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| 1 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 2 | Outcome of multimodal MRI-guided intravenous thrombolysis in patients with stroke with unknown time of onset显示文摘Objective Intravenous tissue plasminogen activator(tPA)is the standard therapy for patients with acute ischaemic stroke(AIS)within 4.5 hours of onset.Recent trials have expanded the endovascular treatment window to 24 hours.We investigated the efficacy and safety of using multimodal MRI to guide intravenous tPA treatment for patients with AIS of unknown time of onset(UTO).Methods Data on patients with AIS with UTO and within 4.5 hours of onset were reviewed.Data elements collected and analysed included:demographics,National Institutes of Health Stroke Scale(NIHSS)score at baseline and 2 hours,24 hours,7 days after thrombolysis and before discharge,the modified Rankin Scale(mRS)score at 3 months after discharge,imaging findings and any adverse event.results Forty-two patients with UTO and 62 in control group treated within 4.5 hours of onset were treated with intravenous tPA.The NIHSS scores after thrombolysis and/or before discharge in UTO group were significantly improved compared with the baseline(p<0.05).Between the two groups,no significant differences in NIHSS score were observed(p>0.05).Utilising the non-inferiority test,to compare mRS scores(0-2)at 3 months between the two groups,the difference was 5.2%(92%CI,OR 0.196).Patients in the UTO group had mRS scores of 0-2,which were non-inferior to the control group.Their incidence of adverse events was similar.Conclusions Utilising multimodal MRI to guide intravenous only thrombolysis for patients with AIS with UTO was safe and effective.In those patients with AIS between 6 and 24 hours of time of onset but without large arterial occlusion,intravenous thrombolysis could be considered an option. | Jie Zhao Hongmei Zhao Runtao Li Jiangtao Li Chang Liu Juan Lv Yanan Li Wei Liu Dongpu Ma Huaihai Hao Xinguang Xiao Junzhong Liu Yongfeng Yin Rongli Liu Qiaoyan Yu Yingjie Wei Pengyan Li Yue Wang Runqing Wang | 2019 | Stroke & Vascular Neurology2019，4，1： | 8 |
| 3 | Effects of 2'-O-methyl nucleotide on ligation capability of T4 DNA ligase显示文摘为了推进,理解结扎机制, T4 DNA 结扎效率上的 2-O-methyl 核苷酸(2 预兆) 的效果被调查。荧光回声精力转移试金被用来由 T4 DNA ligase 监视加入刻痕的进程。结果证明在刻痕的 5 结束和 3 结束的替换减少了在 48.7% | Bin Zhao Zhaoxue Tong Guojie Zhao Runqing Mu Hong Shang Yifu Guan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 5 |
| 4 | Effectiveness of intravenous r- tPA versus UK for acute ischaemic stroke: a nationwide prospective Chinese registry study显示文摘Background Intravenous recombinant tissue plasminogen activator(r-tPA)and urokinase(UK)are both recommended for the treatment of acute ischaemic stroke(AIS)in China,but with few comparative outcome data being available.We aimed to compare the outcomes of these two thrombolytic agents for the treatment of patients within 4.5 hours of onset of AIS in routine clinical practice in China.Methods A pre-planned,prospective,nationwide,multicentre,real-world registry of consecutive patients with AIS(age≥18 years)who received r-tPA or UK within 4.5 hours of symptom onset according to local decision-making and guideline recommendations during 2017-2019.The primary effectiveness outcome was the proportion of patients with an excellent functional outcome(defined by modified Rankin scale scores 0 to 1)at 90 days.The key safety endpoint was symptomatic intracranial haemorrhage according to standard definitions.Multivariable logistic regression was used for comparative analysis,with adjustment according to propensity scores to ensure balance in baseline characteristics.Results Overall,4130 patients with AIS were registered but 320 had incomplete or missing data,leaving 3810 with available data for analysis of whom 2666 received r-tPA(median dose 0.88(IQR 0.78-0.90)mg/kg)and 1144 received UK(1.71(1.43-2.00)×104 international unit per kilogram).There were several significant intergroup differences in patient characteristics:r-tPA patients were more educated,had less history of stroke,lower systolic blood pressure,greater neurological impairment and shorter treatment times from symptom onset than UK patients.However,in adjusted analysis,the frequency of excellent outcome(OR 1.18,95%CI 1.00 to 1.40,p=0.052)and symptomatic intracranial haemorrhage(OR 0.70,95%CI 0.33 to 1.47,p=0.344)were similar between groups.Conclusions UK may be as effective and carry a similar safety profile as r-tPA in treating mild to moderate AIS within guidelines in China.Registration http://www.clinicaltrials.gov.unique identifier:NCT02854592. | Xinhong Wang Xiaoqiu Li Yuming Xu Runhui Li Qingcheng Yang Yong Zhao Fengyun Wang Baoying Sheng Runqing Wang Shaoyuan Chen Lihua Wang Liying Shen Xiaowen Hou Yu Cui Duolao Wang Bin Peng Craig S Anderson Huisheng Chen On behalf of INTRECIS Investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 2 |
