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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1显示文摘UDP-glucuronosyltransferase 1A1(UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug–drug interactions(DDIs), hyperbilirubinemia and drug-induced liver injury. This study aimed to investigate and compare the inhibitory effects of icotinib and erlotinib against UGT1A1, as well as to evaluate their potential DDI risks via UGT1A1 inhibition. The results demonstrated that both icotinib and erlotinib are UGT1A1 inhibitors, but the inhibitory effect of icotinib on UGT1A1 is weaker than that of erlotinib. The IC_(50) values of icotinib and erlotinib against UGT1A1-mediated NCHN-O-glucuronidation in human liver microsomes(HLMs) were 5.15 and 0.68 μmol/L, respectively. Inhibition kinetic analyses demonstrated that both icotinib and erlotinib were non-competitive inhibitors against UGT1A1-mediated glucuronidation of NCHN in HLMs, with the Kivalues of 8.55 and 1.23 μmol/L, respectively. Furthermore, their potential DDI risks via UGT1A1 inhibition were quantitatively predicted by the ratio of the areas under the concentration–time curve(AUC) of NCHN. These findings are helpful for the medicinal chemists todesign and develop next generation tyrosine kinase inhibitors with improved safety, as well as to guide reasonable applications of icotinib and erlotinib in clinic, especially for avoiding their potential DDI risks via UGT1A1 inhibition. | Xuewei Cheng Xia Lv Hengyan Qu Dandan Li Mengmeng Hu Wenzhi Guo Guangbo Ge Ruihua Dong | 2017 | Acta Pharmaceutica Sinica B2017，7，6： | 7 |
| 3 | Comparison of endoscopic papillary large balloon dilation and endoscopic sphincterotomy for retrieval of choledocholithiasis: a meta-analysis of randomized controlled trials显示文摘 | Yadong Feng Hong Zhu Xiaoxing Chen Shunfu Xu Wenfang Cheng Jinliang Ni Ruihua Shi | 2012 | Journal of Gastroenterology2012，，6： | 4 |
| 4 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 5 | A Novel,Amorphous,Non-equiatomic FeCrAlCuNiSi High-Entropy Alloy with Exceptional Corrosion Resistance and Mechanical Properties显示文摘The exceptional corrosion resistance and mechanical properties of high-entropy metallic glasses(HE-MGs)are highly desirable for diverse critical applications.However,a long-standing problem of these alloys is that their alloy design approaches are based on limited equiatomic or near-equiatomic ratios.In this study,a novel senary alloy(non-equiatomic Fe3 Cr2 Al2 CuNi4 Si5)with amorphous structure was prepared.This alloy exhibited exceptional corrosion resistance and Vickers hardness as high as^1150 Hv at room temperature.The processing route involved amorphous powder molding via a mechanical alloying and ultrahigh pressure consolidation technique,resulting in an optimal microstructure of amorphous structure with nanoparticles uniformly distributed in the matrix alloy.This approach can effectively inhibit the crystallization of amorphous structure,thus providing a general pathway for manufacturing next-generation non-equiatomic HE-MGs with both exceptional corrosion resistance and strength. | Xigang Yang Yun Zhou Ruihua Zhu Shengqi Xi Cheng He Hongjing Wu Yuan Gao | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，8： | 2 |
| 6 | Active site transformation during the induction period of ethylene polymerization over the Phillips CrOJSiOz catalyst显示文摘 | Zhortg Lei Liu Zhen Cheng Ruihua | 2012 | ChemCatChem2012，4，： | 1 |
