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| 1 | Peripheral CD4^(+) T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer显示文摘Limited benefit population of immune checkpoint inhibitors makes it urgent to screen predictive biomarkers for stratifying the patients.Herein,we have investigated peripheral CD4^(+) T cell signatures in advanced non-small cell lung cancer(NSCLC)patients receiving anti-PD-1/PD-L1 treatments.It was found that the percentages of IFN-γand IL-17A secreting naïve CD4^(+) T cells(Tn),and memory CD4^(+) T cells(Tm)expressing PD-1,PD-L1 and CTLA-4 were significantly higher in responder(R)than non-responder(NonR)NSCLC patients associated with a longer progression free survival(PFS).Logistic regression analysis revealed that the baseline IFN-γ-producing CD4^(+) Tn cells and PD-1^(+)CD4^(+) Tm cells were the most significant signatures with the area under curve(AUC)value reaching 0.849.This was further validated in another anti-PD-1 monotherapy cohort.Conversely,high percentage of CTLA-4^(+)CD4^(+) Tm cells was associated with a shorter PFS in patients receiving anti-PD-L1 monotherapy.Our study therefore elucidates the significance of functional CD4^(+) Tn and Tm subpopulations before the treatment in predicting the responses to anti-PD-1 treatment in Chinese NSCLC patients.The fact that there display distinct CD4^(+) T cell signatures in the prediction to anti-PD-1 and anti-PD-L1 monotherapy from our study provides preliminary evidence on the feasibility of anti-PD-1 and anti-PD-L1 combination therapy for advanced NSCLC patients. | Liliang Xia Hui Wang Mingjiao Sun Yi Yang Chengcheng Yao Sheng He Huangqi Duan Weimin Xia Ruiming Sun Yaxian Yao Zhiwei Chen Qiong Zhao Hong Li Shun Lu Ying Wang | 2021 | Science China(Life Sciences)2021，64，10： | 7 |
| 2 | Study on Quantum Trust Model Based on Node Trust Evaluation显示文摘Trust is the premise and foundation of secure communication,no matter in the quantum communication or classical communication.In fact,the existing quantum secure communication protocols and technologies are implicitly related to trust;or assume some trust premise in advance;or create or obtain a trust relationship.This paper studies on quantum trust model using node trust evaluation based on author’s own research achievements.We introduce the trust management into quantum communication network to build secure trusted quantum communication network based on evaluating the trust values of nodes,which are used to evaluate the reliability of each user.We put forward a scheme of quantum trust model based on node trust evaluation,and describe the thought and process of trust evaluation in detail based on the principles of quantum entanglement and quantum teleportation.We analyze the feasibility and safety of this scheme,which provides a new thinking and method for establishing a credible secure quantum communication network. | ZHANG Shibin XIE Zhihai YIN Yifen CHANG Yan SHENG Zhiwei YAN Lili WANG Haichun HAN Guihua HUANG Yuanyuan WAN Guogen | 2017 | Chinese Journal of Electronics2017，26，3： | 5 |
| 3 | Quantum Communication Networks and Trust Management: A Survey显示文摘This paper summarizes the state of art in quantum communication networks and trust management in recent years.As in the classical networks,trust management is the premise and foundation of quantum secure communication and cannot simply be attributed to security issues,therefore the basic and importance of trust management in quantum communication networks should be taken more seriously.Compared with other theories and techniques in quantum communication,the trust of quantum communication and trust management model in quantum communication network environment is still in its initial stage.In this paper,the core technologies of establishing secure and reliable quantum communication networks are categorized and summarized,and the trends of each direction in trust management of quantum communication network are discussed in depth. | Shibin Zhang Yan Chang Lili Yan Zhiwei Sheng Fan Yang Guihua Han Yuanyuan Huang Jinyue Xia | 2019 | Computers, Materials & Continua2019，，9： | 3 |