| 5 | Contributions of non-tectonic micro-fractures to hydraulic fracturing—A numerical investigation based on FSD model显示文摘Shale gas has been discovered in the Upper Triassic Yanchang Formation, Ordos Basin, China. Due to the weak tectonic activities in which the shale plays, core observations indicate abundant random non-tectonic micro- fractures in the producing shales. The non-tectonic micro-fractures are different from tectonic fractures and are characterized by being irregular, curved, discontinuous, and randomly distributed. The role of micro-fractures in hydraulic fracturing for shale gas development is currently poorly understood yet potentially critical. Two-dimensional computational modeling studies have been used in an initial attempt toward understanding how naturally random fractured reservoirs respond during hydraulic fracturing. The aim of the paper is to investigate the effect of random non-tectonic fractures on hydraulic fracturing. The numerical models with random non-tectonic micro-fractures are built by extracting the fractures of rock blocks after repeated heating and cooling, using a digital image process. Simulations were conducted as a function of:(1) the in-situ stress ratio;(2) internal friction angle of random fractures;(3) cohesion of random fractures;(4) operational variables such as injection rate; and(5) variable injection rate technology. A sensitivity study reveals a number of interesting observations resulting from these parameters on the shear stimulation in a natural fracture system. Three types of fracturing networks were observed from the studied simulations, and the results also show that variable injection rate technology is most promising for producing complex fracturing networks. This work strongly links the production technology and geomechanical evaluation. It can aid in the understanding and optimization of hydraulic fracturing simulations in naturally random fractured reservoirs. | WANG Yu Li Xiao ZHAO ZhiHeng ZHOU RunQing ZHANG Bo LI GuanFang | 2016 | Science China Earth Sciences2016，59，4： | 1 |
| 6 | Partial pore blockage and polymer chain rigidification phenomena in PEO/ZIF-8 mixed matrix membranes synthesized by in situ polymerization显示文摘Nanostructured zeolitic imidazolate frameworks(ZIF-8) was incorporated into the mixture of poly(ethylene glycol) methyl ether acrylate(PEGMEA) and pentaerythritol triacrylate(PETA) to synthesize mixed matrix membranes(MMMs) by in situ polymerization for CO_2/CH_4 separation. The solvent-free polymerization between PEGMEA and PETA was induced by UV light with 1-hydroxylcyclohexyl phenyl ketone as initiator. The chemical structural characterization was performed by Fourier transform infrared spectroscopy. The morphology was characterized by scanning electron microscope. The average chain-to-chain distance of the polymer chains in MMMs was investigated by X-ray diffraction. The thermal property was evaluated by differential scanning calorimetry. The CH_4 and CO_2 gas transport properties of MMMs are reported. The relationship between gas permeation–separation performances or physical properties and ZIF-8 loading is also discussed. However, the permeation–separation performance was not improved in Robeson upper bound plot compared with original polymer membrane as predicted. The significant partial pore blockage and polymer rigidification effect around the ZIFs confirmed by the increase in glass temperature and the decrease in the d-spacing, were mainly responsible for the failure in performance improvement, which offset the high diffusion induced by porous ZIF-8. | Xiaoli Ding Xu Li Hongyong Zhao Ran Wang Runqing Zhao Hong Li Yuzhong Zhang | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 0 |
