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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Ca_(1−x)Li_(x)Al_(1−x)Si_(1+x)N_(3):Eu^(2+) solid solutions as broadband,color-tunable and thermally robust red phosphors for superior color rendition white light-emitting diodes显示文摘Color rendition,luminous efficacy and reliability are three key technical parameters for white light-emitting diodes(wLEDs)that are dominantly determined by down-conversion phosphors.However,there is usually an inevitable trade-off between color rendition and luminescence efficacy because the spectrum of red phosphor(that is,spectral broadness and position)cannot satisfy them simultaneously.In this work,we report a very promising red phosphor that can minimize the aforementioned trade-off via structure and band-gap engineering,achieved by introducing isostructural LiSi_(2)N_(3) into CaAlSiN_(3):Eu^(2+).The solid solution phosphors show both substantial spectra broadening(88→117 nm)and blueshift(652→642 nm),along with a significant improvement in thermal quenching(only a 6%reduction at 150℃),which are strongly associated with electronic and crystal structure evolutions.The broadband and robust red phosphor thus enables fabrication of super-high color rendering wLEDs(Ra=95 and R9=96)concurrently with the maintenance of a high-luminous efficacy(101 lm W^(−1)),validating its superiority in highperformance solid state lightings over currently used red phosphors. | Le Wang Rong-Jun Xie Yuanqiang Li Xiaojun Wang Chong-Geng Ma Dong Luo Takashi Takeda Yi-Ting Tsai Ru-Shi Liu Naoto Hirosaki | 2016 | Light(Science & Applications)2016，5，1： | 9 |
| 3 | Multi-layered micro/nanofibrous nonwovens for functional face mask filter显示文摘The worldwide COVID-19 pandemic has led to an attention on the usage of personal protective face masks.However,the longevity and safety of the commercial face masks are limited due to the charge dissipation of the electret meltblown nonwovens,which are dominate in the face mask filters.Herein,we design a type of multi-layer structured nonwovens using meltblowing and electrospinning technologies.The complex nonwovens involving meltblown and electrospun fibers are designed to possess multilevel fiber diameters and pore sizes.The micro/nanofibers with porous and wrinkled surface morphologies can well capture particulate matters(PMs),and the multilevel pore sizes contribute to low air resistance under high filtration efficiency.Airflow field simulation was carried out to understand the pressure distribution within the nonwovens in the filtration process.Meanwhile,by adding Ag nanoparticles(AgNPs)as additives,the nonwovens exhibit excellent antibacterial performance.The resultant nonwovens exhibit filtration efficiency of 99.1%for PM0.3 and low pressure drop of 105 Pa under the 10.67 cm/s inlet air velocity,and antibacterial rate of>99.99%for Escherichia coli.These performances and functions make the designed complex nonwovens a promising filter core for face masks. | Yuanqiang Xu Xiaomin Zhang Defang Teng Tienan Zhao Ying Li Yongchun Zeng | 2022 | Nano Research2022，15，8： | 6 |
| 4 | SciFinder-guided rational design of fluorescent carbon dots for ratiometric monitoring intracellular pH fluctuations under heat shock显示文摘Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. Moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications. | Haifang Liu Yuanqiang Sun Zhaohui Li Ran Yang Jie Yang Aaron Albert Aryee Xiaoge Zhang Jia Ge Lingbo Qu Yuehe Lin | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 5 | Multiscale Simulation of a Novel Leaf-vein-inspired Gradient Porous Wick Structure显示文摘With the rapid development of photoelectric products,their miniaturization and high integration have intensified the problem of heat dissipation.Vapor chamber is a special type of heat pipe that is a particularly effective heat spreader for electronics.In this paper,a novel Leaf-vein-inspired Gradient Porous(LGP)wick structure is designed macroscopically and the LGP design is verified using a general model.After that,the gradient porous design Model IGis selected for the subsequent mesoscopic modeling.Then a connected 2D random LGP wick model presenting porosity gradient is generated by the expanded quartet structure generation set method.Using the mesoscopic Lattice Boltzmann Method(LBM),the flow and heat transfer in the LGP wick model is analyzed.For verification,FLUENT based on the macroscopic finite volume method is used as a benchmark.Finally,the microscopic flow behaviors in the 2D random LGP wick model are analyzed using the LBM developed.Observing the entire flowing process from the inlet to outlet,it is possible to explain the mesoscopic and macroscopic phenomena well based on the microscopic flow behaviors. | Yuanqiang Luo Wangyu Liu Jingren Gou | 2019 | Journal of Bionic Engineering2019，16，5： | 2 |