| 4 | Poisson's ratios and S-wave velocities of the Xishancun landslide,Sichuan,China,inferred from high-frequency receiver functions of local earthquakes显示文摘Landslides are recurrent geological phenomena on Earth that cause heavy casualties and property losses annually.In this study,we use the V_(p)-k stacking and nonlinear waveform inversion methods of high-frequency receiver functions extracted from local earthquakes,to sequentially invert Poisson’s ratios and S-wave velocities of the Quaternary Xishancun landslide,which is composed of three segments,i.e.,h1,h2,and h3 from bottom to top.Our results show that Poisson’s ratio values are generally higher than 0.33 and that the S-wave velocities vary from 0.1 to 0.9 km s^(-1).High Poisson’s ratios(>0.44)are mainly distributed in the juncture regions between different segments,as well as the western edge of h2.These zones show significant variation in landslide thickness and are potentially hazardous areas.Low velocities of 0.05–0.2 km s^(-1)with thicknesses of 10–30m are widely observed in the lower layer of the landslide.The high Poisson’s ratios and low-velocity layer may be related to water-rich materials in these areas.Our study suggests that the high-frequency receiver functions from local earthquakes can be used to delineate geotechnical structures,which is valuable for landslide stability analysis and hazard mitigation. | Zigen WEI Risheng CHU Zhiwei LI Minhan SHENG Qiu ZENG | 2021 | Science China Earth Sciences2021，64，7： | 3 |
| 5 | Molecular Clump Extraction Algorithm Based on Local Density Clustering显示文摘The detection and parameterization of molecular clumps are the first step in studying them.We propose a method based on the Local Density Clustering algorithm while physical parameters of those clumps are measured using the Multiple Gaussian Model algorithm.One advantage of applying the Local Density Clustering to the clump detection and segmentation,is the high accuracy under different signal-to-noise levels.The Multiple Gaussian Model is able to deal with overlapping clumps whose parameters can reliably be derived.Using simulation and synthetic data,we have verified that the proposed algorithm could accurately characterize the morphology and flux of molecular clumps.The total flux recovery rate in 13CO(J=1-0)line of M16 is measured as 90.2%.The detection rate and the completeness limit are 81.7%and 20 K km s-1 in 13CO(J=1-0)line of M16,respectively. | Xiaoyu Luo Sheng Zheng Yao Huang Shuguang Zeng Xiangyun Zeng Zhibo Jiang Zhiwei Chen | 2022 | Research in Astronomy and Astrophysics2022，22，1： | 3 |
| 6 | Genetic algorithms on documents clustering 显示文摘 | ZHONG Sheng LIN Zhiwei ZHANG Beihai | 2008 | Journal of Computational Information Systems2008，4，3： | 1 |
| 7 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 8 | Small extracellular vesicles with nanomorphology memory promote osteogenesis显示文摘Nanotopographical cues endow biomaterials the ability to guide cell adhesion, proliferation, and differentiation. Cellular mechanical memory can maintain the cell status by retaining cellular information obtained from past mechanical microenvironments. Here, we propose a new concept “morphology memory of small extracellular vesicles (sEV)” for bone regeneration. We performed nanotopography on titanium plates through alkali and heat (Ti8) treatment to promote human mesenchymal stem cell (hMSC) differentiation. Next, we extracted the sEVs from the hMSC, which were cultured on the nanotopographical Ti plates for 21 days (Ti8-21-sEV). We demonstrated that Ti8-21-sEV had superior pro-osteogenesis ability in vitro and in vivo. RNA sequencing further confirmed that Ti8-21-sEV promote bone regeneration through osteogenic-related pathways, including the PI3K-AKT signaling pathway, MAPK signaling pathway, focal adhesion, and extracellular matrix-receptor interaction. Finally, we decorated the Ti8-21-sEV on a 3D printed porous polyetheretherketone scaffold. The femoral condyle defect model of rabbits was used to demonstrate that Ti8-21-sEV had the best bone ingrowth. In summary, our study demonstrated that the Ti8-21-sEV have memory function by copying the pro-osteogenesis information from the nanotopography. We expect that our study will encourage the discovery of other sEV with morphology memory for tissue regeneration. | Liang Ma Wencan Ke Zhiwei Liao Xiaobo Feng Jie Lei Kun Wang Bingjin Wang Gaocai Li Rongjin Luo Yunsong Shi Weifeng Zhang Yu Song Weibin Sheng Cao Yang | 2022 | Bioactive Materials2022，7，11： | 1 |