| 7 | NO_(2) sensing with CdS nanowires at room temperature under green light illumination显示文摘Detection of ppb-level NO_(2) gas under atmosphere is urgent to meet the requirements of the rapidly developing internet of things.Compared with traditional sensing methods,light illumination has been considered as a key approach for excellent gas sensor performance under moderate conditions.Herein,we developed a green-light-assisted gas sensor based on cadmium sulfide nanowires(CdS NWs)that has good NO_(2) sensing capability at ambient temperature.The response values of NO_(2) are 236%and 11%to 10 ppm and 12.5 ppb,respectively.Furthermore,the CdS NWs sensor has a high selectivity for NO_(2) over a variety of interference gases,as well as good stability.The cleaning light activation and the sulfur vacancy-trapped charge behavior of CdS NWs are observed,which suggest a light-assisted sensing mechanism.These results suggest that light-induced charge separation behavior might significantly improve gas-sensing characteristics. | Peipei Li Hongqiang Jin Jia Yu Weiming Chen Runqing Zhao Changyan Cao Weiguo Song | 2022 | Materials Futures2022，1，2： | 0 |
| 8 | Study on Dynamic Characteristics of the Growth and Development of Armeniaca dasycarpa(Ehrh.) Borkh显示文摘[Objective]This study aimed to analyze the dynamics of growth and development of Armeniaca dasycarpa( Ehrh.) Borkh fruit,thus providing the theoretical basis for cultivation and breeding of good-quality and high-yield A. dasycarpa. [Method] With A. dasycarpa cultivar Yechengzixing as the experimental material,P. cerasifera Ehrh cultivar Huangguoyingtaoli and A. vulgaris Lam. cultivars Luopuhongdaike,Wanshujianali and Kuchetuoyong as control,the vertical diameter,horizontal diameter and fresh weight of fruit and embryos were measured every 7 d during the growth and development period. [Result] The result showed that the whole fruit growth period of Yechengzixing,lasted 93 d from the end of flowering to fruit maturity. The dynamics of fruit vertical diameter,horizontal diameter and fresh weight of Yechengzixing presented'rapid-slow-rapid'double S-shaped curves. The whole fruit growth period of Yechengzixing could be divided approximately into three stages: first rapid growth stage,slow growth stage and second rapid growth stage,which lasted 29,42 and 21 d,respectively. Daily increment of fruit vertical diameter and horizontal diameter of Yechengzixing reached the maximum at the first rapid growth stage,while daily increment of fruit fresh weight reached the maximum at the second rapid growth stage. The dynamics of vertical diameter,horizontal diameter and fresh weight of Yechengzixing embryos presented S-shaped curves. Fruit growth and development dynamics of the tested materials presented double S-shaped curves. The whole fruit growth period of Yechengzixing,Huangguoyingtaoli and three apricot cultivars lasted 93,119 and 77- 98 d,respectively. Thus,the duration of fruit growth period of Yechengzixing was 26 d shorter than that of Huangguoyingtaoli and exhibited no significant difference compared with three apricot cultivars. The duration of each growth stage and daily increment of Yechengzixing fruit had no significant difference compared with three apricot cultivars. Moreover,Huangguoyingtaoli had a longer slow growth stage and lower daily increment than Yechengzixing. [Conclusion]The whole fruit growth period,duration of each growth stage and daily increment of Yechengzixing exhibited no significant difference compared with three apricot cultivars but varied remarkably compared with Huangguoyingtaoli. | Guixiang XU Kang LIAO Shirong ZHAO Hongxiang PANG Yingying NIU Zhenbin JIANG Shengli DONG Runqing DU | 2016 | Agricultural Biotechnology2016，5，3： | 0 |
| 9 | Identification and characterization of human hematopoietic mesoderm显示文摘The embryonic mesoderm comprises heterogeneous cell subpopulations with distinct lineage biases.It is unclear whether a bias for the human hematopoietic lineage emerges at this early developmental stage.In this study,we integrated single-cell transcriptomic analyses of human mesoderm cells from embryonic stem cells and embryos,enabling us to identify and define the molecular features of human hematopoietic mesoderm(HM)cells biased towards hematopoietic lineages.We discovered that BMP4 plays an essential role in HM specification and can serve as a marker for HM cells.Mechanistically,BMP4 acts as a downstream target of HDAC1,which modulates the expression of BMP4 by deacetylating its enhancer.Inhibition of HDAC significantly enhances HM specification and promotes subsequent hematopoietic cell differentiation.In conclusion,our study identifies human HM cells and describes new mechanisms for human hematopoietic development. | Yuqi Wen Jingjing Zhao Runqing Zhang Fan Liu Xiaoyuan Chen Dan Wu Mengge Wang Cuicui Liu Pei Su Panpan Meng Yiyue Zhang Xin Gao Lu Wang Hongtao Wang Jiaxi Zhou | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
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