Gastroenterology2006，12，29： | 13 |
| 6 | Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes显示文摘Objective To examine the association between serum uric acid levels and cardiovascular disease risk among individuals without diabetes. Methods We investigated the association between serum uric acid levels and the risk of prevalent cardiometabolic diseases, 10-year Framingham risk for coronary heart disease, and 10-year risk for atherosclerotic cardiovascular diseases(ASCVD) among 8,252 participants aged ≥ 40 years without diabetes from Jiading district, Shanghai, China. Results Body mass index, waist circumference, blood glucose, glycated hemoglobin, blood pressure, and serum lipids increased progressively across the sex-specific quartiles of uric acid(all P trend < 0.05). Compared with individuals in the lowest quartile, those in the higher quartiles had a significantly higher prevalence of obesity, hypertension, and dyslipidemia(all P trend < 0.05). A fully adjusted logistic regression analysis revealed that individuals in the highest quartile had an increased risk of predicted cardiovascular disease compared with those in the lowest quartile of uric acid. The multivariate adjusted odds ratios(ORs) [95% confidence intervals(CIs)] for the highest quartiles for high Framingham risk were 3.00(2.00-4.50) in men and 2.95(1.08-8.43) in women. The multivariate adjusted ORs(95% CIs) for the highest quartile for high ASCVD risk were 1.93(1.17-3.17) in men and 4.53(2.57-7.98) in women. Conclusion Serum uric acid level is associated with an increased risk of prevalent obesity, hypertension, dyslipidemia, 10-year Framingham risk for coronary heart disease, and 10-year risk for ASCVD among Chinese adults without diabetes. | CHENG Di DU Rui WU Xue Yan LIN Lin PENG Kui MA Li Na XU Yu XU Min CHEN Yu Hong BI Yu Fang WANG Wei Qing DAI Meng LU Jie Li | 2018 | Biomedical and Environmental Sciences2018，31，2： | 13 |
| 7 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 8 | N-methyl-D-aspartic acid receptor 1 (NMDAR1) aggravates secondary inflammatory damage induced by hemin-NLRP3 pathway after intracerebral hemorrhage显示文摘 | Xun Weng Yan Tan Xiang Chu Xiao-Feng Wu Rui Liu Yue Tian Lin Li Feng Guo Qing Ouyang Lei Li | 2015 | Chinese Journal of Traumatology2015，18，5： | 12 |
| 9 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 10 | Synthesis of a benzoxazine monomer containing maleimide and allyloxy groups显示文摘新奇 benzoxazine 单体 3-(4-allyloxy )phenyl-3,4-dihydro-2H-6-(N-maleimido )-1,3-benzoxazine (AMB ) 被综合,结构被英尺红外证实,(1 ) H NMR。AMB 的热分析(DSC ) 证明烯丙氧基组的介绍减少了熔点并且展出了一扇狭窄、对称的治好的发热的窗户。 | Yan Tang Qing Lai Zhao Ke Zeng Pei Kai Miao Ke Zhou Wen Rui Tang Hong Fei Zhou Tao Liu Yi Peng Wang Gang Yang | 2007 | Chinese Chemical Letters2007，18，8： | 10 |
| 11 | Effects of lanthanum(Ⅲ) on nitrogen metabolism of soybean seedlings under elevated UV-B radiation显示文摘The hydroponic culture experiments of soybean bean seedlings were conducted to investigate the effect of lanthanum(La)on nitrogen metabolism under two different levels of elevated UV-B radiation(UV-B,280-320 nm).The whole process of nitrogen metabolism involves uptake and transport of nitrate,nitrate assimilation,ammonium assimilation,amino acid biosynthesis,and protein synthesis. Compared with the control,UV-B radiation with the intensity of low level 0.15 W/m^2 and high level 0.45 W/m^2 significantly affected the whole nitrogen metabolism in soybean seedlings(p<0.05).It restricted uptake and transport of NO_3^-,inhibited activity of some key nitrogen-metabolism-related enzymes,such as:nitrate reductase(NR)to the nitrate reduction,glutamine systhetase(GS)and glutamine synthase(GOGAT)to the ammonia assimilation,while it increased the content of free amino acids and decreased that of