| 7 | DFT functional benchmarking on the energy splitting of chromium spin states and mechanistic study of acetylene cyclotrimerization over the Phillips Cr(lI)/silica catalyst显示文摘 | Liu Zhen Cheng Ruihua He Xuelian | 2012 | The Journal of Physical Chemistry A2012，116，28： | 1 |
| 8 | Comparison of endoscopic papillary large balloon dilation and endoscopic sphincterotomy for retrieval of choledocholithiasis: a meta-analysis of randomized controlled trials显示文摘 | Yadong Feng Hong Zhu Xiaoxing Chen Shunfu Xu Wenfang Cheng Jinliang Ni Ruihua Shi | 2012 | Journal of Gastroenterology2012，，6： | 1 |
| 9 | Experimental and theoretical studies on ethylene polymerization using SiO2-supported silyl chromate type catalysts prepared by a green method显示文摘 | Li Xiaofang Cheng Ruihua Luo Jun | 2010 | Journal of Molecular Catalysis A: Chemical2010，330，12： | 1 |
| 10 | Treatment of 131I-labeled anti-CD147 monoclonal antibody in VX2 carcinoma-inducedliver tumors显示文摘 | Huanzhang Niu Ruihua Wang Jingliang Cheng Shegan Gao Baoping Liu | 2013 | Oncology Reports2013，，1： | 1 |
| 11 | Comparison of endoscopic papillary large balloon dilation and endoscopic sphincterotomy for retrieval of choledocholithiasis: a meta-analysis of randomized controlled trials显示文摘 | Yadong Feng Hong Zhu Xiaoxing Chen Shunfu Xu Wenfang Cheng Jinliang Ni Ruihua Shi | 2012 | Journal of Gastroenterology2012，，6： | 1 |
| 12 | Effects of the processing steps on parathion levels during honey production and parathion removal by macroporous adsorption resins显示文摘 | Ruihua Xu Ni Cheng Wei Hua | 2012 | Food Control2012，，32： | 1 |
| 13 | High resolution spectroscopy(XPS,1H MAS solid state NMR)and DFT investigations on Ti-modified Phillips CrOx/SiO2catalysts显示文摘 | Cheng Ruihua Xu Chen Liu Zhen | 2010 | Journal of Catalysis2010，273，： | 1 |
| 14 | Synthesis and characterization of high surface area molybdenum phosphide显示文摘 | Cheng Ruihua | 2007 | Applied Catalysis A:Gener- al2007，316，2： | 1 |
| 15 | Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease显示文摘 | Wenyu Jiang Jiewen Su Xiaofei Zhang Xiuqin Cheng Jun Zhou Ruihua Shi Hongjie Zhang | 2014 | Inflammation Research2014，，11： | 1 |
| 16 | Phillips Cr/silica catalyst for ethylene polymerization显示文摘 | Cheng Ruihua Liu Zhen Zhong Lei | 2013 | Advances in Polymer Science2013，257，： | 1 |
| 17 | Chromium catalysts for ethylene polymerization and oligomerization显示文摘 | Liu Zhen He Xulian Cheng Ruihua t al | 2014 | Advances in Chemical Engineering2014，44，： | 1 |
| 18 | Comparison of unicompartmental knee arthroplasty and total knee arthroplasty in the treatment of unicompartmental osteoarthritis: a meta-analysis显示文摘 | Qidong Zhang Wanshou Guo Qian Zhang Ruihua Sun Zhaohui Liu Liming Cheng Yinyin Xia Guanggang Chen Ran Ding Di Zhu Zirong Li | 2010 | Current Orthopaedic Practice2010，，5： | 1 |
| 19 | Metabolic features of the tumor microenvironment of gastric cancer and the link to the systemic macroenvironment显示文摘 | Jiye Aa Lianzhen Yu Min Sun Linsheng Liu Mengjie Li Bei Cao Jan Shi Jin Xu Liping Cheng Jun Zhou Tian Zheng Xinwen Wang Chunyan Zhao Rongrong Gu Fengyi Zhang Ruihua Shi Guangji Wang | 2012 | Metabolomics2012，，1： | 1 |
| 20 | Experimental and computational approaches on the isospecific role of monoestertype internal electron donor for TiCL/MgCl2 Ziegler-Natta catalysts显示文摘 | Liu Boping Cheng Ruihua Liu Zhen | 2007 | Macromol Syrup2007，260，1： | 1 |
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