| 6 | Synthesis of model predictive control based on data-driven learning显示文摘Dear editor,Model predictive control(MPC)is a practically effective and attractive approach in the field of industrial processes[1]owing to its excellent ability to handle constraints,nonlinearity,and performance/cost trade-offs.The core of all model-based predictive algorithms is to use'open-loop optimal control'instead of'closed-loop optimal control'within a moving horizon[2]. | Yuanqiang ZHOU Dewei LI Yugeng XI Zhongxue GAN | 2020 | Science China(Information Sciences)2020，63，8： | 2 |
| 7 | Dual-atom active sites embedded in two-dimensional C_(2)N for efficient CO_(2) electroreduction: A computational study显示文摘Double-atom catalysts(DACs)have emerged as an enhanced platform of single-atom catalyst for promoting electrocatalytic CO_(2) reduction reaction(CO_(2) RR).Herein,we present a density-functional theory study on CO_(2) RR performance of seven C_(2) N-supported homo-and heteronuclear DACs,denoted as M_(2)@C_(2) N.Our results demonstrate that there exists substantial synergistic effect of dual-metal-atom N_(2) M_(2) N_(2) active site and C_(2) N matrix on O=C=O bond activation.The dual-atom M_(2) sites are able to drive CO_(2) RR beyond C1 products with low limiting potential(UL).Specifically,C_(2) H4 formation is preferred on FeM@C_(2) N(M=Fe,Co,Ni,Cu)versus CH4 formation on CuM@C_(2) N(M=Co,Ni,Cu).Furthermore,^(*)CO+^(*)CO cobinding strength can serve as a descriptor for CO_(2) RR activity for making C_(2) products such that the moderate binding results in the lowest UL.Remarkably,C-affinity matters most to C-C bond coupling and C_(2) H4 formation while both C-and O-affinity control CH4 formation.Our results provide theoretical insight into rational design of DACs for efficient CO_(2) RR. | Haimei Liu Qingliang Huang Wei An Yuanqiang Wang Yong Men Shuang Liu | 2021 | Journal of Energy Chemistry2021，30，10： | 1 |
| 8 | Change of Hydraulic Conductivity During Compression of Undisturbed and Remolded Clays显示文摘 | Zeng Lingling Hong Zhenshun Cai Yuanqiang | | 0，，： | 1 |
| 9 | Active faulttolerant control of a flexible beam显示文摘 | Bai Yuanqiang Grigoriadis K M Song G | 2007 | Proceeding ofSPIE2007，6253，： | 1 |
| 10 | Iridoids and Sesquiterpenoids with NGF - Potentiating Activity from the Rhizomes and Roots of Valeriana fauriei 显示文摘 | Yuanqiang Gao Jing Xu Yushan Li | 2006 | Chem Pharm Bul2006，154，1： | 1 |
| 11 | Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis显示文摘 | Jin Su Jiangtian Yu Tingting Ren Wei Zhang Yuanqiang Zhang Xinping Liu Tiezheng Sun Houshan Lu Keiji Miyazawa Libo Yao | 2009 | 2009 (1-2)2009，，1： | 1 |
| 12 | Scattering of SH waves induced by a non‐symmetrical V‐shaped canyon显示文摘 | Ning Zhang Yufeng Gao Yuanqiang Cai Dayong Li Yongxin Wu | 2012 | Geophysical Journal International2012，，1： | 1 |
| 13 | Validity of fully drained, fully undrained and u – p formulations for modeling a poroelastic half-space under a moving harmonic point load显示文摘 | Li Shi Honglei Sun Yuanqiang Cai Changjie Xu Peng Wang | 2012 | Soil Dynamics and Earthquake Engineering2012，，： | 1 |
| 14 | Crystalline-Amorphous Phase Transition of a Poly (ethylene glycol) /Cellulose Blend 显示文摘 | Liang Xuehai Guo Yuanqiang Gu Lianzhen Ding Enyong | 1995 | Macromolecules1995，28，： | 1 |
| 15 | A new alkaloid from the roots of Celastrus orbiculatus 显示文摘 | Yuanqiang Guo Xian Li Jinghui Wang | 2005 | Fitoterapia2005，76，02： | 1 |
| 16 | Semi-Analytic Analysis of the Isolation to Moving-Load In- duced Ground Vibrations by Trenches on a Poroelastic Half-Space 显示文摘 | CAO Zhigang CAI Yuanqiang BOSTROM A | 2012 | Journal of Sound and Vibration2012，331，4： | 1 |
| 17 | Discrete element modeling of the microbond test of fiber reinforced composite显示文摘 | Dongmin Yang Yong Sheng Jianqiao Ye Yuanqiang Tan | 2010 | Computational Materials Science2010，，2： | 1 |
| 18 | Molecular orbital indexes criteria for friction modifiers in boundary lubrication显示文摘 | Yuanqiang Tan Weijiu Huang Xueye Wang | 2002 | Tribology International2002，35，： | 1 |
| 19 | The binding of anti-wear additives to iron surfaces: quantum chemical calculations and tribological tests显示文摘 | Weijiu Huang Yuanqiang Tan Boshui Chen | 2003 | Tribology International2003，36，： | 1 |
| 20 | Geographical influences on content of 10-hydroxy-trans-2-decenoic acid in royal jelly in China显示文摘 | WEI Wenting HU Yuanqiang ZHENG Huoqing | 2013 | Journal of Economic Entomology2013，106，5： | 1 |
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