soluble protein as well.The damage effect of high level of UV-B radiation on nitrogen metabolism was greater than that of low level. And UV-B radiation promoted the activity of the anti-adversity enzyme glutamate dehydrogenase(GDH),which reduced the toxicity of excess ammonia in plant.After pretreatment with the optimum concentration of La(20 mg/L),La could increase the activity of NR, GS,GOGAT,and GDH,and ammonia assimilation,but decrease nitrate and ammonia accumulation.In conclusion,La could relieve the damage effect of UV-B radiation on plant by regulating nitrogen metabolism process,and its alleviating effect under low level was better than that under the high one. | CAO Rui HUANG Xiao-hua ZHOU Qing CHENG Xiao-ying | 2007 | Journal of Environmental Sciences2007，19，11： | 9 |
| 12 | Characteristics and tectonic setting of volcanic rocks in Early Cretaceous Baiyingaolao Formation of Keyouzhongqi area,Inner Mongolia显示文摘The authors studied zircon LA-ICP-MS U-Pb dating,the zircon Hf isotope and geochemistry of acidic volcanic rocks in Baiyingaolao Formation of Keyouzhongqi area,Inner Mongolia,and discussed the chronology,source region and tectonic setting of the volcanic rocks in the studied area. The clear oscillatory zoning of zircons indicates a typical magmatic origin,and the results of dating show that the volcanic rocks of Baiyingaolao Formation were formed in Early Cretaceous( 121. 5 ± 1. 0 Ma). The features of major and trace elements show that the rocks are alkali-rich,poor in calcium and magnesium with enrichment in LILEs like Th,U,K and Gd and depletion in HFSEs,e. g. Nb,Ta,Sr and Ti. The fact implies that they were the products of partial melting of the crust. εHf( t) =( +6.30--+9.06) and TDM2= 600--835 Ma,suggest the magma originated from partial melting of the young crust. Combined with the evolution of regional tectonic structure,the authors conclude that the acidic volcanic rocks of Baiyingaolao Formation may be formed under the extensional environment related to the subduction of Paleo-Pacific Plate. | KONG Yuanming MA Rui HE Zhonghua YANG Deming WU Qing WANG Yang | 2014 | Global Geology2014，17，2： | 8 |
| 13 | Magnesium degradation under physiological conditions - Best practice显示文摘This review focusses on the application of physiological conditions for the mechanistic understanding of magnesium degradation.Despite the undisputed relevance of simplified laboratory setups for alloy screening purposes,realistic and predictive in vitro setups are needed.Due to the complexity of these systems,the review gives an overview about technical measures,defines some caveats and can be used as a guideline for the establishment of harmonized laboratory approaches. | Jorge Gonzalez Rui Qing Hou Eshwara P.S.Nidadavolu Regine Willumeit-Romer Frank Feyerabend | 2018 | Bioactive Materials2018，3，2： | 8 |
| 14 | Distribution characteristics of poly-and perfluoroalkyl substances in the Yangtze River Delta显示文摘In this work, a method was developed and optimized for the analysis of polyfluoroalkyl and/or perfluoroalkyl substances(PFASs) content in surface water and sediment samples with high instrumental response and good separation. Surface water and sediment samples were collected from the Yangtze River Delta(YRD) to analyze the distribution characteristics of perfluoroalkyl carboxylic acids(PFCAs), perfluoroalkane sulfonic acids(PFSAs), perfluoroalkyl phosphonic acids(PFPAs), perfluoroalkyl phosphinic acids(PFPiAs), and polyfluoroalkyl phosphoric acid diesters(di PAPs). The results showed that the total concentrations of PFCAs and PFSAs in YRD varied from 31 to 902 ng/L. PFCAs(≥ 11 carbons) and PFSAs(≥ 10 carbons atoms) were not detected in any surface water samples. The mean concentrations of all PFCAs and PFSAs in