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| 1 | Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018显示文摘Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more serious.This study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and 2018.Methods:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this study.Viral RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)protocol.The Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral drugs.Results:The prevalence of TDR was not significantly increased over time.The prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,respectively.Conclusions:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance. | Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing | 2021 | China CDC weekly2021，3，53： | 13 |
| 2 | Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms显示文摘 | Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 3 | Interaction of Restin with transcription factors显示文摘Restin, a member of melanoma-associated antigen superfamily gene, was first cloned from differentiated leukemia cell induced by all trans-retinoic acid, and was able to inhibit cell proliferation, but the molecular mechanism was not clear. Since Restin was localized in cell nucleus, and its homolog member, Necdin (neuronal growth suppressor factor), could interact with transcription factors p53 and E2F1, we proposed that Restin might also function as Necdin through interacting with some transcription factors. In this study, transcription factors p53, AP1, ATFs and E2Fs were cloned and used in the mammalian two-hybrid system to identify their in- teraction with Restin. The results showed that only ATF3 had a strong interaction with Restin. It is interesting to know that ATF3 was an important transcription factor for G1 cell cycle initiation in physiological stress response. It was possible that the inhibition of cell proliferation by Restin might be related with the inhibition of ATF3 activity. | WU Yousheng LU Fan QI Yinxin WANG Ruihua ZHANG Jian LU Zifan ZHAO Zhongliang | 2005 | Science China(Life Sciences)2005，48，3： | 5 |
| 4 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 5 | Aberrantly expressed GFRα-1/RET in patients with lacrimal adenoid cystic carcinoma is associated with high recurrence risk:a retrospective study of 51 LACC cases显示文摘Objective:Because of the poor prognosis of lacrimal adenoid cystic carcinoma(LACC),we aimed to investigate the effects of perineural invasion(PNI)and consequent aberrations in GDNF/GFRα-1/RET protein expression on LACC recurrence.Methods:Clinicopathological data for 51 histologically confirmed patients with LACC enrolled between 2001 and 2017 were retrospectively analyzed.Hematoxylin and eosin staining was applied to assess PNI.Tissue-based immunohistochemistry(IHC)detection of GDNF,GFRα-1,and RET proteins was performed on LACC formalin-fixed,paraffin-embedded specimens.We generated semi-quantitative data of the IHC results and compared them with the clinicopathological data for the 51 patients.Results:Of the 51 patients,19(37.3%)were PNI positive.Recurrence was more common for LACC with than without PNI(73.7%vs.37.5%,P=0.01).GDNF,GFRα-1,and RET proteins were expressed in 62.7%,62.7%,and 54.9%of the 51 patients with LACC,respectively.The expression of all 3 proteins was more common in patients with than without PNI.In agreement with previous findings,PNI-associated GFRα-1 and RET positivity,as detected by IHC,remained significantly associated with recurrence,whereas GDNF expression,as detected by IHC,was not correlated with LACC recurrence.Specifically,patients with concurrent GFRα-1 and RET expression may have a high risk of PNI(89.5%positivity rate)and recurrence(84.2%positivity rate).Conclusions:PNI may contribute to LACC recurrence.The concurrent expression of GFRα-1 and RET proteins,as detected by IHC,may potentially be associated with LACC PNI and recurrence. | Lin Liu Liqiong Zhao Jie Zhang Guoxiang Song Carol LShields Ruihua Wei | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 6 | Two New C19-Diterpenoid Alkaloids with Anti-inflammatory Activity from Aconitum iochanicum显示文摘二新 C 19-diterpenoid 碱, 7,8-epoxy-franchetine (1 ) 和 N (19 )-en-austroconitine A (2 ) ,从 Aconitum iochanicum 被孤立。化合物 1 是有一个 7,8 环氧基树脂单位的新 C 19-diterpenoid 碱。他们的结构被包括的全面分光镜的分析阐明紫外,红外, MS, 1D 和 2D NMR。生物活动测试显示二新混合物对氮的氧化物展出了禁止的活动(没有) 在激活 LPS 的 RAW264.7 巨噬细胞的生产。与积极控制相比,二新混合物分别地与 27.3% 和 29.2% 的抑制率显示出弱反煽动性的效果。 | Ruihua Guo Chengxin Guo Dan He Dake Zhao Yong Shen | 2017 | Chinese Journal of Chemistry2017，35，10： | 3 |