| 9 | Expert Consensus on Diagnosis and Treatment of End-Stage Liver Disease Complicated with Infections显示文摘End-stage liver disease(ESLD)is a life-threatening clinical syndrome that markedly increases mortality in patients with infections.In patients with ESLD,infections can induce or aggravate the occurrence of liver decompensation.Consequently,infections are among the most common complications of disease progression.There is a lack of working procedure for early diagnosis and appropriate management for patients with ESLD complicated by infections as well as local and international guidelines or consensus.This consensus assembled up-to-date knowledge and experience across Chinese colleagues,providing data on principles as well as working procedures for the diagnosis and treatment of patients with ESLD complicated by infections. | Qin Ning Tao Chen Guiqiang Wang Dong Xu Yanyan Yu Qing Mao Taisheng Li Lanjuan Li Jun Li Xiaoju Lu Jiabin Li Zhiwei Li Wenhong Zhang Yonghong Xiao Qinghua Meng Yuqiang Mi Jia Shang Yunsong Yu Yingren Zhao Caiyan Zhao Hong Zhao Jianrong Huang Jie Peng Hong Tang Xiaoping Tang Jinhua Hu Bijie Hu Wei Guo Bo Zheng Baiyi Chen Yuexin Zhang Jia Wei Jifang Sheng Zhi Chen Minggui Wang Qing Xie Yuming Wang Fu-Sheng Wang Jinlin Hou Zhongping Duan Lai Wei Jidong Jia Chinese Society of Infectious Disease of Chinese Medical Association | 2022 | Infectious Diseases & Immunity2022，2，3： | 0 |
| 10 | Correction to: Influence of Orifice Position Deviations on Distribution Performance of Gravity-Type Liquid Distributor Analyzed Through Mathematical Pathway显示文摘Correction to:Transactions of Tianjin University https://doi.org/10.1007/s12209-017-0078-6 In the original publication of the article,the authorization or reference of Fig.1 cited for describing the installation location of liquid distributor(pink)in column wasn’t nor-matively provided.Considering that many literatures can provide information like Fig.1,and the relationship between this picture and the contents can be negligible,Fig.1 will be deleted.Meanwhile,the words“as shown in Fig.1”in the first sentence of the introduction will also be deleted. | Jinsheng Sun Zhiwei Zhang Chengtian Cui Tianpei Li Sheng Fu | 2021 | Transactions of Tianjin University2021，27，6： | 0 |
| 11 | Sequential Inverse Optimal Control of Discrete-Time Systems显示文摘This paper presents a novel sequential inverse optimal control(SIOC)method for discrete-time systems,which calculates the unknown weight vectors of the cost function in real time using the input and output of an optimally controlled discrete-time system.The proposed method overcomes the limitations of previous approaches by eliminating the need for the invertible Jacobian assumption.It calculates the possible-solution spaces and their intersections sequentially until the dimension of the intersection space decreases to one.The remaining one-dimensional vector of the possible-solution space’s intersection represents the SIOC solution.The paper presents clear conditions for convergence and addresses the issue of noisy data by clarifying the conditions for the singular values of the matrices that relate to the possible-solution space.The effectiveness of the proposed method is demonstrated through simulation results. | Sheng Cao Zhiwei Luo Changqin Quan | 2024 | IEEE/CAA Journal of Automatica Sinica2024，11，3： | 0 |
| 12 | Estimation of an Object's Physical Parameter by Force Sensors of a Dual-arm Robot显示文摘 | CAO Sheng LUO Zhiwei QUAN Changqin | 2017 | Journal of Mechanics Engineering and Automation2017，7，3： | 0 |