surface water from the sampling areas decreased in the following order:Yangtze river(191 ng/L) ≈ Taihu lake(189 ng/L) > Huangpu river(122 ng/L) ≈ Qiantang river(120 ng/L) > Jiaxing urban river(100 ng/L). Strong significant(p < 0.05) correlations between the concentrations of many of the compounds were found in the sampling areas, suggesting a common source for these compounds. Only perfluorooctanoic acid(PFOA) was observed in all sediment samples, at concentrations varying from 0.02 to 1.35 ng/g. Finally, detection rates of two di PAPs were only 8% and 10%, respectively and the concentration of di PAPs was two to three times lower compared to PFCAs and PFSAs. | Binghui Zheng Xiaolei Liu Rui Guo Qing Fu Xingru Zhao Shanjun Wang Sheng Chang Xing Wang Mengjiao Geng Guang Yang | 2017 | Journal of Environmental Sciences2017，29，11： | 8 |
| 15 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 16 | A cohort autopsy study defines COVID-19 systemic pathogenesis显示文摘Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs.However,the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown.We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan,China,and determined the systemic distribution of SARS-CoV-2. | Xiao-Hong Yao Tao Luo Yu Shi Zhi-Cheng He Rui Tang Pei-Pei Zhang Jun Cai Xiang-Dong Zhou Dong-Po Jiang Xiao-Chun Fei Xue-Quan Huang Lei Zhao Heng Zhang Hai-Bo Wu Yong Ren Zhen-Hua Liu Hua-Rong Zhang Cong Chen Wen-Juan Fu Heng Li Xin-Yi Xia Rong Chen Yan Wang Xin-Dong Liu Chang-Lin Yin Ze-Xuan Yan Juan Wang Rui Jing Tai-Sheng Li Wei-Qin Li Chao-Fu Wang Yan-Qing Ding Qing Mao Ding-Yu Zhang Shu-Yang Zhang Yi-Fang Ping Xiu-Wu Bian | 2021 | Cell Research2021，31，8： | 7 |
| 17 | Induction of cytotoxic T lymphocyte respones in vivo after immunotherapy with dendritic cells in patients with nasopharyngeal carcinoma显示文摘The aim of the present study was to determine the efficacy of immunotherapy with dendritic cells to elicit EBV-specific CTL-immunity in advanced cases of EBV-positive patients with nasopharyngeal carcinoma (NPC) and to determine the safety and toxicity of this preparation. Nine cases of histologically confirmed patients with NPC undergoing treatment with radiological therapy were enrolled in this study. Dendritic cells, generated in vitro from blood monocytes of patients were cultured and matured with cytokines and then infected with recombinant adenovirus vaccine containing EBV-latent membrane protein-2 (Ad-LMP2). On 9 days' cultivation of cells, the matured DCs were harvested, irradiated with Co and then injected intradermally to patients with NPC. The injections were performed 3 times totally. After immunization, the CTL responses were assayed by means of cytotoxicity and epitope-specific IFN-γproduction. The results of this trial showed that all patients could tolerate this kind of treatment without any side effect, during which marked increase of LMP2-specific CTL-responses could be demonstrated in 5 patients of this group. And the level of IgA/VCA antibody decreased in 8 of 9 patients, thus accounting for a better prognosis for these patients. All patients will be followed up for another one year. At least, the present work shows that intradermal vaccination with autologous DCs infected with recombinant Ad-LMP2 adenovirus is a safe procedure in NPC patients, in which this procedure can enhance the LMP2-specific CTL responses in patients. These data are encouraging to develop more effective vaccine strategies for the treatment of nasopharyngeal carcinoma. | JIAN MIN ZUO LING ZHOU ZHI JIAN CHEN DE RUI LI QI WANG JIONG YU CHEN ZHAN WANG SI-IU QING WE YI ZENG | 2006 | Journal of Microbiology and Immunology2006，4，1： | 7 |