| 7 | Awareness intervention for Beijing neurologists regarding secondary prevention of cerebral infarction/transient ischemia Cross-sectional investigation显示文摘BACKGROUND: Stroke prevention guidelines should be made available to neurologists for clinical application to aid in uniformity, timing, preciseness, and acceptance of disease. OBJECTIVE: To investigate the awareness of neurologists in some Beijing hospitals of intervention in secondary prevention of cerebral infarction/transient ischemia. DESIGN: Cross-sectional study. SETTING: Beijing Tiantan Hospital, Beijing Anzhen Hospital, General Hospital of Beijing Military Area, Command of Chinese PLA, Beijing Chuiyangliu Hospital, Beijing 6th Hospital, Beijing Hepingli Hospital, and Beijing Daxing District Hospital. PARTICIPANTS: A total of 28 (associate) chief physicians, 58 attending physicians, and 54 resident physicians who engaged in clinical treatment of cerebrovascular diseases were selected from 8 hospitals in Beijing from March to April 2007. All physicians provided informed consent. METHODS: Self-made closed questionnaires were provided for data collection, consisting of 16 questions that were single choice or multiple choice. Specifically, questions 1-7 focused on awareness of blood pressure regulation in different patients and first choice of decompression drug; questions 8-12 focused on awareness of lipid regulation; and questions 13-16 focused on awareness of anti-blood platelet drugs applied in secondary prevention. The scores ranged from 0-100 points, and each question was worth 6.25 points. The scores positively correlated with the awareness rate. To test leveling real-time, the survey lasted for a maximum of 20 minutes. One questionnaire was independently finished by each subject in the survey. MAIN OUTCOME MEASURES: Awareness intervention among neurologists during secondary prevention of cerebral infarction/transient ischemia and questionnaire scores. RESULTS: 140 subjects were included in the final analysis. ① The awareness rate among neurologists for intervention during secondary prevention of cerebral infarction/transient ischemia ranged from 0.7-57.9%, the scores ranged between 0-56 points, and the mean score was 26 points. ② Scores of resident physicians were 0-56 points with a mean score of 26 points; attending physicians scored 6-50 points, with a mean score of 26 points; and chief physicians scored 6-50 points, with a mean score of 23 points. There were no significant differences among the various physicians (F = 0.771, t = 0.465, P > 0.05). CONCLUSION: Awareness among neurologists of intervention during secondary prevention of cerebral infarction/transient ischemia is not ideal. However, there was no significant difference between professional titles. | Ruihua Ma Chunxue Wang Xianwei Wang Yuhui Zhang Yongjun Wang Yilong Wang Xingquan Zhao Jingjing Li Ying Lu Mingjie Xu Zhuo Zhang Li Wang Weiwei Zhang Lang Lin Jiping Tan Yao Li Ming Wei Hongtao Li | 2008 | Neural Regeneration Research2008，3，3： | 2 |
| 8 | Distribution and spectral characteristics of chromophoric dissolved organic matter in a coastal bay in northern China显示文摘The absorption spectra of chromophoric dissolved organic matter(CDOM),along with general physical,chemical and biological variables,were determined in the Bohai Bay,China,in the springs of 2011 and 2012. The absorption coefficient of CDOM at 350 nm(a350) in surface water ranged from 1.00 to 1.83 m-1(mean: 1.35 m-1) in May 2011 and from 0.78 to 1.92 m-1(mean:1.19 m-1) in April 2012. Little surface-bottom difference was observed due to strong vertical mixing. The a350 was weakly anti-correlated to salinity but positively correlated to chlorophyll a(Chl-a) concentration. A shoulder over 260–290 nm,suggestive of biogenic molecules,superimposed the overall pattern of exponentially decreasing CDOM absorption with wavelength. The wavelength distribution of the absorption spectral slope manifested a pronounced peak at ca. 300 nm characteristic of algal-derived CDOM. All a250/a365 ratios exceeded 6,corresponding to CDOM molecular weights(Mw) of less than 1 kDa. Spectroscopically,CDOM in the Bohai Bay differed substantively from that in the Haihe River,the bay's dominant source of land runoff; photobleaching of the riverine CDOM enlarged the difference.Results point to marine biological production being the principal source of CDOM in the Bohai Bay during the sampling seasons. Relatively low runoff,fast dilution,and selective photodegradation are postulated to be among the overarching elements responsible for the lack of terrigenous CDOM signature in the bay water. | Guiju Li Jing Liu Yulan Ma Ruihua Zhao Suzheng Hu Yijie Li Hao Wei Huixiang Xie | 2014 | Journal of Environmental Sciences2014，26，8： | 2 |