| 13 | Genetic Parameters of Body Length and Response to Selection for Growth Across Four Generations of Artemia sinica显示文摘To investigate the genetic components of growth in the brine shrimp Artemia sinica, we estimated the genetic parameters of body length and the response to selection using a fully pedigreed population of A. sinica. The base population was generated from four wild founder populations. We tested 4160 offspring in 360 families over four generations for growth and survival performance. Across four generations, we produced full-and half-sib families with nested mating, where two dams were mated to the same sire. Individual body length was measured for each nauplius at day 20 post-hatching. Heritability of body length was estimated across four generations with the restricted maximum likelihood method. The heritability of body length in A. sinica was low(0.14 ± 0.05), and the common environmental effect was 0.14 ± 0.02. We estimated the response to selection for body length by calculating the difference in the mean breeding values between different generations. The accumulated genetic gain in body length was 278.94 μm after three generations of selection. This low response to selection was probably caused by the low heritability of body length, small sample size, and the low selection intensity(50%). The results suggest that A. sinica selective breeding programs must be changed to generate any substantial, sustainable genetic increases in body length. We suggest that optimal genetic gains could be achieved by introducing wild strains into the nuclear breeding population to increase genetic variation, and by increasing the size of the breeding population to allow for increased selection intensity. | KONG Zhangwei KONG Jie LUAN Sheng ZHANG Zhiwei YU Chifang LUO Kun | 2019 | Journal of Ocean University of China2019，18，1： | 0 |
| 14 | Influence of Orifice Position Deviations on Distribution Performance of Gravity-Type Liquid Distributor Analyzed Through Mathematical Pathway显示文摘The distribution performance of the gravity-type liquid distributor(GTLD) significantly affects column operation efficiency and the consequent product quality. In industrial settings, maldistribution is normally considered to be caused by vertical positional or coplanarity errors stemming from deflections associated with manufacture and installation, or even by excessive weight. The lack ofestimation protocols or standards impedes the description ofthis error, which influences the corresponding outflow rates. Given this situation, the paper proposes a lumped parameter, orifice position deviation(OPD), to facilitate the calculation of the relative discharge rate error(RDRE)based on a formula derivation, which allows the systematic analysis of the influence ofa single orifice or weir OPD.The paper introduces a sensitivity factor K as a concise and unified expression in theoretical RDREs for calibrating the influence of OPD on the RDREs ofgeometrically different orifices and weirs. With respect to the GTLD, a larger K indicates the need for more strict OPD requirements. The paper verifies that the extent of GTLD outflow nonuniformity is associated with diverging tendencies regarding its morphology, especially in the orifice and weir, which can be determined using our proposed procedures. | Jinsheng Sun Zhiwei Zhang Chengtian Cui Tianpei Li Sheng Fu | 2018 | Transactions of Tianjin University2018，24，2： | 0 |
| 15 | On Energy-based Robust Passive Impedance Control of a Robot Manipulator显示文摘 | CAO Sheng LUO Zhiwei QUAN Changqin | 2017 | Journal of Mechanics Engineering and Automation2017，7，2： | 0 |
| 16 | On Observer-based Passive Robust Impedance Control of a Robot Manipulator显示文摘 | CAO Sheng LUO Zhiwei QUAN Changqin | 2017 | Journal of Mechanics Engineering and Automation2017，7，2： | 0 |
| 17 | 急性髓系白血病致癌性RNA去甲基酶FTO的小分子靶向干预研究显示文摘文章简介RNA甲基化是高等生物mRNA上最普遍的修饰,参与RNA稳定性、定位、运输、剪切等调控,在基因表达调控中发挥重要作用。2011年FTO被鉴定为m^6A修饰去甲基化酶,开辟了'表观转录'研究新方向。2017年报导急性髓系白血病(AML)高表达FTO导致下游某些mRNA上甲基化丰度降低,引起蛋白水平变化,促进AML形成。然而由于缺乏高质量的小分子工具,FTO是否可以成为抗肿瘤药物的作用靶标有待于深入确证。 | 黄悦 Rui Su Yue Sheng Lei Dong Ze Dong Hongjiao Xu Tengfeng Ni Zijie Scott Zhang Tao Zhang Chenying Li Li Han Zhenyun Zhu Fulin Lian Jiangbo Wei Qiangqiang Deng Yungui Wang Mark Wunderlich Zhiwei Gao Guoyu Pan Dafang Zhong Hu Zhou Naixia Zhang Jianhua Gan Hualiang Jiang James C.Mulloy Zhijian Qian Jianjun Chen 杨财广 | 2020 | 科学新闻2020，，2： | 0 |