| 18 | PdAg bimetallic electrocatalyst for highly selective reduction of CO2 with low COOH^* formation energy and facile CO desorption显示文摘For electrocatalytic reduction of CO2 to CO,the stabilization of intermediate COOH^* and the desorption of CO^* are two key steps.Pd can easily stabilize COOH^*,whereas the strong CO^* binding to Pd surface results in severe poisoning,thus lowering catalytic activity and stability for CO2 reduction.On Ag surface,CO^* desorbs readily,while COOH^* requires a relatively high formation energy,leading to a high overpotential.In light of the above issues,we successfully designed the PdAg bimetallic catalyst to circumvent the drawbacks of sole Pd and Ag.The PdAg catalyst with Ag-terminated surface not only shows a much lower overpotential(-0.55 V with CO current density of 1 mA/cm^2)than Ag(−0.76 V),but also delivers a CO/H2 ratio 18 times as high as that for Pd at the potential of-0.75 V vs.RHE.The issue of CO poisoning is significantly alleviated on Ag-terminated PdAg surface,with the stability well retained after 4h electrolysis at-0.75 V vs.RHE.Density functional theory(DFT)calculations reveal that the Ag-terminated PdAg surface features a lowered formation energy for COOH^* and weakened adsorption for CO^*,which both contribute to the enhanced performance for CO2 reduction. | Rui Lin Xuelu Ma Weng-Chon Cheong Chao Zhang Wei Zhu Jiajing Pei Kaiyue Zhang Bin Wang Shiyou Liang Yuxi Liu Zhongbin Zhuang Rong Yu Hai Xiao Jun Li Dingsheng Wang Qing Peng Chen Chen Yadong Li | 2019 | Nano Research2019，12，11： | 7 |
| 19 | Convenient fabrication of BiOBr ultrathin nanosheets with rich oxygen vacancies for photocatalytic selective oxidation of secondary amines显示文摘Photocatalytic oxidation has been widely employed in organic synthesis,by virtue of the green,mild and simple reaction conditions as well as high selectivity.Introducing oxygen vacancies (OVs) with proper concentrations into the photocatalysts has been proven as an effective strategy to boost the catalytic performances.However,the currently used treatment method under high temperature at reducing atmosphere inevitably introduces a large number of OVs at the interior of the catalyst and serving as the recombination centers of carriers.To address this issue,here we develop a facile solvothermal process to prepare ultrathin BiOBr nanosheets with rich surface OVs.This method effectively decreases the bulk of the material and the ratio of interior OVs,rendering most of the OVs exposed on the surfaces which act as exposed catalytic sites and enhance the separation of carriers,therefore significantly elevates the photocatalytic performances.For the photo-oxidation reaction of secondary amines,under the conditions of visible light,ambient temperature and atmosphere,the BiOBr nanosheets featuring rich surface OVs deliver a doubled conversion compared to those with low OV concentrations,and a high selectivity of 99%,a high stability as the performance shows no reduction after 5 times of circular reaction. | Xuanjue Tong Xing Cao Tong Han Weng-Chon Cheong Rui Lin Zheng Chen Dingsheng Wang Chen Chen Qing Peng Yadong Li | 2019 | Nano Research2019，12，7： | 7 |
| 20 | Preparation and characterization of cross-linked β-cyclodextrin polymer/Fe_3O_4 composite nanoparticles with core-shell structures显示文摘有核心壳的合成 nanoparticles 组织的 Cross-linked -cyclodextrin polymer/Fe3O4 在 carboxymethyl -cyclodextrin 的表面上经由生气连接反应被准备(厘米 -- CD ) 在 -cyclodextrin 的修改 Fe3O4 nanoparticles 由把 epichlorohydrin 用作 crosslinking 的碱的答案代理人。准备合成 nanoparticles 的形态学,结构和磁性被传播电子显微镜学(TEM ) 调查, Fourier 变换红外线(FTIR ) spectrometry, X 光检查衍射(XRD ) 测量, thermogravimetric 分析(TGA ) 和颤动的样品 magnetometry (VSM ) 分别地。 | Rui Xue Li Shu Mei Liu Jian Qing Zhao Hideyuki Otsuka Atsushi Takahara | 2011 | Chinese Chemical Letters2011，22，2： | 6 |
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