| 9 | Investigation on Host Species and Damage Degree of Bemisia tabaci (Gennadius) in Shaanxi Area显示文摘The host plants of Bemisia tabaci( Gennadius) in Shaanxi were investigated,and its damage degree was evaluated by hazard index in 2013 and 2014.There were 73 species( variants) of host plants of B. tabaci belonging to 28 families,mainly concentrated in Cucurbitaceae,Cruciferae,Solanaceae,Laguminosae and Malvaceae. There were seven species of vegetables that suffered the damage of grade 4. B. tabaci was more serious in southern Shaanxi and lighter in northern Shaanxi. According to the distribution of host plants,the occurrence status of B. tabaci in Shaanxi Province was analyzed and its development tendency was predicted. | Zhao Ruihua Deng Zhenshan Yun Long Yang Xun Yang Lin He Xiaolong | 2016 | Plant Diseases and Pests2016，7，1： | 2 |
| 10 | Comparison of Mastoscopic and Conventional Axillary Lymph Node Dissection in Breast Cancer: Long-term Results From a Randomized, Multicenter Trial显示文摘 | Chengyu Luo Wenbin Guo Jie Yang Qiuru Sun Wei Wei Suhua Wu Shubing Fang Qingliang Zeng Zhensheng Zhao Fanjie Meng Xuandong Huang Xianlan Zhang Ruihua Li Xiufeng Ma Chaoying Luo Yun Yang | 2012 | Mayo Clinic Proceedings2012，，12： | 1 |
| 11 | Effects of sizes of nano-copper oxide on the equilibrium constant and thermodynamic properties for the reaction in nanosystem显示文摘 | Jianping Du Ruihua Zhao Yongqiang Xue | 2011 | The Journal of Chemical Thermodynamics2011，，1： | 1 |
| 12 | The impact of influent mode on nitrogen removal in horizontal subsurface flow constructed wetlands: A simple analysis of hydraulic efficiency and nutrient distribution显示文摘 | Yuhui Wang Xinshan Song Yi Ding Ruihua Niu Xiaoxiang Zhao Denghua Yan | 2013 | Ecological Engineering2013，，： | 1 |
| 13 | Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2显示文摘Constitutive activation of RAS-RAF-MEK-ERK signaling pathway(MAPK pathway)frequently occurs in many cancers harboring RAS or RAF oncogenic mutations.Because of the paradoxical activation induced by a single use of BRAF or MEK inhibitors,dual-target RAF and MEK treatment is thought to be a promising strategy.In this work,we evaluated erianin is a novel inhibitor of CRAF and MEK1/2 kinases,thus suppressing constitutive activation of the MAPK signaling pathway induced by BRAF V600E or RAS mutations.KinaseProfiler enzyme profiling,surface plasmon resonance(SPR),isothermal titration calorimetry(ITC),cellular thermal shift assay,computational docking,and molecular dynamics simulations were utilized to screen and identify erianin binding to CRAF and MEK1/2.Kinase assay,luminescent ADP detection assay,and enzyme kinetics assay were investigated to identify the efficiency of erianin in CRAF and MEK1/2 kinase activity.Notably,erianin suppressed BRAF V600E or RAS mutant melanoma and colorectal cancer cell by inhibiting MEK1/2 and CRAF but not BRAF kinase activity.Moreover,erianin attenuated melanoma and colorectal cancer in vivo.Overall,we provide a promising leading compound for BRAF V600E or RAS mutant melanoma and colorectal cancer through dual targeting of CRAF and MEK1/2. | Penglei Wang Xuechao Jia Bingbing Lu Han Huang Jialin Liu Xuejiao Liu Qiong Wu Yamei Hu Pan Li Huifang Wei Tingting Liu Dengyun Zhao Lingwei Zhang Xueli Tian Yanan Jiang Yan Qiao Wenna Nie Xinli Ma Ruihua Bai Cong Peng Zigang Dong Kangdong Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 14 | Formation of stable fullerenelike Ga, As, clusters(6:n:9) : gradient-corrected density- functional theory and a genetic global optimization approach显示文摘 | Zhao Jijun Xie Ruihua Zhou Xiaolan | 2006 | Phys Rev B2006，74，03： | 1 |
| 15 | Interleukin-6 expression was regulated by epigenetic mechanisms in response to influenza virus infection or dsRNA treatment显示文摘 | Bikui Tang Ruihua Zhao Yong Sun Ying Zhu Jiang Zhong Guoping Zhao Naishuo Zhu | 2011 | Molecular Immunology2011，，8： | 1 |