| 18 | 马氏体钢中的离子辐照和LBE腐蚀协同效应显示文摘Lead bismuth eutectic(LBE)has been proposed as a core coolant for Lead-cooled Fast Reactor(LFR)due to its several advantages,low melting point,chemically inert and good natural circulation[1].However,the LFR presents a harsh environment where the core components and mainly steels will suffer not only from the irradiation damage produced by neutrons,but also from the corrosion induced by the liquid LBE.Over the past decades,the irradiation effect and corrosion mechanism of LBE in both ferritic/martensitic alloys and austenitic steels have been investigated separately by both experimental and theoretical approach.However,the synergistic effects of irradiation and LBE corrosion on structural materials have rarely been studied[2,3]. | Yao Cunfeng Wang Zhiguang Zhang Hongpeng Chang Hailong Shen Tielong Zhu Yabin Pang Lilong Cui Minghuan Wei Kongfang Sun Jianrong Sheng yanbin Ma Zhiwei Liu Chao | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 19 | Quantum Secure Direct Communication Protocol with Mutual Authentication Based on Single Photons and Bell States显示文摘Quantum secure direct communication(QSDC)can transmit secret messages directly from one user to another without first establishing a shared secret key,which is different from quantum key distribution.In this paper,we propose a novel quantum secure direct communication protocol based on signal photons and Bell states.Before the execution of the proposed protocol,two participants Alice and Bob exchange their corresponding identity IDA and IDB through quantum key distribution and keep them secret,respectively.Then the message sender,Alice,encodes each secret message bit into two single photons(|01>or|10>)or a Bell state(1|φ^(+)>=1/√2(|0>|-|1>1>)),and composes an ordered secret message sequence.To insure the security of communication,Alice also prepares the decoy photons and inserts them into secret message sequence on the basis of the values of IDA and IDB.By the secret identity IDA and IDB,both sides of the communication can check eavesdropping and identify each other.The proposed protocol not only completes secure direct communication,but also realizes the mutual authentication.The security analysis of the proposed protocol is presented in the paper.The analysis results show that this protocol is secure against some common attacks,and no secret message leaks even if the messages are broken.Compared with the two-way QSDC protocols,the presented protocol is a one-way quantum communication protocol which has the immunity to Trojan horse attack.Furthermore,our proposed protocol can be realized without quantum memory. | Lili Yan Shibin Zhang Yan Chang Zhibin Sun Zhiwei Sheng | 2020 | Computers, Materials & Continua2020，，6： | 0 |
| 20 | Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals显示文摘Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA,adenoviral vector and inactivated vaccines fail to induce.Here,we describe a candidate live attenuated vaccine strain of SARS-CoV-2 in which the NSP16 gene,which encodes 2′-O-methyltransferase,is catalytically disrupted by a point mutation.This virus,designated d16,was severely attenuated in hamsters and transgenic mice,causing only asymptomatic and nonpathogenic infection.A single dose of d16 administered intranasally resulted in sterilizing immunity in both the upper and lower respiratory tracts of hamsters,thus preventing viral spread in a contact-based transmission model.It also robustly stimulated humoral and cell-mediated immune responses,thus conferring full protection against lethal challenge with SARS-CoV-2 in a transgenic mouse model.The neutralizing antibodies elicited by d16 effectively cross-reacted with several SARS-CoV-2 variants.Secretory immunoglobulin A was detected in the blood and nasal wash of vaccinated mice.Our work provides proof-of-principle evidence for harnessing NSP16-deficient SARS-CoV-2 for the development of live attenuated vaccines and paves the way for further preclinical studies of d16 as a prototypic vaccine strain,to which new features might be introduced to improve safety,transmissibility,immunogenicity and efficacy. | Zi-Wei Ye Chon Phin Ong Kaiming Tang Yilan Fan Cuiting Luo Runhong Zhou Peng Luo Yun Cheng Victor Sebastien Gray Pui Wang Hin Chu Jasper Fuk-Woo Chan Kelvin Kai-Wang To Honglin Chen Zhiwei Chen Kwok-Yung Yuen Guang Sheng Ling Shuofeng Yuan Dong-Yan Jin | 2022 | Cellular & Molecular Immunology2022，19，5： | 0 |
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