| 16 | Hormone-like activities of Kuntai capsule in the uteri of ovariectomized rats and immature rabbits显示文摘OBJECTIVE: To investigate the hormone-like activities of Kuntai capsule(KTC) in the uteri of ovariectomized rats and immature rabbits.METHODS: Following bilateral ovariectomy, rats were randomly divided into six groups including sham group, control group, estradiol valerate group, KTC 0.24, 0.6, and 1.5 g/kg groups. The rats were treated with 0.5% CMC-Na, estradiol valerate and KTC(0.24, 0.6, and 1.5 g/kg), respectively for 28 consecutive days. Then the estrous cycle, uterine changes and pathological changes were examined.Serum levels of estradiol(E2), and progesterone(P4)were measured by enzyme-linked immunosorbent assay(ELISA). Protein levels of estradiol receptor(ER), progesterone receptor(PR), vascular endothelial growth factor(VEGF), proliferating cell nuclear antigen(PCNA) and nuclear-associated antigen-67(Ki-67) in uterine tissues were detected by western blot. Immature rabbits were estrogen-primed prior to intragastric administration with KTC for 6 d consecutively. Then, the uteri underwent hematoxylin-eosin staining to observe endometrial transformation.RESULTS: Compared with the control group, 0.6and 1.5 g/kg KTC markedly decreased the uterine organ coefficient and endometrial thickness(P <0.05). The serum level of P4 was increased in the KTC 0.6 g/kg group(P < 0.05). There were no significant variations in the serum level of E2 in the KTC groups compared with the control group. ERβ, but not ERα, was markedly upregulated after KTC administration(P < 0.05). Furthermore, 1.5 g/kg KTC significantly decreased the protein level of PRA(P <0.05) and 0.6 g/kg KTC increased the protein level of PRB in the uteri(P < 0.05). VEGF was highly expressed after treatment with 0.24 and 0.6 g/kg KTC,and Ki-67 was markedly reduced in ovariectomized rats treated with 1.5 g/kg KTC. No difference was found in the expression of PCNA. KTC 0.24 and0.6 g/kg promoted endometrial transformation in immature rabbit uteri.CONCLUSION: KTC does not demonstrate obvious estrogen-like effect on uteri after ovariectomy, but it does exhibit weak progestogen-like effect, by which mechanism of action is yet to be further investigated. | Zhong Ruihua Xie Shuwu Li Guoting Yang Wenjie Guo Xiangjie Li Zhao Zhou Jieyun Ma Aying Zhu Yan | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 1 |
| 17 | VEGF-A not Ang2 mediates endothelial-like differentiation of immatureDCs by ERK1/2 signaling in the microenvironment of human colon adenocarcinoma显示文摘 | Jing Lu Kangdong Liu Jimin Zhao Jun Zhao Junfen Ma Hongyan Yang Youtian Huang Zhenzhu Qin Ruihua Bai Lili Jiang Fengshou Lv Pei Li Wenhai Yan Mingyao Zhao Ziming Dong | 2011 | International Journal of Oncology2011，，6： | 1 |
| 18 | Relationship of energy charge and toxin content of Microcystis aeruginosa in nitrogen-limited or phosphorous-limited cultures显示文摘 | Ruihua Dai Huijuan Liu Jiuhui Qu Xu Zhao Jia Ru Yining Hou | 2007 | Toxicon2007，，4： | 1 |
| 19 | Proteomic analysis revealed the altered tear protein profile in a rabbit model of S j?gren’s syndrome‐associated dry eye显示文摘 | Lei Zhou Ruihua Wei Ping Zhao Siew Kwan Koh Roger W. Beuerman Chuanqing Ding | 2013 | Proteomics2013，，16： | 1 |
| 20 | Simple self-assembly of 3D laminated CuO/SnO2 hybrid for the detection of triethylamine显示文摘Tin dioxide is important gas sensor material and has wide applications in the detection of toxic gases and volatile organic compounds.Here,we synthesized a 3D laminated structural CuO/SnO2 material possessing p-n heterostructures.The morphology and structure were characterized by XRD,SEM,TEM and XPS techniques and the sensing properties were investigated for the detection of triethylamine(TEA).The results indicate that 3D laminated CuO/SnO2 material,assembled by lamellae consisting of ordered nanoparticles,exhibit an enhanced sensing performance compared with SnO2,and notably,CuO/SnO2 with size less than 1μm has obvious high selectivity in the detection of 100 ppm TEA.Particularly,it has a high response and stability to 1 and 5 ppm TEA(S is 8 and 33),and that is higher than SnO2 material,suggesting 3D laminated CuO/SnO2 is an effective ca ndidate material served as sensor platform to detect low-concentration amines. | Yangyang Shang Wenqiong Shi Ruihua Zhao Md.Maruf Ahmed Jinping Li Jianping Du | 2020 | Chinese Chemical Letters2020，31，8： | 1 |
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